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The Great Harmony in Translational Medicine: Biomaterials and Stem Cells

  • Evren Erten
  • Yavuz Emre ArslanEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1119)

Abstract

Thanks to novel approaches and emerging technologies, tissue engineering and regenerative medicine have made a great effort to regenerate damaged tissue or organ with no donor needed. The approaches involve two fundamental components: bioengineered scaffolds and stem cells. Bioengineered scaffolds which can also be enriched with bioactive molecules such as cytokines, growth factors, and so on have been fabricated using a wide range of synthetically or naturally derived biodegradable and biocompatible polymers. These scaffolds should support cell attachment, migration, proliferation, and/or differentiation by mimicking the duty of native extracellular matrix. Stem cells are the other significant players in formation of the neotissue. Stem cells, bone marrow, or adipose-derived mesenchymal stem cells, in particular, have been widely used for this purpose. Recently, investigators have preferred to use progenitor cells including cardiac and neural cells in tissue engineering and regenerative medicine applications. The synergy of the bioengineered scaffolds and autologous stem cells is crucial for the successful reconstruction of damaged or missing tissues.

This review summarizes a number of excellent studies conducted on current applications of bioengineered scaffolds, novel fabrication methods, stem cells used in tissue engineering and regenerative medicine, and the future of the tissue-engineered products.

Keywords

Stem cells Bioengineered scaffolds Industry Translational medicine Regenerative therapy Tissue engineering 

Abbreviations

3D

Three-dimensional

AMSCs

Adipose-derived mesenchymal stem cells

CSCs

Cardiac stem cells

ECM

Extracellular matrix

ECSs

Embryonic stem cells

FDA

Food and Drug Administration

FDM

Fused deposition modeling

hAMSCs

Human adipose-derived mesenchymal stem cells

HUVECs

Human umbilical vein endothelial cells

iPSCs

Induced pluripotent stem cells

MSCs

Mesenchymal stem cells

NCSs

Neural stem cells

NPCs

Neural progenitor cells

PFP

Powder-fusion printing

SCI

Spinal cord injury

SLA

Stereolithographic Apparatus

Notes

Acknowledgments

The authors would like to thank Prof. Kaan C. Emregul for his comments and language proofreading.

Conflict of Interest

The authors declare that they have no conflict of interest.

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Regenerative Biomaterials Laboratory, Department of Bioengineering, Engineering FacultyCanakkale Onsekiz Mart UniversityCanakkaleTurkey

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