Decellularization Concept in Regenerative Medicine

  • Özge Sezin SomuncuEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1212)


Decellularized organs and tissues are effectively utilized in a diversity of regenerative medicine purposes, and the decellularization approaches employed differ as broadly as the tissues/organs of concern. Biological scaffold substances formed by extracellular matrix (ECM) are mostly produced with methods that include decellularization of tissues. Conservation of the multifaceted arrangement and three-dimensional (3D) construction of the ECM is very wanted but it is documented that almost every approach of decellularization cause disturbance of the organization and possible forfeiture of surface organization and conformation. The competence of cell elimination from a tissue is reliant on the basis of the tissue and the precise physical, chemical, and enzymatic approaches that are utilized. Here, the most frequently applied and newly developed decellularization techniques are designated, organ engineering with decellularized scaffolds for different organs, recent knowledge in the field are explained.


Decellularization Regenerative medicine Recellularization Tissue engineering 



Three dimensional


Adipose-derived stem cells


Secretoglobin Family 1A


Clara cell secretory protein

CD 31

Cluster of differentiation 31


Keratin 18


Extracellular matrix


Embryonic stem cells


Forkhead box protein J1






Mouse insulinoma 6


Nano gram


NK2 Homeobox 1


Phosphate buffered saline


Platelet derived growth factor receptor


Alveolar type 2 cell marker


Sodium dodecyl sulfate


Pulmonary-associated surfactant protein C


Tumor necrosis factor


Transcription termination factor 1


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Medical BiologyBahçeşehir University Faculty of MedicineİstanbulTurkey

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