Shaping Microbiota During the First 1000 Days of Life

  • Marta Selma-Royo
  • Maria Tarrazó
  • Izaskun García-Mantrana
  • Carlos Gómez-Gallego
  • Seppo Salminen
  • Maria Carmen ColladoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1125)


The data obtained in prior studies suggest that early microbial exposition begins prior to conception and gestation. Given that the host-microbe interaction is shaped by the immune system response, it is important to understand the key immune system-microbiota relationship during the period from conception to the first years of life. The present work summarizes the available evidence concerning early microbiota exposure within the male and the female reproductive tracts at the point of conception and during gestation, focusing on the potential impact on infant development during the first 1000 days of life. Furthermore, we conclude that some dietary strategies including specific probiotics could become potentially valuable tools to modulate the gut microbiota during this early critical window of opportunity for targeted health outcomes throughout the entire lifespan.


Diet Gestation Health Meconium Microbiota Placenta Probiotics Semen Vagina 



Authors would like to acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (ERC Starting Grant, project no. 639226). MSR would acknowledge the support from ACIF program of Generalitat Valenciana with European Social Fund (ESF).

Conflicts of Interest

The authors declare that there are no conflicts of interest associated with the publication of this paper.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Marta Selma-Royo
    • 1
  • Maria Tarrazó
    • 2
  • Izaskun García-Mantrana
    • 1
  • Carlos Gómez-Gallego
    • 3
    • 4
  • Seppo Salminen
    • 3
  • Maria Carmen Collado
    • 1
    • 3
    Email author
  1. 1.Department of BiotechnologyInstitute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC)ValenciaSpain
  2. 2.Service of Obstetrics and GynecologyHospital Universtario Doctor PesetValenciaSpain
  3. 3.Functional Foods ForumUniversity of TurkuTurkuFinland
  4. 4.Institute of Public Health and Clinical NutritionUniversity of Eastern FinlandKuopioFinland

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