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Transplantation and Alternatives to Treat Autoimmune Diseases

  • Pravin Shende
  • Bernice Rodrigues
  • R. S. Gaud
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1089)

Abstract

Transplantation is considered as one of the methods for the treatment of autoimmune diseases. There are different sorts of transplantation which improved the situation for the cure of different kinds of autoimmune diseases. Cord blood transplantation is favored over other transplant techniques. The propelled treatments incorporate interferon administrative elements and mesenchymal stromal cells for the management of immune system issue particularly in the treatment of rheumatoid joint inflammation. According to the studies conducted, it was proven that cord blood/UC mesenchymal cells along with DMARDs, without consistent organization expanded the level of administrative regulatory T-cells of the peripheral blood which might be a protected and huge technique for the treatment of patients experiencing rheumatoid joint inflammation. This review article focusses on different organ transplantation and alternative methods to treat autoimmune condition like rheumatoid arthritis. Using 3D printing and artificial intelligence are some of the recent trends that may be used for the management of autoimmune diseases.

Keywords

Stem cells Mesenchymal stromal cells Rheumatoid arthritis Transplantation 

Abbreviations

DMARDs

Disease-Modifying Antirheumatic Drugs

UC

Umbilical Cord

MSCs

Mesenchymal Stromal Cells

RA

Rheumatoid Arthritis

SCs

Stem Cells

HSCs

Hematopoietic Stem Cells

GVHD

Graft Versus Host Disease

RBCs

Red Blood Cells

IRFs

Interferon Regulatory Factors

HLA

Human Leukocyte Antigen

FLSs

Fibroblast-like synoviocytes

TH1

T helper 1

IL-18BP

Inter-leukin18 Binding Protein

TNFα-

Tumor Necrosis Factor alpha

NFKB

Nuclear Factor kappa-light-chain-enhancer of activated B cells

cJUN

c-Jun N-terminal kinase

ACPAs

Anticitrullinated protein antibodies

EULAR

European Group Against Ailment

DAS

Disease Activity Scores

UC-MSC

Umbilical Cord-derived MSC

NOTA

National Organ Transplant Act

OPTN

Organ Procurement and Transplantation Network

PSDA

Patient Self-Determination Act

SGB V

Sozialgesetzbuch Fünftes Buch

TPG

German Transplantation Law

ZTCC

Zonal Transplant Coordination Center

ANNs

Artificial Neural Network

ESCs

Embryonic Stem Cells

siRNA

small interfering Ribonucleic Acid

NOC

No Objection Certificate

NGO

Non-Governmental Organization

3D

3 Dimensional

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Shobhaben Pratapbhai Patel School of Pharmacy and Technology ManagementSVKM’S NMIMSMumbaiIndia

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