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Graphene-Based Nanomaterials Toxicity in Fish

  • Asok K. Dasmahapatra
  • Thabitha P. S. Dasari
  • Paul B. TchounwouEmail author
Chapter
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 247)

Abstract

Due to their unique physicochemical properties, graphene-based nanoparticles (GPNs) constitute one of the most promising types of nanomaterials used in biomedical research. GPNs have been used as polymeric conduits for nerve regeneration and carriers for targeted drug delivery and in the treatment of cancer via photothermal therapy. Moreover, they have been used as tracers to study the distribution of bioactive compounds used in healthcare. Due to their extensive use, GPN released into the environment would probably pose a threat to living organisms and ultimately to human health. Their accumulation in the aquatic environment creates problems to aquatic habitats as well as to food chains. Until now the potential toxic effects of GPN are not properly understood. Despite agglomeration and long persistence in the environment, GPNs are able to cross the cellular barriers successfully, entered into the cells, and are able to interact with almost all the cellular sites including the plasma membrane, cytoplasmic organelles, and nucleus. Their interaction with DNA creates more potential threats to both the genome and epigenome. In this brief review, we focused on fish, mainly zebrafish (Danio rerio), as a potential target animal of GPN toxicity in the aquatic ecosystem.

Keywords

Agglomeration Apoptosis Aquatic environment Bioaccumulation Biomedical research Common carp Epigenome Few-layer graphene Genome Graphene nanosheets Graphene oxide Graphene quantum dots Graphene ribbons Graphene-based nanoparticles Japanese medaka fish Neurodegenerative disorders Oxidative stress Parkinson’s disease Reduced graphene oxide Reduced graphene quantum dots Single-layer graphene Sleeping disorder Toxicity Zebrafish Zebrafish embryos Zebrafish larvae 

Abbreviations

AChE

Acetylcholinesterase

AhR

Aromatic hydrocarbon receptor

AP

Acid phosphatase

BER

Base excision repair

bwGO

Base-washed graphene oxide

CAT

Catalase

cysGO

L-cysteine GO hybrids

DNA

Deoxyribonucleic acid

dpf

Days postfertilization

ERM

Embryo-rearing medium

FLG

Few-layer graphene

GO

Graphene oxide

GOBS

Graphene oxide nanosheets coated with biological secretion

GO-FITC

Graphene oxide-fluorescein isothiocyanate

GONS

Graphene oxide nanosheets

GP

Graphene

GPN

Graphene-based nanomaterials

GQD

Graphene quantum dots

GST

Glutathione s-transferase

HA

Humic acid

HCE

High choriolytic enzyme

HO

Heme oxygenase

hpf

Hours postfertilization

iNOS

Inducible nitric oxide synthase

ISV

Intersomitic vessels

LCE

Low choriolytic enzyme

LSCM

Laser scanning confocal microscope

MDA

Malondialdehyde

MFG

Multifunctional graphene

MHRA

Medicines and Healthcare Products Regulatory Agency

NGO

Nanographene oxide

NOM

Natural organic matter

NPs

Nanoparticles

O-GNRS

Oxidized graphene nanoribbons

PFOS

Perfluorooctanesulfonate

QDs

Quantum dots

rGO

Reduced graphene oxide

rGQD

Reduced graphene quantum dots

RNA-seq

RNA sequencing

RNS

Reactive nitrogen species

ROS

Reactive oxygen species

SOD

Superoxide dismutase

TEM

Transmission electron microscope

UK

United Kingdom

US FDA

United States Food and Drug Administration

VEGF

Vascular endothelial growth factor

Notes

Acknowledgments

This research was financially supported by National Institutes of Health NIMHD Grant No. G12MD007581, through the RCMI Center for Environmental Health, and by National Science Foundation #HRD-1547754 through the CREST Center for Nanotoxicity Studies at Jackson State University.

Supplementary material

462643_1_En_15_MOESM1_ESM.pptx (134 kb)
Supplementary Fig. 1 ■ (PPTX 134 kb)
462643_1_En_15_MOESM2_ESM.docx (25 kb)
Supplementary Table 1 ■ (DOCX 25 kb)

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Asok K. Dasmahapatra
    • 1
  • Thabitha P. S. Dasari
    • 1
  • Paul B. Tchounwou
    • 1
    Email author
  1. 1.Research Centers in Minority Institutions, Center for Environmental HealthJackson State UniversityJacksonUSA

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