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Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration

  • Parisa Goodarzi
  • Bagher Larijani
  • Sepideh Alavi-Moghadam
  • Akram Tayanloo-Beik
  • Fereshteh Mohamadi-Jahani
  • Negar Ranjbaran
  • Moloud Payab
  • Khadijeh Falahzadeh
  • Maryamsadat Mousavi
  • Babak ArjmandEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1119)

Abstract

Wound healing is a complex process with the considerable burden on healthcare system. There are several cellular therapy methods that have been introduced to treat different types of wounds. Despite the advantages of cellular therapy, it is needed to overcome different limitations of this method such as; tumorigenicity and immune rejection. Accordingly, scientists have suggested cell-based vesicles and exosomes. Exosomes can promote proliferation, migration, and angiogenesis process in the wound environment. They have also some advantages such as the potential for drug and gene delivery, easy to storage, and stability in the body. These advantages make them as a novel approach in regenerative medicine without the limitations of cellular therapy. In this review, the authors emphasize on biological properties of MSC-exosomes and their therapeutic effects as a new strategy for wound regeneration.

Keywords

Exosomes Mesenchymal stromal cells Regenerative medicine Transport vesicles Wound healing 

Abbreviations

ANGPT1

Angiopoietin 1

ASCs

Adipose-derived stem cells

BBB

Blood-Brain Barrier

BM-MSCs

Bone marrow-derived mesenchymal stem cells

CHA

Composite collagen–hydroxyapatite

ECM

Extra-cellular matrix

DFU

Diabetic foot ulcers

EGF

Epidermal growth factor

EVs

Extra-cellular vesicles

FDA

Food and Drug Administration

FGF 2

Fibroblast growth factor 2

IGF-1

Insulin growth factor 1

IL-1

Interlukin 1

IL-6

Interlukin 6

iPS

Induced pluripotent stem cells

MSCs

Mesenchymal stem cells

PDGF

Platelet-derived growth factor

STAT3

Signal transducer and activator of transcription 3

TGF-β1

Transforming growth factor beta 1

TNF-α

Tumor necrosis factor-alpha

UCB-MSCs

Umbilical cord blood mesenchymal stem cells

VEGF

Vascular endothelial growth factor

MSC Exo

Mesenchymal stem cells-derived exosomes

HGF

Hepatocyte growth factor

IGF-1

Insulin-like growth factor 1

SDF-1

Stromal cell-derived factor 1

Notes

Acknowledgement

The authors would like to acknowledge Dr. Mohsen khorshidi, Firooze Hajipour, Rasta Arjmand, and Maryam Afshari for their kind support.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Parisa Goodarzi
    • 1
  • Bagher Larijani
    • 2
  • Sepideh Alavi-Moghadam
    • 3
  • Akram Tayanloo-Beik
    • 3
  • Fereshteh Mohamadi-Jahani
    • 1
  • Negar Ranjbaran
    • 3
  • Moloud Payab
    • 4
  • Khadijeh Falahzadeh
    • 5
  • Maryamsadat Mousavi
    • 5
  • Babak Arjmand
    • 3
    • 5
    Email author
  1. 1.Brain and Spinal Cord Injury Research Center, Neuroscience InstituteTehran University of Medical SciencesTehranIran
  2. 2.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran
  3. 3.Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  4. 4.Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  5. 5.Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran

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