Dental Stem Cells and Tooth Regeneration
Dental stem cells are a minor population of mesenchymal stem cells existing in specialized dental tissues, such as dental pulp, periodontium, apical papilla, dental follicle and so forth. Standard methods have been established to isolate and identify these stem cells. Due to their differentiation potential, these mesenchymal stem cells are promising for tooth repair. Dental stem cells have been emerging to regenerated teeth and periodontal tissues, ascribe to their self-renewal, multipotency and tissue specific differentiation potential. Therefore, dental stem cells based regeneration medicine highlights a promising access to repair damaged dental tissues or generate new teeth. In this review, we provide an overview of human dental stem cells including isolation and identification, involved pathways and outcomes of regenerative researches. A number of basic researches, preclinical studies and clinical trials have investigated that dental stem cells efficiently improve formation of dental specialized structure and healing of periodontal diseases, suggesting a great feasibility and prospect of these approaches in translational medicine of dental regeneration.
KeywordsDental stem cells Mesenchymal stem cells Tooth regeneration
base fibroblast growth factor
bone marrow mesenchymal stem cells
bone morphogenetic protein 2
dental follicle cells
dentin matrix protein1
dentin noncollagenous proteins
dental pulp stem cells
enamel matrix derivate
general control nonrepressed protein 5
granulocyte colony-stimulating factor
guided tissue regeneration
hydroxy apatite/tricalcium phosphate
intercellular adhesion molecule 1
insulin-like growth factor-1
induced pluripotent stem cells
mitogen-activated protein kinase
matrix extracellular phosphoglycoprotein
periodontal ligament stem cells
platelet rich plasma
stem cells from apical papilla
stem cells of human exfoliated deciduous teeth
treated dentin matrix; GMP: Good Manufacturing Practice.
telomerase reverse transcriptase
tumor necrosis factor-α
This work was financially supported by grants from the Nature Science Foundation of China (81620108007) and the National Natural Science Foundation of China (31571532).
All the authors declare that they have no competing interests.
- Bakopoulou A, Leyhausen G, Volk J, Tsiftsoglou A, Garefis P, Koidis P et al (2011) Comparative analysis of in vitro osteo/odontogenic differentiation potential of human dental pulp stem cells (DPSCs) and stem cells from the apical papilla (SCAP). Arch Oral Biol 56(7):709–721CrossRefPubMedGoogle Scholar
- Needleman IG, Worthington HV, Giedrys-Leeper E, Tucker RJ (2006) Guided tissue regeneration for periodontal infra-bony defects. Cochrane Database Syst Rev 2:CD001724Google Scholar
- Prescott RS, Alsanea R, Fayad MI, Johnson BR, Wenckus CS, Hao J et al (2008) In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice. J Endod 34(4):421–426CrossRefPubMedPubMedCentralGoogle Scholar
- Sun J, Li J, Li H, Yang H, Chen J, Yang B et al (2017b) tBHQ suppresses osteoclastic resorption in xenogeneic-treated dentin matrix-based scaffolds. Adv Healthc Mater 6(18)Google Scholar