Skin Stem Cells, Their Niche and Tissue Engineering Approach for Skin Regeneration

  • Nur Kübra Çankirili
  • Ozlem Altundag
  • Betül Çelebi-SaltikEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1212)


Skin is the main organ that covers the human body and acts as a protective barrier between the human body and the environment. Skin tissue as a stem cell source can be used for transplantation in therapeutic application in terms of its properties such as abundant, easy to access, high plasticity and high ability to regenerate. The immunological profile of these cells makes it a suitable resource for autologous and allogeneic applications. The lack of major histo-compatibility complex 1 is also advantageous in its use. Epidermal stem cells are the main stem cells in the skin and are suitable cells in tissue engineering studies for their important role in wound repair. In the last 30 years, many studies have been conducted to develop substitutions that mimic human skin. Stem cell-based skin substitutions have been developed to be used in clinical applications, to support the healing of acute and chronic wounds and as test systems for dermatological and pharmacological applications. In this chapter, tissue specific properties of epidermal stem cells, composition of their niche, regenerative approaches and repair of tissue degeneration have been examined.


Epidermal stem cells Niche Skin Stem cells Tissue engineering 



Three dimensional


All-Trans Retinoic Acid


Basement Membrane


Bone Marrow Mesenchymal Stem Cell


Bone Morphogenic Protein


Cluster of Differentiation


Deoxyribonucleic acid


Dermal Papilla


Extracellular matrix


Epidermolysis Bullosa


Epidermal Growth Factor


Epidermal Proliferative Unit


Food and Drug Administration


Fibroblast Growth Factor




Human Adipose Tissue Derived Stem/Stromal Cells


Hair Follicle Bulge


Interfollicular Epidermis


Inner Root Sheath




Messenger RNA




Matrix Metalloproteinase


Multilineage Differentiating Stress Enduring


Outer Root Sheath




Rough Endoplasmic Reticulum


Ribonucleic acid


Sonic Hedgehog


Stage-Spesific Embryonic Antigen


Transforming Growth Factor-beta


Umbilical cord pericyte cell


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nur Kübra Çankirili
    • 1
    • 2
  • Ozlem Altundag
    • 1
    • 2
  • Betül Çelebi-Saltik
    • 1
    • 2
    Email author
  1. 1.Department of Stem Cell SciencesHacettepe University Graduate School of Health SciencesAnkaraTurkey
  2. 2.Center for Stem Cell Research and DevelopmentHacettepe UniversityAnkaraTurkey

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