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Oocyte Aging: The Role of Cellular and Environmental Factors and Impact on Female Fertility

  • Toka A. Ahmed
  • Sara M. Ahmed
  • Zaynab El-Gammal
  • Shaimaa Shouman
  • Ashrakat Ahmed
  • Ragaa Mansour
  • Nagwa El-BadriEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series

Abstract

Female aging is one of the most important factors that impacts human reproduction. With aging, there is a natural decline in female fertility. The decrease in fertility is slow and steady in women aged 30–35 years; however, this decline is accelerated after the age of 35 due to decreases in the ovarian reserve and oocyte quality. Human oocyte aging is affected by different environmental factors, such as dietary habits and lifestyle. The ovarian microenvironment contributes to oocyte aging and longevity. The immediate oocyte microenvironment consists of the surrounding cells. Crosstalk between the oocyte and microenvironment is mediated by direct contact with surrounding cells, the extracellular matrix, and signalling molecules, including hormones, growth factors, and metabolic products. In this review, we highlight the different microenvironmental factors that accelerate human oocyte aging and decrease oocyte function. The ovarian microenvironment and the stress that is induced by environmental pollutants and a poor diet, along with other factors, impact oocyte quality and function and contribute to accelerated oocyte aging and diseases of infertility.

Graphical Abstract

Keywords

Aging and longevity Human Microenvironment Oocytes 

Abbreviations

AGEs

Advanced glycation end products

AKT

Protein kinase B

BCL2

B-cell lymphoma-2

CaMKII

Calmodulin-dependent protein kinase II

CAT

Catalase

CCs

Cumulus cells

cGMP

Cyclic guanosine monophosphate

COC

Cumulus-oocyte complex

COIII

Cytochrome oxidase subunit 3

CoQ10

Coenzyme Q10

Cx-43

Connexin 43

EGF

Epidermal growth factor

EGFR

EGF receptor

FADD

Fas-Associated protein with a Death Domain

FAS

Free α-subunit

FasL

Fas/Fas ligand

FoxO

Forkhead box O

FSH

Follicle-stimulating hormone

GCs

Granulosa cells

GnRH

Gonadotropin-releasing hormone

GSSPx

Glutathione peroxidase

GST

Glutathione S transferase

GTP

Guanosine triphosphate

HMGA2

High-mobility group AT-hook 2

HPG axis

Hypothalamic-pituitary-gonadal axis

IKBKG

Inhibitor nuclear factor kappa B kinase subunit gamma

IR

Insulin resistance

IVF

In vitro fertilization

LH

Luteinising hormone

LINE-1

Long interspersed element

MAPKs

Mitogen-activated protein kinases

MII

Meiotic metaphase II

MnSOD

Mitochondrial SOD

MPF

Maturation-promoting factor

mtDNA

Mitochondrial DNA

NAC

N-acetyl-L-cysteine

NAD+

Nicotinamide adenine dinucleotide

NF-κB

Nuclear factor kappa B

ORFs

Open reading frame

PCOS

Polycystic ovary syndrome

PDE3A

Phosphodiesterase 3A

PGC-1 α

Proliferator-activated receptor coactivator-1α

PGCs

Primordial germ cells

PI3K

Phosphatidylinositol 3-kinase

PTEN

Phosphatase and tensin homolog

RAB5B

Ras-related protein Rab-5B

RAGE

Receptor for advanced glycation end products

ROS

Reactive oxygen species

SDHA

Subunit A of succinate dehydrogenase

sFasL

Soluble fasl

SIRT1

Silent information regulator-1

SOD1

Superoxide dismutase

Notes

Acknowledgement

This work was supported by grant # 5300 from the Science and Technology. Development Fund.

Financial Disclosure

The authors report no financial conflicts to disclose.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Toka A. Ahmed
    • 1
  • Sara M. Ahmed
    • 1
  • Zaynab El-Gammal
    • 1
  • Shaimaa Shouman
    • 1
  • Ashrakat Ahmed
    • 1
  • Ragaa Mansour
    • 2
  • Nagwa El-Badri
    • 1
    Email author
  1. 1.Center of excellence for stem cells and Regenerative MedicineZewail City of Science and TechnologyGizaEgypt
  2. 2.The Egyptian IVF-ET CenterCairoEgypt

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