Transplantation and Alternatives to Treat Autoimmune Diseases

  • Pravin Shende
  • Bernice Rodrigues
  • R. S. Gaud
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1089)


Transplantation is considered as one of the methods for the treatment of autoimmune diseases. There are different sorts of transplantation which improved the situation for the cure of different kinds of autoimmune diseases. Cord blood transplantation is favored over other transplant techniques. The propelled treatments incorporate interferon administrative elements and mesenchymal stromal cells for the management of immune system issue particularly in the treatment of rheumatoid joint inflammation. According to the studies conducted, it was proven that cord blood/UC mesenchymal cells along with DMARDs, without consistent organization expanded the level of administrative regulatory T-cells of the peripheral blood which might be a protected and huge technique for the treatment of patients experiencing rheumatoid joint inflammation. This review article focusses on different organ transplantation and alternative methods to treat autoimmune condition like rheumatoid arthritis. Using 3D printing and artificial intelligence are some of the recent trends that may be used for the management of autoimmune diseases.


Stem cells Mesenchymal stromal cells Rheumatoid arthritis Transplantation 



Disease-Modifying Antirheumatic Drugs


Umbilical Cord


Mesenchymal Stromal Cells


Rheumatoid Arthritis


Stem Cells


Hematopoietic Stem Cells


Graft Versus Host Disease


Red Blood Cells


Interferon Regulatory Factors


Human Leukocyte Antigen


Fibroblast-like synoviocytes


T helper 1


Inter-leukin18 Binding Protein


Tumor Necrosis Factor alpha


Nuclear Factor kappa-light-chain-enhancer of activated B cells


c-Jun N-terminal kinase


Anticitrullinated protein antibodies


European Group Against Ailment


Disease Activity Scores


Umbilical Cord-derived MSC


National Organ Transplant Act


Organ Procurement and Transplantation Network


Patient Self-Determination Act


Sozialgesetzbuch Fünftes Buch


German Transplantation Law


Zonal Transplant Coordination Center


Artificial Neural Network


Embryonic Stem Cells


small interfering Ribonucleic Acid


No Objection Certificate


Non-Governmental Organization


3 Dimensional


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Shobhaben Pratapbhai Patel School of Pharmacy and Technology ManagementSVKM’S NMIMSMumbaiIndia

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