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Immunization Coverage in Children with Inflammatory Bowel Disease

  • K. Kowalska-Duplaga
  • M. Baranowska-Nowak
  • M. Nescioruk
  • M. Banasiuk
  • K. Karolewska-Bochenek
  • I. Łazowska-Przeorek
  • A. Radzikowski
  • A. BanaszkiewiczEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1113)

Abstract

Patients suffering from inflammatory bowel diseases (IBD) are at increased risk of infections, mainly due to immunosuppressive treatment. Moreover, infections may cause flares of IBD. Vaccination is the most effective way of preventing many infections. The aim of this study was to evaluate the vaccination status of Polish children with IBD. Individual immunization cards of children with IBD and healthy controls were reviewed. Demographic data such as age, sex, and IBD history, including therapy type, were collected. We enrolled 267 children into the study, including 214 children with IBD and 53 controls. None of the children had completed the full up-to-date routine childhood immunization schedule recommended in Poland. Controls were more than 4 times more likely to be vaccinated than the IBD patients, with the vaccines that enjoy the insurance reimbursed (OR 4.1, 95% CI 2.2–7.9). In conclusion, the study demonstrates a poor vaccination status in children suffering from IBD.

Keywords

Crohn’s disease Immunization Immunosuppressive treatment Inflammatory bowel disease Ulcerative colitis Vaccination 

Notes

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

References

  1. Aberra FN, Lichtenstein GR (2005) Methods to avoid infections in patients with inflammatory bowel disease. Inflamm Bowel Dis 11:685–695CrossRefGoogle Scholar
  2. Coenen S, Weyts E, Jorissen C, De Munter P, Noman M, Ballet V, Vermeire S, Van Assche G, Ferrante M (2017) Effects of education and information on vaccination behavior in patients with inflammatory bowel disease. Inflamm Bowel Dis 23:318–324CrossRefGoogle Scholar
  3. Crawford NW, Catto-Smith AG, Oliver MR, Cameron DJ, Buttery JP (2011) An Australian audit of vaccination status in children and adolescents with inflammatory bowel disease. BMC Gastroenterol 11:87CrossRefGoogle Scholar
  4. Davies HD (2016) Committee on Infectious Diseases. Infectious complications with the use of biologic response modifiers in infants and children. Pediatrics 138:e1–e21CrossRefGoogle Scholar
  5. Fleurier A, Pelatan C, Willot S, Ginies JL, Breton E, Bridoux L, Segura JF, Chaillou E, Jobert A, Darviot E, Cagnard B, Delaperriere N, Grimal I, Carre E, Wagner AC, Sylvestre E, Dabadie A (2015) Vaccination coverage of children with inflammatory bowel disease after an awareness campaign on the risk of infection. Dig Liver Dis 47:460–464CrossRefGoogle Scholar
  6. Levine A, Koletzko S, Turner D, Escher JC, Cucchiara S, de Ridder L, Kolho KL, Veres G, Russell RK, Paerregaard A, Buderus S, Greer ML, Dias JA, Veereman-Wauters G, Lionetti P, Sladek M, Martin de Carpi J, Staiano A, Ruemmele FM, Wilson DC, European Society of Pediatric Gastroenterology, Hepatology, and Nutrition (2014) ESPGHAN revised Porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents. J Pediatr Gastroenterol Nutr 58:795–806PubMedGoogle Scholar
  7. Longuet R, Willot S, Giniès JL, Pélatan C, Breton E, Segura JF, Bridoux L, Le Henaff G, Cagnard B, Jobert A, Cardonna J, Grimal I, Balençon M, Darviot E, Delaperrière N, Caldari D, Piloquet H, Dabadie A (2014) Immunization status in children with inflammatory bowel disease. Eur J Pediatr 173:603–608PubMedGoogle Scholar
  8. Nicol S, Lawrence S, Jacobson K (2017) Inadequate vaccination uptake in children receiving anti-TNF therapy for inflammatory bowel disease. Gastroenterology 64(Suppl 1):501Google Scholar
  9. Rahier JF, Magro F, Abreu C, Armuzzi A, Ben-Horin S, Chowers Y, Cottone M, de Ridder L, Doherty G, Ehehalt R, Esteve M, Katsanos K, Lees CW, Macmahon E, Moreels T, Reinisch W, Tilg H, Tremblay L, Veereman-Wauters G, Viget N, Yazdanpanah Y, Eliakim R, Colombel JF, Crohn’s E, Colitis Organisation (2014) Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis 8:443–468CrossRefGoogle Scholar
  10. Sands BE, Cuffari C, Katz J, Kugathasan S, Onken J, Vitek C, Orenstein W (2004) Guidelines for immunization in patients with inflammatory bowel disease. Inflamm Bowel Dis 10:677–692CrossRefGoogle Scholar
  11. Soon IS, de Bruyn JC, Wrobel I (2013) Immunization history of children with inflammatory bowel disease. Can J Gastroenterol 27:213–216CrossRefGoogle Scholar
  12. Wasan SK, Coukos JA, Farraye FA (2011) Vaccinating the inflammatory bowel disease patient: deficiencies in gastroenterologists knowledge. Inflamm Bowel Dis 17:2536–2540CrossRefGoogle Scholar
  13. Weersma RK, van Dullemen HM, van der Steege G, Nolte IM, Kleibeuker JH, Dijkstra G (2007) Review article: inflammatory bowel disease and genetics. Aliment Pharmacol Ther 26(Suppl 2):57–65CrossRefGoogle Scholar
  14. Yeung JH, Goodman KJ, Fedorak RN (2012) Inadequate knowledge of immunization guidelines: a missed opportunity for preventing infection in immunocompromised IBD patients. Inflamm Bowel Dis 18:34–40CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG  2018

Authors and Affiliations

  • K. Kowalska-Duplaga
    • 1
  • M. Baranowska-Nowak
    • 2
  • M. Nescioruk
    • 2
  • M. Banasiuk
    • 2
  • K. Karolewska-Bochenek
    • 2
  • I. Łazowska-Przeorek
    • 2
  • A. Radzikowski
    • 2
  • A. Banaszkiewicz
    • 2
    Email author
  1. 1.Department of Pediatrics, Gastroenterology and NutritionJagiellonian University Medical CollegeCracowPoland
  2. 2.Department of Pediatric Gastroenterology and NutritionWarsaw Medical UniversityWarsawPoland

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