Regenerative Medicine Applications of Mesenchymal Stem Cells

  • Samaneh Hosseini
  • Leila Taghiyar
  • Fatemeh Safari
  • Mohamadreza Baghaban EslaminejadEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1089)


A major research challenge is to develop therapeutics that assist with healing damaged tissues and organs because the human body has limited ability to restore the majority of these tissues and organs to their original state. Tissue engineering (TE) and regenerative medicine (RM) promises to offer efficient therapeutic biological strategies that use mesenchymal stem cells (MSCs). MSCs possess the capability for self-renewal, multilineage differentiation, and immunomodulatory properties that make them attractive for clinical applications. They have been extensively investigated in numerous preclinical and clinical settings in an attempt to overcome their challenges and promote tissue regeneration and repair. This review explores the exciting opportunities afforded by MSCs, their desirable properties as cellular therapeutics in RM, and implicates their potential use in clinical practice. Here, we attempt to identify challenges and issues that determine the clinical efficacy of MSCs as treatment for skeletal and non-skeletal tissues.


Mesenchymal stem cells Regenerative medicine Clinical setting Skeletal tissues Non-skeletal tissues 



Acute kidney injury


Amyotrophic lateral sclerosis


Autologous bone grafts


Autologous chondrocyte implantation


Bone marrow


Bone marrow mononuclear cells


Bone marrow transplantation


Cardiac progenitor cells


C-C chemokine receptor type


Chronic kidney disease


C-X-C chemokine receptor type


Dilated cardiomyopathy


Duchenne muscular dystrophy


Embryonic stem cells


Endothelial progenitor cells


Extracellular matrix


Full-thickness skin wounds


Graft versus host disease


Green fluorescence protein


Heart failure


Hematopoietic cell E-/L-selectin ligand


Hepatocyte growth factor


human adipose derived-MSCs




induced pluripotent stem cells


Insulin-like growth factor 1


International Society for Cellular Therapy








Major histocompatibility complex


Mesenchymal stem cells




MSCs-conditioned medium


Multiple sclerosis


Myocardial infarction


National Institute of Health


New York Heart Association


Nitric oxide




Osteogenesis imperfecta


Platelet-derived growth factor


Pluripotent stem cells




Proximal tubule epithelial cells


Regenerative medicine


Satellite cells


Sinusoidal endothelial cells


Stromal derived factor-1


Tibialis anterior


Tissue engineering


Transforming growth factor-beta


Umbilical cord


Vascular cell adhesion molecule 1


Vascular endothelial growth factor


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Samaneh Hosseini
    • 1
  • Leila Taghiyar
    • 1
  • Fatemeh Safari
    • 2
  • Mohamadreza Baghaban Eslaminejad
    • 1
    Email author
  1. 1.Department of Stem Cells and Developmental Biology, Cell Science Research CenterRoyan Institute for Stem Cell Biology and Technology, ACECRTehranIran
  2. 2.Bone Biology & Orthopaedic Research, Department for BioMedical ResearchUniversity of BernBernSwitzerland

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