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Regenerative Medicine: Injectable Cell-Based Therapeutics and Approved Products

  • Ali GolchinEmail author
  • Forough Shams
  • Parisa Kangari
  • Arezoo Azari
  • Simzar Hosseinzadeh
Chapter
Part of the Advances in Experimental Medicine and Biology book series

Abstract

Cellular-based therapies have drawn a great deal of attention thanks to their regenerative medicine approaches to treat incurable diseases and specific injuries. In this regard, injectable cell delivery systems could actualize the therapeutically beneficial outcomes of cell-based therapeutic products. These systems have found considerable clinical uses. Hence, the recent studies have focused on developing injectable bio-constructs to protect transplanted cells during delivery and stimulating endogenous regeneration through interactions of these cells and host tissue. This paper introduces a framework, as a general concept, to improve cell delivery systems for cell-based therapeutic products. Studies on stable injectable carriers can enhance cell homing, proliferation, viability, dressing of irregular shape of target sites, and subsequently support transplanted cell functionality. However, more studies should be conducted on new technologies for the injectable cell-based product for cell delivery and the clinical applications.

Keywords

Cellular therapy Injectable product Regenerative medicine 

Abbreviations

CAR-T cell

Chimeric antigen receptor T cells

CBER

Center for Biologics Evaluation and Research

CT

Cell-based therapy

DMEM

Dulbecco’s Modified Eagle ́s Medium

FDA

U.S. food and drug administration

GvHD

Graft versus host disease

MSCs

Mesenchymal Stem Cells

OTAT

Tissues and Advanced Therapies

RG

Regenerative medicine

Notes

Acknowledgement

This study is related to the project NO. 1397/69252 From Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. We also appreciate the “Student Research Committee” and “Research & Technology Chancellor” in Shahid Beheshti University of Medical Sciences for their financial support of this study.

Author Contributions

A.G. conceptualized the outline and contents of the article. All authors contributed to writing and editing the manuscript. S.H. had an advisory role.

Conflict of Interest

Authors don’t have conflict of interest.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ali Golchin
    • 1
    Email author
  • Forough Shams
    • 2
  • Parisa Kangari
    • 3
  • Arezoo Azari
    • 4
  • Simzar Hosseinzadeh
    • 4
  1. 1.Student Research Committee, Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of Biotechnology, School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in MedicineShiraz University of Medical SciencesShirazIran
  4. 4.Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehranIran

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