Dental Stem Cells and Tooth Regeneration

  • Yi Shuai
  • Yang Ma
  • Tao Guo
  • Liqiang Zhang
  • Rui Yang
  • Meng Qi
  • Wenjia LiuEmail author
  • Yan JinEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1107)


Dental stem cells are a minor population of mesenchymal stem cells existing in specialized dental tissues, such as dental pulp, periodontium, apical papilla, dental follicle and so forth. Standard methods have been established to isolate and identify these stem cells. Due to their differentiation potential, these mesenchymal stem cells are promising for tooth repair. Dental stem cells have been emerging to regenerated teeth and periodontal tissues, ascribe to their self-renewal, multipotency and tissue specific differentiation potential. Therefore, dental stem cells based regeneration medicine highlights a promising access to repair damaged dental tissues or generate new teeth. In this review, we provide an overview of human dental stem cells including isolation and identification, involved pathways and outcomes of regenerative researches. A number of basic researches, preclinical studies and clinical trials have investigated that dental stem cells efficiently improve formation of dental specialized structure and healing of periodontal diseases, suggesting a great feasibility and prospect of these approaches in translational medicine of dental regeneration.


Dental stem cells Mesenchymal stem cells Tooth regeneration 





alkaline phosphatase


base fibroblast growth factor


bone marrow mesenchymal stem cells


bone morphogenetic protein 2


bone sialoprotein


dental follicle cells


Dickkopf 1


dentin matrix protein1


dentin noncollagenous proteins


dental pulp stem cells


extracellular matrix


enamel matrix derivate


general control nonrepressed protein 5


granulocyte colony-stimulating factor


guided tissue regeneration


hydroxy apatite/tricalcium phosphate


intercellular adhesion molecule 1


insulin-like growth factor-1


induced pluripotent stem cells


integrin b1




mitogen-activated protein kinase


matrix extracellular phosphoglycoprotein




periodontal ligament


periodontal ligament stem cells


platelet rich plasma


stem cells from apical papilla


stem cells of human exfoliated deciduous teeth


treated dentin matrix; GMP: Good Manufacturing Practice.


telomerase reverse transcriptase


tumor necrosis factor-α



This work was financially supported by grants from the Nature Science Foundation of China (81620108007) and the National Natural Science Foundation of China (31571532).


All the authors declare that they have no competing interests.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of StomatologyNanjing General Hospital of Nanjing Military CommandNanjingPeople’s Republic of China
  2. 2.State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral DiseasesCenter for Tissue Engineering, School of Stomatology, Fourth Military Medical UniversityXi’anPeople’s Republic of China
  3. 3.Xi’an Institute of Tissue Engineering and Regenerative MedicineXi’anPeople’s Republic of China
  4. 4.Research and Development Center for Tissue EngineeringFourth Military Medical UniversityXi’an,People’s Republic of China
  5. 5.Shanghai BYBO Dental HospitalShanghaiPeople’s Republic of China
  6. 6.Department of StomatologyPLA Army General HospitalBeijingPeople’s Republic of China

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