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Label-Free MIP Sensors for Protein Biomarkers

  • Katharina J. Jetzschmann
  • Xiaorong Zhang
  • Aysu Yarman
  • Ulla Wollenberger
  • Frieder W. Scheller
Chapter
Part of the Springer Series on Chemical Sensors and Biosensors book series (SSSENSORS, volume 16)

Abstract

Molecularly imprinted polymers (MIPs) have been prepared mostly for low-molecular-weight biomarkers and drugs but also for a spectrum of proteins. As compared with antibodies, MIPs have higher chemical and thermal stability, and they can be regenerated for repeated measurements. Electrochemical methods dominate the read-out of MIP sensors. Many protein MIPs have been tested in artificial urine or spiked semi-synthetic plasma, and point-of-care detection of marker proteins e.g. for cardiac, cancer, Alzheimer’s disease or virus infections is the prospective aim.

In the following chapter, the preparation and analytical performance of a broad spectrum of MIP sensors for protein biomarker are presented. The examples are grouped according to the respective diseases. For the majority of biomarkers, different approaches of sensor preparation and signal read-out can be compared.

Keywords

Biomimetic sensors Electropolymerization Molecularly imprinted polymers Protein biomarkers Protein imprinting 

Notes

Acknowledgements

The authors gratefully acknowledge financial support from the Deutsche Forschungsgemeinschaft (DFG) within the framework of the German Excellence Initiative UniCat (EXC 314), ERA-Chemistry (2014, 61133) and Turkish-German University Scientific Research Projects Commission under the grant No. 2016BF0011 for financial support.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Katharina J. Jetzschmann
    • 1
  • Xiaorong Zhang
    • 1
  • Aysu Yarman
    • 1
    • 2
  • Ulla Wollenberger
    • 1
  • Frieder W. Scheller
    • 1
  1. 1.Institute for Biochemistry and BiologyUniversity of PotsdamPotsdamGermany
  2. 2.Faculty of Science, Molecular BiotechnologyTurkish-German UniversityIstanbulTurkey

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