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Influence of Sleep-Disordered Breathing on Quality of Life and Exercise Capacity in Lung Transplant Recipients

  • Frederike Kruse
  • Bjoern E. Kleibrink
  • Thomas Rabis
  • Yi Wang
  • Gerhard Weinreich
  • Markus Kamler
  • Christian Taube
  • Kurt Rasche
  • Urte SommerwerckEmail author
Part of the Advances in Experimental Medicine and Biology book series


The prevalence of sleep-disordered breathing (SDB) after lung transplantation (LTX) is high. It is well-established that SDB is associated with decreased health-related quality of life (HRQoL), but the impact of SDB on exercise capacity is less clear. In this study we investigated HRQoL and exercise capacity in LTX recipients with or without SDB. In addition, we also investigated associations between sleep parameters and both HRQoL and exercise capacity. There were 53 stable LTX recipients (age > 18 years, 31 males, time from LTX 9–120 months) enrolled into the study. They all underwent polysomnography examination. HRQoL was assessed using the Short Form-36 (SF-36). Exercise capacity was measured using the 6-min walk test and cardiopulmonary exercise testing (CPET). We found inverse correlations between severity of SDB and both the predicted maximal workload (r = 0.24, p = 0.04) and maximal oxygen uptake (r = −0.26, p = 0.03) during CPET. Relative oxygen uptake positively correlated with sleep efficiency (r = 0.27, p = 0.03). SF-36 scores did not differ between patients with and without SDB, and were not significantly associated with SDB parameters. In conclusion, the presence of SDB is associated with a slight reduction in maximal exercise capacity in LTX recipients, and there is no appreciable relationship between SDB and HRQoL.


Cardiopulmonary exercise testing Disordered breathing Exercise capacity Lung transplantation Quality of life Sleep 



We acknowledge the English language editing assistance provided by Nicola Ryan, an independent medical writer.

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of the Medical Faculty of the University of Duisburg-Essen.

Informed Consent

Written informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Frederike Kruse
    • 1
  • Bjoern E. Kleibrink
    • 1
  • Thomas Rabis
    • 1
  • Yi Wang
    • 1
  • Gerhard Weinreich
    • 1
  • Markus Kamler
    • 2
  • Christian Taube
    • 1
  • Kurt Rasche
    • 3
  • Urte Sommerwerck
    • 1
    • 3
    Email author
  1. 1.Department of Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital EssenUniversity Duisburg-EssenDuisburgGermany
  2. 2.Department of Thoracic Transplantation, University Hospital EssenUniversity Duisburg-EssenDuisburgGermany
  3. 3.Bergisches Lungenzentrum, Department of Pneumology, Allergology, Sleep and Respiratory Medicine, Helios University Hospital WuppertalUniversity Witten-HerdeckeWuppertalGermany

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