Skip to main content

Auszug

Auf dem Hintergrund breiter klinischer Erfahrung, empirischer Forschungsergebnisse und stringenter Resultate aus der Grundlagenforschung in den letzten 15 Jahren zeichnen sich inzwischen konstruktvalide Modelle zum komplementären Bedingungsgefüge in der Entstehung und Aufrechterhaltung süchtiger Verhaltenspathologie ab. Die auf unterschiedlichen Untersuchungs- und Funktionsebenen gewonnenen Forschungsergebnisse bestätigen, dass die individuelle Vulnerabilität für eine stoffliche wie nichtstoffgebundene Abhängigkeitserkrankung gleichermaßen durch (neuro-)biologische, verhaltenspsychologische und soziale Kontextvariablen bestimmt wird. Suchtstoffspezifische und nosologieübergreifend unspezifische genetische Einflussfaktoren vor und während der Abhängigkeitsentwicklung gehören ebenso dazu wie manifestationsfördernde Umweltbedingungen der individuellen Lebensgeschichte.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • ABI-DARGHAM A, KRYSTAL JH, ANJILVEL S et al. (1998) Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123l] iomazenil. Am J Psychiatry 155: 1550–1555

    PubMed  CAS  Google Scholar 

  • AGARWAL DP, GOEDDE HW (1992) Pharmacogenetics of alcohol metabolism and alcoholism. Pharmacogenetics 2: 48–62

    Article  PubMed  CAS  Google Scholar 

  • AGGLETON, JP, MISHIN M (1986) The amygdala: sensory gateway to the emotions. In: Plutchik R, Kellermann H (eds) Emotion theory, research and experience, vol 3. Academic Press, Orlando

    Google Scholar 

  • Alexander GE, De Long MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Ann Rev Neurosci 9: 357–381

    Article  PubMed  CAS  Google Scholar 

  • Baxter LR, Phleps ME, Mazziotta JC et al. (1987) Local cerebral glucose metabolic rates in obsessive-compulsive disorder. Arch Gen Psychiatry 44: 211–218

    PubMed  Google Scholar 

  • BEGLEITER H, PORJESZ B, REICH T et al. (1998) Quantitative trait loci analysis of human event-related brain potentials: P3 voltage. Electroencephal Neurophysiol 108: 244–250

    Article  CAS  Google Scholar 

  • Benjamin J, Li L, Patterson C (1996) Population and family association between the dopamine receptor gene and novelty seeking. Nat Genet 12: 81–84

    Article  PubMed  CAS  Google Scholar 

  • Biederman J, Faraone S, Milberger S et al. (1996) Predictors of persistence and remission of ADHD into adolescence: results from a four-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry 35: 343–351

    Article  PubMed  CAS  Google Scholar 

  • Biederman J, Wilens TE, Mick E et al. (1998) Does attention-deficit hyperactivity disorder impact the developmental course of drug and alcohol abuse and dependence? Biol Psychiatry 44: 269–273

    Article  PubMed  CAS  Google Scholar 

  • Biederman J, Mick E, Faraone SV (2000) Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type. Am J Psychiatry 157: 816–818

    Article  PubMed  CAS  Google Scholar 

  • Birbaumer N, Jänig W (1997) Motivation and Emotion. In: Schmidt RF, Thews G (Hrsg) Physiologie des Menschen. Springer, Berlin Heidelberg New York Tokyo, S 167–183

    Google Scholar 

  • Birbaumer N, Schmidt TRF (1999) Biologische Psychologie, 4. Aufl. Springer, Berlin Heidelberg New York Tokyo, S 566

    Google Scholar 

  • Blum K, Cull JG, Braverman ER et al. (1996) Reward deficiency syndrome. Am Sci 84: 132–145

    Google Scholar 

  • Böning J (1991) Zur Neurobiologie und Psychopathologie süchtigen Verhaltens. In: Wanke K, Bühringer G (Hrsg) Grundstörungen der Sucht. Springer, Berlin Heidelberg New York Tokyo, S 1–27

    Google Scholar 

  • Böning J (1994) Warum muß es ein „Suchtgedächtnis“ geben? Klinische Empirie und neurobiologische Argumente. Sucht 40: 244–252

    Google Scholar 

  • Böning J (2000) Zur Neuropsychobiologie und Klinik des „Suchtgedächtnisses“. In: Stetter F (Hrsg) Suchttherapie an der Schwelle der Jahrtausendwende. Neuland, Geesthacht, S 37–50

    Google Scholar 

  • Böning J (2001) Neurobiology of an addiction memory. J Neural Transm 108: 755–756

    Article  Google Scholar 

  • Böning J, Weijers HG, Herrmann MJ (2002) Suchtgedächtnis und Cue-Reaktivität — eine neuropsychobiologische Synopsis. Psychomed 14: 74–80

    Google Scholar 

  • Bonson KR, Grant SJ, Contoreggi CS et al. (2002) Neural systems and cue-induced cocaine craving. Neuropsychopharmacol 26: 376–386

    Article  CAS  Google Scholar 

  • Bottlender M, Soyka M (2005) The impact of different personality dimensions (NEO-FFI) on the outcome of alcohol-dependent patents six and twelve months after treatment. Psychiatry Res (in press)

    Google Scholar 

  • Buchholz KK, Hesselbrock VM, Heath AC et al. (2000) A latent class analysis of antisocial personality disorder symptom data from a multi-centre family study of alcoholism. Addiction 95: 553–567

    Article  Google Scholar 

  • Cantor-Graae E, Nordstrom LG, McNeil TF (2001) Substance abuse in schizophrenia: a review of the literature and a study of correlates in Sweden. Schizophr Res 48: 69–82

    Article  PubMed  CAS  Google Scholar 

  • Christiansen KO (1974) The genesis of aggressive criminality. Implications of a study of crime in a Danish twin study. In: Dewit J, Hartup WW (eds) Determinants and origin of aggressive behaviour. Mouton, The Hague

    Google Scholar 

  • Cloninger CR (1987) Neurogenetic adaptive mechanisms in alcoholism. Science 236: 410–416

    Article  PubMed  CAS  Google Scholar 

  • Cloninger CR, Sigvardsson S, Bohman M (1988) Childhood personality predicts alcohol abuse in young adults. Alcohol Clin Exp Res 4: 494–505

    Article  Google Scholar 

  • Collingridge GL, Davies SN (1989) NMDA receptors and long-term potentiation in the hippocampus. In: Watkins JC, Collingridge GL (eds) The NMDA receptor. IRL Press, Oxford, pp 123–136

    Google Scholar 

  • Comings DE (2001) Clinical and molecular genetics of ADHD and Tourette syndrome. Two related polygenic disorders. Ann NY Acad Sci 931: 50

    Article  PubMed  CAS  Google Scholar 

  • Conrad K (1963) (Hrsg) Der Konstitutionstypus, 2. Aufl. Springer, Berlin Göttingen Heidelberg

    Google Scholar 

  • Dalgaard OS, Kringelen E (1976) A Norwegian study of criminality. Br J Criminol 16: 13–232

    Google Scholar 

  • Deissler K (1977) Der periodische Suchtanfall. Schweiz Ärztetag 13: 514–517

    Google Scholar 

  • de Mendelssohn A, Kaspar S, Tauscher J (2004) Neuroimaging bei Substanzabhängigkeit. Nervenarzt 75: 651–662

    Article  PubMed  Google Scholar 

  • Dervaux A, Bayle FJ, Laqueille X et al. (2001) Is substance abuse in schizophrenia related to impulsivity, sensation seeking, or anhedonia? Am J Psychiatry 158: 492–494

    Article  PubMed  CAS  Google Scholar 

  • di Chiara G (1995) The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug Alc Depend 38: 95–137

    Article  Google Scholar 

  • Donovan JM (1986) An etiologic model of alcoholism. Am J Psychiatry 143: 1–11

    PubMed  CAS  Google Scholar 

  • Dulawa SC, Grandy DK, Low MJ et al. (1999) Dopamine D4 receptor-knock-out-mice exhibit reduced exploration of novel stimuli. J Neurosci 19: 955–956

    Google Scholar 

  • Duke PJ, Pantelis C, Mcphillips MA et al. (2001) Comorbid non-alcohol substance misuses among people with schizophrenia: epidemiological study in central London. Br J Psychiatry 179: 509–513

    Article  PubMed  CAS  Google Scholar 

  • Ebstein RP, Nowick O, Umansky R (1996) Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 12: 78–80

    Article  PubMed  CAS  Google Scholar 

  • Ebstein RP, Segman R, Benjamin J et al. (1997) 5-HT2C (HTR2C) serotinin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms. Am J Med Genet 74: 65–72

    Article  PubMed  CAS  Google Scholar 

  • Emrich HM (1989) A three-component-system hypothesis of psychosis. Impairment of binocular depth inversion as an indicator of a functional dysequilibrium. Br J Psychiatry 155[Suppl 5]: 37–39

    Google Scholar 

  • Enoch MA, Goldman D (1999) Genetics of alcoholism and substance abuse. Psychiatr Clin North Am 22: 289–299

    Article  PubMed  CAS  Google Scholar 

  • Fallgatter AJ, Wiesbeck GA, Weijers HG et al. (1998) Event-related correlates of response suppression as indicators of novelty seeking in alcoholics. Alcoholism 33: 475–481

    CAS  Google Scholar 

  • Faraone SV, Doyle AE, Mick E et al. (2001) Metaanalysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder. Am J Psychiatry 158: 1052–1057

    Article  PubMed  CAS  Google Scholar 

  • Foroud T, Buchholz KK, Edenberg HJ et al. (1998) Linkage of an alcoholism-related severity phenotype to chromosome 16. Alcohol Clin Exp Res 22: 2035–2042

    Article  PubMed  CAS  Google Scholar 

  • Foroud T, Edenberg HJ, Goate A et al. (2000) Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. Alcohol Clin Exp Res 24: 993–945

    Article  Google Scholar 

  • Goldstein A (1989) (ed) Molecular and cellular aspects of the drug addictions. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Goldstein RZ, Volkow ND (2002) Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry 159: 1642–1652

    Article  PubMed  Google Scholar 

  • Gottesmann II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160: 636–645

    Article  Google Scholar 

  • Gouzoulis-Mayfrank E (2004) Doppeldiagnose Psychose und Sucht. Nervenarzt 75: 642–650

    Article  PubMed  CAS  Google Scholar 

  • Grant S, Lond ED, Newlin DB et al. (1996) Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci USA 93: 12040–12045

    Article  PubMed  CAS  Google Scholar 

  • Gray JA, Rawlins JNP (1986) Comparator and buffer memory: an attempt to integrate two models of hippocampal functions. In: Isaacson RL, Pribram KH (eds) The hippocampus. Plenum, New York, pp 159–201

    Google Scholar 

  • Grüsser S, Wölfling K, Heinz A (2002) Sucht, Verlangen und lerntheoretische Erklärungsansätze zur Entstehung und Aufrechterhaltung von süchtigem Verhalten. Psychomed 14: 68–73

    Google Scholar 

  • Haenschel C, Baldeweg T, Croft RJ et al. (2002) Gamma and beta frequency oscillations in response to novel auditory stimuli: a comparison of human electroencephalogram (EEG) data with in vitro models. Proc Natl Acad Sci USA 97: 7645–7650

    Article  Google Scholar 

  • Hartka E, Johnstone B, Leino EV et al. (1991) The collaborative alcohol-related longitudinal project: a meta-analysis of depressive symptomatology and alcohol consumption over time. Br J Addict 86: 1283–1298

    Article  PubMed  CAS  Google Scholar 

  • Heath AC, Buchholz KK, Madden PA et al. (1997) Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol Med 27: 1381–1396

    Article  PubMed  CAS  Google Scholar 

  • Heinz A (1999a) Anthropological and neurobiological aspects of compulsions and rituals. Pharmacopsychiatry 32: 223–229

    Article  PubMed  CAS  Google Scholar 

  • Heinz A (1999b) Neurobiological and anthropological aspects of compulsions and rituals. Pharmacopsychiatry 32: 1–7

    Article  Google Scholar 

  • Heinz A (1999c) Anhedonie — nosologieübergreifendes Korrelat einer Dysfunktion des dopaminergen Verstärkungssystems? Nervenarzt 70: 391–398

    Article  PubMed  CAS  Google Scholar 

  • Heinz A, Batra A (2003) Neurobiologie der Alkohol-und Nikotinabhängigkeit. Kohlhammer, Stuttgart

    Google Scholar 

  • Heinz A, Higley JD, Gorey JG et al. (1998a) In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates. Am J Psychiatry 155: 1023–1028

    PubMed  CAS  Google Scholar 

  • Heinz A, Ragan P, Jones DW et al. (1998b) Reduced serotonin transporters in alcoholism. Am J Psychiatry 155: 1544–1549

    PubMed  CAS  Google Scholar 

  • Heinz A, Reinold M, Wrase J et al. (2005) Stable elevations in striatal μ-opioid receptor availability in detoxified alcoholics correlate with alcohol craving — a [11C] Carfentanil PET study. Gen Arch Psychiatry 62: 57–64

    Article  Google Scholar 

  • Herrmann MJ, Sonnek G, Weijers H-G et al. (2002) Intensity dependence of auditory evoked potentials and the personality dimension “harm avoidance” in alcoholism. Prog Neuropsychopharmacol Biol Psychiatry 26: 127–161

    Article  Google Scholar 

  • Hesselbrock V, Begleiter H, Porjesz B et al. (2001) P 300 event-related potential amplitude as an endophenotype of alcoholism — evidence from the collaborative study on the genetics of alcoholism. J Biomed Sci 8: 77–82

    PubMed  CAS  Google Scholar 

  • Heyne A, May T, Goll P et al. (2000) Persisting consequences of drug intake: towards a memory of addiction. J Neural Transm 107: 613–638

    Article  PubMed  CAS  Google Scholar 

  • Holzberg D, Albrecht U (2003) The circadian clock: a manager of biochemical processes within the organism. J Neuroendocrinol 15: 339–343

    Article  PubMed  CAS  Google Scholar 

  • Hosák L, Preiss M, Halíř M et al. (2004) Temperament and character inventory (TCI) personality profile in metamphetamine abusers: a controlled study. Eur Psychiatry 19: 193–195

    Article  PubMed  Google Scholar 

  • Jacobs EH, Spijker S, Verhoog CW et al. (2002) Active heroin administration induces specific genomic responses in the nucleus accumbens shell. FASEB J 16: 1961–1963

    PubMed  CAS  Google Scholar 

  • Johann M, Bobbe G, Putzhammer A et al. (2003) Comorbidity of alcohol dependence with attention-deficit hyperactivity disorder: differences in phenotype with increased severity of the substance disorder, but not in genotype (serotonin transporter, 5-HT2C receptor). Alcohol Clin Exp Res 27: 1527–1534

    Article  PubMed  CAS  Google Scholar 

  • Johnson EO, van der Bree MB, Pickens RW (1996) Subtypes of alcohol-dependent men: a typology based on relative genetic and environmental loading. Alcohol Clin Exp Res 20: 1472–1480

    Article  PubMed  CAS  Google Scholar 

  • Kampe H, Kunz D, Overbeck-Larisch M et al. (1996) Die Bedeutung des Sondersprachgebrauchs Drogenabhängiger für das Erleben und Verhalten. Sucht 43: 18–36

    Google Scholar 

  • Kendler KS, Neale MC, Heath AC et al. (1994) A twin-family study of alcoholism in women. Am J Psychiatry 151: 707–715

    PubMed  CAS  Google Scholar 

  • Kendler KS, Neale MC, Sullivan P et al. (1999) A population-based twin study in women of smoking initiation and nicotine dependence. Psychol Med 29: 299–308

    Article  PubMed  CAS  Google Scholar 

  • Knop J (1985) Premorbid assessment of young men at high risk for alcoholism. In: Galanter M (ed) Recent developments in alcoholism, vol III. Plenum Press, New York London, pp 53–64

    Google Scholar 

  • Knorring AL V, Bohmann M, Knorring L V et al. (1985) Platelet MAO activity as a biological marker in subgroups of alcoholism. Acta Psychiatr Scand 72: 51–58

    Article  Google Scholar 

  • Krause R (1983) Zur Onto-und Phylogenese des Affektsystems und ihrer Beziehungen zu psychischen Störungen. Psyche 11: 1016–1043

    Google Scholar 

  • Ledoux JE (1999) Das Gedächtnis für Angst. Spektrum der Wissenschaft: 16–23

    Google Scholar 

  • Lee MA, Meltzer HY (2001) Substance abuse in schizophrenia. Biological factors mediating comorbidity and the potential role of atypical antipsychotic drugs. In: Hubbard JR, Martin PR (eds) Substance abuse in the mentally and physically disabled. Marcel Dekker, New York, pp 77–101

    Google Scholar 

  • Lesch KP, Bengel D, Heils A et al. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527–1531

    Article  PubMed  CAS  Google Scholar 

  • Leshner A (1997) Addiction is a brain disease, and it matters. Science 278: 45–47

    Article  PubMed  CAS  Google Scholar 

  • Lörch B (2002) Alkoholverlangen und dessen klinische Bedeutsamkeit. Psychomed 14: 92–97

    Google Scholar 

  • Maier W (1996) Genetik von Alkoholabusus aund Alkoholabhängigkeit. In: Mann K, Buchkremer G (Hrsg) Sucht-Grundlagen. Diagnostik, Therapie. Fischer, Stuttgart Jena New York, S 85–97

    Google Scholar 

  • Maier W (2004) Genetische und Umweltfaktoren bei der Entstehung von Suchterkrankungen. Vortrag, 15. Wissenschaftliche Tagung, Deutsche Gesellschaft für Suchtforschung und Suchttherapie, Essen, 2. April 2004 (unveröffentlicht)

    Google Scholar 

  • Markowitsch HJ (1999) (Hrsg) Gedächtnisstörungen. Kohlhammer, Stuttgart Berlin Köln

    Google Scholar 

  • Melichar JK, Daglish MR, Nutt DJ (2001) Addiction and withdrawal-current views. Curr Opin Pharmacol 1: 84–90

    Article  PubMed  CAS  Google Scholar 

  • Milberger S, Biedermann J, Faraone SV et al. (1997) Associations between ADHD and psychoactive substance use disorders. Findings from a longitudinal study of high-risk siblings of ADHD children. Am J Addict 6: 318–329

    PubMed  CAS  Google Scholar 

  • Morris RGM, Davis S, Butcher SP (1989) The role of NMDA receptors in learning and memory. In: Watkins JC, Collingridge GL (eds) The NMDA receptor. IRL Press, Oxford New York Tokyo, pp 241–268

    Google Scholar 

  • Mueser KT, Yarnold PR, Rosenberg SD et al. (2000) Substance use disorder in hospitalized severely mentally ill psychiatric patients: prevalence, correlates, and subgroups. Schizophr Bull 26: 179–192

    PubMed  CAS  Google Scholar 

  • Mumford D (1991) On the computational architecture of the neocortex. Biol Cybern 65: 133–145

    Article  Google Scholar 

  • Naber PA, Witter MP, Lopes Silva FH (2000) Networks of the hippocampal memory system of the rat. The pivotal role of the subiculum. Ann NY Acad Sci 911: 392–403

    Article  PubMed  CAS  Google Scholar 

  • Netter P, Rammsayer T (1991) Reactivity to dopaminergic drugs and aggression related personality traits. Pers Ind Diff 12: 1009–1017

    Article  Google Scholar 

  • O’brien CP, Childress AR, Ehrmann RN et al. (1998) Conditioning factors in drug abuse: can they explain compulsion? J Psychopharmacol 12: 15–22

    Article  PubMed  CAS  Google Scholar 

  • Osier MV, Pakstis AJ, Soodyall H et al. (2002) A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. Am J Hum Genet 71: 84–99

    Article  PubMed  CAS  Google Scholar 

  • Papousek H, Papousek M, Giese R (1986) Neue wissenschaftliche Ansätze zum Verständnis der Mutter-Kind Beziehung. In: Stork J (Hrsg) Zur Psychologie und Psychopathologie des Säuglings. Fromman-Holzboog, Stuttgart, S 53–71

    Google Scholar 

  • Paulus MP, Hozack NE, Zauscher BE et al. (2002) Behavioral and functional neuroimaging evidence for prefrontal dysfunction in metamphetamine-dependent subjects. Neuropsychopharmacology 26: 53–63

    Article  PubMed  CAS  Google Scholar 

  • Pihl RO, Finn P, Peterson J (1989) Autonomic hyperreactivityand risk for alcoholism. Prog Neuropsychopharmacol Biol Psychiatry 13: 489–496

    Article  PubMed  CAS  Google Scholar 

  • Ploog D (1986) Zur Psychopathologie der Emotionen unter neuroethologischem Aspekt. In: Heimann H, Gaertner HJ (Hrsg) Das Verhältnis der Psychiatrie zu ihren Nachbardisziplinen. Springer, Berlin Heidelberg New York, S 15–31

    Google Scholar 

  • Pollock VE, Gabrielli WF, Mednick SA et al. (1988) EEG identification of subgroups of men at risk for alcoholism? Psychiatry Res 26: 101–114

    Article  PubMed  CAS  Google Scholar 

  • Porjesz B, Almasy L, Edenberg HJ et al. (2002) Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. Proc Natl Acad Sci USA 99: 3729–3733

    Article  PubMed  CAS  Google Scholar 

  • Pritzel M, Brand M, Markowitsch AJ (2003) Gehirn und Verhalten. Spektrum, Heidelberg Berlin

    Book  Google Scholar 

  • Reich T, Edenberg HJ, Goate A et al. (1998) Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81: 207–215

    Article  PubMed  CAS  Google Scholar 

  • Risch NJ (2000) Searching for genetic determinants in the new millennium. Nature 405: 847–856

    Article  PubMed  CAS  Google Scholar 

  • Robbins SJ, Ehrmann RN (1992) Designing studies of drug conditioning in humans. Psychopharmacology 106: 143–153

    Article  PubMed  CAS  Google Scholar 

  • Robbins TW (2002) ADHD and addiction. Nat Med 8: 24–25

    Article  PubMed  CAS  Google Scholar 

  • Robinson TE, Kolb B (1997) Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine. J Neurosci 17: 8491–8497

    PubMed  CAS  Google Scholar 

  • Routtenberg O (1988) Das Belohnungssystem des Gehirns. In: Spektrum der Wissenschaft. Gehirn und Nervensystem. Verlagsgemeinschaft Weinheim, Heidelberg, S 161–167

    Google Scholar 

  • Saccone NL, Kwon JM, Corbett J et al. (2000) A genome screen of maximum number of drinks as an alcoholism phenotype. Am J Med Genet 96: 632–637

    Article  PubMed  CAS  Google Scholar 

  • Samochowiec J, Kucharska-Mazur J, Rybakowski F et al. (2002) Norepinephrine transporter polymorphism and personality trait of reward dependence in male alcoholics. Pharmacopsychiatry 35: 195–196

    Article  PubMed  CAS  Google Scholar 

  • Sandkühler J (2000) Learning and memory in pain pathways. Pain 88: 113–118

    Article  PubMed  Google Scholar 

  • Schiffelholz T, Aldenhoff J (2001) Neuronale Plastizität — das Geheimnis der Gedächtnisbildung? Nervenheilkunde 20: 189–193

    Google Scholar 

  • Schrappe O (1978) Abhängigkeit — Symptom oder Krankheit? In: Keup W (Hrsg) Sucht als Symptom. Thieme, Stuttgart, S 29–37

    Google Scholar 

  • Schrappe O (1980) Toxikomanie. In: Peters UH (Hrsg) Die Psychologie des 20. Jahrhunderts, Bd X. Ergebnisse für die Medizin. 2. Psychiatrie. Kindler, Zürich, S 849–868

    Google Scholar 

  • Schuckit MA (1984) Subjective responses to alcohol in sons of alcoholics and control subjects. Arch Gen Psychiatry 41: 879–884

    PubMed  CAS  Google Scholar 

  • Schuckit MA (1985) The clinical implications of primary diagnostic groups among alcoholics. Arch Gen Psychiatry 42: 1043–1049

    PubMed  CAS  Google Scholar 

  • Schuckit MA (1994a) A clinical model of genetic influences in alcohol dependence. J Stud Alcohol 55: 5–17

    PubMed  CAS  Google Scholar 

  • Schuckit MA (1994b) Low level of response as a predictor of future alcoholism. Am J Psychiatry 151: 184–189

    PubMed  CAS  Google Scholar 

  • Schuckit MA (1996) Auf der Suche nach Prädiktoren für die Entwicklung einer Alkoholabhängigkeit: eine prospektive Studie. In: Mann K, Buchkremer G (Hrsg) Sucht — Grundlagen, Diagnostik, Therapie. Fischer, Stuttgart Jena New York, S 107–117

    Google Scholar 

  • Schuckit MA (1998) Biological, psychological and environmental predictors of alcoholism risk: a longitudinal study. J Stud Alcohol 59: 485–494

    PubMed  CAS  Google Scholar 

  • Schuckit MA, Smith TL (1996) An 8-year follow-up of 450 sons of alcoholics and control subjects. Arch Gen Psychiatry 53: 202–210

    PubMed  CAS  Google Scholar 

  • Schuckit MA, Smith TL (2000) The relationships of a family history of alcohol dependence, a low level of response to alcohol and six domains of life functioning to the development of alcohol use disorders. J Stud Alcohol 61: 827–835

    PubMed  CAS  Google Scholar 

  • Schuckit MA, Smith TL (2001) The clinical course of alcohol dependence associated with a low level of response to alcohol. Addiction 96: 903–910

    Article  PubMed  CAS  Google Scholar 

  • Schuckit MA, Smith TL (2004) Changes over time in the self-reported level of response to alcohol. Alcoholism 39: 433–438

    Google Scholar 

  • Schuckit MA, Smith TL, Tipp JE (1997) The self-rating of the effects of alcohol (SRE) form as a retrospective measure of the risk for alcoholism. Addiction 92: 979–988

    Article  PubMed  CAS  Google Scholar 

  • Schuckit MA, Mazzanti C, Smith TL et al. (1999) Selective genotyping for the role of the 5-HT2A, 5-HT2C and GABAα6 receptors and the serotonin transporter in the level of response to alcohol. A pilot study. Biol Psychiatry 45: 647–651

    Article  PubMed  CAS  Google Scholar 

  • Schuckit MA, Smith TL, Kalmijn J et al. (2000) Response to alcohol in daughters of alcoholics: a pilot study and a comparison with sons of alcoholics. Alcoholism 35: 242–248

    CAS  Google Scholar 

  • Schuckit MA, Edenberg HJ, Kalmijn J et al. (2001) Genome-wide Search for genes that relate to a low level of response to alcohol. Alcohol Clin Exp Res 25: 323–329

    Article  PubMed  CAS  Google Scholar 

  • Schuckit MA, Smith TL, Danko GP et al. (2003) Level of response to alcohol measured on the self-rating of the effects of alcohol questionnaire in a group of 40-year-old women. Am J Drug Alcohol Abuse 29: 191–201

    Article  PubMed  Google Scholar 

  • Schumann G (2004) Genetic analysis of glutamatergic signaling genes in alcohol dependence. Alcohol Clin Exp Res 28[Suppl]: 72A

    Article  Google Scholar 

  • Schumann G, Spanagel R, Mann K (2003a) Candidate genes for alcohol dependence: animal studies. Alcohol Clin Exp Res 27: 880–888

    Article  PubMed  Google Scholar 

  • Schumann G, Rujescu D, Kissling C et al. (2003b) Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. Biol Psychiatry 54: 1422–1426

    Article  PubMed  CAS  Google Scholar 

  • Smalley SL, Bailey JN, Palmer CG et al. (1998) Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder. Mol Psychiatry 3: 427–430

    Article  PubMed  CAS  Google Scholar 

  • Spanagel R (2001) Gibt es ein Drogen-und Suchtgedächtnis? Hinweise aus tierexperimentellen Untersuchungen. Sucht 47: 365–367

    Google Scholar 

  • Spanagel R, Pendyala G, Abarca C, et al. (2005) The clock gene Period2 influences the glutamatergic system and thereby modulates alcohol consumption. Nature Med 11: 35–42

    Article  PubMed  CAS  Google Scholar 

  • Tarter RE, Alterman AL, Edwards KL (1985) Vulnerability to alcoholism in men: a behaviorgenetic perspective. J Stud Alcohol 46: 329–356

    PubMed  CAS  Google Scholar 

  • Tsai G, Coyle JT (1998) The role of glutamatergic neurotransmission in the patho-physiology of alcoholism. Ann Rev Med 49: 173–184

    Article  PubMed  CAS  Google Scholar 

  • Tulving E (1995) Organization of memory: quo vadis? In: Gazzaniga NS (ed) The cognitive neurosciences. MIT Press, Cambridge, pp 839–847

    Google Scholar 

  • Verheul R, van den Brink W, Geerlings P (1999) A three pathway psychobiological model of craving for alcohol. Alcoholism 34: 197–222

    CAS  Google Scholar 

  • Volavka J, Czobor P, Goodwin W et al. (1996) The electroencephalogram after alcohol administration in high-risk men and the development of alcohol use disorders 10 years later. Arch Gen Psychiatry 53: 258–263

    PubMed  CAS  Google Scholar 

  • Volkow ND, Fowler JS (2000) Addiction, a disease of compulsion and drive: involvement of orbitofrontal cortex. Cereb Cortex 10: 318–325

    Article  PubMed  CAS  Google Scholar 

  • Volkow ND, Chang L, Wang GJ et al. (2001) Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. Am J Psychiatry 158: 383–389

    Article  PubMed  CAS  Google Scholar 

  • Volkow ND, Fowler JS, Wang GJ (2002) Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies. Behav Pharmacol 13: 355–366

    PubMed  CAS  Google Scholar 

  • Vorel SR, Liu X, Hayes RJ et al. (2001) Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science 292: 1175–1178

    Article  PubMed  CAS  Google Scholar 

  • Weijers H-G, Wiesbeck GA, Jakob F et al. (2001) Neuroendocrine response to fenfluramine and its relationship to personality in alcoholism. J Neural Transm 108: 1093–1105

    Article  PubMed  CAS  Google Scholar 

  • Weijers H-G, Wiesbeck GA, Wodarz N et al. (2003) Gender and personality in alcoholism. Arch Wom Ment Health 6: 245–252

    Article  Google Scholar 

  • Weijers H-G, Wiesbeck GA, Böning J (2005) Biopsychological personality traits as predictors for relapse in primary alcoholism. Alcohol Clin Exp Res (in press)

    Google Scholar 

  • Wiesbeck GA (2000) Untersuchungen zum Sensation seeking als Vergleichs-, Prädiktions-und Typisierungsmerkmal bei primärer Alkoholabhängigkeit. Habilitationsschrift, Medizinische Fakultät, Universität Würzburg

    Google Scholar 

  • Wiesbeck GA, Böning J (1996) Dopaminerge Aktivität und verhaltensbiologische Persönlichkeitsmerkmale Alkoholabhängiger im „drug challenge“ — Paradigma. In: Mann K, Buchkremer G (Hrsg) Sucht — Grundlagen, Diagnostik, Therapie. Fischer, Stuttgart Jena New York, S 67–75

    Google Scholar 

  • Wiesbeck GA, Mauerer C, Thome J et al. (1996) Sensation seeking, alcoholism and dopamine activity. Eur Psychiatry 11: 87–92

    Article  PubMed  CAS  Google Scholar 

  • Wiesbeck GA, Müller T, Wodarz N et al. (1998) Growth hormone response to apomorphine and to growth hormone releasing hormone in abstinent alcoholics and control subjects. Drug Alc Depend 52: 53–56

    Article  CAS  Google Scholar 

  • Wiesbeck GA, Weijers H-G, Böning J (1999) Untersuchung zur klinischen Gültigkeit der Typ 1/Typ 2 Differenzierung nach Cloninger bei alkoholabhängigen Männern. Suchtmedizin 1: 27–32

    Google Scholar 

  • Wiesbeck GA, Weijers H-G, Wodarz N et al. (2004) Serotonin transporter gene polymorphism and personality traits in primary alcohol dependence. World Biol Psychiatry 5: 45–48

    Article  Google Scholar 

  • Wikler A (1973) Dynamics of drug dependence: implications of a conditioning theory for researchand treatment. Arch Gen Psychiatry 28: 611–616

    PubMed  CAS  Google Scholar 

  • Wikler A (2004) Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issues. Psychiatr Clin North Am 27: 283–301

    Article  Google Scholar 

  • Wise R (1996) Neurobiology of addiction. Curr Opin Neurobiol 6: 243–251

    Article  PubMed  CAS  Google Scholar 

  • Wodarz N (2004) Bedeutung des serotonergen Systems für verschiedene Aspekte der Alkoholabhängigkeit unter besonderer Berücksichtigung des Tabakkonsums. Habilitationsschrift, Medizinische Fakultät, Universität Regensburg

    Google Scholar 

  • Wolffgramm J, Heyne A (1995) From controlled intake to loss of control: the irreversible development of drug addiction in the rat. Behav Brain Res 70: 77–94

    Article  PubMed  CAS  Google Scholar 

  • Wolffgramm J, Galli G, Thimm F et al. (2000) Animal models of addiction: models for therapeutic strategies? J Neural Transm 107: 649–668

    Article  PubMed  CAS  Google Scholar 

  • Young RM, Lawford BR, Nutting A et al. (2004) Advances in molecular genetics and the prevention and treatment of substance misuse: implications of association studies of the A1 allele of the D2 dopamine receptor gene. Addict Behav 29: 1275–1294

    Article  PubMed  Google Scholar 

  • Zimmermann U, Spring K, Wittchen H-U et al. (2004a) Effects of Ethanol administration and induction of anxiety-related affective states on the acoustic startle reflex in sons of alcoholdependent fathers. Alcohol Clin Exp Res 28: 424–432

    Article  PubMed  Google Scholar 

  • Zimmermann U, Spring K, Kunz S et al. (2004b) Effect of ethanol on hypothalamic-pituitaryadrenal system response to psychosocial stress in sons of alcohol-dependent fathers. Neuropsychopharmacol 29: 1156–1165

    Article  CAS  Google Scholar 

  • Zobel A, Maier W (2004) Endophänotypen — ein neues Konzept zur biologischen Charakterisierung psychischer Störungen. Nervenarzt 75: 205–214

    Article  PubMed  CAS  Google Scholar 

  • Zuckerman M (1984) Sensation seeking: a comparative approach to human trait. Behav Brain Sci 7: 413–471

    Article  Google Scholar 

  • Zuckerman M (1993) P-impulsive sensation seeking and its behavioral, psychophysiological and biochemical correlates. Neuropsychobiology 28: 30–36

    Article  PubMed  CAS  Google Scholar 

  • Zuckerman M (1994) Behavioral expressions and biosocial bases of sensation seeking. Cambridge University Press, New York

    Google Scholar 

  • Zuckerman M, Cloninger CR (1996) Relationships between Cloninger’s, Zuckerman’s, and Eysenck’s dimensions of personality. Person Individ Diff 21: 283–285

    Article  Google Scholar 

Literatur

  • Bachteler D, Economidou D, Danysz W et al. (2005) The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat. Neuropsychopharmacology (im Druck)

    Google Scholar 

  • Blizard DA, Mcclearn GE (2000) Association between ethanol and sucrose intake in the laboratory mouse: exploration via congenic strains and conditioned taste aversion. Alcohol Clin Exp Res 24: 253–258

    Article  PubMed  CAS  Google Scholar 

  • Böning J (1992) Zur Neurobiologie und Phänomenologie eines „Suchtgedächtnisses“. Sucht 38: 105–106

    Google Scholar 

  • Boening J (2001) Neurobiology of an addiction memory. J Neural Transm 108: 755–765

    Article  PubMed  CAS  Google Scholar 

  • Cagetti E, Baicy KJ, Olsen RW (2004) Topiramate attenuates withdrawal signs after chronic intermittent ethanol in rats. Neuroreport 15: 207–210

    Article  PubMed  CAS  Google Scholar 

  • Carboni E, Vacca C (2003) Conditioned place preference. A simple method for investigating reinforcing properties in laboratory animals. Methods Mol Med 79: 481–498

    PubMed  CAS  Google Scholar 

  • Chiamulera C, Epping-Jordan MP, Zocchi A et al. (2001) Reinforcing and locomotor stimulant effects of cocaine are absent in GluR5 null mutant mice. Nat Neurosci 4: 873–874

    Article  PubMed  CAS  Google Scholar 

  • Chick J, Lehert P, Landron F et al. (2003) Does acamprosate improve reduction of drinking as well as aiding abstinence? J Psychopharmacol 17: 397–402

    Article  PubMed  CAS  Google Scholar 

  • Ciccocioppo R, Martin-Fardon R, Weiss F (2002) Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcoholseeking behavior by drug-associated stimuli in rats. Neuropsychopharmacology 27: 391–399

    Article  PubMed  CAS  Google Scholar 

  • Ciccocioppo R, Lin D, Martin-Fardon R et al. (2003) Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone. Psychopharmacology 168: 208–215

    Article  PubMed  CAS  Google Scholar 

  • Coper H, Rommelspacher H, Wolffgramm J (1990) The ‘point of no return’ as a target of experimental research on drug dependence. Drug Alcohol Depend 25: 129–134

    Article  PubMed  CAS  Google Scholar 

  • Cunningham CL, Ferree NK, Howard MA (2003) Apparatus bias and place conditioning with ethanol in mice. Psychopharmacology 170: 409–422

    Article  PubMed  CAS  Google Scholar 

  • Ehrenreich H, Krampe H (2004) Does disulfiram have a role in alcoholism treatment today? Not to forget about disulfiram’s psychological effects. Addiction 99: 26–27

    Article  PubMed  Google Scholar 

  • Epstein DH, Preston KL (2003) The reinstatement model and relapse prevention: a clinical perspective. Psychopharmacology 168: 31–41

    Article  PubMed  CAS  Google Scholar 

  • Files FJ, Samson HH, Denning CE (1997) Effects of sucrose-substitution initiation on patterns of drinking by Lewis rats during continuous alcohol access. Alcohol 14: 379–387

    Article  PubMed  CAS  Google Scholar 

  • Fiorillo CD, Tobler PN, Schultz W (2003) Discrete coding of reward probability and uncertainty by dopamine neurons. Science 299: 1898–1902

    Article  PubMed  CAS  Google Scholar 

  • Galli G, Wolffgramm J (2004) Long-term voluntary d-amphetamine consumption and behavioral predictors for subsequent d-amphetamine addiction in rats. Drug Alcohol Depend 73: 51–60

    Article  PubMed  CAS  Google Scholar 

  • Gaveriaux-Ruff C, Kieffer BL (2002) Opioid receptor genes inactivated in mice: the highlights. Neuropeptides 36: 62–71

    Article  PubMed  CAS  Google Scholar 

  • Heyne A (1996a) Die selbstbestimmte Einnahme eines Opiates durch Wistarratten. Dissertation, Freie Universität Berlin (Verlag Dr. Kovac, Hamburg)

    Google Scholar 

  • Heyne A (1996b) The development of opiate addiction in the rat. Pharmacol Biochem Behav 53: 11–25

    Article  PubMed  CAS  Google Scholar 

  • Heyne A, Wolffgramm J (1998) The development of addiction to d-amphetamine in an animal model: same principles as for alcohol and opiate. Psychopharmacology 140: 510–518

    Article  PubMed  CAS  Google Scholar 

  • Heyne A, May T, Goll P et al. (2000) Persisting consequences of drug intake: towards a memory of addiction. J Neural Transm 107: 613–638

    Article  PubMed  CAS  Google Scholar 

  • Holt JD, Watson WP, Little HJ (2001) Studies on a model of long term alcohol drinking. Behav Brain Res 123: 193–200

    Article  PubMed  CAS  Google Scholar 

  • Holter SM, Spanagel R (1999) Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term ethanol-experienced rats. Psychopharmacology 145: 360–369

    Article  PubMed  CAS  Google Scholar 

  • Hölter SM, Danysz W, Spanagel R (2000a) Novel uncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure. J Pharmacol Exp Ther 292: 545–552

    PubMed  Google Scholar 

  • Hölter SM, Linthorst AC, Reul JM et al. (2000b) Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats. Pharmacol Biochem Behav 66: 143–151

    Article  PubMed  Google Scholar 

  • Hummel M, Ansonoff MA, Pintar JE et al. (2004) Genetic and pharmacological manipulation of mu opioid receptors in mice reveals a differential effect on behavioral sensitization to cocaine. Neuroscience 125: 211–220

    Article  PubMed  CAS  Google Scholar 

  • Johnson BA (2004) Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment. CNS Drugs 18: 1105–1118

    Article  PubMed  CAS  Google Scholar 

  • Johnson BA, Ait-Daoud N, Ma JZ et al. (2003) Ondansetron reduces mood disturbance among biologically predisposed, alcohol-dependent individuals. Alcohol Clin Exp Res 27: 1773–1779

    Article  PubMed  CAS  Google Scholar 

  • Kenny PJ, Paterson NE, Boutrel B et al. (2003) Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. Ann NY Acad Sci 1003: 415–418

    Article  PubMed  CAS  Google Scholar 

  • Kiyatkin EA (1995) Functional significance of mesolimbic dopamine. Neurosci Biobehav Rev 19: 573–598

    Article  PubMed  CAS  Google Scholar 

  • Koob GF, Rocio M, Carrera A et al. (1998a) Substance dependence as a compulsive behavior. J Psychopharmacol 12: 39–48

    Article  PubMed  CAS  Google Scholar 

  • Koob GF, Sanna PP, Bloom FE (1998b) Neuroscience of addiction. Neuron 21: 467–476

    Article  PubMed  CAS  Google Scholar 

  • Lankford MF, Myers RD (1994) Genetics of alcoholism: simultaneous presentation of a chocolate drink diminishes alcohol preference in high drinking HAD rats. Pharmacol Biochem Behav 49: 417–425

    Article  PubMed  CAS  Google Scholar 

  • Leri F, Flores J, Rodaros D et al. (2002) Blockade of stress-induced but not cocaine-induced reinstatement by infusion of noradrenergic antagonists into the bed nucleus of the stria terminalis or the central nucleus of the amygdala. J Neurosci 22: 5713–5718

    PubMed  CAS  Google Scholar 

  • Liu X, Weiss F (2002) Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms. J Neurosci 22: 7856–7861

    PubMed  CAS  Google Scholar 

  • Liu X, Weiss F (2003) Stimulus conditioned to foot-shock stress reinstates alcohol-seeking behavior in an animal model of relapse. Psychopharmacology 168: 184–191

    Article  PubMed  CAS  Google Scholar 

  • Mann K (2004) Pharmacotherapy of alcohol dependence: a review of the clinical data. CNS Drugs 18: 485–504

    Article  PubMed  CAS  Google Scholar 

  • May T, Juilfs F, Wolffgramm J (1998) Long-lasting effects of chronic m-opioid intake on the signal transmission via dopamine D1 receptors in the limbic forebrain of drug deprived rats. Neuropharmacology 37: 997–1006

    Article  PubMed  CAS  Google Scholar 

  • McBride WJ, Le AD, Noronha A (2002) Central nervous system mechanisms in alcohol relapse. Alcohol Clin Exp Res 26: 280–286

    PubMed  CAS  Google Scholar 

  • McFarland K, Davidge SB, Lapish CC et al. (2004) Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior. J Neurosci 24: 1551–1560

    Article  PubMed  CAS  Google Scholar 

  • Mundle G, Dedner C, Schäfer G et al. (2001) Erste Eindrücke der klinischen Pilotstudie zur „Kausalen Therapie einer Opiatsucht“. In: Stetter F (Hrsg) Wege aus der Sucht, Bd 2. Suchtforschung für die Suchtkranken. Ergebnisse, Konsequenzen, Perspektiven. Neuland Verlag, Geesthacht, S 72–77

    Google Scholar 

  • Myers RD, Melchior CL (1977) Alcohol drinking: abnormal intake caused by tetrahydropapaveroline in brain. Science 196: 554–556

    Article  PubMed  CAS  Google Scholar 

  • Nestler EJ (2002) Common molecular and cellular substrates of addiction and memory. Neurobiol Learn Mem 78: 637–647

    Article  PubMed  CAS  Google Scholar 

  • Nestler EJ, Aghajanian GK (1997) Molecular and cellular basis of addiction. Science 278:58–63

    Article  PubMed  CAS  Google Scholar 

  • Reinhard C, Wolffgramm J (2005) Long-term voluntary consumption of MDMA and THC in rats is modified by individual and situational factors (zur Veröffentlichung eingereicht)

    Google Scholar 

  • Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18: 247–291

    Article  PubMed  CAS  Google Scholar 

  • Robinson TE, Berridge KC (2000) The psychology and neurobiology of addiction: an incentive-sensitization view. Addiction 95[Suppl 2]:S91–117

    Article  PubMed  Google Scholar 

  • Robinson TE, Berridge KC (2001) Incentive-sensitization and addiction. Addiction 96: 103–114

    Article  PubMed  CAS  Google Scholar 

  • Rodd ZA, Bell RL, Sable HJ et al. (2004) Recent advances in animal models of alcohol craving and relapse. Pharmacol Biochem Behav 79:439–450

    Article  PubMed  CAS  Google Scholar 

  • Samson HH, Sharpe AL, Denning C (1999) Initiation of ethanol self-administration in the rat using sucrose substitution in a sipper-tube procedure. Psychopharmacology 147: 274–279

    Article  PubMed  CAS  Google Scholar 

  • Self DW, Nestler EJ (1995) Molecular mechanisms of drug reinforcement and addiction. Annu Rev Neurosci 18: 463–495

    Article  PubMed  CAS  Google Scholar 

  • Shaham Y, Erb S, Stewart J (2000) Stress-induced relapse to heroin and cocaine seeking in rats: a review. Brain Res Brain Res Rev 33:13–33

    Article  PubMed  CAS  Google Scholar 

  • Shaham Y, Shalev U, Lu L et al. (2003) The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology 168: 3–20

    Article  PubMed  CAS  Google Scholar 

  • Sillaber I, Rammes G, Zimmermann S et al. (2002) Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science 296: 931–933

    Article  PubMed  CAS  Google Scholar 

  • Sinclair JD, Senter RJ (1967) Increased preference for ethanol in rats following alcohol deprivation. Psychonomic Sci 8: 11–12

    Google Scholar 

  • Spanagel R (2000) Recent animal models of alcoholism. Alcohol Res Health 24: 124–131

    PubMed  CAS  Google Scholar 

  • Spanagel R (2003) Alcohol addiction research: from animal models to clinics. Best Pract Res Clin Gastroenterol 17: 507–518

    Article  PubMed  Google Scholar 

  • Spanagel R, Holter SM (2000) Pharmacological validation of a new animal model of alcoholism. J Neural Transm 107: 669–680

    Article  PubMed  CAS  Google Scholar 

  • Spanagel R, Sillaber I, Zieglgansberger W et al. (1998) Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress. Psychopharmacology 139: 391–401

    Article  PubMed  CAS  Google Scholar 

  • Swift JQ, Roszkowski MT (1998) The use of opioid drugs in management of chronic orofacial pain. J Oral Maxillofac Surg 56: 1081–1085

    Article  PubMed  CAS  Google Scholar 

  • Tessari M, Pilla M, Andreoli M et al. (2004) Antagonism at metabotropic glutamate 5 receptors inhibits nicotine-and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking. Eur J Pharmacol 499: 121–133

    Article  PubMed  CAS  Google Scholar 

  • Tiffany ST, Conklin CA (2000) A cognitive processing model of alcohol craving and compulsive alcohol use. Addiction 95[Suppl 2]:S145–153

    Article  PubMed  Google Scholar 

  • Tuszewski-Guerra G (2000) Antizipation einer Alkoholeinnahme: Veränderungen in Verhalten und Hormonkonzentrationen bei süchtigen und nicht-süchtigen Ratten. Dissertation, Freie Universität Berlin

    Google Scholar 

  • Vengeliene V, Siegmund S, Singer MV et al. (2003) A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake. Alcohol Clin Exp Res 27: 1048–1054

    Article  PubMed  Google Scholar 

  • Wiesbeck GA, Weijers HG, Wodarz N et al. (2003) Gender-related differences in pharmacological relapse prevention with flupenthixol decanoate in detoxified alcoholics. Arch Women Ment Health 6: 259–262

    Article  CAS  Google Scholar 

  • Wolffgramm J (1995) Abhängigkeitsentwicklung im Tiermodell. Z Klin Psychol 24: 107–117

    Google Scholar 

  • Wolffgramm J, Heyne A (1991) Social behavior, dominance and social deprivation of rats determine drug choice. Pharmacol Biochem Behav 38: 389–399

    Article  PubMed  CAS  Google Scholar 

  • Wolffgramm J, Heyne A (1995) From controlled intake to loss of control: the irreversible development of drug addiction in the rat. Behav Brain Res 70: 77–94

    Article  PubMed  CAS  Google Scholar 

  • Wolffgramm J, Heyne A (2002) Rückfällige Ratten als Modell für Therapieabbrüche? Sucht 48:456–459

    Google Scholar 

  • Wolffgramm J, Galli G, Thimm F et al. (2000) Animal models of addiction: models for therapeutical strategies? J Neural Transm 107: 649–668

    Article  PubMed  CAS  Google Scholar 

  • Wolffgramm J, Thimm F, Heyne A (2001) Rückprägung: eine Chance zur Heilung von Suchterkrankungen? In: Stetter F (Hrsg) Wege aus der Sucht, Bd 2. Suchtforschung für die Suchtkranken. Ergebnisse, Konsequenzen, Perspektiven. Neuland Verlag, Geesthacht, S 59–71

    Google Scholar 

Literatur

  • Abi-Dargham A, Krystal JH, Anjilvel S et al. (1998) Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil. Am J Psychiatry 155: 1550–1555

    PubMed  CAS  Google Scholar 

  • Akil H, Owens C, Gutstein H et al. (1998) Endogenous opioids: overview and current issues. Drug Alcohol Depend 51: 127–140

    Article  PubMed  CAS  Google Scholar 

  • Ameri A (1999) Wie wird der Glücksgenerator im Gehirn stimuliert? Extracta Psychiatrica 12: 24–27

    Google Scholar 

  • Atack JR (2003) Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site. Curr Drug Target CNS Neurol Disord 2: 213–32

    Article  CAS  Google Scholar 

  • Balldin JI, Berggren UC, Lindstedt G (1992) Neuroendocrine evidence for reduced dopamine receptor sensitivity in alcoholism. Am Clin Exp Res 16: 71–74

    Article  CAS  Google Scholar 

  • Balldin JI, Berggren UC, Lindstedt G et al. (1993) Further neuroendocrine evidence for reduced D2 dopamine receptor function in alcoholism. Drug Alcohol Depend 32: 159–162

    Article  PubMed  CAS  Google Scholar 

  • Baumgarten HG, Grozdanovic Z (1997) Anatomy of central serotoninergic projection systems. In: Baumgarten HG, Göthert (eds) Serotoninergic neurons and 5-HT receptors in the ZNS. Springer, Berlin Heidelberg New York Tokyo, pp 41–89 (Handb Exp Pharmacol 129)

    Google Scholar 

  • Benkert O, Hippius H (2000) Kompendium der Psychiatrischen Pharmakotherapie. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Benwell MEM, Balfour DJK (1979) Effects of nicotine administration and ist withdrawal on plasma corticosterone and brain 5-hydroxindoles. Psychopharmacology 63: 7–11

    Article  PubMed  CAS  Google Scholar 

  • Berezhnoy D, Nyfeler Y, Gonthier A et al. (2004) On the benzodiazepine binding pocket in GABAA-receptors. J Biol Chem 279: 3160–3168

    Article  PubMed  CAS  Google Scholar 

  • Berridge KC, Robinson TE (1998) What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Rev 28: 309–369

    Article  PubMed  CAS  Google Scholar 

  • Blum K, Noble EP, Sheridan PJ et al. (1990) Allelic association of human dopamine D2-receptor gene in alcoholism. JAMA 263: 2055–2060

    Article  PubMed  CAS  Google Scholar 

  • Bond C, Laforge KS, Tian M et al. (1998) Singlenucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci 95: 9608–9613

    Article  PubMed  CAS  Google Scholar 

  • Boot BP, Mcgregor IS, Hall W (2000) MDMA (Extasy) neurotoxicity: assessing and communicating the risks. Lancet 355: 1818–1821

    Article  PubMed  CAS  Google Scholar 

  • Buck KJ, Metten P, Belknap JK et al. (1997) Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci 17: 3946–3955

    PubMed  CAS  Google Scholar 

  • Buisson B, Bertrand D (2001) Chronic exposure to nicotine upregulates the human α4β2 nicotinic acetylcholine receptor function. J Neurosci 21: 1819–1829

    PubMed  CAS  Google Scholar 

  • Carboni S, Isola R, Gessa GL et al. (1993) Ethanol prevents the glutamate release induced by N-methyl-D-aspartate in the rat striatum. Neurosci Lett 152: 133–136

    Article  PubMed  CAS  Google Scholar 

  • Chakrabarti S, Law P-Y, Loh HH (1995) Neuroblastoma neuro2A cells stably expressing a cloned mu-opioid receptor: a specific cellular model to study acute and chronic effects of morphine. Mol Brain Res 30: 269–278

    Article  PubMed  CAS  Google Scholar 

  • Chakrabarti S, Wang I, Tang W-J et al. (1998) Chronic morphine augments adenylyl cyclase phosphorylation: relevance to altered signaling during tolerance/dependence. Mol Pharmacol 54: 949–953

    PubMed  CAS  Google Scholar 

  • Champtiaux N, Gotti C, Cordero-Erausquin M et al. (2003) Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci 23: 7820–7829

    PubMed  CAS  Google Scholar 

  • Changeux JP, Devillers-Thiery A, Galzi JL et al. (1992) The acetylcholine receptor: a model of an allosteric membrane protein mediating intercellular communication. Ciba Found Symp 164: 66–89

    PubMed  CAS  Google Scholar 

  • Cheung HH, Gurd JW (2001) Tyrosine phosphorylation of the N-methyl_D-aspartate receptor by exogenous and postsynaptic density-associated Src-family kinases. J Neurochem 78: 524–534

    Article  PubMed  CAS  Google Scholar 

  • Collingridge GL, Lester RA (1989) Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev 41: 143–210

    PubMed  CAS  Google Scholar 

  • Copper JR, Bloom FE, Roth RH (1991) The biochemical basis of neuropharmacology, 6th edn. Oxford University Press, New York

    Google Scholar 

  • Dahchour A, Quertemont E, de Witte P (1994) Acute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis study. Alcohol Alcoholism 29: 485–487

    CAS  Google Scholar 

  • Dahchour A, Quertemont E, de Witte P (1996) Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats. Brain Res 735: 9–19

    Article  PubMed  CAS  Google Scholar 

  • Dani JA, Heinemann S (1996) Molecular and cellular aspects of nicotine abuse. Neuron 16: 905–908

    Article  PubMed  CAS  Google Scholar 

  • Dani JA, de Biasi M (2001) Cellular mechanisms of nicotine addiction. Pharmacol Biochem Behav 70: 439–446

    Article  PubMed  CAS  Google Scholar 

  • Davis KM, Wu JY (2001) Role of glutamatergic and GABAergic systems in alcoholism. J Biomed Sci 8: 7–19

    Article  PubMed  CAS  Google Scholar 

  • de Vries TJ, Shippenberg TS (2002) Neural systems underlying opiate addiction. J Neurosci 22: 3321–3325

    PubMed  Google Scholar 

  • Devillers-Thiéry A, Galzi JL, Eiselé JL et al. (1993) Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels. J Memb Biol 136: 97–112

    Article  Google Scholar 

  • Di Chiara G (1995) The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug Alcohol Depend 38: 95–137

    Article  PubMed  Google Scholar 

  • Di Chiara G (1997) Alcohol and dopamine. Alcohol Health Res World 21: 108–113

    PubMed  Google Scholar 

  • Elgoyhen AB, Johnson DS, Boulter J et al. (1994) α9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79: 705–715

    Article  PubMed  CAS  Google Scholar 

  • Elgoyhen AB, Vetter DE, Katz E et al. (2001) α10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc Natl Acad Sci USA 98: 3501–3506

    Article  PubMed  CAS  Google Scholar 

  • Fábián G (2001) Heterotrimeric G-proteins and their role in opioid receptor function. Acta Biol Szeged 45: 13–21

    Google Scholar 

  • Fehr C, Rademacher BL, Buck KJ (2003) Evaluation of the glutamate decarboxylase genes Gad1 and Gad2 as candidate genes for acute ethanol withdrawal severity in mice. Prog Neuropsychopharmacol Biol Psychiatry 27: 467–472

    Article  PubMed  CAS  Google Scholar 

  • Fils-Aime ML, Eckhardt MJ, George DT et al. (1996) Early-onset alcoholics have lower cerebrospinal fluid 5-hydroxyindolacetic acid levels than late-onset alcoholics. Arch Gen Psychiatry 53: 211–216

    PubMed  CAS  Google Scholar 

  • Flores CM, Rogers SW, Pabreza LA et al. (1991) A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is upregulated by chronic nicotine treatment. Mol Pharmacol 41: 31–37

    Google Scholar 

  • Forth W (1996) Allgemeine und spezielle Pharmakologie und Toxikologie, 7 Aufl. Spektrum Verlag, Heidelberg

    Google Scholar 

  • Froehlich JC (1997) Opioid peptides. Alcohol Health Res World 21: 132–136

    PubMed  CAS  Google Scholar 

  • Gardner EL, Vorel SR (1998) Cannabinoid transmission and reward-related events. Neurobiol Dis 5(6 Pt B): 502–533

    Article  PubMed  CAS  Google Scholar 

  • Ghozland S, Matthes HW, Simonin F et al. (2002) Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors. J Neurosci 22: 1146–1154

    PubMed  CAS  Google Scholar 

  • Gintzler AR, Chakrabarti S (2000) Opioid tolerance and the emergence of new opioid receptor — coupled signaling. Mol Neurobiol 21: 21–33

    Article  PubMed  CAS  Google Scholar 

  • Glennon RA, Dukat M, Westkaemper RB (1999) Serotonin receptors and ligands. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York

    Google Scholar 

  • Gonzales RA, Weiss F (1998) Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanolinduced increase in dialysate dopamine levels in the nucleus accumbens. J Neurosci 18: 10663–10671

    PubMed  CAS  Google Scholar 

  • Gorwood P, Martes MP, Ades J et al. (1995) Lack of association between alcohol-dependence and D3 dopamine receptor gene in three independent samples. Am J Med Genet 60: 529–531

    Article  PubMed  CAS  Google Scholar 

  • Heinemann S, Boulter J, Deneris E et al. (1990) The brain nicotinic acetylcholine receptor gene family. Prog Brain Res 86: 195–203

    Article  PubMed  CAS  Google Scholar 

  • Heinz A (2000) Das dopaminerge Verstärkungssystem: Funktion, Interaktion mit anderen Neurotransmittersystemen und psychopathologische Korrelate. In: Hippius H, Sass H, Sauer H (Hrsg) Monographien aus dem Gesamtgebiet der Psychiatrie. Steinkopff, Darmstadt

    Google Scholar 

  • Heinz A, Goldman D (2000) Genotype effects on neurodegeneration and neuroadaption in monoaminergic neurotransmitter systems. Neurochem Int 37: 425–432

    Article  PubMed  CAS  Google Scholar 

  • Heinz A, Mann K (2001) Neurobiologie der Alkoholabhängigkeit. Dtsch Ärztebl Serie: Alkoholismus 36: 2279–2285

    Google Scholar 

  • Heinz A, Batra A (2003) Neurobiologie der Alkoholabhängigkeit. In: Brandt T, Cohen R, Helmchen H et al. (Hrsg) Psychiatrie, Neurologie, Klinische Psychologie. Grundlagen, Methoden, Ergebnisse. Kohlhammer, Stuttgart

    Google Scholar 

  • Heinz A, Dettling M, Kuhn S et al. (1995) Blunted growth hormone response is associated with early relapse in alcohol-dependent patients. Alc Clin Exp Res 19: 62–65

    CAS  Google Scholar 

  • Heinz A, Dufeu P, Kuhn S et al. (1996a) Psychopathological and behavioral correlates of dopaminergic sensitivity in alcohol-dependent patients. Arch Gen Psychiatry 53: 1123–1128

    PubMed  CAS  Google Scholar 

  • Heinz A, Sander T, Harms H et al. (1996b) Lack of allelic associatin of dopamine D1 and D2 (TaqA1) receptor gene polymorphism with reduced dopaminergic sensitivity in alcoholism. Alc Clin Exp Res 20: 1109–1113

    Article  CAS  Google Scholar 

  • Heinz A, Higley JD, Gorey JG et al. (1998) In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates. Am J Psychiatry 155: 1023–1028

    PubMed  CAS  Google Scholar 

  • Herz A (1997) Endogenous opioid systems and alcohol addiction. Psychopharmacology 129: 99–111

    Article  PubMed  CAS  Google Scholar 

  • Higley JD, Suomi SJ, Linnoila M (1991) CSF monoamine metabolite concentrations vary according to age, rearing, and sex, and are influenced by the stressor of social separation in rhesus monkeys. Psychopharmacology 103: 551–556

    Article  PubMed  CAS  Google Scholar 

  • Higley JD, Suomi SJ, Linnoila M (1996) A nonhuman primate model of type II excessive alcohol consumption. Alc Clin Exp Res 20: 629–650

    Article  CAS  Google Scholar 

  • Higuchi S, Muramatsu T, Matsushita S et al. (1996) No evidence of association between structural polymorphism at the dopamine D3-receptor locus and alcoholism in the Japanese. Am J Med Gen 26: 412–414

    Article  Google Scholar 

  • Hogg RC, Raggenbass M, Bertrand D (2003) Nicotinic acetylcholine receptors: from structure to brain function. Rev Physiol Biochem Pharmacol 147: 1–46

    Article  PubMed  CAS  Google Scholar 

  • Hollt V (2002) A polymorphism (A118G) in the mu-opioid receptor gene affects the response to morphine-6-glucuronide in humans. Pharmacogenetics 12: 1–2

    Article  PubMed  Google Scholar 

  • Imperato A, di Chiara G (1986) Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther 239: 219–228

    PubMed  CAS  Google Scholar 

  • Ishikawa H, Ohtsuki T, Ishiguro H et al. (1999) Association between serotonin transporter gene polymorphism and smoking among Japanese males. Cancer Epidemiol Biomarkers Prev 8: 831–833

    PubMed  CAS  Google Scholar 

  • Kaplan JR, Martin LJ, Comuzzie AG et al. (2000) Heritability of monoaminergic metabolites measured in the cerebrospinal fluid of baboons. Soc Neurosci Abstr 26: 1439

    Google Scholar 

  • Kieffer BL (1999) Opioids: first lessons from knockout mice. Trends Pharmacol Sci 20: 19–26

    Article  PubMed  CAS  Google Scholar 

  • Klink R, de Kerchove D’Exaerde, Zoli M et al. (2001) Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 21: 1452–1463

    PubMed  CAS  Google Scholar 

  • Koob GF, Le Moal M (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278: 52–58

    Article  PubMed  CAS  Google Scholar 

  • Korpi ER (1994) Role of GABAA-receptors in the actions of alcohol and in alcoholism: recent advances. Alcohol 29: 115–129

    CAS  Google Scholar 

  • Kotler M, Cohen H, Kremer I et al. (1999) No association between the serotonin transporter promoter region (5-HTTLPR) and the dopamine D3-receptor (BalI D3DR) polymorphisms and heroin addiction. Mol Psychiatry 4: 313–314

    Article  PubMed  CAS  Google Scholar 

  • Kreek MJ (1996) Cocaine, dopamine and the endogenous opioid system. J Addict Dis 15: 73–96

    Article  PubMed  CAS  Google Scholar 

  • Kruger H, Wilce PA, Shanley BC (1993) Ethanol and protein kinase C in rat brain. Neurochem Int 22: 575–581

    Article  PubMed  CAS  Google Scholar 

  • Kumari M, Ticku MK (2000) Regulation of NMDA receptors by ethanol. Prog Drug Res 54: 152–189

    PubMed  CAS  Google Scholar 

  • Kuryatov A, Olale F, Cooper J et al. (2000a) Human α2 AchR subtypes: subunit composition, assembly, and pharmacological responses. Neuropharmacology 39: 2570–2590

    Article  PubMed  CAS  Google Scholar 

  • Kuryatov A, Olale FA, Choi C et al. (2000b) Acetylcholine receptor extracellular domain determines sensitivity to nicotine-induced inactivation. Eur J Pharmacol 393: 11–21

    Article  PubMed  CAS  Google Scholar 

  • LaForge KS, Yuferov V, Kreek MJ (2000) Opioid receptor and peptide gene polymorphisms: potential implications for addictions. Eur J Pharm 410: 249–268

    Article  CAS  Google Scholar 

  • Lappalainen J, Long JC, Eggert M et al. (1998) Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Arch Gen Psychiatry 55: 989–994

    Article  PubMed  CAS  Google Scholar 

  • Le Foll B, Schwartz JC, Solokoff P (2000) Dopamine D3-receptor agents as potential new medication for drug addiction. Eur Psychiatry 15: 140–146

    Article  PubMed  Google Scholar 

  • Le Novére N, Changeux J-P (1995) Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. J Mol Evol 40: 155–172

    Article  PubMed  Google Scholar 

  • Lesch KP, Bengel D, Heils A et al. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527–1531

    Article  PubMed  CAS  Google Scholar 

  • Lindstrom J (1996) Neuronal nicotinic acetylcholine receptors. Ion Channels 4: 377–450

    PubMed  CAS  Google Scholar 

  • Lindstrom JM (2003) Nicotinic acetylcholine receptors of muscles and nerves: comparison of their structures, functional roles, and vulnerability to pathology. Ann NY Acad Sci 998: 41–52

    Article  PubMed  CAS  Google Scholar 

  • Lingford-Huges A, Nutt D (2003) Neurobiology of addiction and implications for treatment. Br J Psychiatry 182: 97–100

    Article  Google Scholar 

  • Liu JG, Anand KJ (2001) Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence. Brain Res Brain Res Rev 38: 1–19

    Article  PubMed  CAS  Google Scholar 

  • Lovinger DM (1997) Serotonin’s role in alcohol’s effects on the brain. Alcohol Health Res World 21: 114–120

    PubMed  CAS  Google Scholar 

  • Lovinger DM, White G, Weight FF (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243: 1721–1724

    Article  PubMed  CAS  Google Scholar 

  • Lovinger DM, Zhou Q (1994) Alcohols potentiate ion current mediated by recombinant 5-HT3RA receptors expressed in a mammalian cell line. Neuropharmacology 33: 1567–1572

    Article  PubMed  CAS  Google Scholar 

  • Luetje CW, Patrick J (1991) Both alpha-and beta-subunits contribute to the agonist sensivity of the neuronal nicotinic acetylcholine receptor. J Neurosci 11: 837–845

    PubMed  CAS  Google Scholar 

  • Maldonado R, Rodriguez De Fonseca F (2002) Cannabinoid addiction: behavioral models and neural correlates. J Neurosci 22: 3326–3331

    PubMed  CAS  Google Scholar 

  • Mansvelder HD, McGehee DS (2002) Cellular and synaptic mechanisms of nicotine addiction. J Neurobiol 53: 606–617

    Article  PubMed  CAS  Google Scholar 

  • Mascia MP, Trudell JR, Harris RA (2000) Specific binding sites for alcohol and anesthetics on ligand-gated ion channels. Proc Natl Acad Sci USA 97: 9305–9310

    Article  PubMed  CAS  Google Scholar 

  • Matsuda LA, Lolait SJ, Brownstein MJ et al. (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561–564

    Article  PubMed  CAS  Google Scholar 

  • Mayer ML, Westbrook GL (1987) The physiology of excitatory amino acids in the vertebrate central nervous system. Prog Neurobiol 28: 197–276

    Article  PubMed  CAS  Google Scholar 

  • Mayer P, Hollt V (2001) Allelic somatic variations in the endogenous opioid system of humans. Pharmacol Ther 91: 167–177

    Article  PubMed  CAS  Google Scholar 

  • McGehee DS, Role LW (1995) Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. Annu Rev Physiol 57: 521–546

    Article  PubMed  CAS  Google Scholar 

  • McKernan RM, Whiting PJ (1996) Which GABAA-receptor subtypes really occur in the brain? Trends Neurosci 19: 139–143

    Article  PubMed  CAS  Google Scholar 

  • Mereu G, Yoon KW, Boi V et al. (1987) Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine. Eur J Pharmacol 141: 395–399

    Article  PubMed  CAS  Google Scholar 

  • Michaelis EK (1998) Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog Neurobiol 54: 369–415

    Article  PubMed  CAS  Google Scholar 

  • Mihic S, Harris A (1997) GABA and the GABAA-receptor. Alcohol Health Res World 21: 127–131

    PubMed  CAS  Google Scholar 

  • Miyakawa T, Yagi T, Kitazawa H et al. (1997) Fynkinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science 278: 698–701

    Article  PubMed  CAS  Google Scholar 

  • Moghaddam B, Bolinao ML (1994) Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens. Neurosci Lett 178: 99–1002

    Article  PubMed  CAS  Google Scholar 

  • Myers RD, Veale WL (1968) Alcohol preference in the rat: reduction following depletion of brain serotonin. Science 160: 1469–1471

    Article  PubMed  CAS  Google Scholar 

  • Naranjo CA, Knoke DM (2001) The role of selective serotonin reuptake inhibitors in reducing alcohol consumption. J Clin Psychiatry 62[Suppl 20]: 18–25

    PubMed  CAS  Google Scholar 

  • Navarro M, Carrera MR, Fratta W et al. (2001) Functional interaction between opioid and cannabinoid receptors in drug self-administration. J Neurosci 21: 5344–5350

    PubMed  CAS  Google Scholar 

  • Nevo I, Hamon M (1995) Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism. Neurochem Int 26: 305–336

    Article  PubMed  CAS  Google Scholar 

  • Nie Z, Madamba SG, Siggins GR (1994) Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms. J Pharmacol Exp Ther 271: 1566–1573

    PubMed  CAS  Google Scholar 

  • Nielsen DA, Virkkunen M, Lappalainen J et al. (1998) A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 55: 593–602

    Article  PubMed  CAS  Google Scholar 

  • Nille U (2000) Zur Neurobiologie des Alkoholismus. Abhängigkeiten 3: 27–31

    Google Scholar 

  • Noble EP, Blum K, Ritchie T et al. (1991) Allelic association of the D2 receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 48: 648–654

    PubMed  CAS  Google Scholar 

  • OMIM (2004) Online mendelian inheritance in men: OPIOID RECEPTOR, MU-1; OPRM1; *600018; Genbank; www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600018

    Google Scholar 

  • Pandey SC (1998) Neuronal signaling systems and ethanol dependence. Mol Neurobiol 17: 1–15

    Article  PubMed  CAS  Google Scholar 

  • Pandey SC, Davis JM, Pandey GN (1995) Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates. J Psychiatry Neurosci 20: 215–225

    PubMed  CAS  Google Scholar 

  • Parsian A, Chakraverty S, Fisher L et al. (1997) No association between polymorphism in the human dopamine D3-and D4-receptors genes and alcoholism. Am J Med Genet 74: 281–285

    Article  PubMed  CAS  Google Scholar 

  • Patkar AA, Berrettini WH, Hoehe M et al. (2001) Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to cocaine dependence among African-American individuals. Addict Biol 6: 337–345

    Article  PubMed  CAS  Google Scholar 

  • Pato CN, Macchiardi F, Pato MT et al. (1993) Review of the putative association of the D2 dopamine receptor and alcoholism: a metaanalysis. Am J Genet (Neuropsychiatr Genet) 48: 78–82

    Article  CAS  Google Scholar 

  • Picciotto MR, Corrigall WA (2002) Neuronal systems underlying behaviours related to nicotine addiction: neural circuits and molecular genetics. J Neurosci 22: 3338–3341

    PubMed  CAS  Google Scholar 

  • Picciotto MR, Zoli M, Rimondini R et al. (1998) Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine. Nature 391: 173–177

    Article  PubMed  CAS  Google Scholar 

  • Pilla M, Perachon S, Sautel F et al. (1999) Selective inhibition of kokaine-seeking behaviour by a partial dopamine D3-receptor agonist. Nature 400: 371–375

    Article  PubMed  CAS  Google Scholar 

  • Rivera M, Gintzler RA (1998) Differential effect of chronic morphine on mRNA encoding adenylyl cyclase isoforms: relevance to physiological sequela of tolerance/dependence. Mol Brain Res 54: 165–169

    Article  PubMed  CAS  Google Scholar 

  • Robinson TE, Berridge KC (1993) The neural basis of drug craving: anincentiv-sensitization theory od addiction. Brain Res Brain Res Rev 18: 247–291

    Article  PubMed  CAS  Google Scholar 

  • Roivainen R, Hundle B, Messing RO (1994) Proteinkinase C and adaption to ethanol. In: Jansson B, Jornvall H, Rydberg U et al. (eds) Toward a molecular basis of alcohol use and abuse. Birkhäuser, Basel, pp 29–38

    Google Scholar 

  • Role LW (1992) Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels. Curr Opin Neurobiol 2: 254–262

    Article  PubMed  CAS  Google Scholar 

  • Rommelspacher H, Raeder C, Kaulen P et al. (1992) Adaptive changes of dopamine-D2-Receptors in rat brain following ethanol withdrawal: a quantitative autoradiographic investigation. Alcohol 9: 1–8

    Article  Google Scholar 

  • Rossetti ZL, Melis F, Carboni S et al. (1992) Alcohol withdrawal in rats is associated with a marked fall in extraneural dopamine. Alc Clin Exp Res 16: 529–532

    Article  CAS  Google Scholar 

  • Rush R, Kuryatov A, Nelson ME et al. (2002) First and second transmembrane segments of 3, 4, 2, and 4 nicotinic acetylcholine receptor subunits influence the efficacy and potency of nicotine. Mol Pharmacol 61: 1416–1422

    Article  PubMed  CAS  Google Scholar 

  • Sander T, Harms H, Dufeu P et al. (1998) Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biol Psychiatry 43: 908–912

    Article  PubMed  CAS  Google Scholar 

  • Sargent PB (1993) The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 16: 403–443

    Article  PubMed  CAS  Google Scholar 

  • Schmeller T, Sporer F, Sauerwein M et al. (1995) Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptors. Pharmazie 50: 493–495

    PubMed  CAS  Google Scholar 

  • Schuckit MA, Mazzanti C, Smith TL (1999) Selective genotyping for the role of 5-HT2A, 5-HT2C, und GABAAa6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. Biol Psychiatry 45: 647–651

    Article  PubMed  CAS  Google Scholar 

  • Schultz W, Dayan P Montague PR (1997) A neural substrate of prediction and reward. Sience 275: 1593–1599

    CAS  Google Scholar 

  • Schumann G, Rujescu D, Kissling C et al. (2003c) Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. Biol Psychiatry 54: 1422–1426

    Article  PubMed  CAS  Google Scholar 

  • Schumann G, Rujescu D, Szegedi A et al. (2003a) No association of alcohol dependence with a NMDA-receptor 2B gene variant. Mol Psychiatry 8: 11–12

    Article  PubMed  CAS  Google Scholar 

  • Schumann G, Spanagel R, Mann K (2003b) Candidate genes for alcohol dependence: animal studies. Alcohol Clin Exp Res 27: 880–888

    Article  PubMed  Google Scholar 

  • Schwartz RD, Kellar KJ (1983) Nicotinic cholinergic receptor binding sites: in vivo regulation. Science 220: 214–216

    Article  PubMed  CAS  Google Scholar 

  • Shimizu K, Matsubara K, Uezono T et al. (1998) Reduced dorsal hippocampal glutamate release significantly correlates with the spatial memory deficits produced by benzodiazepines and ethanol. Neuroscience 83: 701–706

    Article  PubMed  CAS  Google Scholar 

  • Shippenberg TS, Herz A (1987) Place preference conditioning reveals the involvment of D1-dopamine receptors, in the motivational properties of μ-and κ-opioid agonists. Brain Res 436: 169–172

    Article  PubMed  CAS  Google Scholar 

  • Sigel E (2002) Mapping of the benzodiazepine recognition site on GABA(A) receptors. Curr Top Med Chem 2: 833–839

    Article  PubMed  CAS  Google Scholar 

  • Sim LJ, Selley DE, Dworkin SI et al. (1996) Effects of chronic morphine administration on mu opioid receptor-stimulated [35S]GTPgammaS autoradiography in rat brain. J Neurosci 16: 2684–2492

    PubMed  CAS  Google Scholar 

  • Slater SJ, Cox KJA, Lombardi JV et al. (1993) Inhibition of protein kinase C by alcohols and anaesthetics. Nature 364: 82–84

    Article  PubMed  CAS  Google Scholar 

  • Smith AP, Lee NM (2003) Opioid receptor interactions: local and nonlocal, symmetric and asymmetric, physical and functional. Life Sci 73: 1873–1893

    Article  PubMed  CAS  Google Scholar 

  • Spanagel R, Bienkowski P (2002) Glutamatergic mechanisms in alcohol dependence and addiction. In: Lodge D, Danysz W, Parsons FP (eds) Therapeutic potential of ionotropic glutamate receptor antagonists and modulators. Graham Publishing Co., pp 375–403

    Google Scholar 

  • Spanagel R, Herz A, Shippenberg TS (1992) Opposing tonically active endogeneous opioid systems modulate the mesolimbic dopaminergic pathway. Proc Natl Acad Sci USA 89: 2046–2050

    Article  PubMed  CAS  Google Scholar 

  • Stolerman IP, Jarvis MJ (1995) The scientific case that nicotine is addictive. Psychopharmacology 117: 2–10

    Article  PubMed  CAS  Google Scholar 

  • Tomkins DM, Tampakeras M (1999) Effects of discrete central injections of 5-HT1B agonists on ethanol self-administration. Alc Clin Exp Res 23: 20A

    Google Scholar 

  • Tsai G, Coyle JT (1998) The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 49: 173–184

    Article  PubMed  CAS  Google Scholar 

  • Tsai G, Gastfried DR, Coyle T (1995) The glutamatergic basic of human alcoholism. Am J Psychiatry 153: 332–340

    Google Scholar 

  • Türker T, Sodmann R, Goebel U et al. (1998) High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene. Neurosci Lett 248: 147–150

    Article  PubMed  Google Scholar 

  • Tyndale RF (2003) Genetics of alcoholism and tobacco use in humans. Ann Med 35: 94–121

    Article  PubMed  CAS  Google Scholar 

  • Ueno S, Wick MJ, Ye Q et al. (1999) Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes. Br J Pharmacol 127: 377–82

    Article  PubMed  CAS  Google Scholar 

  • Unterwald EM (2001) Regulation of opioid receptors by cocaine. Ann NY Acad Sci 937: 74–92

    Article  PubMed  CAS  Google Scholar 

  • Verheul R, van den Brink W, Geerlings P (1999) A three-pathway psychobiological model of craving for alcohol. Alcohol Alcohol 34: 197–222

    PubMed  CAS  Google Scholar 

  • Voet D, Voet JG (1990) Biochemistry. Wiley and Sons, New York Chichester Brisbane Toronto Singapure

    Google Scholar 

  • Wafford KA, Whiting PJ (1992) Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the γ2 subunit. FEBS Lett 313: 113–117

    Article  PubMed  CAS  Google Scholar 

  • Wang F, Nelson ME, Kuryatov A et al. (1998) Chronic nicotine treatment up-regulates human α3β2 but not α3β4 acetylcholine receptors stably transfected in human embryonic kidney cells. J Biol Chem 273: 28721–2873

    Article  PubMed  CAS  Google Scholar 

  • Weed MR, Wolverton WL (1995) The reinforcing effects of dopamine D1-receptor agonists in the rhesus monkeys. J Pharmacol Exp Ther 275: 1367–1374

    PubMed  CAS  Google Scholar 

  • Whiting P, Schoepfer R, Lindstrom J et al. (1991) Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblast. Mol Pharmacol 40: 463–472

    PubMed  CAS  Google Scholar 

  • Whiting PJ, Mckernan RM, Wafford KA (1995) Structure and pharmacology of vertebrate GABAA receptor subtypes. In: Bradley RJ, Harris RA (eds) International review of neurobiology. Academic Press, San Diego

    Google Scholar 

  • Whitten RJ, Maitra R, Reynolds JN (1996) Modulation of GABAA receptor function by alcohols: effects of subunit composition and differential effects of ethanol. Alcoholism: Clin Exp Res 20: 1313–1319

    Article  CAS  Google Scholar 

  • Wise RA (1988) The neurobiology of craving: implications for the understanding of addiction. J Abnorm Psychol 97: 118–132

    Article  PubMed  CAS  Google Scholar 

  • Yan QS, Reith ME, Yan SG et al. (1998) Effect of systemic ethanol on basal and stimulated glutamate releases in the nucleus accumbens of freely moving Sprague-Dawly rats: a microdialysis study. Neurosci Lett 258: 29–32

    Article  PubMed  CAS  Google Scholar 

  • Zubieta J, Greenwald MK, Lombardi U et al. (2000) Buprenorphine — induced changes in muopioid receptor availability in male heroindependent volunteers: a preliminary study. Neuropsychopharmacology 23: 226–334

    Article  Google Scholar 

Literatur

  • Abarca C, Albrecht U, Spanagel R (2002) Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Proc Natl Acad Sci USA 99: 9026–9030

    Article  PubMed  CAS  Google Scholar 

  • Agarwal DP (1997) Molecular genetic aspects of alcohol metabolism and alcoholism. Pharmacopsychiatry 30: 79–84

    Article  PubMed  CAS  Google Scholar 

  • American Psychiatric Association (1994) Diagnostic criteria from DSM-IV. American Psychiatric Association, Washington DC

    Google Scholar 

  • Baer JS, Sampson PD, Barr HM et al. (2003) A 21-year longitudinal analysis of the effects of prenatal alcohol exposure on young adult drinking. Arch Gen Psychiatry 60: 377–385

    Article  PubMed  Google Scholar 

  • Begleiter H, Porjesz B (1999) What is inherited in the predisposition toward alcoholism? A proposed model. Alcohol Clin Exp Res 23: 1125–1135

    Article  PubMed  CAS  Google Scholar 

  • Begleiter H, Porjesz B, Reich T et al. (1998) Quantitative trait loci analysis of human event-related brain potentials: P3 voltage. Electroencephalogr Clin Neurophysiol 108: 244–2450

    Article  PubMed  CAS  Google Scholar 

  • Berrettini WH, Ferraro TN, Alexander RC et al. (1994) Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. Nature Genet 7: 54–58

    Article  PubMed  CAS  Google Scholar 

  • Bierut LJ, Diwiddie SH, Begleiter H et al. (1998) Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism. Arch Gen Psychiatry 55: 982–988

    Article  PubMed  CAS  Google Scholar 

  • Bleich S, Bandelow B, Javaheripour K et al. (2003) Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism. Neurosci Lett 335: 179–182

    Article  PubMed  CAS  Google Scholar 

  • Blum K, Noble EP, Sheridan PJ et al. (1990) Allelic association of human D2 dopamin receptor gene in alcoholism. JAMA 263: 2055–2060

    Article  PubMed  CAS  Google Scholar 

  • Brennan PA, Grekin ER, Mortensen EL, Mednick SA (2002) Relationship of maternal smoking during pregnancy with criminal arrest and hospitalization for substance abuse in male and female adult offspring. Am J Psychiatry 159: 48–54

    Article  PubMed  Google Scholar 

  • Buck KJ, Hood HM (1998) Genetic association of a GABA(A)-receptor gamma2 subunit variant with severity of acute physiological dependence on alcohol. Mamm Genome 9: 975–978

    Article  PubMed  CAS  Google Scholar 

  • Bunney WE, Bunney BG, Vawter MP et al. (2003) Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders. Am J Psychiatry 60: 657–666

    Article  Google Scholar 

  • Cloninger CR (1987) Neurogenetic adaptive mechanisms in alcoholism. Science 236: 410–416

    Article  PubMed  CAS  Google Scholar 

  • Cloninger CR, Bohman M, Sigvardsson S (1981) Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Arch Gen Psychiatry 38: 861–868

    PubMed  CAS  Google Scholar 

  • Crabbe JC, Belknap JK, Buck KJ (1994) Genetic animal-models of alcohol and drug-abuse. Science 264: 1715–1723

    Article  PubMed  CAS  Google Scholar 

  • De Witt H, Pierri J, Johanson CE (1989) Assessing individual differences in ethanol preference using a culmulative dosing procedure. Psychopharmacology 98: 113–119

    Article  Google Scholar 

  • Di Chiara G, Imperato A (1988) Drugs of abuse preferentially stimulate dopamine release in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85: 5274–5278

    Article  PubMed  Google Scholar 

  • Dick DM, Nurnberger J, Edenberg HJ et al. (2002) Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype. Alc Clin Exp Res 26: 1453–1460

    CAS  Google Scholar 

  • Everitt BJ, Wolf ME (2002) Psychomotor stimulant addiction: a neural systems perspective. J Neurosci 22: 3312–3320

    PubMed  CAS  Google Scholar 

  • Finn PR, Pihl RO (1987) Men at high risk for alcoholism: the effect of alcohol on cardiovascular response to unavoidable shock. J Abnorm Psychol 96: 230–236

    Article  PubMed  CAS  Google Scholar 

  • Flannery BA, Volpicelli JR, Pettinati HM (1999) Psychometric properties of the Penn Alcohol Craving Scale. Alcohol Clin Exp Res 23: 1289–1295

    PubMed  CAS  Google Scholar 

  • Foroud T, Bucholz KK, Edenberg HJ et al. (1998) Linkage of an alcoholism-related severity phenotype to chromosome 16. Alcohol Clin Exp Res 22: 2035–2042

    Article  PubMed  CAS  Google Scholar 

  • Franke P, Maier W (1999) Genetik des Alkoholismus. In: Soyka M (Hrsg) Klinische Alkoholismusdiagnostik. Steinkopff, Darmstadt, S 30–39

    Google Scholar 

  • Gerrits MA, Lesscher HB, Van Ree JM (2003) Drug dependence and the endogenous opioid system. Eur Neuropsychopharmacol 13: 424–434

    Article  PubMed  CAS  Google Scholar 

  • Gessa GL, Muntoni F, Collu M et al. (1985) Low doses of ethanol activate dopaminergic neurons of the ventral tegmental area. Brain Res 348: 201–204

    Article  PubMed  CAS  Google Scholar 

  • Grace AA (2000) The tonic/phasic model of dopamine system regulation and its implication for understanding alcohol and psychostimulant craving. Addiction 95[Suppl 2]: S119–128

    Article  PubMed  Google Scholar 

  • Gurling HMD, Cook CCH (1999) The genetic predisposition to alcohol dependence. Curr Opin Psychiatry 12: 269–275

    Article  Google Scholar 

  • Heath AC, Madden PAF (1998) Statistical methods in genetic research on smoking. Stat Methods Med Res 7: 165–186

    Article  PubMed  CAS  Google Scholar 

  • Heath AC, Meyer J, Jardine R et al. (1991a) The inheritance of alcohol consumption patterns in a general population twin sample. II. Determinants of consumption frequency and quantity consumed. J Stud Alcohol 52: 425–433

    PubMed  CAS  Google Scholar 

  • Heath AC, Meyer J, Eaves LJ et al. (1991b) The inheritance of alcohol consumption patterns in a general population twin sample. I. Multidimensional scaling of quantity/frequency data. J Stud Alcohol 52: 345–352

    PubMed  CAS  Google Scholar 

  • Heinz A, Jones DW, Bissette G et al. (2002) Relationship between cortisol and serotonin metabolites and transporters in alcoholism. Pharmacopsychiat 35: 127–134

    Article  CAS  Google Scholar 

  • Helmuth L (2001) Addiction. Beyond the pleasure principle. Science 294: 983–984

    Article  PubMed  CAS  Google Scholar 

  • Higuchi S, Matsushita S, IMazeki H et al. (1994) Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet 343: 741–742

    Article  PubMed  CAS  Google Scholar 

  • Jacobs, EH, Spijker S, Verhoog CW et al. (2002) Active heroin administration induces specific genomic responses in the nucleus accumbens shell. FASEB J 16: 1961–1963

    PubMed  CAS  Google Scholar 

  • Kendler KS, Jacobson KC, Prescott CA et al. (2003) Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. Am J Psychiatry 160: 687–695

    Article  PubMed  Google Scholar 

  • Koob GF (2003) Alcoholism allostasis and beyond. Alcohol Clin Exp Res 27: 232–243

    Article  PubMed  CAS  Google Scholar 

  • Koob GF, Lemoal M (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24: 97–129

    Article  PubMed  CAS  Google Scholar 

  • Lander ES, Schork NJ (1994) Genetic dissection of complex traits. Science 265: 2037–2048

    Article  PubMed  CAS  Google Scholar 

  • Long JC, Knowler WC, Hanson RL et al. (1998) Evidence for genetic linkage to alcohol dependence on chromosome 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81: 216–221

    Article  PubMed  CAS  Google Scholar 

  • Maier W (1995) Mechanismen der familiären Übertragung von Alkoholabhängigkeit und Alkoholabusus. Z Klin Psychol 24: 147–158

    Google Scholar 

  • Meaney MJ, Diorio J, Francis D et al. (1994) Environmental regulation of the development of glucocorticoid receptor systems in the rat forebrain. The role of serotonin. Ann NY Acad Sci 746: 260–273

    Article  PubMed  CAS  Google Scholar 

  • Merikangas KR, Stolar M, Stevens DE et al. (1998) Familial transmission of substance use disorders. Arch Gen Psychiatry 55: 973–979

    Article  PubMed  CAS  Google Scholar 

  • Mobbs D, Greicius MD, Abdel-Azim E et al. (2003) Humor modulates the mesolimbic reward centers. Neuron 40: 1041–1048

    Article  PubMed  CAS  Google Scholar 

  • Morgan D (2002) Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nat Neurosci 5: 169–174

    Article  PubMed  CAS  Google Scholar 

  • Nestler AJ, Agjanian GK (1997) Molecular and cellular basis of addiction. Science 278: 58–63

    Article  PubMed  CAS  Google Scholar 

  • Nestler EJ (2000) Genes and addiction. Nature Gen 26: 277–281

    Article  CAS  Google Scholar 

  • Nielsen DA, Virkkunen M, Lappalainen J et al. (1998) A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 55: 593–602

    Article  PubMed  CAS  Google Scholar 

  • Prescott CA, Kendler KS (1999) Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. Am J Psychiatry 156: 34–40

    PubMed  CAS  Google Scholar 

  • Reich T, Edenberg HJ, Goate A et al. (1998) Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81: 207–215

    Article  PubMed  CAS  Google Scholar 

  • Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 18: 247–291

    Article  PubMed  CAS  Google Scholar 

  • Schmidt LG, Harms H, Kuhn S et al. (1998) Modification of alcohol withdrawal by the A9 allele of the dopamine transporter gene. Am J Psychiatry 155: 474–478

    PubMed  CAS  Google Scholar 

  • Schuckit MA (1994) Low levels of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151: 184–189

    PubMed  CAS  Google Scholar 

  • Schuckit MA, Mazzanti C, Smith TL et al. (1999) Selective genotyping for the role of 5-HT2A, 5-HT-2C, and GABA α6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. Biol Psychiatry 45: 647–651

    Article  PubMed  CAS  Google Scholar 

  • Schultz W (1997) Dopamine neurons and their role in reward mechanisms. Curr Opin Neurobiol 7: 191–197

    Article  PubMed  CAS  Google Scholar 

  • Self D (2003) Neurobiology: dopamine as chicken and egg. Nature 422: 573–574

    Article  PubMed  CAS  Google Scholar 

  • Self DW, Nestler EJ (1998) Relapse to drug-seeking: neural and molecular mechanisms. Drug Alcohol Depend 58: 49–60

    Article  Google Scholar 

  • Spanagel R, Weiss F (1999) The dopamine hypothesis of reward: past and current status. Trends Neurosci 22: 521–527

    Article  PubMed  CAS  Google Scholar 

  • Spanagel R, Herz A, Shippenberg TS (1992) Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc Natl Acad Sci USA 89: 2046–2050

    Article  PubMed  CAS  Google Scholar 

  • Tiffany ST (1990) A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. Psychol Rev 97: 147–168

    Article  PubMed  CAS  Google Scholar 

  • True WR, Xian H, Scherrer JF et al. (1999) Common genetic vulnerability for nicotine and alcohol dependence in men. Arch Gen Psychiatry 56: 655–661

    Article  PubMed  CAS  Google Scholar 

  • Ungless MA, Whistler JL, Malenka RC et al. (2001) Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411: 583–587

    Article  PubMed  CAS  Google Scholar 

  • Volkow ND, Swanson JM (2003) Variables that affect the clinical use and abuse of methyl-phenidate in the treatment of ADHD. Am J Psychiatry 160: 1909–1918

    Article  PubMed  Google Scholar 

  • Weltgesundheitsorganisation (WHO) (2000) Internationale Klassifikation psychischer Störungen. ICD-10 Kapitel (F). Klinisch-diagnostische Leitlinien, 4. Aufl. Huber, Bern

    Google Scholar 

  • Wise R (1996) Neurobiology of addiction. Curr Opin Neurobiol 6: 243–251

    Article  PubMed  CAS  Google Scholar 

  • Wolfgramm J, Heyne A (1995) From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat. Behav Brain Res 70: 77–94

    Article  Google Scholar 

  • Zimmermann U, Hundt W, Spring K et al. (2003) Hypothalamic-pituitary-adrenal system adaptation to detoxification in alcohol-dependent patients is affected by family history of alcoholism. Biol Psychiatry 53: 75–84

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Abi-Dargham A, Krystal JH, Anjilvel S et al. (1998) Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil. Am J Psychiatry 155: 1550–1555

    PubMed  CAS  Google Scholar 

  • Agartz I, Momenan R, Rawlings RR et al. (1999) Hippocampal volume in patients with alcohol dependence. Arch Gen Psychiatry 56: 356–363

    Article  PubMed  CAS  Google Scholar 

  • Bendszus M, Weijers HG, Wiesbeck G et al. (2001) Sequential MR imaging and proton MR spectroscopy in patients who underwent recent detoxification for chronic alcoholism: correlation with clinical and neuropsychological data. Am J Neuroradiol 22: 1926–1932

    PubMed  CAS  Google Scholar 

  • Berridge KC, Robinson TE (1998) What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28: 309–369

    Article  PubMed  CAS  Google Scholar 

  • Berridge KC, Robinson TE (2003) Parsing reward. Trends Neurosci 26: 507–514

    Article  PubMed  CAS  Google Scholar 

  • Braus DF, Wrase J, Grusser S et al. (2001) Alcohol-associated stimuli activate the ventral striatum in abstinent alcoholics. J Neural Transm 108: 887–894

    Article  PubMed  CAS  Google Scholar 

  • Breiter HC, Gollub RL, Weisskoff RM et al. (1997) Acute effects of cocaine on human brain activity and emotion. Neuron 19: 591–611

    Article  PubMed  CAS  Google Scholar 

  • Breiter hc rauch sl kwong kk et al. 1996 Functional Magnetic Resonance Imaging of Symptom Provocation in Obsessive-Compulsive Disorder. Arch gen Psychiatry 53 595–606

    Google Scholar 

  • Buchert R, Thomasius R, Nebeling B et al. (2003) Long-term effects of “ecstasy” use on serotonin transporters of the brain investigated by PET. J Nucl Med 44: 375–38

    PubMed  CAS  Google Scholar 

  • Budney AJ, Hughes JR, Moore BA et al. (2001) Marijuana abstinence effects in marijuana smokers maintained in their home environment. Arch Gen Psychiatry 58: 917–924

    Article  PubMed  CAS  Google Scholar 

  • Büttner A, Mall G, Penning R et al. (2000) The neuropathology of heroin abuse. Forensic Sci Int 113: 435–442

    Article  PubMed  Google Scholar 

  • Chan GC, Hinds TR, Impey S et al. (1998) Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol. J Neurosci 18: 5322–5332

    PubMed  CAS  Google Scholar 

  • Chang L, Ernst T, Grob CS et al. (1999) Cerebral (1)H MRS alterations in recreational 3,4-methylendioxymethamphetamine (MDMA, ecstasy) users. J Magn Reson Imaging 10: 521–526

    Article  PubMed  CAS  Google Scholar 

  • Chang L, Grob CS, Ernst T et al. (2000) Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: a coregistered SPECT and MRI study. Psychiatry Res 98: 15–28

    Article  PubMed  CAS  Google Scholar 

  • Childress AR, Mozley PD, Mcelgin W et al. (1999) Limbic activation during cue-induced cocaine craving. Am J Psychiatry 56: 11–18

    Google Scholar 

  • Christensen JD, Kaufman MJ, Levin JM et al. (1996) Abnormal cerebral metabolism in polydrug abusers during early withdrawal: a 31P MR spectroscopy study. Magn Reson Med 35: 658–663

    Article  PubMed  CAS  Google Scholar 

  • Dagher A, Bleicher C, Aston JA et al. (2001) Reduces dopamine D1 receptor binding in the ventral striatum of cigarette smokers. Synapse 42: 48–53

    Article  PubMed  CAS  Google Scholar 

  • Diana M, Muntoni AL, Pistis M et al. (1999) Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal. Eur J Neurosci 11: 1037–1041

    Article  PubMed  CAS  Google Scholar 

  • Doudet D, Hommer D, Higley JD et al. (1995) Cerebral glucose metabolism, CSF 5-HIAA levels, and aggressive behavior in rhesus monkeys. Am J Psychiatry 152: 1782–1787

    PubMed  CAS  Google Scholar 

  • Drevets WC, Gautier C, Price JC et al. (2001) Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria. Biol Psychiatry 49: 81–96

    Article  PubMed  CAS  Google Scholar 

  • Ernst M, Matochik JA, Heishman SJ et al. (2001) Effect of nicotine on brain activation during performance of a working memory task. Proc Natl Acad Sci USA 98: 4728–4733

    Article  PubMed  CAS  Google Scholar 

  • Ferrucci M, Gesi M, Lenzi P et al. (2002) Noradrenergic loss enhances MDMA toxicity and induces ubiquitin-positive striatal whorls. Neurol Sci [Suppl 2]: 75–76

    Article  Google Scholar 

  • Fischer C, Hatzidimitriou G, Wlos J et al. (1995) Reorganization of ascending 5-hat axon projections in animals previously exposed to the recreational drug 3,4-methylendioxymethamphetamine (MDMA, Ecstasy). J Neurosci 15: 5476–5485

    PubMed  CAS  Google Scholar 

  • Fletcher JM, Page JB, Francis DJ et al. (1996) Cognitive correlates of long-term cannabis use in Costa Rican men. Arch Gen Psychiatry 53: 1051–1057

    PubMed  CAS  Google Scholar 

  • Fowler JS, Wang G-J, Volkow ND (1996) Inhibition of monoamine oxidase B in brains of smokers. Nature 379: 733–736

    Article  PubMed  CAS  Google Scholar 

  • Fowler JS, Wang GJ, Volkow ND et al. (1999) Smoking a single cigarette does not produce a measurable reduction in brain MAO B in non smokers. Nicotine Tobacco Res 1: 325–329

    Article  CAS  Google Scholar 

  • Franklin TR, Acton PD, Maldjian JA et al. (2002) Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. Biol Psychiatry 51: 134–142

    Article  PubMed  CAS  Google Scholar 

  • Galynker II, Watras-Ganz S, Miner C et al. (2000) Cerebral metabolism in opiate-dependent subjects: effects of methadone maintenance. Mt Sinai J Med 67: 381–387

    PubMed  CAS  Google Scholar 

  • Garavan H, Pankiewicz J, Bloom A et al. (2000) Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli. Am J Psychiatry 157: 1789–1798

    Article  PubMed  CAS  Google Scholar 

  • Garavan H, Ross TJ, Stein EA (1999) Right hemispheric dominance of inhibitory control: an event-related functional MRI study. Proc Natl Acad Sci USA 96: 8301–8306

    Article  PubMed  CAS  Google Scholar 

  • George DT, Lindquist T, Rawlings RR et al. (1992) Pharmacologic maintenance of abstinence in patients with alcoholism: no efficacy of 5-hydroxytryptophan or levodopa. Clin Pharmacol Ther 52: 553–560

    Article  PubMed  CAS  Google Scholar 

  • Ghatan PH, Ingvar M, Eriksson L et al. (1998) Cerebral effects of nicotine during cognition in smokers and non-smokers. Psychopharmacology (Berl) 136: 179–189

    Article  PubMed  CAS  Google Scholar 

  • Giove F, Mangia S, Bianciardi M et al. (2003) The physiology and metabolism of neuronal activation: in vivo studies by NMR and other methods. Magn Reson Imaging 1: 283–293

    Google Scholar 

  • Goldstein RZ, Volkow ND (2002) Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry 159: 1642–1652

    Article  PubMed  Google Scholar 

  • Grant S, London ED, Newlin DB et al. (1996) Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci USA 93: 12040–12045

    Article  PubMed  CAS  Google Scholar 

  • Grusser SM, Heinz A, Flor H (2000) Standardized stimuli to assess drug craving and drug memory in addicts. J Neural Transm 107: 715–720

    Article  PubMed  CAS  Google Scholar 

  • Hatzidimitriou G, Mccann DU, Ricuarte GA (1999) Altered serotonin innervation patterns in the forebrain of monkeys treated with 3,4-methylendioxymethamphetamine seven years previously: factors influencing abnormal recovery. J Neurosci 19: 5096–5107

    PubMed  CAS  Google Scholar 

  • Heath RG, Fitzjarrell AT, Fontana CJ et al. (1980) Cannabis sativa: effects on brain function and ultrastructure in rhesus monkeys. Biol Psychiatry 15: 657–690

    PubMed  CAS  Google Scholar 

  • Heinz A (2002) Dopaminergic dysfunction in alcoholism and schizophrenia — psychopathological and behavioral correlates. Eur Psychiatry 17: 9–16

    Article  PubMed  CAS  Google Scholar 

  • Heinz A, Batra A (2003) Neurobiologie der Alkohol und Nikotinabhängigkeit. In: Brandt T, Cohen R, Helmchen H, Schmidt L (Hrsg) Psychiatrie, Neurologie, Klinische Psychologie. Kohlhammer, Stuttgart

    Google Scholar 

  • Heinz A, Goldman D (2000) Genotype effects on neurodegeneration and neuroadaptation in monoaminergic neurotransmitter systems. Neurochem Int 37: 425–432

    Article  PubMed  CAS  Google Scholar 

  • Heinz A, Jones DW (2000) Serotonin transporters in ecstasy users. Br J Psychiatry 176: 193

    Article  PubMed  CAS  Google Scholar 

  • Heinz A, Dufeu P, Kuhn S et al. (1996) Psychopathological and behavioral correlates of dopaminergic sensitivity in alcohol-dependent patients. Arch Gen Psychiatry 53: 1123–1128

    PubMed  CAS  Google Scholar 

  • Heinz A, Ragan P, Jones DW et al. (1998) Reduced central serotonin transporters in alcoholism. Am J Psychiatry 155: 1544–1549

    PubMed  CAS  Google Scholar 

  • Heinz A, Mann K, Weinberger DR et al. (2001) Serotonergic dysfunction, negative mood states, and response to alcohol. Alcohol Clin Exp Res 25: 487–495

    Article  PubMed  CAS  Google Scholar 

  • Heinz A, Smolka MN, Mann K (2003a) Brain imaging in opiate addiction. In: Kuntze MF, Müllerspahn F, Ladewig D et al. (eds) Basic and clinical science of opioid addiction. Karger, Basel Freiburg Paris, S 46–54

    Chapter  Google Scholar 

  • Heinz A, Jones DW, Gorey JG et al. (2003b) Serotonin transporter availability correlates with alcohol intake in non-human primates. Mol Psychiatry 8: 231–234

    Article  PubMed  CAS  Google Scholar 

  • Herman BH, O’Brien CP (1997) Clinical medications development for opiate addiction: focus on nonopioids and opioid antagonists for the amelioration of opiate withdrawal symptoms and relapse prevention. Semin Neurosci 9:158–172

    Article  CAS  Google Scholar 

  • Higley JD, Suomi SJ, Linnoila M (1996) A nonhuman primate model of type II alcoholism, part 2. Diminished social competence and excessive aggression correlates with low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations. Alcohol Clin Exp Res 20: 643–650

    Article  PubMed  CAS  Google Scholar 

  • Hollister LE (1998) Health aspects of cannabis: revisited. Int J Neuropsychopharmacol 1: 71–80

    Article  PubMed  CAS  Google Scholar 

  • Hommer D, Momenan R, Rawlings R et al. (1996) Decreased corpus callosum size among alcoholic women. Arch Neurol 53: 359–363

    PubMed  CAS  Google Scholar 

  • Howell LL, Hoffmann JM, Votaw JR et al. (2003) Cocaine-induced brain activation determined by positron emission tomography neuroimaging in conscious rhesus monkeys. Psychopharmacology 159: 154–160

    Article  CAS  Google Scholar 

  • Hurt RD, Sachs D, Glover ED et al. (1997) A comparison of sustained-release bupropion and placebo for smoking cessation. N Engl J Med 337: 1195–1202

    Article  PubMed  CAS  Google Scholar 

  • Iversen L (2003) Cannabis and the brain. Brain 126: 1252–1270

    Article  PubMed  Google Scholar 

  • Jacobsen LK, Giedd JN, Gottschalk C et al. (2001) Quantitative morphology of the caudate and putamen in patients with cocaine dependence. Am J Psychiatry 158: 486–489

    Article  PubMed  CAS  Google Scholar 

  • Jorenby DE, Leischow SJ, Nides MA et al. (1999) A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. N Engl J Med 340: 685–689

    Article  PubMed  CAS  Google Scholar 

  • Kaufman MJ, Pollack MH, Villafuerte RA et al. (1999) Cerebral phosphorus metabolite abnormalities in opiate-dependent polydrug abusers in methadone maintenance. Psychiatry Res 90: 143–152

    Article  PubMed  CAS  Google Scholar 

  • Koob GF, le Moal M (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278: 52–58

    Article  PubMed  CAS  Google Scholar 

  • Krystal JH, Woods SW, Kosten TR et al. (1995) Opiate dependence and withdrawal: preliminary assesment using single photon emission computerized tomography (SPECT). Am J Drug Alcohol Abuse 21: 47–63

    Article  PubMed  CAS  Google Scholar 

  • Landfield PW, Cadwallader LB, Vinsant S (1988) Quantitative changes in hippocampal structure following long-term exposure to delta 9-tetrahydrocannabinol: possible mediation by glucocorticoid systems. Brain Res 443: 47–62

    Article  PubMed  CAS  Google Scholar 

  • Laruelle M, Abi-Dargham A, van Dyck CH et al. (1995) SPECT imaging of striatal dopamine release after amphetamine challenge. J Nucl Med 36: 1182–1190

    PubMed  CAS  Google Scholar 

  • Laruelle M, D’Souza CD, Baldwin RM et al. (1997) Imaging D2 receptor occupancy by endogenous dopamine in humans. Neuropsychopharmacology 17: 162–174

    Article  PubMed  CAS  Google Scholar 

  • Lim KO, Choi SJ, Pomara N, Wolkin A et al. (2002) Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study. Biol Psychiatry 51: 890–895

    Article  PubMed  CAS  Google Scholar 

  • London ED, Ernst M, Grant S et al. (2000) Orbitofrontal cortex and human drug abuse: functional imaging. Cereb Cortex 10: 334–342

    Article  PubMed  CAS  Google Scholar 

  • Maas LC, Lukas SE, Kaufman MJ et al. (1998) Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving. Am J Psychiatry 155: 124–126

    PubMed  CAS  Google Scholar 

  • Malison RT, Mccance E, Carpenter LL et al. (1998) [123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts. Psychopharmacology (Berl) 137: 321–235

    Article  PubMed  CAS  Google Scholar 

  • Mann K, Agartz I, Harper C et al. (2001) Neuroimaging in alcoholism: ethanol and brain damage. Alcohol Clin Exp Res 25[5 Suppl ISBRA]:104S–109S

    PubMed  CAS  Google Scholar 

  • Myrick H, Anton RF, Li X et al. (2004) Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to craving. Neuropsychopharmacology 29: 393–402

    Article  PubMed  CAS  Google Scholar 

  • Noble F, Cox BM (1996) Differential desensitization of m-and δ-opioid receptors in selected neural pathways following chronic morphine treatment. Br J Pharmacol 117: 161–169

    PubMed  CAS  Google Scholar 

  • O’Brien CP (2003) Research advances in the understanding and treatment of addiction. Am J Addict 12[Suppl 2]: S36–47

    PubMed  Google Scholar 

  • Panikkar GP (1999) Cocaine addiction: neurobiology and related current research in pharmacotherapy. Subst Abuse 20: 149–166

    Article  Google Scholar 

  • Papp M, Klimek V, Willner P (1994) Parallel changes in dopamine D2 receptor binding in limbic forebrain associated with chronic mild stress-induced anhedonia and its reversal by imipramine. Psychopharmacology 115: 441–446

    Article  PubMed  CAS  Google Scholar 

  • Paulus MP, Hozack NE, Zauscher BE et al. (2002) Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects. Neuropsychopharmacology 26: 53–63

    Article  PubMed  CAS  Google Scholar 

  • Pfefferbaum A, Sullivan EV, Mathalon DH et al. (1995) Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol Clin Exp Res 19: 1177–1191

    Article  PubMed  CAS  Google Scholar 

  • Porrino LJ, Lyons D (2000) Orbital and medial prefrontal cortex and psychostimulant abuse: studies in animal models. Cereb Cortex 10:326–333

    Article  PubMed  CAS  Google Scholar 

  • Rauch SL, Jenike MA, Alpert NM et al. (1994) Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch Gen Psychiatry 51: 62–70

    PubMed  CAS  Google Scholar 

  • Ricaurte GA, Yuan J, Hatzidimitriou G et al. (2003) Retraction. Science 301: 1479

    Article  PubMed  CAS  Google Scholar 

  • Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18: 247–291

    Article  PubMed  CAS  Google Scholar 

  • Robinson TE, Berridge KC (2003) Addiction. Annu Rev Psychol 54: 25–53

    Article  PubMed  Google Scholar 

  • Robinson TE, Gorny G, Mitton E et al. (2001) Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex. Synapse 39: 257–266

    Article  PubMed  CAS  Google Scholar 

  • Rose RJ, Viken RJ, Dunlap JE et al. (1994) Individual differences in subjective response to alcohol challenge: data from studies of twins. Alc Clin Exp Res 18: 453

    Google Scholar 

  • Royall DR, Lauterbach EC, Cummings JL et al. (2002) Executive control function: a review of its promise and challenges for clinical research. A report from the Committee on Research of the American Neuropsychiatric Association. J Neuropsychiatry Clin Neurosci 14:377–405

    PubMed  Google Scholar 

  • Salmeron BJ, Stein EA (2002) Pharmacological applications of magnetic resonance imaging. Psychopharmacol Bull 36: 102–129

    PubMed  Google Scholar 

  • Salmeron BJ, Risinger RC, Ross TJ et al. (2001) Neural correlates of high and craving during human cocaine self-administration. NIDA Monograph 182

    Google Scholar 

  • Salokangas RK, Vilkman H, Ilonen T et al. (2000) High levels of dopamine activity in the basal ganglia of cigarette smokers. Am J Psychiatry 157: 632–634

    Article  PubMed  CAS  Google Scholar 

  • Schlaepfer TE, Strain EC, Greenberg BD et al. (1998) Site of opioid action in the human brain: mu and kappa agonists’ subjective and cerebral blood flow effects. Am J Psychiatry 155: 470–473

    PubMed  CAS  Google Scholar 

  • Schneider F, Habel U, Wagner M et al. (2001) Subcortical correlates of craving in recently abstinent alcoholic patients. Am J Psychiatry 158: 1075–1083

    Article  PubMed  CAS  Google Scholar 

  • Schuckit MA, Smith TL (1996) An 8-year followup of 450 sons of alcoholic and control subjects. Arch Gen Psychiatry 53: 202–210

    PubMed  CAS  Google Scholar 

  • Schultz W, Dayan P, Montague PR (1997) A neural substrate of prediction and reward. Science 275: 1593–1599

    Article  PubMed  CAS  Google Scholar 

  • Sekine Y, Iyo M, Ouchi Y et al. (2001) Methamphetamine-related psychiatric symptoms and reduced brain dopamine transporters studied with PET. Am J Psychiatry 158: 1206–1214

    Article  PubMed  CAS  Google Scholar 

  • Sora I, Hall FS, Andrews AM et al. (2001) Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proc Natl Acad Sci USA 98: 5300–5305

    Article  PubMed  CAS  Google Scholar 

  • Staley JK, Krishnan-Sarin S et al. (2001) Sex differences in [123I]β-CIT SPECT measures of dopamine and serotonine transporter availability in healthy smokers and non smokers. Synapse 41: 275–284

    Article  PubMed  CAS  Google Scholar 

  • Stolerman IP, Mirza NR, Shoaib M (1995) Nicotine psychopharmacology: addiction, cognition and neuroadaptation. Med Res Rev 15: 47–72

    Article  PubMed  CAS  Google Scholar 

  • Sullivan EV, Lane B, Deshmukh A et al. (1999) In vivo mammillary body volume deficits in amnesic and nonamnesic alcoholics. Alcohol Clin Exp Res 23: 1629–1636

    PubMed  CAS  Google Scholar 

  • Sullivan EV, Marsh L, Mathalon DH et al. (1996) Relationship between alcohol withdrawal seizures and temporal lobe white matter volume deficits. Alcohol Clin Exp Res 20: 348–354

    Article  PubMed  CAS  Google Scholar 

  • Thanos PK, Volkow ND, Freimuth P et al. (2001) Overexpression of dopamine D2 receptors reduces alcohol self-administration. J Neurochem 78: 1094–1103

    Article  PubMed  CAS  Google Scholar 

  • Thomasius R, Petersen K, Buchert R et al. (2003) Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users. Psychopharmacology (Berl) 167: 85–96

    PubMed  CAS  Google Scholar 

  • Tiihonen J, Vilkman H, Rasanen P et al. (1998) Striatal presynaptic dopamine function in type 1 alcoholics measured with positron emission tomography. Mol Psychiatry 3: 156–161

    Article  PubMed  CAS  Google Scholar 

  • Tsai G, Gastfriend DR, Coyle JT (1995) The glutamatergic basis of human alcoholism. Am J Psychiatry 152: 332–340

    PubMed  CAS  Google Scholar 

  • VAN Dyck CH, Rosen MI, Thomas HM et al. (1994) SPECT regional cerebral blood flow alterations in naltrexone precipitated withdrawal from buprenorphine. Psychiatry Res 55: 181–191

    Article  PubMed  CAS  Google Scholar 

  • Volkow ND, Chang L, Wang GJ et al. (2001) Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. Am J Psychiatry 158: 2015–2021

    Article  PubMed  CAS  Google Scholar 

  • Volkow ND, Fowler JS, Wang G (2003) The addicted human brain: insights from imaging studies. J Clin Invest 111: 1444–1451

    Article  PubMed  CAS  Google Scholar 

  • Volkow ND, Fowler JS, Wang GJ et al. (1993) Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse 14: 169–177

    Article  PubMed  CAS  Google Scholar 

  • Volkow ND, Wang GJ, Fischman MW et al. (1997a) Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 386: 827–830

    Article  PubMed  CAS  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS et al. (1994) Imaging endogenous dopamine competition with [11C]raclopride in the human brain. Synapse 16: 255–262

    Article  PubMed  CAS  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS et al. (1996) Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcohol Clin Exp Res 20: 1594–1598

    PubMed  CAS  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS et al. (1997b) Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. Nature 386: 830–833

    Article  PubMed  CAS  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS et al. (1999a) Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels. Am J Psychiatry 156: 1440–1443

    PubMed  CAS  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS et al. (1999b) Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors. J Pharmacol Exp Ther 291: 409–415

    PubMed  CAS  Google Scholar 

  • Volpicelli JR, Watson NT, King AC et al. (1995) Effect of naltrexone on alcohol “high” in alcoholics. Am J Psychiatry 152: 613–615

    PubMed  CAS  Google Scholar 

  • Wang GJ, Volkow ND, Fowler JS et al. (1997) Dopamine D2 receptor availability in opiate-dependent subjects before and after naloxone-precipitated withdrawal. Neuropsychopharmacology 16: 174–182

    Article  PubMed  CAS  Google Scholar 

  • Weber W, Henkes H, Moller P et al. (1998) Toxic spongiform leucoencephalopathy after inhaling heroin vapour. Eur Radiol 8: 749–755

    Article  PubMed  CAS  Google Scholar 

  • Weinstein A, Feldtkeller B, Malizia A et al. (1998) Integrating the cognitive and physiological aspects of craving. J Psychopharmacol 12: 31–38

    Article  PubMed  CAS  Google Scholar 

  • Wexler BE, Gottschalk CH, Fulbright RK et al. (2001) Functional magnetic resonance imaging of cocaine craving. Am J Psychiatry 158:86–95

    Article  PubMed  CAS  Google Scholar 

  • White NM (1996) Addictive drugs as reinforcers multiple partial actions on memory systems. Addiction 91: 921–949

    Article  PubMed  CAS  Google Scholar 

  • Wrase J, Grusser SM, Klein S et al. (2002) Development of alcohol-associated cues and cueinduced brain activation in alcoholics. Eur Psychiatry 17: 287–291

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Adams RD, Victor M (eds) (1993) Principles of neurology, 5th edn. pp 66–88

    Google Scholar 

  • Addolorato G, Castelli E, Stefanini GF et al. (1996) An open multicentre study evaluating 4-hydroxybutyric acid sodium salt in the medium-term treatment of 179 alcohol dependent subjects. Alcohol Alcoholism 31: 341–345

    CAS  Google Scholar 

  • Addolorato G, Caputo F, Stefanini GF et al. (1997) Gamma-hydroxybutyric acid in the treatment of alcohol dependence: possible craving development for the drug. Addiction 92: 1035–1036

    Article  PubMed  CAS  Google Scholar 

  • Addolorato G, Cibin M, Caprista E et al. (1998) Maintaining abstinence from alcohol with gamma-hydroxybutyric acid. Lancet 351: 38

    Article  PubMed  CAS  Google Scholar 

  • Babor TF, Dolinsky Z, Meyer RE et al. (1992A) Types of alcoholics: concurrent and predictive validity of some common classification schemes. Br J Addict 87: 1415–1431

    Article  PubMed  CAS  Google Scholar 

  • Babor TF, Hofmann M, Del Boca FK et al. (1992b) Types of alcoholics. 1. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 49: 599–608

    PubMed  CAS  Google Scholar 

  • Ballenger J, Goodwin F, Major L et al. (1979) Alcohol and central serotonin metabolism in man. Arch Gen Psychiatry 36: 224–227

    PubMed  CAS  Google Scholar 

  • Banki CM (1981) Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence. J Neural Transm 59: 89–101

    Article  Google Scholar 

  • Barz J, Freudenstein P, Bonte W et al. (1988) Besonderheiten des Methanolstoffwechsels bei chronischen Alkoholikern. Wiener Z Suchtforsch 11/4: 25–28

    Google Scholar 

  • Baumann P (Hrsg) (1994) Biologische Psychiatrie der Gegenwart. Springer, Wien New York, S 636–640

    Google Scholar 

  • Berner P, Lesch OM, Walter H (1986) Alcohol and depression. Psychopathology 19/2: 177–183

    Article  Google Scholar 

  • Besson J, Aeby F, Kasas A et al. (1998) Combined efficacy of acamprosate and disulfirame in the treatment of alcoholism: a controlled study. Alcoholism: Clin Exp Res 22/3: 573–579

    Article  Google Scholar 

  • Bleich S, Bayerlein K, Reulbach U et al. (2004) Homocysteine levels in patients classified to Lesch’s typology. Alcohol Alcoholism (in press)

    Google Scholar 

  • Carroll KM, Nich C, Ball SA et al. (2000) Oneyear follow-up of disulfiram and psychotherapy for cocaine-alcohol users: sustained effects of treatment. Addiction 95/9: 1335–1349

    Article  Google Scholar 

  • Chick J (1995) Acamprosate as an aid in the treatment of alcoholism. Alcohol Alcoholism 30: 785–787

    CAS  Google Scholar 

  • Chick J, Howlett H, Morgan MY et al. (2000a) United Kingdom Multicentre Acamprosate Study (UKMAS): a 6-month prospective study of acamprosate versus placebo in preventing relapse after withdrawal from alcohol. Alcohol Alcoholism 35/2: 176–187

    Article  Google Scholar 

  • Chick J, Anton R, Checinski K et al. (2000b) A multicentre, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse. Alcohol Alcoholism 35: 587–593

    Article  CAS  Google Scholar 

  • Cloninger CR, Bohman M, Sigvardsson S (1981) Inheritance of alcohol abuse: cross-fostering analysis of adopted men. Arch Gen Psychiatry 38: 861–868

    PubMed  CAS  Google Scholar 

  • Collins DM, Myers RD (1987) Buspirone attenuates volitional alcohol intake in the chronically drinking monkeys. Alcohol Alcoholism 4: 49–56

    CAS  Google Scholar 

  • Cornelius JR, Salloum IM, Cornelius MD et al. (1995) Preliminary report: double-blind, placebo-controlled study of fluoxetine in depressed alcoholics. Psychopharmacol Bull 31: 297–303

    PubMed  CAS  Google Scholar 

  • Cornelius JR, Salloum IM, Ehler JG et al. (1997) Fluoxetine in depressed alcoholics: a doubleblind, placebo-controlled trial. Arch Gen Psychiatry 54: 700–705

    PubMed  CAS  Google Scholar 

  • Cornelius JR, Salloum IM, Thase ME et al. (1998) Fluoxetine versus placebo in depressed alcoholic cocaine abusers. Psychopharmacol Bull 34/1: 117–121

    Google Scholar 

  • De Witte PH, Pinto E, Ansseau M et al. (2003) Alcohol and withdrawal: from animal research to clinical issues. Neurosci Biobehav Rev 27: 189–197

    Article  PubMed  CAS  Google Scholar 

  • Dvorak A, Ramskogler K, Hertling I et al. (2003) Alcohol dependence and depressive syndromes. Int Clin Psychopharmacol 18/1: 47–53

    Google Scholar 

  • Eison AS, Temple DL (1986) Buspirone: review of its pharmacology and current perspectives on its mechanism of action. Am J Med 80(3B): 1–9

    Article  PubMed  CAS  Google Scholar 

  • Engel JA, Fahlke C, Hard E et al. (1992) Serotonergic and dopaminergic involvment in ethanol intake. Clin Neuropharmacol 15[Suppl 1]: 64A–65A

    PubMed  Google Scholar 

  • Fuller RK, Branchey L, Brightwell DR et al. (1986) Disulfiram treatment of alcoholism: a Veterans Administration cooperative study. J Am Med Assoc 256: 1449–1455

    Article  CAS  Google Scholar 

  • Gallimberti L, Gentile N, Cibin M et al. (1989) Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome. Lancet 334/8666: 787–789

    Article  Google Scholar 

  • Gallimberti L, Ferri M, Ferrara SD et al. (1992) Gammahydroxybutyric acid in the treatment of alcohol dependance: a double blind study. Alcoholism: Clin Exp Res 16: 673–676

    Article  CAS  Google Scholar 

  • Grünberger J, Lesch OM, Linzmayer L (1988) Bestimmung von vier Alkoholikertypen mit Hilfe der statischen und lichtevozierten dynamischen Pupillometrie. Wiener Z Suchtforsch 11/4: 29–34

    Google Scholar 

  • Guardia J, Catafau A, Batlle F et al. (2000) Striatal dopaminergic D2 receptor density measured by (123I) Iodobenzamide SPECT in the prediction of treatment outcome of alcohol-dependent patients. Am J Psychiatry 157: 127–129

    PubMed  CAS  Google Scholar 

  • Heimann H, Mayer K, Schied HW (Hrsg) (1989) Psychiatrische und neurologische Aspekte des Alkoholismus heute. Fischer, Stuttgart, S 267–284

    Google Scholar 

  • Heinz A (1999) Serotonerge Dysfunktion als Folge sozialer Isolation. Bedeutung für die Entstehung von Aggression und Alkoholabhängigkeit. Nervenarzt 70: 780–789

    Article  PubMed  CAS  Google Scholar 

  • Heinz A, Dettling M, Kuhn S et al. (1995a) Blunted growth hormone response is associated with early relapse in alcohol-dependent patients. Alcoholism: Clin Exp Res 19: 62–65

    CAS  Google Scholar 

  • Heinz A, Lichtenberg-Kraag B, Sällström-Baum S et al. (1995b) Evidence for prolonged recovery of dopaminergic transmission after detoxification in alcoholics with poor treatment outcome. J Neural Transm (Gen Sect) 102: 149–157

    Article  CAS  Google Scholar 

  • Hertling I, Ramskogler K, Riegler A et al. (2001a) Entzugsbehandlung von alkoholabhängigen Patienten. Wiener Z Suchtforsch 24/1: 41–46

    Google Scholar 

  • Hertling I, Ramskogler K, Riegler A et al. (2001b) Craving for alcohol and prevention of relapse. Wien Klin Wochenschr 113/19: 717–726

    Google Scholar 

  • Hester RK, Miller WR (eds) (2003) Handbook of alcoholism treatment approaches. Effective alternatives, 3rd edn.

    Google Scholar 

  • Janiri L, Gobbi G, Mannelli P et al. (1996) Effects of fluoxetine at antidepressant doses on shortterm outcome of detoxified alcoholics. Int Clin Psychopharmacol 11: 109–117

    Article  PubMed  CAS  Google Scholar 

  • Johnson BA (2000) Serotonergic agents and alcoholism treatment: rebirth of the subtype concept — a hypothesis. Alcoholism: Clin Exp Res 24: 1597–1601

    CAS  Google Scholar 

  • Johnson BA, Ait-Daoud N (1999) Neuropharmacological treatments for alcoholism: scientific basis and clinical findings. Psychopharmacology 149: 327–344

    Article  Google Scholar 

  • Johnson BA, Roache JD, Javors MA et al. (2000) Odansetron for reduction of drinking among biologically predisposed alcoholic patients: a randomised controlled trial. J Am Med Assoc 284: 963–971

    Article  CAS  Google Scholar 

  • Johnson BA, Ruiz P, Galanter M (eds) (2003) Handbook of clinical alcoholism treatment. Lippincot, Williams & Wilkins, Baltimore

    Google Scholar 

  • Kabel DI, Petty F (1996) A placebo-controlled, double-blind study of fluoxetine in severe alcohol dependence: adjunctive pharmacotherapy during and after inpatient treatment. Alcoholism: Clin Exp Res 20: 780–784

    Article  CAS  Google Scholar 

  • Kiefer F, Barocka A (1999) Secondary depression in weaned alcoholics: implications of Lesch’s typology of chronic alcoholism. Alcohol Alcoholism 34/6: 916–917

    Article  Google Scholar 

  • Kiefer F, Jahn H, Tarnaska T et al. (2003) Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study. Arch Gen Psychiatry 60: 92–99

    Article  PubMed  CAS  Google Scholar 

  • Kiefer F, Helwig H, Tarnaske T et al. (2005) Pharmacological relapse prevention of alcoholism: clinical predictors of outcome. Eur Addict Res 11(2): 83–91

    Article  PubMed  Google Scholar 

  • Knapp DJ, Pohorecky LA (1992) Zacopride, a 5-HT3-receptor antagonist, reduces voluntary ethanol consumption in rats. Pharmacol Biochem Behav 41: 847–850

    Article  PubMed  CAS  Google Scholar 

  • Koob G, Roberts A (1999) Brain reward circuits in alcoholism. CNS Spectrums 4: 23–37

    Google Scholar 

  • Koob G, Weiss F (1992) Neuropharmacology of cocaine and ethanol dependence. Rec Dev Alcoholism 10: 201–233

    CAS  Google Scholar 

  • Kranzler HR, Burleson JA, Delboca FK et al. (1994) Buspirone treatment of anxious alcoholics: a placebo-controlled trial. Arch Gen Psychiatry 51: 720–731

    PubMed  CAS  Google Scholar 

  • Kranzler HR, Burleson JA, Korner P et al. (1995) Placebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholics. Am J Psychiatry 152: 391–397

    PubMed  CAS  Google Scholar 

  • Kranzler HR, Burleson JA, Brown J et al. (1996) Fluoxetine treatment seems to reduce the beneficial effects of cognitive-behavioral therapy in type B alcoholics. Alcoholism: Clin Exp Res 20: 1534–1541

    Article  CAS  Google Scholar 

  • Krejcar J, Kirchweger S, Kepplinger B (2003) Abhängigkeit als menschliches Phänomen. Edition Selva, Amstetten Linz

    Google Scholar 

  • Krystal JH, Cramer JA, Krol WF et al. (2001) Naltrexone in the treatment of alcohol dependence. N Engl J Med 345/24: 1734–1739

    Article  Google Scholar 

  • Lee MA, Meltzer HY (1991) Neuroendocrine responses to serotonergic agents in alcoholics. Biol Psychiatry 30: 1017–1030

    Article  PubMed  CAS  Google Scholar 

  • Lee AD, Sellers EM (1994) Interaction between opiate and 5-HT3 receptor antagonists in the regulation of alcohol intake. Alcohol Alcoholism [Suppl 2]: 545–549

    Google Scholar 

  • Leitner A, Gierth L, Lentner S et al. (1994) Untergruppen Alkoholkranker. Gibt es biologische Marker? Harman-und Norharman-Befunde. In: Baumann P (Hrsg) Biologische Psychiatrie der Gegenwart. Springer, Wien New York, S 636–640

    Google Scholar 

  • Lesch OM (1985) Chronischer Alkoholismus — Typen und ihr Verlauf. Eine Langzeitstudie. G Thieme, Stuttgart New York

    Google Scholar 

  • Lesch OM, Walter H (1996) Subtypes of alcoholism and their role in therapy. Alcohol Alcoholism 31[Suppl 1]: 63–67

    Google Scholar 

  • Lesch OM, Lesch E, Dietzel M et al. (1986) Chronischer Alkoholismus — Folgekrankheiten — Todesursachen. Wien Med Wochenschr 19: 505–515

    Google Scholar 

  • Lesch OM, Dietzel M, Musalek M et al. (1988a) The course of alcoholism. Long term prognosis in different types. Forensic Sci Int 36: 121–138

    Article  PubMed  CAS  Google Scholar 

  • Lesch OM, Walter H, Mader R et al. (1988b) Chronic alcoholism in relation to attempted or effected suicide — a long-term-study. Psychiatr Psychobiol 3: 181–188

    Google Scholar 

  • Lesch OM, Kefer J, Lentner S et al. (1990) Diagnosis of chronic alcoholism — classificatory problems. Psychopathology 23: 88–96

    Article  PubMed  CAS  Google Scholar 

  • Lesch OM, Riegler A, Gutierrez K et al. (2001) The European Acamprosate Trials: conclusions for research and therapy. J Biomed Sci 8: 89–95

    Article  PubMed  CAS  Google Scholar 

  • Lindner H (2002) Heterogenität des Rauchverhaltens und Verlangens nach Nikotin bei alkoholabhängigen Patienten in der qualifizierten stationären Therapie — Klassifikatorische Konzepte. Dissertation, Medizinische Hochschule Hannover

    Google Scholar 

  • Littleton J, Zieglgänsberger W (2003) Pharmacological mechanisms of naltrexone and acamprosate the prevention of relapse in alcohol dependence. Am J Addict 12: 3–11

    Article  Google Scholar 

  • Malcolm R, Anton RF, Randall DL et al. (1992) A placebo-controlled trial of buspirone in anxious inpatient alcoholics. Alcoholism: Clin Exp Res 16: 1007–1013

    Article  CAS  Google Scholar 

  • Mason BJ, Kocsis JH, Ritvo EC et al. (1996) A double-blind, placebo-controlled trials of desipramine for primary alcohol dependence stratified on the presence or absence of major depression. J Am Med Assoc 275: 761–767

    Article  CAS  Google Scholar 

  • Mason BJ, Ownby RL (2000) Acamprosate for the treatment of alcohol dependence: a review of double-blind, placebo-controlled trials. CNS Spectrums 5: 58–69

    PubMed  CAS  Google Scholar 

  • McGrath PJ, Nunes EV, Stewart JW et al. (1996) Imipramine treatment of alcoholics with primary depression: a placebo-controlled clinical trial. Arch Gen Psychiatry 53: 232–240

    PubMed  CAS  Google Scholar 

  • McGrath P (1998) Fluoxetine for the treatment of alcoholism and depression. In: Litten R (Chair) Does 5-HT pharmacotherapy have a role in alcohol treatment? Symposium, Annual Meeting of Research Society on Alcoholism, Hilton Head, SC

    Google Scholar 

  • Miller WR, Meyers RJ, Tonigan JS et al. (2001) Community reinforcement and traditional approaches: findings of a controlled trial. In: Meyers RJ, Miller WR (eds) A community reinforcement approach to addiction treatment. Cambridge University Press, Cambridge, pp 79–103

    Chapter  Google Scholar 

  • Moak DH, Voronin KE, Latham PK et al. (2001) A double-blind placebo-controlled treatment study of sertraline in depressed alcoholics: preliminary analysis. Alcoholism: Clin Exp Res 25: 94A

    Google Scholar 

  • Möller HJ (1993) Therapie psychiatrischer Erkrankungen. Enke, Stuttgart, S 634–645

    Google Scholar 

  • Musshoff F, Daldrup T, Bonte W et al. (1995) Ethanolunabhängige Methanolelimination bei chronischen Alkoholikern. Blutalkohol 32: 317–336

    PubMed  CAS  Google Scholar 

  • Naranjo CA, Poulos CX, Lanctot KL et al. (1995) Ritanserin, a central 5-HT2 antagonists, in heavy social drinkers: desire to drink, alcohol intake and related effects. Addiction 90: 893–905

    Article  PubMed  CAS  Google Scholar 

  • Naranjo CA, Knoke DM (2001) The role of selective serotonin reuptake inhibitors in reducing alcohol consumption. J Clin Psychiatry 62: 18–25

    PubMed  CAS  Google Scholar 

  • Nimmerrichter A, Walter H, Gutierrez-Lobos KE et al. (2002) Double-blind controlled trial of gamma-hydroxybutyrate and clomethiazole in the treatment of alcohol withdrawal. Alcohol Alcoholism 37: 67–73

    Article  CAS  Google Scholar 

  • Palmer NT (ed) (1991) Alcoholism: a molecular perspective. Plenum Press, New York, pp 421–444 (Nato Asci Series A: Life Sciences 206)

    Google Scholar 

  • Peter K (Hrsg) (2002) Fortschritte in Psychiatrie und Psychotherapie. Interdisziplinäre und integrative Aspekte. Springer, Berlin Heidelberg New York Tokyo, S 83–96

    Google Scholar 

  • Pettinatti HM (2001) The use of selective serotonin reuptake inhibitors in treating alcoholic subtypes. J Clin Psychiatry 62: 26–31

    Google Scholar 

  • Pettinatti HM, Oslin D, Decker K (2000a) Role of serotonin and serotonin-selective pharmacotherapy in alcohol dependence. CNS Spectrums 5(2): 33–46

    Google Scholar 

  • Pettinatti HM, Rukstalis MR, Luck GJ et al. (2000b) Gender and psychiatric comorbidity: impact on clinical presentation of alcohol dependence. Am J Addict 9: 242–252

    Article  Google Scholar 

  • Pettinatti HM, Volpicelli JR, Kranzler HR et al. (2000c) Sertraline treatment for alcohol dependence: interactive effects of medication and subtype. Alcoholism: Clin Exp Res 24: 1041–1049

    Article  Google Scholar 

  • Pettinatti HM, Volpicelli JR, Luck G et al. (2001) Double-blind clinical trial of sertraline treatment for alcohol dependence. J Clin Psychopharmacol 21: 143–153

    Article  Google Scholar 

  • Platz WE (2004) § 29 Die Begutachtung der strafrechtlichen Verantwortung. In: Brüssow R, Gatzweiler N, Krekeler W et al. (Hrsg) Strafverteidigung in der Praxis. Deutscher Anwaltverlag, S 2312–2314 und 2334

    Google Scholar 

  • Powell BJ, Campbell JL, Landon JF et al. (1995) A double-blind, placebo-controlled study of nortriptyline and bromocriptine in male alcoholics sub-typed by comorbid psychiatric disorders. Alcoholism: Clin Exp Res 19: 462–468

    Article  CAS  Google Scholar 

  • Privette TH, Hornsby RI, Myers RD (1988) Buspirone alters alcohol drinking induced in rats by tetrahydropapaveroline injected into brain monoaminergic pathways. Alcohol 5: 147–152

    Article  PubMed  CAS  Google Scholar 

  • Ramskogler K, Walter H, Hertling I et al. (2001) Subgroups of alcohol dependence and their specific therapeutic management: a review and introduction to the Lesch-typology. Ejournal, International Society of Addiction Medicine — International Addiction

    Google Scholar 

  • Roberts AJ, Mc Arthur RA, Hull EE et al. (1998) Effects of amperozide, 8-OH-DPAT, and FG5974 on operant responding for ethanol. Psychopharmacology 137: 25–32

    Article  PubMed  CAS  Google Scholar 

  • Roy A (1998) Placebo-controlled study of sertraline in depressed recently abstinent alcoholics. Biol Psychiatry 44: 633–637

    Article  PubMed  CAS  Google Scholar 

  • Roy A, Virkkunen M, Linnoila M (1990) Serotonin in suicide, violence, and alcoholism. In: Coccaro EF, Murphy DL (eds) Serotonin in major psychiatric disorders. American Psychiatric Press, Washington DC, pp 187–208

    Google Scholar 

  • Sass H, Soyka M, Mann K et al. (1996) Relapse prevention by acamprosate: results from a placebo-controlled study on alcohol dependence. Arch Gen Psychiatry 53: 673–680

    PubMed  CAS  Google Scholar 

  • Schuckit MA (1985) The clinical implications of primary diagnostic groups among alcoholics. Arch Gen Psychiatry 42: 1043–1049

    PubMed  CAS  Google Scholar 

  • Schwoon DR, Krausz M (1990) Suchtkranke — die ungeliebten Kinder der Psychiatrie. Enke, Stuttgart, S 81–91

    Google Scholar 

  • Sinclair JD (2001) Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism. Alcohol Alcoholism 36: 2–10

    Article  CAS  Google Scholar 

  • Soyka M (1999) Alkoholabhängigkeit — Grundlagen und Therapie. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Sperling W, Frank H, Lesch OM et al. (1999) Untergruppen Alkoholabhängiger und ihre primäre Vulnerabilität — eine Untersuchung zweier Typologien (Cloninger, Lesch). Wiener Z Suchtforsch 22/4: 21–26

    Google Scholar 

  • Sperling W, Frank H, Martus P et al. (2000) The concept of abnormal hemispheric organization in addiction research. Alcohol Alcoholism 35: 394–399

    Article  CAS  Google Scholar 

  • Sprung R, Bonte W, Lesch OM (1988) Methanol — ein bisher verkannter Bestandteil aller alkoholischen Getränke. Eine neue biochemische Annährung an das Problem des chronischen Alkoholismus. Wien Klin Wochenschr 9: 282–288

    Google Scholar 

  • Svensson L, Fahlke C, Hard E et al. (1993) Involvement of the serotonergic system in ethanol intake in the rat. Alcohol 10: 219–224

    Article  PubMed  CAS  Google Scholar 

  • Tiihonen J, Ryynänen OP, Kauhanen J et al. (1996) Citalopram in the treatment of alcoholism: a double-blind placebo-controlled study. Pharmacopsychiatry 29: 27–29

    Article  PubMed  CAS  Google Scholar 

  • Tollefson GD, Montague-Clouse J, Tollefson SL (1992) Treatment of comorbid generalized anxiety in a recently detoxified alcoholic population with a selective serotonergic drug (buspirone). J Clin Psychopharmacol 12: 19–26

    Article  PubMed  CAS  Google Scholar 

  • Volpicelli JR, Alterman AL, Hayashida M et al. (1992) Naltrexone in the treatment of alcohol dependance. Arch Gen Psychiatry 49: 876–880

    PubMed  CAS  Google Scholar 

  • Volpicelli JR (1995) Naltrexone in alcohol dependence. Lancet 346: 456

    Article  PubMed  CAS  Google Scholar 

  • Walter H, Ramskogler K, Semler B et al. (2001) Dopamine and alcohol relapse: D1 and D2 antagonists increase relapse rates in animal studies and in clinical trials. J Biomed Sci 8: 83–88

    PubMed  CAS  Google Scholar 

  • Weller MPI, van Kammen DP (1996) Drugs of abuse. In: Rommelspacher H, Schuckit M (eds) Baillière’s clinical psychiatry, 2, 3. Baillière Tindall, London Philadelphia Sydney Tokio Toronto, pp 421–444

    Google Scholar 

  • Wiesbeck GA, Boening J, Weijers HG et al. (2001) Flupentixol does not prevent relapse in alcoholics. Result from a placebo-controlled study. Alcohol Alcoholism 36/4: 329–334

    Article  Google Scholar 

  • Withworth A, Fischer F, Lesch OM et al. (1996) Acamprosate versus placebo in the long term treatment of patients with alcohol dependence. Lancet 347: 1438–1442

    Article  Google Scholar 

Literatur

  • Allen JP, Litten RZ (2001) The role of laboratory testing in alcoholism treatment. J Subst Abuse Treatm 20: 81–85

    Article  CAS  Google Scholar 

  • Alling C, Gustavsson L, Änggård E (1983) An abnormal phospholipid in rat organs after ethanol. FEBS Lett 152: 24–28

    Article  PubMed  CAS  Google Scholar 

  • Alt A, Janda I, Seidl S et al. (2000) Determination of ethyl glucuronide in hair samples. Alcohol Alcoholism 35: 313–314

    Article  CAS  Google Scholar 

  • Anton RF (2001) Pharmacologic approaches to the management of alcoholism. J Clin Psychiatry 62(S20): 11–17

    PubMed  CAS  Google Scholar 

  • Apter A, van Praag HM, Plutchik R et al. (1990) Interrelationships among anxiety, aggression, impulsivity and mood: a serotonergically linked cluster? Psychiatry Res 32: 191–199

    Article  PubMed  CAS  Google Scholar 

  • Babor TF, Hofmann M, Delboca FK et al. (1992a) Types of alcoholics. I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 49: 599–608

    PubMed  CAS  Google Scholar 

  • Babor TF, Delboca FK, Kadden RM et al. (1992b) Types of alcoholics. II. Application of an empirically derived typology to treatment matching. Arch Gen Psychiatry 49: 609–614

    PubMed  Google Scholar 

  • Balldin J, Berggren U, Engel J et al. (1994) Effect of citalopram on alcohol intake in heavy drinkers. Alcohol Clin Exp Res 18: 1113–1136

    Google Scholar 

  • Baumgarten HG (1991) Neuroanatomie und Neurophysiologie des zentralen 5-HT-Systems. In: Heinrich K, Hippius H, Pöldinger W (Hrsg) Serotonin — ein funktioneller Ansatz für die psychiatrische Diagnose und Therapie? Springer, Berlin Heidelberg New York Tokyo, S 17–44

    Google Scholar 

  • Böning J (1991) Zur Neurobiologie und Psychopathologie süchtigen Verhaltens. In: Wanke K, Bühringer G (Hrsg) Grundstörungen der Sucht. Springer, Berlin Heidelberg New York Tokyo, S 1–27

    Google Scholar 

  • Böning J (1994) Warum muss es ein „Suchtgedächtnis“ geben? Klinische Empirie und neurobiologische Argumente. Sucht 40: 244–252

    Google Scholar 

  • Böning J (1996) Supportive medikamentöse Rückfallprophylaxe bei der Alkoholabhängigkeit. Ergebnisse kontrollierter Doppelblindstudien mit „Anticraving“-Substanzen. Nervenheilkunde 15: 72–79

    Google Scholar 

  • Böning J (2001) Neurobiology of an addiction memory. J Neural Transm 108: 755–765

    Article  Google Scholar 

  • Böning J, Wiesbeck GA, Weijers H-G (2004) Biopsychological personality traits as predictors for relapse. Eur Arch Psychiatry Clin Neurosci 254[Suppl 1]: I/9

    Google Scholar 

  • Bonnaffoux D, Jeanparis F, Bourgeat P et al. (1982) Follow-up treatment after alcohol withdrawal: results after two years in 200 cases. La semaine des hopitaux de Paris 58: 2079–2081

    CAS  Google Scholar 

  • Borg S (1983) Bromocriptine in the prevention of alcohol abuse. Acta Psychiatr Scand 68: 100–110

    Article  PubMed  CAS  Google Scholar 

  • Burling TA, Reilly PM, Moltzen JO et al. (1989) Self-efficacy and relapse among inpatient drug and alcohol abusers: a predictor of outcome. J Stud Alcohol 50: 354–360

    PubMed  CAS  Google Scholar 

  • Buydens-Branchey L, Branchey MH, Noumair D (1989) Age of alcoholism onset. I. Relationship to psychopathology. II. Relationship to susceptibility to serotonin precursor availability. Arch Gen Psychiatry 46: 225–230, 231–236

    PubMed  CAS  Google Scholar 

  • Cloninger CR (1987) A systematic method for clinical description and classification of personality variants: a proposal. Arch Gen Psychiatry 44: 573–588

    PubMed  CAS  Google Scholar 

  • Costall B, Jones BJ, Kelly ME et al. (1990) Ondansetron inhibits a behavioural consequence of withdrawing from drugs of abuse. Pharmacol Biochem Behav 36: 339–344

    Article  PubMed  CAS  Google Scholar 

  • Dahl H, Stephanson N, Beck O et al. (2002) Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide. J Anal Toxicol 26: 201–204

    PubMed  CAS  Google Scholar 

  • Dan L, Laposata M (1997) Ethyl palmitate and ethyl oleate are the predominant fatty acid ethyl esters in the blood after ethanol ingestion and their synthesis is differentially influenced by the extracellular concentrations of their corresponding fatty acids. Alcohol Clin Exp Res 21: 286–292

    PubMed  CAS  Google Scholar 

  • Delamaire D, Carpentier MC, Eudier F et al. (1986) Essai ambulatoire du tiapridal après sevrage alcoholique hospitalier. Etude randomisée de cinquante et une hépatopathies alcooliques en double insu. Le semaine des hopitaux de Paris 62: 3109–3114

    Google Scholar 

  • Diczfalusy MA, Bjorkhem I, Einarsson C et al. (1999) Formation of fatty acid ethyl esters in rat liver microsomes. Evidence for a keyrole of acyl-CoA: ethanol O-acyltransferase. Eur J Biochem 259: 404–411

    Article  PubMed  CAS  Google Scholar 

  • Dongier M, Vachon L, Schwartz G (1991) Bromocriptine in the treatment of alcohol dependence. Alcoholism: Clin Exp Res 15: 970–977

    Article  CAS  Google Scholar 

  • Ebstein RP, Nemanov L, Klotz I et al. (1997) Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of novelty seeking. Mol Psychiatry 2: 472–477

    Article  PubMed  CAS  Google Scholar 

  • Eriksson M, Berggren U, Blennow K et al. (2001) Further investigation of citalopram on alcohol consumption in heavy drinkers: responsiveness possibly linked to the DRD2 A2/A2 genotype. Alcohol Alcoholism 24: 15–23

    CAS  Google Scholar 

  • Fallgatter A, Wiesbeck GA, Weijers H-G et al. (1998) Event-related correlates of response suppression as indicators of novelty seeking in alcoholics. Alcohol Alcoholism 33: 475–481

    Article  CAS  Google Scholar 

  • Favre JD, Guelfi-Sozzi C, Delalleau B et al. (1997) Tianeptine and alcohol dependence. Eur Neuropsychopharmacol 7: S 347–S351

    Article  Google Scholar 

  • Fawcett J, Kravitz HM, Mcguire M et al. (2000) Pharmacological treatments for alcoholism: revisiting lithium and considering buspirone. Alcohol Clin Exp Res 24: 666–674

    Article  PubMed  CAS  Google Scholar 

  • Gastpar M, Rösinger C, Bender S (1993) A german multicenter study with tiapride in the long-term management of alcoholics. Pharmacopsychiatry 26: 154

    Google Scholar 

  • George DT, Rawlings R, Eckardt MJ et al. (1999) Buspirone treatment of alcoholism: age of onset, and cerebrospinal fluid 5-hydroxyindolacetc acid and homovanillic acid concentrations, but not medication treatment, predict return to drinking. Alcohol Clin Exp Res 23: 272–278

    PubMed  CAS  Google Scholar 

  • Gilg T, Soyka M (1997) Wertigkeit biologischer Marker für Alkoholabusus und Alkoholismus. Nervenheilkunde 16: 362–371

    Google Scholar 

  • Glaser T, Fassbender M, Mauler F (1998) Receptor binding of flupenthixol and other neuroleptics. PT06004, XXIst CINP Congress, Glasgow

    Google Scholar 

  • Gorelick DA, Paredes A (1992) Effect of fluoxetine on alcohol consumption in male alcoholics. Alcohol Clin Exp Res 16: 261–265

    Article  PubMed  CAS  Google Scholar 

  • Graeff FL (1986) 5-Hydroxytryptamine, aversion and anxiety. Behav Brain Sci 9: 339–340

    Article  Google Scholar 

  • Hansson P, Caron M, Johnson G et al. (1997) Blood phosphatidylethanol of alcoholic abuse: levels in alcoholic males during withdrawal. Alcohol Clin Exp Res 21: 108–110

    PubMed  CAS  Google Scholar 

  • Helander A, Beck O, Jacobsson G et al. (1992) Characterization of elevated urinary 5-hydroxytryptophol as a marker of recent alcohol consumption. Alcohol Clin Exp Res 16: 607

    Google Scholar 

  • Janiri L, Gobbi G, Mannelli P (1996) Effects of fluoxetine at antidepressant doses on short-term outcome of detoxified alcoholics. Int Clin Psychopharmacol 11: 109–117

    Article  PubMed  CAS  Google Scholar 

  • Johnson BA, Jasinski DR, Galloway GP et al. (1996) Ritanserin in the treatment of alcohol dependence — a multi-center clinical trial. Psychopharmacology 128: 206–215

    Article  PubMed  CAS  Google Scholar 

  • Johnson BA (2000) Serotonergic agents and alcoholism treatment: rebirth of the subtype concept — a hypothesis. Alcohol Clin Exp Res 24: 1597–1601

    PubMed  CAS  Google Scholar 

  • Kabel DI, Petty F (1996) A placebo-controlled double-blind study of fluoxetine in severe alcohol dependence: adjunctive pharmacotherapy during and after inpatient treatment. Alcohol Clin Exp Res 20: 780–784

    Article  PubMed  CAS  Google Scholar 

  • Kiefer F, Jahn H, Holzbach R et al. (2003) Die NALCAM-Studie: Wirksamkeit, Verträglichkeit, Outcome. Sucht 49: 342–351

    Google Scholar 

  • Kranzler HR, Burleson JA, Korner P et al. (1995) Placebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholics. Am J Psychiatry 152: 391–397

    PubMed  CAS  Google Scholar 

  • Kranzler HR, Burleson JA, Brown J et al. (1996) Fluoxetine treatment seems to reduce the beneficial effects of cognitive-behavioral therapy in type B alcoholics. Alcohol Clin Exp Res 20: 1534–1541

    Article  PubMed  CAS  Google Scholar 

  • Kranzler HR, Modesto-Lowe V, van Kirk J (2000) Naltrexone vs Nefazodone for treatment of alcohol dependence. A placebocontrolled trial. Neuropsychopharmacology 22: 493–503

    CAS  Google Scholar 

  • Kranzler HR, Pierucci-Lagha A, Feinn R et al. (2003) Effects of ondansetron in early-versus late-onset al.coholics: a prospective, open-label study. Alcohol Clin Exp Res 27: 1150–1155

    Article  PubMed  CAS  Google Scholar 

  • Laposata M (1999) Assessment of ethanol intake — current tests and new assays on the horizon. Am J Clin Pathol 112: 443–450

    PubMed  CAS  Google Scholar 

  • Lee MA, Meltzer HY (1991) Neuroendocrine responses to serotonergic agents in alcoholics. Biol Psychiatry 30: 1017–1030

    Article  PubMed  CAS  Google Scholar 

  • Le Marquand D, Pohl RO, Benkelfat C (1994) Serotonin and alcohol intake, abuse and dependence. Clinical evidence. Biol Psychiatry 1994: 326–337

    Article  Google Scholar 

  • LEsch KP, Bengel D, Heils A et al. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527–1531

    Article  PubMed  CAS  Google Scholar 

  • Lesch OM (1985) Chronischer Alkoholismus — Typen und ihr Verlauf. Eine Langzeitstudie. Thieme, Stuttgart New York

    Google Scholar 

  • Lesch OM, Walter H (1996) Subtypes of alcoholism and their role in therapy. Alcohol Alcoholism 31[Suppl 1]: 63–67

    Google Scholar 

  • Leysen JE, Gommeren W, van Gompel P et al. (1985) Receptor binding properties in vitro and in vivo of ritanserin: a very potent and long acting serotonin-S2 antagonist. Mol Pharmacol 27: 600–611

    PubMed  CAS  Google Scholar 

  • Linnoila M, Eckardt M, Durcan M et al. (1987) Interactions of serotonin with ethanol: clinical and animal studies. Psychopharmacol Bull 23: 452–457

    PubMed  CAS  Google Scholar 

  • Malka R, Loo H, Ganry H et al. (1992) Long-term administration of tianeptine in depressed patients after alcohol withdrawal. Br J Psychiatry 160: 66–71

    Google Scholar 

  • Malec E, Malec T, Gagne MA et al. (1996) Buspirone in the treatment of alcohol dependence: a placebo-controlled trial. Alcohol Clin Exp Res 20: 307–312

    Article  PubMed  CAS  Google Scholar 

  • Meert TF, Janssen PAJ (1991) Ritanserin, a new therapeutic approach for drug abuse. Drug Dev Res 25: 39–53, 55–66

    Article  Google Scholar 

  • Meyer RE (1989) Prospects for a rational pharmacotherapy of alcoholism. J Clin Psychiatry 50: 403–412

    PubMed  CAS  Google Scholar 

  • Naranjo CA, Sellers EM, Roach CA et al. (1984) Zimelidine-induced variations in alcohol intake by nondrepressed heavy drinkers. Clin Pharmacol Ther 35: 374–381

    Article  PubMed  CAS  Google Scholar 

  • Naranjo CA, Sellers EM, Sullivan JT et al. (1987) The serotonin uptake inhibitor citalopram attenuates ethanol intake. Clin Pharmacol Ther 41: 266–274

    Article  PubMed  CAS  Google Scholar 

  • Naranjo CA, Sullivan JT, Kadlec K et al. (1989) Differential effects of viqualine on alcohol intake and other consummatory behaviors. Clin Pharmacol Ther 46: 301–309

    Article  PubMed  CAS  Google Scholar 

  • Naranjo CA, Kadlec K, Sanhueza P et al. (1990) Fluoxetine differentially alters alcohol intake and other consummatory behaviours in problem drinkers. Clin Pharmacol Ther 47: 490–498

    Article  PubMed  CAS  Google Scholar 

  • Naranjo CA, Poulos CX, Bremner KE et al. (1992) Citalopram decreases desirability, liking, and consumption of alcohol in alcohol-dependent drinkers. Clin Pharmacol Ther 51: 729–739

    Article  PubMed  CAS  Google Scholar 

  • Naranjo CA, Poulos CX, Bremner KE et al. (1994) Fluoxetine attentuates alcohol intake and desire to drink. Int Clin Psychopharmacol 9: 163–172

    Article  PubMed  CAS  Google Scholar 

  • Naranjo CA, Bremner KE, Lanctot KL (1995) Effects of citalopram on a brief psychosocial intervention on alcohol intake, dependence and problems. Addiction 90: 87–99

    Article  PubMed  CAS  Google Scholar 

  • Naranjo CA, Dongier M, Bremner KE (1997) Long-acting injectable bromocriptine does not reduce relapse in alcoholics. Addiction 92: 969–978

    Article  PubMed  CAS  Google Scholar 

  • Pettinati HM, Volpicelli JR, Luck G et al. (2001) Double-blind clinical trial of sertraline treatment for alcohol dependence. J Clin Psychopharmacol 21: 143–153

    Article  PubMed  CAS  Google Scholar 

  • Powell BJ, Campbell JL, Landon JF et al. (1995) A double-blind, placebo-controlled study of nortriptyline and bromocriptine in male alcoholics subtyped by comorbid psychiatric disorders. Alcohol Clin Exp Res 19: 462–468

    Article  PubMed  CAS  Google Scholar 

  • Roy A, Vierkkunen M, Linnoila M (1987) Reduced central serotonin turnover in a subgroup of alcoholism. Prog Neuropsychopharmacol Biol Psychiatry 11: 173–177

    Article  PubMed  CAS  Google Scholar 

  • Sabourin A (1985) Effects of various therapeutic procedures on maintenance of abstinence in alcoholic patients: a statistical analysis. La semaine des hopitaux de Paris 61: 669–676

    Google Scholar 

  • Saletu-Zylharz GM, Arnold O, Anderer P et al. (2004) Differences in brain fuction between relapsing and abstaining alcohol-dependent patients, evaluated by EEG-Mapping. Alcohol Alcoholism 39: 233–240

    Article  Google Scholar 

  • Schmidt LG, Dufeu P, Kuhn S et al. (1994) Relapse prevention in alcoholics with an anticraving drug treatment: first results of the Berlin study. Pharmacopsychiatry 27[Suppl 1]: 21–23

    Article  PubMed  Google Scholar 

  • Schmidt LG, Dufeu P, Kuhn S et al. (1995) Perspektiven einer Pharmakotherapie der Alkoholabhängigkeit. Nervenarzt 66: 323–330

    PubMed  CAS  Google Scholar 

  • Schmidt LG, Kuhn S, Smolka M et al. (2002) Lisuride, a dopmine D2 receptor agonist, and anticraving drug expectancy as modifiers of relapse in alcohol dependence. Prog Neuropsychopharmacol Biol Psychiatry 26: 209–217

    Article  PubMed  CAS  Google Scholar 

  • Schrappe O (1980) Toxikomanie. In: Peters UH (Hrsg) Die Psychologie des 20. Jahrhunderts, Bd X. Ergebnisse für die Medizin (2). Psychiatrie. Kindler, Zürich, S 849–86

    Google Scholar 

  • Schuckit MA (1985) The clinical implications of primary diagnostic groups among alcoholics. Arch Gen Psychiatry 42: 1043–1049

    PubMed  CAS  Google Scholar 

  • Sellers EM, Toneatto R, Romach MK et al. (1994) Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence. Alcohol Clin Exp Res 18: 879–885

    Article  PubMed  CAS  Google Scholar 

  • Shaw GK, Majumdar SK, Waller S et al. (1987) Tiapride in the long-term management of alcoholics of anxious or depressive temperament. Br J Psychiatry 150: 164–168

    Article  PubMed  CAS  Google Scholar 

  • Shaw GK, Waller S, Majumdar SK et al. (1994) Tiapride in the prevention of relapse in recently detoxified alcoholics. Br J Psychiatry 165: 515–523

    Article  PubMed  CAS  Google Scholar 

  • Solomon KE, Annis HM (1990) Outcome and efficacy expectancy in the prediction of posttreatment drinking behaviour. Br J Addict 85: 659–665

    Article  PubMed  CAS  Google Scholar 

  • Soyka M, Aichmueller C, v Bardeleben U et al. (2003) Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: results from an open clinical study. Eur Addict Res 9: 65–72

    Article  PubMed  Google Scholar 

  • Tarter RE, Mcbride H, Buonpane N et al. (1977) Differentiation of alcoholics. Childhood history of minimal brain dysfunction, family history, and drinking pattern. Arch Gen Psychiatry 34: 761–768

    PubMed  CAS  Google Scholar 

  • Taylor DP, Rhines KC, Eison AS et al. (1995) Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug. J Clin Psychiatry 56: 3–11

    PubMed  Google Scholar 

  • Thomas R (1990) Fluvoxamine and alcoholism. Int Clin Psychopharmacol 6[Suppl 3]: 85–92

    Google Scholar 

  • Thorner MO, Fluckiger E, Calne DB (1980) Bromocriptine. A clinical and pharmacological review. Raven Press, New York

    Google Scholar 

  • Tiihonen J, Ryynanen OP, Kauhanen J et al. (1996) Citalopram in the treatment of alcoholism: a double-blind placebo-controlled study. Pharmacopsychiatry 29: 27–29

    Article  PubMed  CAS  Google Scholar 

  • Tollefson GD (1989) Serotonin and alcohol: interrelationships. Psychopathology 22[Suppl]: 37–48

    Article  PubMed  Google Scholar 

  • Toleffson GD, Lancaster SP, Montague-Clouse J (1991) The association of buspirone and its metabolite 1-pyrimidinylpiperazine in the remission of comorbid anxiety with depressive features and alcohol dependency. Psychopharmcol Bull 27: 163–170

    Google Scholar 

  • Varga A, Hansson P, Lundqvist C et al. (1998) Phosphatidylethanol in blood as a marker of ethanol consumption in healthy volunteers: comparison with other markers. Alcohol Clin Exp Res 22: 1832–1837

    PubMed  CAS  Google Scholar 

  • Verheul R, van den Brink W, Geerlings P (1999) A three-pathway psychobiological model of craving for alcohol. Alcohol Alcoholism 34: 197–222

    Article  CAS  Google Scholar 

  • Weijers H-G, Wiesbeck GA, Jakob F et al. (2001) Neuroendocrine response to fenfluramine and its relationship to personality in alcoholism. J Neural Transm 108: 1093–1105

    Article  PubMed  CAS  Google Scholar 

  • Weijers H-G, Wiesbeck GA, Wodarz N et al. (2003) Gender and personality in alcoholism. Arch Wom Ment Health 6: 245–252

    Article  Google Scholar 

  • Wiesbeck GA, Weijers HG, Chick J et al. (1999) Ritanserin in relapse prevention in abstinent alcoholics: results from a placebo-controlled double-blind international multicenter trial. Alcohol Clin Exp Res 23: 206–215

    Google Scholar 

  • Wiesbeck GA, Weijers H-G, Lesch OM et al. (2001) Flupenthixol decanoate and relapse prevention in alcoholics: results from a placebo-controlled study. Alcohol Alcoholism 36: 329–334

    Article  CAS  Google Scholar 

  • Wiesbeck GA, Weijers H-G, Wodarz N et al. (2003) Gender related differences in pharmacological relapse prevention with flupenthixol decanoate. Arch Wom Ment Health 6: 259–262

    Article  CAS  Google Scholar 

  • Wiesbeck GA, Weijers H-G, Wodarz N et al. (2004) Serotonin transporter gene polymorphism and personality traits in primary alcohol dependence. World J Biol Psychiatry 5: 42–45

    Article  Google Scholar 

  • Wolffgramm J, Heyne A (1995) From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat. Behav Brain Res 70: 77–94

    Article  PubMed  CAS  Google Scholar 

  • Wurst FM, Metzger JW on behalf of the WHO/ISBRA study on biological state and trait markers of alcohol use and dependence (2002) The direct ethanol metabolite ethyl glucuronide is a specific marker of recent alcohol consumption. Alcohol Clin Exp Res 26: 1114–1119

    Article  PubMed  CAS  Google Scholar 

  • Wurst FM, Vogel R, Jachau K et al. (2003a) Ethyl glucuronide discloses recent covert alcohol use not detected by standard testing in forensic psychiatric inpatients. Alcohol Clin Exp Res 27: 471–476

    Article  PubMed  CAS  Google Scholar 

  • Wurst FM, Skipper GE, Weinmann W (2003b) Ethyl glucuronide-the direct ethanol metabolite on the threshold from science to routine use. Addiction 98[Suppl 2]: 51–61

    Article  PubMed  Google Scholar 

  • Wurst FM, Alexson S, Wolfersdorf M et al. (2004) Concentration of fatty acid ethyl esters in hair of alcoholics: comparison to other biological state markers and self reported ethanol intake. Alcohol Alcoholism 39: 33–38

    Article  CAS  Google Scholar 

  • Zuckerman M (1994) Behavioral expressions and biosocial bases of sensation-seeking. Cambridge University Press, New York

    Google Scholar 

Literatur

  • Barrowclough C, Haddock G, Tarrier N et al. (2001) Randomized controlled trial of motivational interviewing, cognitive behavior therapy, and family intervention for patients with comorbid schizophrenia and substance use disorders. Am J Psychiatry 158: 1706–1713

    Article  PubMed  CAS  Google Scholar 

  • Borges G, Walters EE, Kessler RC (2000) Associations of substance use, abuse, and dependence with subsequent suicidal behavior. Am J Epidemiol 151: 781–789

    PubMed  CAS  Google Scholar 

  • Cacciola JS, Alterman AI, Rutherford MJ et al. (2001) The relationship of psychiatric comorbidity to treatment outcomes in methadone maintained patients. Drug Alcohol Depend 61: 271–280

    Article  PubMed  CAS  Google Scholar 

  • Covey LS, Glassman AH, Stetner F (1998) Cigarette smoking and major depression. J Addict Dis 17: 35–46

    Article  PubMed  CAS  Google Scholar 

  • Covey LS, Glassman AH, Stetner F et al. (2002) A randomized trial of sertraline as a cessation aid for smokers with a history of major depression. Am J Psychiatry 159: 1731–1737

    Article  PubMed  Google Scholar 

  • Dean AJ, Bell J, Mascord DJ et al. (2002) A randomised, controlled trial of fluoxetine in methadone maintenance patients with depressive symptoms. J Affect Disord 72: 85–90

    Article  PubMed  CAS  Google Scholar 

  • Farrell M, Howes S, Taylor C et al. (1998) Substance misuse and psychiatric comorbidity: an overview of the OPCS National Psychiatric Morbidity Survey. Addict Behav 23: 909–918

    Article  PubMed  CAS  Google Scholar 

  • Griffiths RR, Wolf B (1990) Relative abuse liability of different benzodiazepines in drug abusers. J Clin Psychopharmacol 10: 237–243

    Article  PubMed  CAS  Google Scholar 

  • Hansen SS, Munk-Jorgensen P, Guldbaek B et al. (2000) Psychoactive substance use diagnoses among psychiatric in-patients. Acta Psychiatr Scand 102: 432–438

    Article  PubMed  CAS  Google Scholar 

  • Hunt GE, Bergen J, Bashir M (2002) Medication compliance and comorbid substance abuse in schizophrenia: impact on community survival 4 years after a relapse. Schizophr Res 54: 253–264

    Article  PubMed  Google Scholar 

  • Jacobsen LK, Southwick SM, Kosten TR (2001) Substance use disorders in patients with posttraumatic stress disorder: a review of the literature. Am J Psychiatry 158: 1184–1190

    Article  PubMed  CAS  Google Scholar 

  • Kavanagh DJ, McGrath J, Saunders JB et al. (2002) Substance misuse in patients with schizophrenia: epidemiology and management. Drugs 62: 743–755

    Article  PubMed  Google Scholar 

  • Krystal JH, D’Souza DC, Madonick S et al. (1999) Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients. Schizophr Res 35: S35–S49

    Article  PubMed  Google Scholar 

  • Merikangas KR, Mehta RL, Molnar BE et al. (1998) Comorbidity of substance use disorders with mood and anxiety disorders: results of the International Consortium in Psychiatric Epidemiology. Addict Behav 23: 893–907

    Article  PubMed  CAS  Google Scholar 

  • Murphy GE, Wetzel RD (1990) The lifetime risk of suicide in alcoholism. Arch Gen Psychiatry 47: 383–392

    PubMed  CAS  Google Scholar 

  • Raimo EB, Schuckit MA (1998) Alcohol dependence and mood disorders. Addict Behav 23: 933–946

    Article  PubMed  CAS  Google Scholar 

  • Regier DA, Farmer ME, Rae DS et al. (1990) Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264: 2511–2518

    Article  PubMed  CAS  Google Scholar 

  • Sherwood Brown E, Suppes T et al. (2001) Drug abuse and bipolar disorder: comorbidity or misdiagnosis? J Affect Disord 65: 105–115

    Article  Google Scholar 

  • Soyka M, Aichmuller C, Bardeleben U et al. (2003) Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: results from an open clinical study. Eur Addict Res 9: 65–72

    Article  PubMed  Google Scholar 

  • Weiner E, Ball MP, Summerfelt A et al. (2001) Effects of sustained-release bupropion and supportive group therapy on cigarette consumption in patients with schizophrenia. Am J Psychiatry 158: 635–637

    Article  PubMed  CAS  Google Scholar 

  • Wodarz N, Johann M (2003) Veränderte Wirksamkeit von Arzneimitteln bei Suchterkrankungen. Arzneimitteltherapie 21: 336–341

    CAS  Google Scholar 

Literatur

  • Athen D (1986) Comparative investigation of chlormethiazole and neuroleptic agents in the treatment of alcoholic delirium. Acta Psychiatr Scand 73: 167–170

    Article  Google Scholar 

  • Athen D, Hippius H, Meyendorf R et al. (1977) Ein Vergleich der Wirksamkeit von Neuroleptika und Chlormethiazol bei Behandlung des Alkoholdelirs. Nervenarzt 48: 528–532

    PubMed  CAS  Google Scholar 

  • BAnz-Nr. 116 (27. 06. 1991) ATC-Code: NO5CMO2, Monografie: Clomethiazol

    Google Scholar 

  • Bayer AJ, Bayer EM, Pathy MSJ et al. (1986) A double-blind controlled study of chlormethiazole and triazolam as hypnotics in the elderly. Acta Psychiatr Scand 73: 104–111

    Article  Google Scholar 

  • Beckmann H, Athen D (1978) Die Therapie des Delirium tremens. Dtsch Med Wochenschr 103: 1427–1428

    Article  PubMed  CAS  Google Scholar 

  • Calverley PMA, Carmichael GLM, Scott DB (1984) The effect of chlormethiazole on the hypoxic drive to breathing in normal man. Br J Clin Phamacol 18: 163–167

    CAS  Google Scholar 

  • Douglas NJ, White DP, Weil JV et al. (1982) Hypoxic ventilatory response decrease during sleep in normal man. Am Rev Resp Dis 1235: 286–289

    Google Scholar 

  • Evans J, Lewis SA, Tinker M (1972) Chlormethiazole, sleep an drug withdrawal. Psychol Med 2: 239–247

    Article  PubMed  CAS  Google Scholar 

  • Feuerlein W (1989) Aktuelle Beiträge zur Definition und Therapie der Alkoholkrankheit. Neuropsychiatrie 3: 7–12

    Google Scholar 

  • Fischer PA (1977) Intensivbehandlung des Alkoholentzugssyndroms. Diagnostik Intensivther 2: 9–11

    Google Scholar 

  • Fritze J, Schmauss M, Holsboer F (2003) Was bedeutet die Vorschlagsliste verordungsfähiger Arzneimittel (sog. Positivliste) für die Psychopharmakatherapie? Nervenarzt 2: 195–197

    Article  Google Scholar 

  • Geisler I, Herberg D (1967) Studies on the effect of some commonly used drugs on the excitability of the respiratory centre in man. Therapiewoche 47: 1941–1947

    Google Scholar 

  • Giacobini E, Salum I (1961) Treatment of delirium tremens. A comparative study of different therapeutic methods in 434 cases. Acta Psychiatr Scand 37: 198–208

    Article  PubMed  CAS  Google Scholar 

  • Gsell S, Ossenkopp G, Weigeldt HD et al. (1972) Atem-und Herzstillstand unter Distraneurin. Nervenarzt 43: 635

    PubMed  CAS  Google Scholar 

  • Helbig H (1962) Das tödliche Alkoholdelir. Nervenarzt 33: 221–226

    PubMed  CAS  Google Scholar 

  • Hoensch HP (1986) Effect of chlormethiazole on the hepatic monooxygenase enzyme system. Acta Psychiatr Scand 73: 66–68

    Article  Google Scholar 

  • Holzbach E, Bühler KE (1978) Die Behandlung des Delirium tremens mit Haldol. Nervenarzt 49: 405–409

    PubMed  CAS  Google Scholar 

  • Hunnius Pharmazeutisches Wörterbuch, 8. Aufl (1998) de Gruyter, Berlin, S 344

    Google Scholar 

  • Jostell KG, Agurell S, Hollister LE et al. (1978) Kinetics of chlormethiazole in patients with alcohol withdrawal manifestations. Clin Pharmacol: 181–187

    Google Scholar 

  • Jostell KG, Mitchell RM, Scott DB et al. (1986) The bioavailability and pharmacodynamics of chlormethiazole in healthy young and elderly volunteers: preliminary findings. Acta Psychiatr Scand 73: 32–33

    Article  Google Scholar 

  • Jostell KG, Fagan D, Björk M et al. (1987) Pharmacokinetics of chlormethiazole in healthy young and elderly volunteers using stable isotope methodology. In: Jostell KG (ed) Pharmacokinetics of chlormethiazole in man and influence of altered physiological conditions. Thesis, University of Uppsala

    Google Scholar 

  • Kalant H, Khanna JM (1986) Metabolic and functional aspects of tolerance to chlormethiazole and cross-tolerance to ethanol in the rat. Acta Psychiatr Scand 73: 45–53

    Article  Google Scholar 

  • Kalant H, Khanna JM, Liewellyn M et al. (1986) Functional tolerance to chlormethiazole and crosstolerance to ethanol in the rat: importance of test and mode of drug administration. Acta Psychiatr Scand 73: 54–65

    Article  Google Scholar 

  • Keup W (1977) Das Abhängigkeitspotential des Clomethiazol (Distraneurin). Dtsch Ärztebl 74: 1902–1905

    Google Scholar 

  • Klotz U, Avant GR, Hoyumpa A et al. (1975) The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J Clin Invest 55: 347–359

    Article  PubMed  CAS  Google Scholar 

  • Koo KW, Sax DS, Snider GL (1975) Arterial blood gases and pH during sleep in chronic obstructive pulmonary disease. Am J Med 58: 663–670

    Article  PubMed  CAS  Google Scholar 

  • Laborit H, Coirault R (1957) L’utilisation en clinique mèdicale et psychiatrique de Paction hypogène d’un dèrivè du moyan thiazolique de la Vitamine B1, Le S.C.T.Z. Sem Med (Paris) 33: 1704

    CAS  Google Scholar 

  • Laborit H, Coirault R, Damasio R et al. (1957) Surun type nouveau d’anesthèsie chirugicale et sur e’emploi en thèrapeutique d’un dèpresseur du cortex cèrèbral. (S.C.T.Z.). Aneth Analg 14: 384

    CAS  Google Scholar 

  • Laux G (2003a) Versorgung des akut verwirrten alten Menschen — eine interdisziplinäre Aufgabe/Akutbehandlung? Dtsch Ärztebl 100, Ausgabe 49: A-3253–A-3254

    Google Scholar 

  • Laux G (2003b) Notfalltherapie. Fortschr Neurol Psychiatr 71: 483–501

    Article  PubMed  CAS  Google Scholar 

  • Lesch OM, Walter H, in Zusammenarbeit Mit Gierth L, Leitner A, Platz WE, Zylharz G (1994) „Cutt off“-Punkte zur Bestimmung der Trinktypen nach Lesch, 2. Aufl. Vivantes, Berlin

    Google Scholar 

  • Liljenberg B, Almquist M, Broman JE et al. (1986) The effects of chlormethiazole in EEG recorded sleep in normal elderly volunteers. Acta Psychiatr Scand 73: 34–39

    Article  Google Scholar 

  • Lucht M, Kuehn KU, Armbruster J et al. (2003) Alcohol withdrawal treatment in intoxicated vs non-intoxicaded patients: a controlled open-label study with tiapride/carbamazepine, clomethiazole and diazepam. Alcohol Alcoholism 38: 168–175

    Article  CAS  Google Scholar 

  • Majumdar SK (1978) The effect of chlormethiazole on hepatic microsomal enzymes. Pharmatherapeutica 2: 27–30

    CAS  Google Scholar 

  • Majumdar SK (1981) Effects on the endocrine system of drugs used in treating the ethanol withdrawal syndrome: a survey. Drug Alcohol Depend 7: 379–385

    Article  PubMed  CAS  Google Scholar 

  • Majumdar SK (1986) The influence of chlormethiazole on the neuroendocrine system in chronic alcoholics. Acta Psychiatr Scand 73:69–72

    Article  Google Scholar 

  • Maxion H, Schneider E (1970) Der Einfluss von Chlormethiazol (Distraneurin) auf das Schlaf-Elektroencephalogramm nach Alkoholdelir. Pharmakopsychiatr Neuro Psychopharm 3: 233–238

    Google Scholar 

  • Möller HJ, Laux G, deister A (2001) Psychiatrie und Psychotherapie, 2. Aufl. Thieme, Stuttgart

    Google Scholar 

  • Moore RG, Triggs EJ, Shanks CM et al. (1975a) Pharmacokinetics of chlormethiazole in humans. Eur J Clin Pharmacol 8: 353–357

    Article  PubMed  CAS  Google Scholar 

  • Moore RG, Robertson AV, Smyth MP et al. (1975b) Metabolism and urinary excretion of chlormethiazole in humans. Xenobiotica 5: 687–696

    Article  PubMed  CAS  Google Scholar 

  • Müller-Oerlinghausen B (2001) Abhängigkeit und Missbrauch von Substanzen. Dtsch Ärztebl 39,24: A-1625–A-1627

    Google Scholar 

  • Nies AS, Shand PG, Wilkinson GR (1976) Altered hepatic blood flow and drug disposition. Clin Pharmacokinet 1: 135–155

    Article  PubMed  CAS  Google Scholar 

  • Ögren SO (1986) Chlormethiazole-mode of action. Acta Psychiatr Scand 73: 13–27

    Article  Google Scholar 

  • Pälsson A (1986) The efficacy of early chlormethiazole medication in the prevention of delirium tremens. A retrospective study of the outcome of different drug treatment strategies at the Helsingborg Psychiatric Clinics, 1975–1980. Acta Psychiatr Scand 73: 140–145

    Article  Google Scholar 

  • Pentikäinen PJ, Neuvonen PJ, Jostell KG (1980) Pharmacokinetics of clormethiazole in healthy volunteers and patients with cirrhosis of the liver. Eur J Clin Pharmacol 17: 275–84

    Article  PubMed  Google Scholar 

  • Platz W (1981) Therapie medikamentös bedingter deliranter Syndrome, insbesondere bei Clomethiazol-Abhängigkeit. In: Keup W (Hrsg) Behandlung der Sucht und des Missbrauchs chemischer Stoffe. 4. Wissenschaftliches Symposium, Deutsche Hauptstelle gegen die Suchtgefahren, Tutzing, 1980. Thieme, Stuttgart New York, S 65–73

    Google Scholar 

  • Platz W (1985) Medikamentöse Therapie bei gerontopsychiatrischen Notfällen. Med Klin 80: 511–513

    Google Scholar 

  • Schied HW, Mann K (1989) Die Behandlung des Delirium tremens und des Alkoholentzugssyndroms. In: Schied HW, Heimann H, Mayer K (Hrsg) Der chronische Alkoholismus. Fischer, Stuttgart New York, S 285–300

    Google Scholar 

  • Schmehling E (1967) Atemdepression nach Distraneurin? Nervenarzt 38: 266–269

    PubMed  CAS  Google Scholar 

  • Schmidt L (1986) Alkoholkrankheit Alkoholmissbrauch. Kohlhammer, Stuttgart Berlin Köln Mainz

    Google Scholar 

  • Scott DB (1986) Circulatory and respiratory effects of chlormethiazole. Acta Psychiatr Scand 73: 28–31

    Article  Google Scholar 

  • Stille G (1986) Das Abhängigkeitspotential von Clomethiazol. In: Evans G, Feuerlein W, Glatt MM et al. (Hrsg) Clomethiazol. Verlag für angewandte Wissenschaften, München, S 103–109

    Google Scholar 

  • Swift CG, Procter AW (1994) Chlormethiazole, a clinical profile, rev edn. The Medicine Group, Abingdon

    Google Scholar 

  • Who Expert Committe on Drug Dependence (1988) Twenty-fourth report. Technical Report Series 915. World Health Organization, Geneva, pp 11–13

    Google Scholar 

Literatur

  • Al Quatari M, Bouchenafa O, Littleton J (1998) Mechanisms of action of acamprosate, part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex. Alcohol Clin Exp Res 22: 810–814

    Google Scholar 

  • Ansoms C, Deckers F, Lehert P et al. (2000) An open study with acamprosate in Belgium and Luxemburg: results on sociodemographcs, supportive treatment and outcome. Eur Addict Res 6: 132–140

    Article  PubMed  CAS  Google Scholar 

  • Barrias JA, Chabac S, Ferreira L et al. (1997) Acamprosate: multicenter Portuguese efficacy and tolerance evaluation study. Psiquiatria Clinica 18: 149–160

    Google Scholar 

  • Berglund M, Thelander S, Jonsson E (2003) Treating alcohol and drug abuse. An evidence based review. Wiley VCH Verlag, Weinheim

    Book  Google Scholar 

  • Besson J, Aeby F, Kasas A et al. (1998) Combined efficacy of acamprosate and disulfiram in the treatment of alcoholism: a controlled study. Alcohol Clin Exp Res 22: 573–579

    Article  PubMed  CAS  Google Scholar 

  • Chick J, Howlett H, Morgan MY et al. (2000) United Kingdom Multicentre Acamprosate Study (UKMAS): a 6-month prospective study of acamprosate versus placebo in preventing relapse after withdrawal from alcohol. Alcohol Alcohol 35: 176–187

    PubMed  CAS  Google Scholar 

  • Engelhard K, Werner C, Lu H et al. (2000) The neuroprotective effect of the glutamate antagonist acamprosate following experimental cerebral ischemia. A study with the lipid peroxidase inhibitor u-101033e. Anaesthesist 49: 816–821

    Article  PubMed  CAS  Google Scholar 

  • Geerlings P, Ansoms C, van den BRINK W (1995) Acamprosate and relapse prevention in outpatient alcoholics: results from a randomized, placebo-controlled double-blind study in the Netherlands, Belgium and Luxembourg. Eur Addict Res 3: 129–137

    Article  Google Scholar 

  • Gual A, Lehert P (2001) Acamprosate during and after acute alcohol withdrawal: a double-blind placebo-controlled study in Spain. Alcohol Alohol 36: 413–418

    CAS  Google Scholar 

  • Harris BR, Prendergast MA, Gibson DA et al. (2002) Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors. Alcohol Clin Exp Res 26: 1779–1793

    PubMed  CAS  Google Scholar 

  • Kiefer F, Wiedemann K (2004) Zur differentiellen Indikationsstellung von Anti-Craving-Substanzen bei Alkoholabhänngigkeit. Nervenheilkunde 23: 521–526

    Google Scholar 

  • Kiefer F, Jahn H, Tarnaske T et al. (2003) Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study. Arch Gen Psychiatry 60: 92–99

    Article  PubMed  CAS  Google Scholar 

  • Koob GF, Mason BJ, De Witte P et al. (2002) Potential neuroprotective effects of acamprosate. Alcohol Clin Exp Res 26: 586–592

    Article  PubMed  CAS  Google Scholar 

  • Ladewig D, Knecht T, Leher P et al. (1993) Acamprosate — a stabilizing factor in long-term withdrawal of alcoholic patients. Ther Umsch 50: 182–188

    PubMed  CAS  Google Scholar 

  • Lhuintre JP, Daoust M, Moore ND et al. (1985) Ability of calcium bis acetyl homotaurine, a GABA agonist, to prevent relapse in weaned alcoholics. Lancet 1: 1014–1016

    Article  PubMed  CAS  Google Scholar 

  • Lhuintre JP, Moore N, Tran G et al. (1990) Acamprosate appears to decrease alcohol intake in weaned alcoholics. Alcohol Alcohol 25: 613–622

    PubMed  CAS  Google Scholar 

  • Littleton J, Zieglgänsberger W (2003) Pharmacological mechanisms of naltrexone and acam-prosate in the prevention of relapse in alcohol dependence. Am J Addict 12[Suppl 1]: S3–S11

    Article  PubMed  Google Scholar 

  • Mann K (2004) Project PREDICT. Suchtforschungsverbund Baden-Württemberg. www.bw-suchtweb.de

    Google Scholar 

  • Mann K, Lehert P, Morgan MY (2004) The efficacy of acamprosate in maintaining abstinence in alcohol dependent individuals: results of a meta-analysis. Alcohol Clin Exp Res 28: 51–63

    Article  PubMed  Google Scholar 

  • Namkoong K, Lee B-O, Lee P-G et al. (2003) Acamprosate in Korean alcohol-dependent patients: a multi-centre, randomized, doubleblind, placebo-controlled study. Alcohol Alcohol 38: 135–141

    PubMed  CAS  Google Scholar 

  • Paille FM, Guelfi JD, Perkins AC et al. (1995) Double-blind randomized multicentre trial of acamprosate in maintaining abstinence from alcohol. Alcohol Alcohol 30: 239–247

    PubMed  CAS  Google Scholar 

  • Pelc I, Le Bon O, Verbanck P et al. (1992) Calcium acetyl homotaurinate for maintaining abstinence in weaned alcoholic patients; a placebo controlled double-blind multi-centre study. In: Naranjo C, Sellers E (eds) Novel pharmacological interventions for alcoholism. Springer, New York, pp 348–352

    Google Scholar 

  • Pelc I, Verbanck P, Le Bon O et al. (1997) Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients. A 90-day placebo-controlled dose-finding study. Br J Psychiatry 171: 73–77

    Article  PubMed  CAS  Google Scholar 

  • Pelc I, Ansoms C, Lehert P et al. (2003) The European NEAT program: an integrated approach using acamprosate and psychosocial support for the prevention of relapse in alcohol-dependent patients with a statistical modeling of therapy success prediction. Alcohol Clin Exp Res 26: 1529–1538

    Google Scholar 

  • Poldrugo F (1997) Acamprosate treatment in a long-term community-based alcohol rehabilitation programme. Addiction 92: 1537–1546

    Article  PubMed  CAS  Google Scholar 

  • Rammes G, Mahal B, Putzke J et al. (2001) The anticraving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Neuropharmacology 40: 749–760

    Article  PubMed  CAS  Google Scholar 

  • Rousseaux JP, Hers D, Ferauge M (1996) Does acamprosate influence alcohol consumption of weaned alcoholics? J Pharm Belg 51: 65–68

    Google Scholar 

  • Sass H, Soyka M, Mann K et al. (1996) Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence. Arch Gen Psychiatry 53: 673–680

    PubMed  CAS  Google Scholar 

  • Soyka M, Chick J (2003) Use of acamprosate and opioid antagonists in the treatment of alcohol dependence: an European perspective. Am J Addict 12[Suppl 1]: S69–S80

    Article  PubMed  Google Scholar 

  • Soyka M, Preuss U, Schuetz C (2002) Use of acamprosate and different kinds of psychosocial support in relapse prevention of alcoholism. Results of a non-blind multicentre study. Drugs R D 3: 1–12

    Article  PubMed  CAS  Google Scholar 

  • Spanagel R, Pendyala G, Abarca C et al. (2004) The circadian clock gene Period 2 influences the glutamatergic system and thereby modulates alcohol consumption. Nature Med 11: 35–42

    PubMed  Google Scholar 

  • Tempesta E, Janiri L, Bignamini A et al. (2000) Acamprosate and relapse prevention in the treatment of alcohol dependence: a placebocontrolled study. Alcohol Alcohol 35: 202–209

    PubMed  CAS  Google Scholar 

  • Whitworth AB, Fischer F, Lesch OM et al. (1996) Comparison of acamprosate and placebo in long-term treatment of alcohol dependence. Lancet 347: 1438–1442

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Altshuler HL, Phillips PA, Feinhandler DA (1980) Alternation of ethanol self-administration by naltrexone. Life Sci 26: 679–688

    Article  PubMed  CAS  Google Scholar 

  • Anton RF, Moak DH, Waid R et al. (1999) Naltrexone and cognitive behavioral therapy of outpatient alcoholics: results of a placebocontrolled trial. Am J Psychiatry 156: 1758–1764

    PubMed  CAS  Google Scholar 

  • Anton RF, Moak DH, Latham PK et al. (2001) Posttreatment results of combining naltrexone and cognitive behavior therapy for the treatment of alcoholism. J Clin Psychopharmacol 21: 72–77

    Article  PubMed  CAS  Google Scholar 

  • Balldin J, Berglund M, Borg S et al. (2003) A 6-month controlled naltrexone study: combined effect with cognitive behavioral therapy in outpatient treatment of alcohol dependence. Alc Clin Exp Res 27: 1142–1149

    Article  CAS  Google Scholar 

  • Croop RS, Faulkner EB, Labriola DF (1997) The safety profile of naltrexone in the treatment of alcoholism. Results from a multicenter usage study. The Naltrexone Usage Study Group. Arch Gen Psychiatry 54: 1130–1135

    PubMed  CAS  Google Scholar 

  • Chick J, Anton R, Checinski K et al. (2000) A multicentre, randomised, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence in adults. Alcohol Alcohol 35: 587–593

    PubMed  CAS  Google Scholar 

  • Garbutt, JC, West SL, Carey TS et al. (1999) Pharmacological treatment of alcohol dependence: a review of the evidence. JAMA 281: 1318–1325

    Article  PubMed  CAS  Google Scholar 

  • Gastpar M, Bonnet U, Boening J (2002) Lack of efficacy of naltrexone in the prevention of alcohol relapse. Results from a German multicenter study. J Clin Psychopharmacol 22: 592–598

    Article  PubMed  CAS  Google Scholar 

  • Gillan MG, Kosterlitz HW, Paterson SJ (1980) Comparison of the binding characteristics of tritiated opiates and opioid peptides. Br J Pharmacol 70: 481–490

    PubMed  CAS  Google Scholar 

  • Guardia J, Caso C, ARIAS F et al. (2002) A double-blind, placebo-controlled study of naltrexone in the treatment of alcohol-dependence disorder: results from a multicenter clinical trial. Alcohol Clin Exp Res 26: 1381–1387

    PubMed  CAS  Google Scholar 

  • Hersh D, van Kirk JR, Kranzler HR (1998) Naltrexone treatment of comorbid alcohol and cocaine use disorders. Psychopharmacology 139: 44–52

    Article  PubMed  CAS  Google Scholar 

  • Heinälä P, Alho H, Kiianmaa K et al. (2001) Targeted use of naltrexone without prior detoxification in the treatment of alcohol dependence: a factorial double-blind, placebo-controlled trial. J Clin Psychopharmacol 21: 287–292

    Article  PubMed  Google Scholar 

  • Heinz A, Reimold M, Wrase J et al. (2005) Stable elevations in striatal μ-opioid receptor availability in detoxified alcoholics correlate with alcohol craving-a [11C] Carfentanil PET study. Arch Gen Psychiatry 62: 57–64

    Article  PubMed  Google Scholar 

  • Jaffe AJ, Rounsaville B, Chang G et al. (1996) Naltrexone, relapse prevention, and supportive therapy with alcoholics: an analysis of patient treatment matching. J Consult Clin Psychol 64: 1044–1053

    Article  PubMed  CAS  Google Scholar 

  • Kiefer F, Jahn H, Tarnaske T et al. (2003) Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study. Arch Gen Psychiatry 60: 92–99

    Article  PubMed  CAS  Google Scholar 

  • Kranzler HR, van Kirk J (2001) Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. Alcohol Clin Exp Res 25: 1335–1341

    Article  PubMed  CAS  Google Scholar 

  • Kranzler HR, Modesto-Lowe V, Nuwayser ES (1998) Sustained-release naltrexone for alcoholism treatment: a preliminary study. Alcohol Clin Exp Res 22: 1074–1079

    PubMed  CAS  Google Scholar 

  • Kranzler HR, Modesto-Lowe V, van Kirk JR (2000) Naltrexone vs. nefazodone for treatment of alcohol dependence. A placebo-controlled trial. Neuropsychopharmacology 22: 493–503

    Article  PubMed  CAS  Google Scholar 

  • Krystal JH, Cramer JA, Krol WF et al. (2001) Naltrexone in the treatment of alcohol dependence. N Engl J Med 345: 1734–1739

    Article  PubMed  CAS  Google Scholar 

  • Latt NC, Jurd S, Houseman J et al. (2002) Naltrexone in alcohol dependence: a randomized controlled trial of effectiveness in a standard clinical setting. Med J Aust 176: 530–534

    PubMed  Google Scholar 

  • Lee MC, Wagner HN, Tanada S et al. (1988) Duration of occupancy of opiate receptors by naltrexone. J Nucl Med 29: 1207–1211

    PubMed  CAS  Google Scholar 

  • Magnan J, Paterson SJ, Tavani A et al. (1982) The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties. Naunyn Schmiedebergs Arch Pharmacol 319: 197–205

    Article  PubMed  CAS  Google Scholar 

  • Mann K (2004) Pharmacotherapy of alcohol dependence: a review of the clinical data. CNS Drugs 18: 485–504

    Article  PubMed  CAS  Google Scholar 

  • Mann K, Lehert P, Morgan MY (2004) The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis. Alcohol Clin Exp Res 28: 51–63

    Article  PubMed  Google Scholar 

  • Mccaul ME, Wand GS, Eissenberg T et al. (2000) Naltrexone alters subjective responses to alcohol in heavy drinking subjects. Neuropsychopharmacology 22: 80–492

    Article  Google Scholar 

  • Monterosso JR, Flannery BA, Pettinati HM et al. (2001) Predicting treatment response to naltrexone: the influence of craving and family history. Am J Addict 10: 258–268

    Article  PubMed  CAS  Google Scholar 

  • Monti PM, Rohsenow DJ, Hutchison KE et al. (1999) Naltrexone’s effect on cue-elicited craving among alcoholics in treatment. Alcohol Clin Exp Res 23: 1386–1394

    PubMed  CAS  Google Scholar 

  • Monti PM, Rohsenow DJ, Swift RM et al. (2001) Naltrexone and cue exposure with coping and communication skills training for alcoholics: treatment process and 1-year outcomes. Alcohol Clin Exp Res 25: 1634–1647

    Article  PubMed  CAS  Google Scholar 

  • Morris PL, Hopwood M, Whelan G et al. (2001) Naltrexone for alcohol dependence: a randomized controlled trial. Addiction 96: 1565–1573

    Article  PubMed  CAS  Google Scholar 

  • O’Brien C (2005) Naltrexone: clinical data. In: Spanagel R, Mann K (eds) Drugs for relapse prevention of alcoholism. Birkhäuser, Basel

    Google Scholar 

  • O’Malley SS, Jaffe AJ, Chang G et al. (1992) Naltrexone and coping skills therapy for alcohol dependence. A controlled study. Arch Gen Psychiatry 49: 881–887

    PubMed  CAS  Google Scholar 

  • O’Malley SS, Jaffe AJ, Chang G et al. (1996) Sixmonth follow-up of naltrexone and psychotherapy for alcohol dependence. Arch Gen Psychiatry 53: 217–224

    PubMed  CAS  Google Scholar 

  • Oslin D, Liberto JG, O’Brien J et al. (1997) Naltrexone as an adjunctive treatment for older patients with alcohol dependence. Am J Geriatr Psychiatry 5: 324–332

    Article  PubMed  CAS  Google Scholar 

  • Rohsenow DJ, Colby SM, Monti PM et al. (2000) Predictors of compliance with naltrexone among alcoholics. Alcohol Clin Exp Res 24: 1542–1549

    Article  PubMed  CAS  Google Scholar 

  • Sinclair JD (2001) Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism. Alcohol Alcohol 36: 2–10

    PubMed  CAS  Google Scholar 

  • Smolka MN, Kiefer R, Mann K (2003) Fortschritte in der Behandlung von Alkoholabhänngigen: die medikamentöse Rückfallprophylaxe. MMW Fortschr Med 145: 65–69

    PubMed  Google Scholar 

  • Soyka M (siehe Kap. 4.4.1 in diesem Band, Riederer, zu Acamprosat)

    Google Scholar 

  • Srisurapanont M, Jarusuraisin N (2003) Opioid antagonists for alcohol dependence. Cochrane Database Syst Rev 3: CD001867

    Google Scholar 

  • Streeton C, Whelan G (2001) Naltrexone, a relapse-prevention maintenance treatment of alcohol dependence: a meta-analysis of randomized controlled trials. Alcohol Alcohol 36: 544–552

    PubMed  CAS  Google Scholar 

  • Volpicelli JR, O’Brien CP, Alterman AI et al. (1990) Naltrexone and the treatment of alcohol dependence: initial observations. In: Reid LB (ed) Opioids, bulimia, alcohol abuse and alcoholism. Springer, New York, pp 195–214

    Google Scholar 

  • Volpicelli JR, Alterman AI, Hayashida M (1992) Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49: 876–880

    PubMed  CAS  Google Scholar 

  • Volpicelli JR, Rhines KC, Rhines JS et al. (1997) Naltrexone and alcohol dependence. Role of subject compliance. Arch Gen Psychiatry 54: 737–742

    PubMed  CAS  Google Scholar 

Literatur

  • Azrin NH, Sisson RW, Meyer SR et al. (1982) Alcoholism treatment by disulfiram and community reinforcement therapy. J Behav Ther Exp Psychiatry 13: 105–112

    Article  PubMed  CAS  Google Scholar 

  • Bartmann U, Fautsch J (1991) Eine Chance für die ambulante Therapie. Psycho 17: 192–202

    Google Scholar 

  • Bartonicek V, Teisinger J (1962) Effect of tetraethyl thiuram disulphide (disulfiram) on metabolism of trichloro-ethylene in man. Br J Industr Med 19: 216–221

    CAS  Google Scholar 

  • Bilbao JM, Briggs SJ, Gray TA (1984) Filamentous axonopathy in disulfiram neuropathy. Ultrastruct Pathol 7: 295–300

    Article  PubMed  CAS  Google Scholar 

  • Chick J, Gough K, Falkowski W et al. (1992) Disulfiram treatment of alcoholism. Br J Psychiatry 161: 84–89

    Article  PubMed  CAS  Google Scholar 

  • Christensen JK, Ronsted P, Vaag VH (1984) Side effects after disulfiram. Acta Psychiatr Scand 69: 265–273

    Article  PubMed  CAS  Google Scholar 

  • Ciraulo DA, Barnhill J, Boxenbaum H (1985) Pharmacokinetic interaction of disulfiram and antidepressants. Am J Psychiatry 142: 1373–1374

    PubMed  CAS  Google Scholar 

  • Coger RW, Dymond AM, Serafetinides EA et al. (1976) Averaged visual evoked response amplitude-intensity slope and symmetry in withdrawal. Biol Psychiatry 11: 435–443

    PubMed  CAS  Google Scholar 

  • Cushmann P (1986) Sedative drug interactions of clinical importance. In: Galanter M (ed) Alcoholism, vol 4. Plenum Press, New York London

    Google Scholar 

  • Feuerlein W (1989) Alkoholismus — Mißbrauch und Abhängigkeit, 4. Aufl. G Thieme, Stuttgart

    Google Scholar 

  • Fischer I (1945) Säregen svampförgiftining. Sv Läk-Tidn 42: 2513–2515

    Google Scholar 

  • Fuller RK (1988) Disulfiram treatment of alcoholism. In: Rose RM, Barret JE (eds) Alcoholism: origins and outcome. Raven Press, New York, pp 237–244

    Google Scholar 

  • Fuller RK, Roth HP (1979) Disulfiram for the treatment of alcoholism: an evaluation in 128 men. Ann Intern Med 90: 901–904

    PubMed  CAS  Google Scholar 

  • Fuller RK, Williford WO (1980) Life-table analysis of abstinence in a study evaluating the efficacy of disulfiram. Alcohol Clin Exp Res 4: 298–301

    Article  PubMed  CAS  Google Scholar 

  • Gill K, Amit Z (1989) Serotonin uptake blockers and voluntary alcohol consumption. A review of recent studies. In: Galanter M (ed) Alcoholism, vol 7. Plenum Press, New York London, pp 225–248

    Google Scholar 

  • Hald E, Jacobson I (1948) A drug sensitising the organism to ethylalcohol. Lancet ii: 1001–1003

    Article  Google Scholar 

  • Haubroe K (1980) What we know today about “Antabuse® (Disulfiram)”. Manedsskrift for praktisk Laegegerning 58: 30–40

    Google Scholar 

  • Iber FL, Lee K, Lacoursiere R et al. (1987) Liver toxicity encoutered in the Veterans Administration trial of disulfiram in alcoholics. Alcohol Clin Res 11: 301–304

    Article  CAS  Google Scholar 

  • Jacobsen E (1967a) Neues über die theoretische Grundlage der Disulfiram-Wirkung. Med Welt 18(N.F.): 2169–2173

    Google Scholar 

  • Jacobsen E (1967b) Die Verwendung von Disulfiram (Antabuse®). Med Welt 18 (N.F.): 2230–2234

    Google Scholar 

  • Jaffe JH, Ciraulo DA (1985) Drugs used in the treatment of alcoholism. In: Mendelson JH, Mello NK (eds) The diagnosis and treatment of alcoholism, 2nd edn. McGraw-Hill, New York

    Google Scholar 

  • Jensen E (1984) A proper use of Antabuse, the Danish model of treatment. Br J Clin Pract [Suppl 36] 38: 2–4

    Google Scholar 

  • Kingsbury SJ, Salzman C (1990) Disulfiram in the treatment of alcoholic patients with schizophrenia. Hosp Commun Psychiatry 41: 133–134

    CAS  Google Scholar 

  • Kitson TM (1977) The disulfiram-ethanol reaction. J Stud Alcohol 38: 96–113

    PubMed  CAS  Google Scholar 

  • Koelsch F (1914) Über neuartige gewerbliche Erkrankungen in Kalkstickstoffbetrieben. Münch Med Wochenschr 35: 1869–1870

    Google Scholar 

  • Koivusalo M (1956) Studies on the metabolism of methanol and formaldehyde in the animal organism. Acta Physiol Scand 39[Suppl 131]

    Google Scholar 

  • Küfner H, Feuerlein W (1989) In-patient treatment for alcoholism. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Lenz H (1957) Zur Ursache der fehlenden Antabus-Alkohol-Reaktion. Wien Klin Wochenschr 38/39: 743

    Google Scholar 

  • Lindros KO, Stowell A, Pikkarainen P et al. (1981) The disulfiram (Antabuse) alcohol reaction in male alcoholics: its efficient management by 4-methylpyrazole. Alcohol Clin Exp Res 5: 528–530

    Article  PubMed  CAS  Google Scholar 

  • Macleod SM, Sellers EM, Giles HG et al. (1978) Interaction of disulfiram with benzodiazepines. Clin Pharmacol Ther 24: 583–589

    PubMed  CAS  Google Scholar 

  • Mccrady B (1989) Outcomes of family-involved alcoholism treatment. In: Galanter M (ed) Alcoholism, vol 7. Plenum Press, New York London, pp 165–182

    Google Scholar 

  • Nutt D, Adinoff B, Limoila M (1989) Benzodiazepines in the treatment of alcoholism. In: Galanter M (ed) Alcoholism, vol 7. Plenum Press, New York London, pp 283–313

    Google Scholar 

  • Pattison EM (1985) The selection of treatment modalities for the alcoholic patient. In: Mendelson JH, Mello NK (eds) The diagnosis and treatment of alcoholism, 2nd edn. McGraw-Hill, New York

    Google Scholar 

  • Peeke SC, Prael AR, Herning RI et al. (1979) Effect of disulfiram on cognition, subjective response, and cortical event-related alcoholic in nonalcoholic subjects. Alcohol Clin Exp Res 3: 223–229

    Article  PubMed  CAS  Google Scholar 

  • Perman ES (1962) Effect of ethanol on oxygen uptake and on blood glucose concentration in anesthetized rabbits. Acta Physiol Scand 55: 189–202

    Article  PubMed  CAS  Google Scholar 

  • Platz WE (1995) Alkoholkriminalität. In: Schaffstein F, Schöch H, Schüler-Springorum H (Hrsg) Neue kriminologische Studien, Bd 12. Fink, München

    Google Scholar 

  • Rainey JM (1977) Disulfiram toxicity and carbon disulfide poisoning. Am J Psychiatry 134: 371–378

    PubMed  CAS  Google Scholar 

  • Robichaud C, Strickler D, Bigelow G et al. (1979) Disulfiram maintenance employee alcoholism treatment: a three-phase evaluation. Behav Ther 14: 618–621

    Google Scholar 

  • Schmidt L (1986) Alkoholkrankheit und Alkoholmißbrauch. Kohlhammer, Stuttgart

    Google Scholar 

  • Schuckit MA (1981) Disulfiram (Antabuse) and the treatment of alcoholic men. Adv Alcohol 11: 1–4

    Google Scholar 

  • Schuckit MA (1985a) Treatment of alcoholism in offices and outpatient settings. In: Mendelson JH, Mello NK (eds) The diagnosis and treatment of alcoholism, 2nd edn. McGraw-Hill, New York

    Google Scholar 

  • Schuckit MA (1985b) A one-year follow-up of men alcoholics given disulfiram. J Stud Alcohol 46: 191–195

    PubMed  CAS  Google Scholar 

  • Schuckit MA (1985c) Inpatient and residential approaches to the treatment of alcoholism. In: Mendelson JH, Mello NK (eds) The diagnosis and treatment of alcoholism, 2nd edn. Mc-Graw-Hill, New York

    Google Scholar 

  • Schuckit MA (1989) Drug and alcohol abuse. Plenum, New York London

    Google Scholar 

  • Sellers EM, Naranjo CA, Peachey JE (1981) Drugs to decrease alcohol consumtion. N Engl J Med 305: 1255–1262

    Article  PubMed  CAS  Google Scholar 

  • Staub H (1955) Beiträge zum Antabuse-Problem. Helv Physiol Acta 13: 121–140

    CAS  Google Scholar 

  • Strömme JH, Eldjarn L (1966) Distribution and chemical forms of diethyldithiocarbamate and tetraethylthiuram disulphide (Disulfiram) in mice in relation to radioprotection. Biochem Pharmacol 15: 287–297

    Article  PubMed  Google Scholar 

  • Truitt EB, Duritz G, Morgan AM et al. (1962) Disulfiram-like actions produced by hypoglycemic sulfonylurea compounds. Q J Stud Alcohol 23: 197–207

    PubMed  CAS  Google Scholar 

  • Usdin GL, Rond PC, Hinchcliffe JA et al. (1952) The meaning of disulfiram to alcoholics in group psychotherapy. Q J Stud Alcohol 13: 590–599

    PubMed  CAS  Google Scholar 

  • Volpicelli JR, Altermann AI, Hayashida M et al. (1992) Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49: 876–880

    PubMed  CAS  Google Scholar 

  • Walter H, Nimmerrichter A, Mader R et al. (2002) Double blind controlled trial of GHB and clomethiazole in the tratment of alcohol withdrawal. Alcohol Alcoholism 37: 67–73

    Article  Google Scholar 

  • Willams EE (1937) Effects of alcohol on workers with carbon disulfide. JAMA 109: 1472–1473

    Google Scholar 

Literatur

  • Agosti V (1995) The efficacy of treatments in reducing alcohol consumption: a meta-analysis. Int J Addict: 1067–1077

    Google Scholar 

  • Ajima M, Usuki K, IGarashi A et al. (1997) Cyanamide-induced granulcytopenia. Intern Med 36: 640–642

    Article  PubMed  CAS  Google Scholar 

  • Azrin NH (1976) Improvements in the community-reinforcement approach to alcoholism. Behav Res Ther 14: 339–348

    Article  PubMed  CAS  Google Scholar 

  • Azrin NH, Sisson RW, Meyers R et al. (1982) Alcoholism treatment by disulfiram and community reinforcement therapy. J Behav Ther Exp Psychiat 13: 105–112

    Article  CAS  Google Scholar 

  • Besson J, Aeby F, Kasas A et al. (1998) Combined efficacy of acamprosate and disulfiram in the treatment of alcoholism: a controlled study. Alcoholism: Clin Exp Res 22: 573–579

    Article  CAS  Google Scholar 

  • Bevilacqua JA, Diaz M, Diaz V et al. (2002) Neuropatía por disulfiram. Comunicación de tres casos clinicos. Rev Med Chil 130: 1037–1042

    PubMed  Google Scholar 

  • Brewer C (2003) Cyanamide or disulfiram in the treatment of adolescent alcohol misusers. Alcohol Alcoholism 38: 442–445

    Article  Google Scholar 

  • Carroll KM, Nich C, Ball SA et al. (2000) One year follow-up of disulfiram and psychotherapy for cocaine-alcohol users: sustained effects of treatment. Addiction 95: 1325–1349

    Article  Google Scholar 

  • Carroll KM, Fenton LR, Ball SA et al. (2004) Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial. Arch Gen Psychiatry 61: 264–272

    Article  PubMed  CAS  Google Scholar 

  • Chick J (1999) Safety issues concerning the use of disulfiram in treating alcohol dependence. Drug Saf 20: 427–435

    Article  PubMed  CAS  Google Scholar 

  • Christensen JK, Moeller IW, Ronstedt P et al. (1991) Dose-effect relationship of disulfiram in human volunteers. I. Clinical studies. Pharmacol Toxicol 68: 163–165

    Article  PubMed  CAS  Google Scholar 

  • Demaster EG, Redfern B, Nagasawa HT (1998) Mechanism of inhibiton of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide. Biochem Pharmacol 55: 2007–2015

    Article  PubMed  CAS  Google Scholar 

  • Desousa A, Desousa A (2004) A one-year pragmatic trial of naltrexone vs disulfiram in the treatment of alcohol dependence. Alcohol Alcoholism 39: 528–531

    Article  CAS  Google Scholar 

  • Ehrenreich H, Mangholz A, Schmitt M et al. (1997) OLITA: an alternative in the treatment of therapy-resistant chronic alcoholics. First evaluation of a new approach. Eur Arch Psychiatry Clin Neurosci 247: 51–54

    Article  PubMed  CAS  Google Scholar 

  • Foddai M, Dosia G, Spiga S et al. (2004) Acetaldehyde increases dopaminergic neuronal activity in the VTA. Neuropsychopharmacology 29: 530–536

    Article  PubMed  CAS  Google Scholar 

  • Frisoni GB, di Monda V (1989) Disulfiram neuropathy: a review (1971–1988) and report of a case. Alcohol Alcoholism 24: 429–437

    CAS  Google Scholar 

  • Fuller RK Branchey L, Brightwell DR et al. (1986) Disulfiram treatment of alcoholism: a veterans administration coorporative study. J Am Med Assoc 256: 1449–1455

    Article  CAS  Google Scholar 

  • Fuller RK, Gordis E (2004) Does disulfiram treatment have a role in alcoholism treatment today. Addiction 99: 21–24

    Article  PubMed  Google Scholar 

  • Gessner PK, Gessner T (1992) Disulfiram and its metabolite diethylthiocarbamate. Chapman & Hall, London Glasgow New York Tokyo Melbourne Madras

    Google Scholar 

  • Helander A, Tottmar O (1988) Effects of disulfiram, cyanamide and 1-aminocyclopropanol on the aldehyde dehydrogenase in human erythrocytes and leukocytes. Pharmacol Toxicol 63: 262–265

    Article  PubMed  CAS  Google Scholar 

  • Jacobsen E (1952) Deaths of alcoholic patients treated with disulfiram (tetraethylthiuram disulfide) in Denmark. Q J Stud Alcohol 13: 16–26

    PubMed  CAS  Google Scholar 

  • Jacobsen E, Martensen-Larsen O (1949) Treatment of alcoholism with tretraethylthiuram disulfide (Antabus). J Am Med Assoc 139: 918–922

    PubMed  CAS  Google Scholar 

  • Jacobsen E (1987) The road to antabuse. Dumex, Copenhagen

    Google Scholar 

  • Johnsen J, Stowell A, Stensrud T et al. (1990) A double-blind placebo controlled study of healthy volunteers given a subcutanous disulfiram implant. Pharmacol Toxicol 66: 227–230

    Article  PubMed  CAS  Google Scholar 

  • Landabaso MA, Iraurgi I, Sanz J et al. (1999) Naltrexone in the treatment of alcoholism: two year follow-up results. Eur J Psychiatry 13: 97–105

    Google Scholar 

  • Lewis MJ, Bland RC, Baile W (1975) Disulfiram implantation for alcoholism. Can Psychiatr Assoc J 20: 283–286

    PubMed  CAS  Google Scholar 

  • Liddon SC, Satran R (1967) Disulfiram (Antabuse) psychosis. Am J Psychiatry 123: 1284–1289

    PubMed  CAS  Google Scholar 

  • Lindros KO, Stowell A, Pekkarainen P et al. (1981) The disulfiram(antabuse)-alcohol reaction in male alcoholics: its efficient management by 4-methylpyrazole. Alcohol Clin Exp Res 5: 528–530

    Article  PubMed  CAS  Google Scholar 

  • Madan A, Parkinson A, Faiman MD (1998) Indentification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldiethiocarbamate methyl ester: role of P-450 enzymes in disulfiram biocativation. Alcohol Clin Exp Res 22: 1212–1219

    PubMed  CAS  Google Scholar 

  • Marie C (1955) A propos d’un nouveau mode de traitement de l’alcoolism chronique par implantation de disulfure de tétra-éthyl-thiurame. Thèse, Paris

    Google Scholar 

  • Martensen-Larsen O (1948) Nye linier i alkoholist-behandlingen. Ugeskr Laeg 110: 1207–1213

    PubMed  CAS  Google Scholar 

  • Martin B, Clapp L, Bialkowsky D et al. (2003) Compliance to supervised disulfiram therapy: a comparison of voluntary and court-ordered patients. Am J Addict 12: 137–143

    Article  PubMed  Google Scholar 

  • Martin B, Alfers J, Kulig C et al. (2004) Disulfiram therapy in patients with hepatitis C: a 12-month, controlled, follow-up study. J Stud Alcohol 65: 651–657

    PubMed  Google Scholar 

  • Mørland J, Johnsen J, Bache-Wiig JE et al. (1985) Implanted disulfiram: pharmacological and clinical studies in man. In: Pharmacological treatment of alcoholism: withdrawal and aversion therapy. Socialstyreslsens Lakemedelsavdelning, Uppsala, pp 89–98

    Google Scholar 

  • Mueser KT, Noordsy DL, Fox L et al. (2003) Disulfiram treatment for alcoholism in severe mental illness. Am J Addict 12: 242–252

    PubMed  Google Scholar 

  • Niederhofer H, Staffen W, Mair A (2003) Comparison of cyanamide and placebo in the treatment of alcohol dependence of adolescents. Alcohol Alcoholism 38: 50–53

    Article  CAS  Google Scholar 

  • Petersen EN (1989) Pharmacological effects of diethylthiocarbamic acid methyl ester, the active metaboliter of disulfiram? Eur J Pharmcol 1966: 419–425

    Article  Google Scholar 

  • Poikolainen K (2004) The Disulfiram-Ethanol Reaction (DER) experience. Addiction 99: 26

    Article  PubMed  Google Scholar 

  • Rodd-Henricks ZA, Melendez RI, Zaffaroni A et al. (2002) The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol preffering rats. Pharmacol Biochem Behav 72: 55–64

    Article  PubMed  CAS  Google Scholar 

  • Sisson RW, Azrin NH (1986) Family-member involvement to initiate and promote treatment of problem drinkers. J Behav Ther Exp Psychiat 17: 15–21

    Article  CAS  Google Scholar 

  • Sauna ZE, Peng XH, Nandigama K et al. (2004) The molecular basis of the action of disulfiram as a modulator of the multiple resistance-linked ATP binding cassette transporters MDR1 (ABCB1) and MRP1 (ABCC1). Mol Pharmacol 65: 675–684

    Article  PubMed  CAS  Google Scholar 

  • Tamai H, Yokoyama A, Okuyama K et al. (2000) Comparison of cyanamide and disulfiram in effects on liver function. Alcohol Clin Exp Res 24[Suppl]: 97S–99S

    PubMed  CAS  Google Scholar 

  • Verheul R, Lehert P, Geerlings PJ et al. (2005) Predictors of acamprosate efficacy: results from a pooled analysis of seven European trials including 1485 alcohol-dependent patients. Psychopharmacology 178: 167–173

    Article  PubMed  CAS  Google Scholar 

  • Wagner T, Krampe H, Stawicki S et al. (2004) Substantial decrease of psychiatric comobidity in chronic alcoholics upon integrated outpatient treatment — results of a prospective study. J Psychiatr Res 38: 619–635

    Article  PubMed  Google Scholar 

  • Wright C, Vafir JA, Lake C (1988) Disulfiram induced fulminating hepatitis: guidelines for liver-panel monitoring. J Clin Psychiatry 49: 430–434

    PubMed  Google Scholar 

Literatur

  • Addolorato G, Caputo F, Capristo E et al. (2002) Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study. Alcohol Alcohol 37: 504–508

    PubMed  CAS  Google Scholar 

  • Anand A, Charney DS, Cappiello A et al. (2000) Lamotrigine attenuates ketamine effects in humans: support for hyperglutamatergic effects of NMDA antagonists. Arch Gen Psychiatry 57: 270–276

    Article  PubMed  CAS  Google Scholar 

  • Anstrom KK, Cromwell HC, Markowski T et al. (2003) Effect of baclofen on alcohol and sucrose self-administration in rats. Alcohol Clin Exp Res 27: 900–908

    PubMed  CAS  Google Scholar 

  • Altamura AC, Regazzetti MG, Porta M (1990) Nimodipine in human alcohol withdrawal syndrome — an open study. Eur Neuropsychopharmacol 1: 37–40

    Article  PubMed  CAS  Google Scholar 

  • Bienkowski P, Stefanski R, Kostowski W (1997) Discriminative stimulus effects of ethanol: lack of antagonism with N-methyl-D-aspartate and D-cycloserine. Alcohol 14: 345–350

    Article  PubMed  CAS  Google Scholar 

  • Bienkowski P, Krzascik P, Koros E et al. (2001) Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol selfadministration and ethanol withdrawal seizures in the rat. Eur J Pharmacol 413: 81–89

    Article  PubMed  CAS  Google Scholar 

  • Blanpied TA, Boeckman FA, Aizenman E et al. (1997) Trapping channel block of NMDAactivated responses by amantadine and memantine. J Neurophysiol 77: 309–323

    PubMed  CAS  Google Scholar 

  • Bleich S, Degner D, Wiltfang J et al. (2000a) Elevated homocysteine levels in alcohol withdrawal. Alcohol Alcohol 35: 351–354

    PubMed  CAS  Google Scholar 

  • Bleich S, Degner D, Bandelow B et al. (2000b) Plasma homocysteine is a predictor of alcohol withdrawal seizures. Neuroreport 11: 2749–2752

    Article  PubMed  CAS  Google Scholar 

  • Bleich S, Bandelow B, Javaheripour K et al. (2003a) Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism. Neurosci Lett 335: 179–182

    Article  PubMed  CAS  Google Scholar 

  • Bleich S, Römer K, Wiltfang J et al. (2003b) Glutamate and the glutamate receptor system: a target for drug action. Int J Geriatr Psychiatry 18[Suppl 1]: S33–S40

    Article  PubMed  Google Scholar 

  • Bleich S, Degner D, Sperling W et al. (2004) Homocysteine as a neurotoxin in chronic alcoholism. Prog Neuropsychopharmacol Biol Psychiatry 28: 453–464

    Article  PubMed  CAS  Google Scholar 

  • Böning JAL, Lesch OM, Spanagel R et al. (2001) Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials. Alcohol Clin Exp Res 25: 127S–131S

    Google Scholar 

  • Bouvier M, Szatkowski M, Amato A et al. (1992) The glial cell glutamate uptake carrier countertransports pH-changing anions. Nature 360: 471–474

    Article  PubMed  CAS  Google Scholar 

  • Bustos GA, Abarca J, Forray MI et al. (1992) Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies. Brain Res 585: 105–115

    Article  PubMed  CAS  Google Scholar 

  • Carboni S, Isola R, Gessa GL et al. (1993) Ethanol prevents the glutamate release induced by N-methyl-D-aspartate in the rat striatum. Neurosci Lett 152: 133–136

    Article  PubMed  CAS  Google Scholar 

  • Chen X, Michaelis MR, Michaelis EK (1997) Effects of chronic ethanol treatment on the expression of calcium transport carriers and NMDA receptor proteins in brain synaptic membranes. J Neurochem 69: 1559–1569

    Article  PubMed  CAS  Google Scholar 

  • Chen HS, Pellegrini JW, Aggarwal SK et al. (1992) Open-channel block of N-methyl-Daspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci 12: 4427–4436

    PubMed  CAS  Google Scholar 

  • Clements JD, Lester RAJ, Tong G et al. (1992) The time course of glutamate in the synaptic cleft. Science 258: 1498–1501

    Article  PubMed  CAS  Google Scholar 

  • Colombo G, Agabio R, Carai MA et al. (2000) Ability of baclofen in reducing alcohol intake and withdrawal severity. I. Preclinical evidence. Alcohol Clin Exp Res 24: 58–66

    PubMed  CAS  Google Scholar 

  • D’Souza DC, Charney DS, Krystal JH (1995) Glycine site agonists of the NMDA receptor: a review. CNS Drug Rev 1: 227–260

    Article  CAS  Google Scholar 

  • D’Souza DC, Gil R, Cassello K et al. (2000) IV Glycine and oral D-cycloserine effects on plasma and CSF amino acids in healthy humans. Biol Psychiatry 47: 450–462

    Article  PubMed  CAS  Google Scholar 

  • Danysz W, Janowska E, Glazewsky S et al. (1992) The involvement of NMDA receptors in acute and chronic effects of ethanol. Alcohol Clin Exp Res 16: 499–504

    Article  PubMed  CAS  Google Scholar 

  • Davidson M, Shanley B, Wilce PA (1995) Increased NMDA-induced excitability during ethanol withdrawal: a behavioural and histological study. Brain Res 674: 91–96

    Article  PubMed  CAS  Google Scholar 

  • Durand GM, Bennett MV, Zukin RS (1993) Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. Proc Natl Acad Sci USA 90: 6731–6735

    Article  PubMed  CAS  Google Scholar 

  • Follesa P, Ticku MK (1996) Chronic ethanolmediated up-regulation of the N-methyl-Daspartate receptor polypeptide. J Biol Chem 271: 13297–13299

    Article  PubMed  CAS  Google Scholar 

  • Garbutt JC, West SL, Carey TS et al. (1999) Pharmacological treatment of alcohol dependence: a review of the evidence. JAMA 281: 1318–1325

    Article  PubMed  CAS  Google Scholar 

  • Gonzales R, Bungay PM, Kiianmaa K et al. (1996) In vivo links between neurochemistry and behavioral effects of ethanol. Alcohol Clin Exp Res 20: 203A–205A

    Article  PubMed  CAS  Google Scholar 

  • Green KL, Grant KA (1999) Effects of L-type voltage-sensitive calcium channel modulators on the discriminative stimulus effects of ethanol in rats. Alcohol Clin Exp Res 23: 806–814

    PubMed  CAS  Google Scholar 

  • Harris RA, Valenzuela CF, Brozowski S et al. (1998) Adaptation of δ-aminobutyric acid type A receptors to alcohol exposure: studies with stably transfected cells. J Pharmacol Exp Ther 284: 180–188

    PubMed  CAS  Google Scholar 

  • Hodge CW, Cox AA (1998) The discriminative stimulus effects of ethanol are mediated by NMDA and GABAA receptors in specific limbic brain regions. Psychopharmacology 139: 95–107

    Article  PubMed  CAS  Google Scholar 

  • Hoffman PL, Rabe CS, Grant KA et al. (1990) Ethanol and the NMDA receptor. Alcohol 7: 229–231

    Article  PubMed  CAS  Google Scholar 

  • Hölter SM, Danysz W, Spanagel R (1996) Evidence for alcohol anti-craving properties of memantine. Eur J Pharmacol 314: 1–2

    Article  Google Scholar 

  • Hölter SM, Danysz W, Spanagel R (2000) Novel uncompetitive N-Methyl-D-Aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure. J Pharmacol Exp Ther 292: 545–552

    PubMed  Google Scholar 

  • Hundt W, Danysz W, Hölter SM et al. (1998) Ethanol and N-methyl-D-aspartate receptor complex interactions: a detailed drug discrimination study in the rat. Psychopharmacology 135: 44–51

    Article  PubMed  CAS  Google Scholar 

  • Iorio KR, Reinlib L, Tabakoff B et al. (1992) Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-Daspartate receptor function. Mol Pharmacol 41: 1142–1148

    PubMed  CAS  Google Scholar 

  • Javitt DC, Frusciante MJ, Zukin SR (1990) Rat brain N-methyl-D-aspartate receptors require multiple molecules of agonist for activation. J Pharmacol Exp Ther 37: 603–607

    CAS  Google Scholar 

  • Javitt DC, Sershen H, Hashim A et al. (1997) Reversal of phencyclidine-induced hyperactivity by glycine and the glycine up-take inhibitor glycyldodecylamide. Neuropsychopharmacology 17: 202–204

    Article  PubMed  CAS  Google Scholar 

  • Johnson BA, Roache JD, Javors MA et al. (2000) Ondansetron for reduction of drinking among biologically predisposed alcoholic patients-a randomized controlled trial. JAMA 284: 963–971

    Article  PubMed  CAS  Google Scholar 

  • Johnson BA, Ait-Daoud N, Bowden CL et al. (2003) Oral topiramate for treatment of alcohol dependence: a randomised controlled trial. Lancet 361: 1677–1685

    Article  PubMed  CAS  Google Scholar 

  • Kashiwagi K, Masuko T, Nguyen CD et al. (2002) Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore. Mol Pharmacol 61: 533–545

    Article  PubMed  CAS  Google Scholar 

  • Kornhuber J, Weller M (1995) Predicting psychotomimetic properties of PCP-like NMDA receptor antagonists. In: Fog R, Gerlach J, Hemmingsen R (eds) Schizophrenia-Alfred Benzon Symposium. Munksgaard, Copenhagen, pp 314–325

    Google Scholar 

  • Kornhuber J, Weller M (1997) Psychotogenicity and NMDA receptor antagonism: implications for neuroprotective pharmacotherapy. Biol Psychiatry 41: 135–144

    Article  PubMed  CAS  Google Scholar 

  • Kornhuber J, Bleich S (1999) Memantin. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuro-Psychopharmaka, Bd 5, 2. Aufl. Springer, Wien New York, S 687–704

    Google Scholar 

  • Kornhuber J, Bormann J, Retz W et al. (1989) Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex. Eur J Pharmacol 166: 589–590

    Article  PubMed  CAS  Google Scholar 

  • Kornhuber J, Bormann J, Hübers M et al. (1991) Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptorgated ion channel: a human postmortem brain study. Eur J Pharmacol Mol Pharmacol Sect 206: 297–300

    Article  CAS  Google Scholar 

  • Kornhuber J, Schoppmeyer K, Riederer P (1993) Affinity of 1-aminoadamantanes for the sigma binding site in post-mortem human frontal cortex. Neurosci Lett 163: 129–131

    Article  PubMed  CAS  Google Scholar 

  • Kornhuber J, Weller M, Schoppmeyer K et al. (1994) Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties. J Neural Transm [Suppl 43]: 91–104

    Google Scholar 

  • Kornhuber J, Retz W, Sitzmann L et al. (1996) The NMDA-receptor antagonist memantine is not psychotomimetic in young healthy volunteers. Soc Neurosci Abstr 22: 178

    Google Scholar 

  • Kostowski W, Bienkowski P (1999) Discriminative stimulus effects of ethanol: neuropharmacological characterization. Alcohol 17: 63–80

    Article  PubMed  CAS  Google Scholar 

  • Kotlińska J (2001) NMDA antagonists inhibit the development of ethanol dependence in rats. Pol J Pharmacol 53: 47–50

    PubMed  Google Scholar 

  • Krupitsky EM, Burakov AM, Romanova TN et al. (2001) Attenuation of ketamine effects by nimodipine in recently detoxified ethanol dependent men: psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists. Neuropsychopharmacology 25: 936–947

    Article  PubMed  CAS  Google Scholar 

  • Krystal JH, Karper LP, Seibyl JP et al. (1994) Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 51: 199–214

    PubMed  CAS  Google Scholar 

  • Krystal JH, Petrakis IL, Mason G et al. (2003) N-methyl-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacol Ther 99: 79–94

    Article  PubMed  CAS  Google Scholar 

  • Kumari M, Ticku MK (2000) Regulation of NMDA receptors by ethanol. Prog Drug Res 54: 151–189

    CAS  Google Scholar 

  • Kurth C, Wegerer V, Degner D et al. (2001) Risk assessment of alcohol withdrawal seizures with a Kohonen Feature Map. NeuroReport 12: 45–49

    Article  Google Scholar 

  • Liljequist S (1991) The competitive NMDA receptor antagonist, CGP-39551, inhibits ethanol withdrawal seizures. Eur J Pharmacol 192: 197–198

    Article  PubMed  CAS  Google Scholar 

  • Lipton SA, Rosenberg PA (1994) Excitatory amino acids as a final common pathway for neurological disorders. N Engl J Med 330: 613–622

    Article  PubMed  CAS  Google Scholar 

  • Lovinger DM, White G, Weight FF (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243: 1721–1724

    Article  PubMed  CAS  Google Scholar 

  • Luby ED, Cohen BD, Rosenbaum G et al. (1959) Study of a new schizophrenomimetic drug — sernyl. Arch Neurol Psychiatry 81: 363–369

    CAS  Google Scholar 

  • Maler JM, Esselmann H, Wiltfang J et al. (2005) Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons (submitted)

    Google Scholar 

  • Malinowska B, Napiorkowska-Pawlak D, Pawlak R et al. (1999) Ifenprodil influences changes in mouse behaviour related to acute and chronic ethanol administration. Eur J Pharmacol 377: 13–19

    Article  PubMed  CAS  Google Scholar 

  • Marks SS, Watson DL, Carpenter CL et al. (1989) Calcium channel antagonist receptors in cerebral cortex from alcoholic patients. Brain Res 478: 196–198

    Article  PubMed  CAS  Google Scholar 

  • Mason BJ, Kocsis JH, Ritvo EC et al. (1996) A doubleblind, placebo-controlled trial of desipramine for primary alcohol dependence stratified on the presence or absence of major depression. JAMA 275: 761–767

    Article  PubMed  CAS  Google Scholar 

  • Maurice T, Casalino M, Lacroix M et al. (2003) Involvement of the sigma1 receptor in the motivational effects of ethanol in mice. Pharmacol Biochem Behav 74: 869–876

    Article  PubMed  CAS  Google Scholar 

  • Meldrum BS (2000) Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr [Suppl] 130: 1007–1015

    Google Scholar 

  • Meyer RC, Knox J, Purwin DA et al. (1998) Combined stimulation of the glycine and polyamine sites of the NMDA receptor attenuates NMDA blockade-induced learning deficits of rats in a 14-unit T-maze. Psychopharmacology 135: 290–295

    Article  PubMed  CAS  Google Scholar 

  • Miller NS (1995) Pharmacotherapy in alcoholism. J Addict Dis 14: 23–46

    Article  PubMed  CAS  Google Scholar 

  • Miyazaki J, Nakanishi S, Jingami H (1999) Expression and characterization of a glycine-binding fragment of the N-methyl-D-aspartate receptor subunit NR1. Biochem J 340: 687–692

    Article  PubMed  CAS  Google Scholar 

  • Moghaddam B, Bolinao M (1994) Biphasic effects of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens. Neurosci Lett 178: 99–102

    Article  PubMed  CAS  Google Scholar 

  • Moriyoshi K, Masu M, Ishii T et al. (1991) Molecular cloning and characterization of the rat NMDA receptor. Nature 354: 31–37

    Article  PubMed  CAS  Google Scholar 

  • Morrisett RA, Rezvani AH, Overstreet D et al. (1990) MK-801 potently inhibits alcohol withdrawal seizures in rats. Eur J Pharmacol 176: 103–106

    Article  PubMed  CAS  Google Scholar 

  • Nagy J, Horvath C, Farkas S et al. (2004) NR2B subunit selective NMDA antagonists inhibit neurotoxic effect of alcohol-withdrawal in primary cultures of rat cortical neurones. Neurochem Int 44: 17–23

    Article  PubMed  CAS  Google Scholar 

  • Nestler EJ (2001) Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2: 119–128

    Article  PubMed  CAS  Google Scholar 

  • Okabe S, Vicario-Abejon C, Segal M et al. (1998) Survival and synaptogenesis of hippocampal neurons without NMDA receptor function in culture. Eur J Neurosci 10: 2192–2198

    Article  PubMed  CAS  Google Scholar 

  • Parsons CG, Gruner R, Rozental J et al. (1993) Patch clamp studies on the kinetic and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacology 32: 1337–1350

    Article  PubMed  CAS  Google Scholar 

  • Parsons CG, Quack G, Bresink I et al. (1995) Comparison of the potency, kinetics and voltage-dependency of open channel blockade for a series of uncompetitive NMDA antagonists in vitro with anticonvulsive and motor impairment activity in vivo. Neuropharmacology 34: 1239–1258

    Article  PubMed  CAS  Google Scholar 

  • Parsons CG, Danysz W, Quack G (1998) Glutamate in CNS disorders as a target for drug development: an update. Drug News Perspect 11: 523–569

    Article  PubMed  CAS  Google Scholar 

  • Peoples RW, Weight FF (1995) Cutoff in potency implicates alcohol inhibition of N-methyl-Daspartate receptors in alcohol intoxication. Proc Natl Acad Sci USA 92: 2825–2829

    Article  PubMed  CAS  Google Scholar 

  • Peoples RW, White G, Lovinger DM et al. (1997) Ethanol inhibition of N-methyl-D-aspartate-activated current in mouse hippocampal neurones: whole-cell patch-clamp analysis. Br J Pharmacol 122: 1035–1042

    Article  PubMed  CAS  Google Scholar 

  • Popp RL, Lovinger DM (2000) Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons. Eur J Pharmacol 394: 221–231

    Article  PubMed  CAS  Google Scholar 

  • Priestley T, Kemp JA (1994) Kinetic study of the interactions between the glutamate and glycine recognition sites on the N-methyl-D aspartic acid receptor complex. Mol Pharmacol 46: 1191–1196

    PubMed  CAS  Google Scholar 

  • Rammes G, Mahal B, Putzke J et al. (2001) The anticraving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Neuropharmacology 40: 749–760

    Article  PubMed  CAS  Google Scholar 

  • Riederer P, Lange KW, Kornhuber J et al. (1991) Pharmacotoxic psychosis after memantine in Parkinson’s disease. Lancet 338: 1022–1023

    Article  PubMed  CAS  Google Scholar 

  • Ripley TL, Little HJ (1995) Effects of chronic ethanol withdrawal hyperexcitability of chronic treatment with a competitive N-methyl-D-aspartate receptor antagonist. J Pharmacol Exp Ther 272: 112–118

    PubMed  CAS  Google Scholar 

  • Ronald KM, Mirshahi T, Woodward JJ (2001) Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue. J Biol Chem 276: 44729–44735

    Article  PubMed  CAS  Google Scholar 

  • Rosen MI, Persall HR, Kosten TR (1998) The effect of lamotrigine on naloxone-precipitated opiate withdrawal. Drug Alcohol Depend 52: 173–176

    Article  PubMed  CAS  Google Scholar 

  • Rosetti ZL, Carboni S (1995) Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum. Eur J Pharmacol 283: 177–183

    Article  Google Scholar 

  • Rothman SM, Olney JW (1987) Excitotoxicity and the NMDA receptor. Trends Neurosci 10: 299–302

    Article  CAS  Google Scholar 

  • Schütz CG, Soyka M (2000) Dextromethorphan challenge in alcohol-dependent patients and controls. Arch Gen Psychiatry 57: 291–292

    Article  PubMed  Google Scholar 

  • Seeburg PH (1993) The TINS/TiPS lecture. The molecular biology of mammalian glutamate receptor channels. Trends Neurosci 16: 359–365

    Article  PubMed  CAS  Google Scholar 

  • Spanagel R, Kornhuber J (1999) Glutamatrezeptorantagonisten und Alkoholabhängigkeit. Präklinische Befunde. Nervenarzt 70: 479–481

    Article  PubMed  CAS  Google Scholar 

  • Spanagel R, Zieglgänsberger W, Hundt W (1996a). Acamprosate and alcohol. III. Effects on alcohol discrimination in the rat. Eur J Pharmacol 305: 51–56

    Article  PubMed  CAS  Google Scholar 

  • Spanagel R, Hölter SM, Allingham K et al. (1996b) Acamprosate and alcohol. I. Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol 305: 39–44

    Article  PubMed  CAS  Google Scholar 

  • Spanagel R, Siegmund S, Cowen M et al. (2002) The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol. J Neurosci 22: 8676–8683

    PubMed  CAS  Google Scholar 

  • Staley JK, Gottschalk PC, Petrakis IL et al. (2002) Assessment of cortical benzodiazepine-GABA-A receptors in recovering alcoholics over the first month of sobriety. Alcohol Clin Exp Res 26: 68A

    Google Scholar 

  • Szatkowski M, Attwell D (1994) Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms. Trends Neurosci 17: 359–365

    Article  PubMed  CAS  Google Scholar 

  • Thomson AM, West DC, Lodge D (1985) An Nmethylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine? Nature 313: 479–481

    Article  PubMed  CAS  Google Scholar 

  • Traynelis SF, Burgess MF, Zheng F et al. (1998) Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit. J Neurosci 18: 6163–6175

    PubMed  CAS  Google Scholar 

  • Trevisan L, Nammanworth S, Petrakis I et al. (1995) Cycloserine modulation of human ethanol intoxication: implications for NMDA receptor contributions to human ethanol intoxication. Alcohol Clin Exp Res 19: 4A

    Article  Google Scholar 

  • Tsai G (1998) Glutamatergic neurotransmission in alcoholism. J Biomed Sci 5: 309–320

    Article  PubMed  CAS  Google Scholar 

  • Tsai G, Gastfriend DR, Coyle JT (1995) The glutamatergic basis of human alcoholism. Am J Psychiatry 152: 332–340

    PubMed  CAS  Google Scholar 

  • Vollenweider FX, Leenders KL, Øye I et al. (1997) Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)-and (R)-ketamine in healthy volunteers using positron emission tomography (PET). Eur Neuropsychopharmacol 7: 25–38

    Article  PubMed  CAS  Google Scholar 

  • Watson GB, Bolanowski MA, Baganoff MP et al. (1990) D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes. Brain Res 510: 158–160

    Article  PubMed  CAS  Google Scholar 

  • Wenk GL, Baker LM, Hauss-Wegrzyniak B et al. (1998) Novel glycine B antagonists show neuroprotective activity in vivo. Amino Acids 14: 223–226

    Article  PubMed  CAS  Google Scholar 

  • Woodward JJ (2000) Ethanol and NMDA receptor signaling. Crit Rev Neurobiol 14: 69–89

    PubMed  CAS  Google Scholar 

  • Yamakura T, Mori H, Masaki H et al. (1993) Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists. Neuro Report 4: 687–690

    CAS  Google Scholar 

Literatur

  • Ammon S, Hofmann U, Griese EU et al. (1999) Pharmacokinetics of dihydrocodeine and its active metabolites after single and multiple oral dosing. Br J Clin Pharmacol 48: 317–322

    Article  PubMed  CAS  Google Scholar 

  • Anggard E, Gunne LM, Homstrand J et al. (1975) Disposition of methadone in methadone maintenance. Clin Pharmacol Ther 17: 258–266

    PubMed  CAS  Google Scholar 

  • Ball J C, Ross A (1991) The effectiveness of methadone maintenance treatment. Springer, New York

    Google Scholar 

  • Bodkin JA, Zomberg GL, Lukas SE et al. (1995) Buprenorphine treatment of refractory depression. J Clin Psychopharmacol 15: 49–57

    Article  PubMed  CAS  Google Scholar 

  • Boulton DW, Arnaud P, Devane CL et al. (2001) Pharmacokinetics and pharmacodynamics of methadone enantiomers after a single oral dose of racemate. Clin Pharmacol Ther 70: 48–57

    Article  PubMed  CAS  Google Scholar 

  • Brooner RK, King VL, Kidorf M et al. (1997) Psychiatric and substance use comorbidity among treatment-seeking opioid abusers. Arch Gen Psychiatry 54: 71–80

    PubMed  CAS  Google Scholar 

  • BUB-Richtlinien (2003) Bekanntmachung des Bundesausschusses der Ärzte und Krankenkassen. Dtsch Ärztebl 100: B 132–134

    Google Scholar 

  • Bundesärztekammer (2002) Richtlinien der Bundesärztekammer zur Durchführung der substitutionsgestützten Behandlung Opiatabhängiger. Dtsch Ärztebl 99: B-1218–1221

    Google Scholar 

  • Darke S, Ross J (1997) Polydrug dependence and psychiatric comorbidity among heroin injectors. Drug Alcohol Depend 48: 135–141

    Article  PubMed  CAS  Google Scholar 

  • Davids E, Gastpar M (2004) Buprenorphine in the treatment of opioid dependence. Eur Neuropsychopharmacol 14: 209–216

    Article  PubMed  CAS  Google Scholar 

  • Degwitz P (1996) Substitutionsbehandlung von Heroinabhängigen mit codeinhaltigen Präparaten — Ergebnisse einer Studie bei niedergelassenen Ärzten. Sucht 42: 257–259

    Google Scholar 

  • Dole VP, Nyswander ME (1965) A medical treatment for diacethylmorphine (heroin) addiction. JAMA 193: 646–650

    PubMed  CAS  Google Scholar 

  • Eap CB, Cuendet C, Baumann P (1990) Binding of d-methadone, l-methadone, and dl-methadone to proteins in plasma of healthy volunteers: role of the variants of alpha 1-acid glycoprotein. Clin Pharmacol Ther 47: 338–346

    Article  PubMed  CAS  Google Scholar 

  • Eap CB, Finkbeiner T, Gastpar M et al. (1996) Replacement of (R)-methadone by a double dose of (R,S)-methadone in addicts: interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics. Eur J Clin Pharmacol 50: 385–389

    Article  PubMed  CAS  Google Scholar 

  • Eap CB, Bourquin M, Martin J et al. (2000) Plasma concentrations of the enantiomers of methadone and therapeutic response in methadone maintenance treatment. Drug Alcohol Depend 61: 47–54

    Article  PubMed  CAS  Google Scholar 

  • Eap CB, Buclin T, Baumann P (2002) Individual variability of the clinical pharmacokinetics of methadone. Clin Pharmacokinet 41: 1153–1193

    Article  PubMed  CAS  Google Scholar 

  • Finkbeiner T, Gastpar M (1997) Der aktuelle Stand der Substitutionsbehandlung Drogenabhängiger. Nervenheilkunde 16: 215–221

    Google Scholar 

  • Finn P, Wilcock K (1997) Levo-Alpha Acetyl Methadol (LAAM). Its advantages and drawbacks. J Subst Abuse Treat 14: 559–564

    Article  PubMed  CAS  Google Scholar 

  • Geschwinde T (2003) Rauschdrogen, 5. Aufl. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Ghodse H (2002) Drugs and addictive behaviour, 3rd edn. Cambridge University Press, Cambridge New York Melbourne

    Google Scholar 

  • Goedecke H, Lander C, Menges K et al. (1994) Dihydrocodein/Codein — kein Mittel zur Substitution bei Drogenabhängigen. Bundesgesundheitsblatt 37: 207–212

    Google Scholar 

  • Gossop M, Marsden J, Stewart D et al. (2003) The National Treatment Outcome Research Study (NTORS): 4–5 years follow-up results. Addiction 98: 291–303

    Article  PubMed  Google Scholar 

  • Gourevitch MN, Hartel D, Tenore P et al. (1999) Three oral formulations of methadone: a clinical and pharmacodynamic comparison. J Subst Abuse Treat 17: 237–241

    Article  PubMed  CAS  Google Scholar 

  • Inturrisi CE, Verebely K (1972) Disposition of methadone in man after a single oral dose. Clin Pharmacol Ther 13: 923–930

    PubMed  CAS  Google Scholar 

  • Kleber HD (1999) Opioids: detoxification. In: Galanter M, Kleber HD (eds) Textbook of substance abuse treatment, 2nd edn. American Psychiatric Press, Washington, pp 251–269

    Google Scholar 

  • Krantz MJ, Lewkowiez L, Hays H et al. (2002) Torsade de pointes associated with very-high-dose methadone. Ann Intern Med 137: 501–504

    PubMed  CAS  Google Scholar 

  • Krantz MJ, Kutinsky IB, Robertson AD et al. (2003) Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. Pharmacotherapy 23: 802–805

    Article  PubMed  CAS  Google Scholar 

  • Krausz M, Degkwitz P, Kuhne A et al. (1998) Comorbidity of opiate dependence and mental disorders. Addict Behav 23: 767–783

    Article  PubMed  CAS  Google Scholar 

  • Kristensen K, Blemmer T, Angelo HR et al. (1996) Stereoselective pharmacokinetics of methadone in chronic pain patients. Ther Drug Monit 18: 221–227

    Article  PubMed  CAS  Google Scholar 

  • Lang F (1994) Zur Umstellung von Polamidon auf Methadon. Berliner Tinke Magazin 5: 4–6

    Google Scholar 

  • Limbeek J V, Wouters L, Kaplan CD et al. (1992) Prevalence of psychopathology in drug-addicted Dutch. J Subst Abuse Treatment 9: 43–52

    Article  Google Scholar 

  • Mattick RP, Breen C, Kimber J et al. (2003) Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence. In: The Cochrane Library, Issue 1. Update Software, Oxford

    Google Scholar 

  • Newman RG, Whitehill WB (1979) Double-blind comparison of methadone and placebo maintenance treatments of narcotic addicts in Hong Kong. Lancet 2(8141): 485–488

    Article  PubMed  CAS  Google Scholar 

  • Prognos (1998) Medikamentengestützte Rehabilitation i.v. Opiatabhängiger. Ministerium für Arbeit, Gesundheit und Soziales, NRW

    Google Scholar 

  • Regier DA, Farmer ME, Rae DS et al. (1990) Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264: 2511–2518

    Article  PubMed  CAS  Google Scholar 

  • Scherbaum N, Gastpar M (1991) Die Substitution mit Methadon als Therapieansatz in der Behandlung Opiatabhängiger. Nervenarzt 62: 529–535

    PubMed  CAS  Google Scholar 

  • Scherbaum N, Finkbeiner TH, Leifert K et al. (1996) The efficacy of l-methadone and racemic methadone in substitution treatment for opiate addicts — a double-blind comparison. Pharmacopsychiatry 29: 212–215

    Article  PubMed  CAS  Google Scholar 

  • Scherbaum N, Blanke J, Wolstein J et al. (2003) Maternal health and drug abuse in Germany. ECCAS Monogr Series 3: 41–45

    Google Scholar 

  • Schindler SD, Eder H, Ortner R et al. (2003) Neonatal outcome following buprenorphine maintenance during conception and throughout pregnancy. Addiction 98: 103–110

    Article  PubMed  Google Scholar 

  • Schmoldt A, von Meyer L, Riesselmann B et al. (2000) Drogenpolitik: Erobert Methadon die Drogenszene? Dtsch Ärztebl 97: A–1784

    Google Scholar 

  • Sells SB, Simpson DD (1980) The case for drug abuse treatment effectiveness, based on the DARP research program. Br J Addict 75: 117–131

    Article  PubMed  CAS  Google Scholar 

  • Senay EC (1999) Opioids: methadone maintenance. In: GALANTER M, KLEBER HD (eds) Textbook of substance abuse treatment, 2nd edn. American Psychiatric Press, Washington, pp 271–279

    Google Scholar 

  • Simpson DD (1981) Treatment for drug abuse. Follow-up outcomes and length of time spent. Arch Gen Psychiatry 38: 875–880

    PubMed  CAS  Google Scholar 

  • Simpson DD, Savage LJ (1980) Drug abuse treatment readmissions and outcomes. Three-year follow-up of DARP patients. Arch Gen Psychiatry 37: 896–901

    PubMed  CAS  Google Scholar 

  • Simpson DD, Joe GW, Bracy SA (1982) Six-year follow-up of opioid addicts after admission to treatment. Arch Gen Psychiatry 39: 1318–1323

    PubMed  CAS  Google Scholar 

  • Stimson GV, Metrebian N (2003) Prescribing heroin. What is the evidence? York Publishing Services Ltd, York

    Google Scholar 

  • Uchtenhagen A (2003) Substitution management in opioid dependence. J Neural Transm [Suppl 66]: 33–60

    CAS  Google Scholar 

  • Wolff K, Hay AW, Raistrick D et al. (1993) Steady-state pharmacokinetics of methadone in opioid addicts. Eur J Clin Pharmacol 44: 189–194

    Article  PubMed  CAS  Google Scholar 

  • Wolstein J, Rösinger C, Gastpar M (1998) Children and families in substance misuse. Curr Opin Psychiatry 11: 279–283

    Article  Google Scholar 

Literatur

  • Arzneimittelkommission der Deutschen Ärzteschaft (2001) Therapieempfehlungen Tabakabhängigkeit. Arzneiverordnungen in der Praxis, Sonderheft

    Google Scholar 

  • Batra A (2000) Tabakabhängigkeit: biologische und psychosoziale Entstehungsbedingungen und Therapiemöglichkeiten. Steinkopff, Darmstadt

    Google Scholar 

  • Batra A, Buchkremer G (Arbeitskreis Raucherentwöhnung) (Hrsg) (1997) Nichtraucher in 6 Wochen — Ein Selbsthilfeprogramm für alle, die das Rauchen aufgeben wollen. Preuss, Ratingen

    Google Scholar 

  • Batra A, Buchkremer G (2004) Tabakabhängigkeit — Ein Therapeutenleitfaden. Kohlhammer, Stuttgart

    Google Scholar 

  • Batra A, Fagerström KO (1997) New aspects of tobacco dependency and smoking cessation. Sucht 43: 277–282

    Google Scholar 

  • Batra A, Lindinger P, Schütz C (2004) AWMFLeitlinien zur Behandlung der Tabakabhängigkeit. www.leitlinien.net

    Google Scholar 

  • Blondal T, Franzon M, Westin A (1997) A doubleblind randomized trial of nicotine nasal spray as an aid in smoking cessation. Eur Respir J 10:1585–1590

    Article  PubMed  CAS  Google Scholar 

  • Blondal T, Gudmundsson LJ, Olafsdottir I et al. (1999) Nicotine nasal spray with nicotine patch for smoking cessation: randomized trial with sic year follow up. Br Med J 318:285–289

    CAS  Google Scholar 

  • Bohadana A, Nilsson F, Rasmussen T et al. (2000) Nicotine inhaler and nicotine patch as a combination therapy for smoking cessation. Arch Intern Med 160: 3128–3134

    Article  PubMed  CAS  Google Scholar 

  • Bollinger CT, Zellweger JP, Danielsson T et al. (2000) Smoking reduction with oral nicotine inhalers: double blind, randomised clinical trial of efficacy and safety. Br Med J 321: 329–333

    Article  Google Scholar 

  • Cerny EH, Lévy R, Mauel J et al. (2002) Preclinical development of a vaccine against smoking. Oncology 25: 406–411

    Article  CAS  Google Scholar 

  • Choi J, Dresler CM, Norton M et al. (2003) Pharmacokinetics of a nicotine polacrilex lozenge. Nicotine Tob Res 5: 635–644

    Article  PubMed  CAS  Google Scholar 

  • Dale L, Anthenelli R, Despres JP et al. (2004) Effects of Rimonabant in the reduction of major cardiovasular risk factors: results from the STRATUS-US Trial (Smoking cessation in smokers motivated to quit) and the RIO-LIPIDS Trial (weight reducing and metabolic effects in overweight/obese patients with dyslipidaemia). American College of Cardiology (ACC), 53th Annual Scientific Session, March 3–10, 2004, New Orleans

    Google Scholar 

  • DHS (Deutsche Hauptstelle für Suchtfragen) (Hrsg) (2003) Jahrbuch Sucht 04. Neuland, Geesthacht

    Google Scholar 

  • Eliasson B, Hjalmarson A, Kruse E et al. (2001) Effect of smoking reduction and cessation on cardiovascular risk factors. Nicotine Tob Res 3: 249–255

    Article  PubMed  CAS  Google Scholar 

  • Fagerström KO (2003) Clinical treatment of tobacco dependence: the endurance of pharmacologic efficacy. J Clin Psychiatry Monogr 18(1): 35–40

    Google Scholar 

  • Fiore MC, Bailey WC, Cohen SJ et al. (2000) Treating tobacco use and dependence. Clinical Practice Guideline. U.S. Department of Health and Human Services, Public Health Service, Rockville, MD

    Google Scholar 

  • Garvey AJ, Kinnunen T, Nordstrom BL (2000) Effects of nicotine gum dose by level of nicotine dependence. Nicotine Tob Res 2:53–63

    Article  PubMed  CAS  Google Scholar 

  • George TP, O’Malley SS (2004) Current pharmacological treatments for nicotine dependence. Trends Pharmacol Sci 25(1): 42–48

    Article  PubMed  CAS  Google Scholar 

  • Gourlay SG, Stead LF, Benowitz NL (2001) Clonidine for smoking cessation (Cochrane Review). In: The Cochrane Library, Issue 2. Update Software, Oxford

    Google Scholar 

  • Hajek P, West R, Foulds J, Nilsson F, Burrows S, Meadow A (1999) Randomized comparative trial of nicotine polacrilex, a transdermal patch, nasal spray, and an inhaler. Arch Intern Med 159: 2033–2038

    Article  PubMed  CAS  Google Scholar 

  • Hays JT, Hurt RD, Rigotti NA et al. (2001) Sustained-release Bupropion for pharmacologic relapse prevention after smoking cessation: a randomized, controlled trial. Ann Intern Med 135: 423–433

    PubMed  CAS  Google Scholar 

  • Hieda Y, Keyler DE, Ennifar S et al. (2000) Vaccination against nicotine during continued nicotine administration in rats: immunogenicity of the vaccine and effects on nicotine distribution to brain. Int J Immunopharmacol 22:809–819

    Article  PubMed  CAS  Google Scholar 

  • Hjalmarson A, Franzon M, Westin A et al. (1994) Effect of nicotine nasal spray on smoking cessation: a randomised, placebo-controlled, double-blind study. Arch Intern Med 154:2567–2572

    Article  PubMed  CAS  Google Scholar 

  • Hjalmarson A, Nilsson F, Sjöström L et al. (1997) The nicotine inhaler in smoking cessation. Arch Intern Med 157: 1721–1728

    Article  PubMed  CAS  Google Scholar 

  • Hughes JR, Shiffman S, Callas P et al. (2003) A meta-analysis of the efficacy of over-the-counter nicotine replacement. Tobacco Control 12: 21–27

    Article  PubMed  CAS  Google Scholar 

  • Hurt RD, Offord KP, Croghan IT et al. (1998) Temporal effects of nicotine nasal spray and gum on nicotine withdrawal symptoms. Psychopharmacology 140: 98–104

    Article  PubMed  CAS  Google Scholar 

  • Hurt RD, Sachs D, Glover ED (1997) A comparison of sustained-release Bupropion and placebo for smoking cessation. N Engl J Med 337:1195–202

    Article  PubMed  CAS  Google Scholar 

  • John U, Hanke M (2002) Tobacco smoking-and alcohol drinking-attributable cancer mortality in Germany. Eur J Cancer Prev 11: 11–17

    Article  PubMed  CAS  Google Scholar 

  • Johnston JA, Ascher J, Leadbetter R et al. (2002) Pharmacokinetic optimisation of sustained-release bupropion for smoking cessation. Drugs 62[Suppl 2]: 11–24

    Article  PubMed  CAS  Google Scholar 

  • Jorenby DE, Leischow SJ, Nides MA et al. (1999) A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. N Engl J Med 340: 685–689

    Article  PubMed  CAS  Google Scholar 

  • Lancaster T, Stead LF (2003) Self-help interventions for smoking cessation. (Cochrane Review). In: The Cochrane Library, Issue 2. Update Software, Oxford

    Google Scholar 

  • Mcrobbie H, Hajek P (2001) Nicotine replacement therapy in patients with cardiovascular disease: guidelines for health professionals. Addiction 96: 1547–1551

    Article  PubMed  CAS  Google Scholar 

  • Molander L, Lunell E (2001) Pharmacokinetic investigation of a nicotine sublingual tablet. Eur J Clin Pharmacol 56: 813–819

    Article  PubMed  CAS  Google Scholar 

  • Pentel P, Malin D (2002) A vaccine for nicotine dependence: targeting the drug rather than the brain. Respiration 69: 193–197

    Article  PubMed  CAS  Google Scholar 

  • Schneider NG, Olmstead R, Mody FV et al. (1995) Efficiency of a nicotine nasal spray in smoking cessation: a placebo controlled, double-blind trial. Addiction 90: 1671–1682

    Article  PubMed  CAS  Google Scholar 

  • Schneider NG, Olmstead RE, Franzon MA et al. (2001) The nicotine inhaler. Clinical pharmacokinetics and comparsion with other nicotine treatments. Clin Pharmacokinet 40(9):661–684

    Article  PubMed  CAS  Google Scholar 

  • Shiffman S, Dresler CM, Hajek P et al. (2002) Efficacy of a nicotine lozenge for smoking cessation. Arch Intern Med 162: 1267–1276

    Article  PubMed  CAS  Google Scholar 

  • Silagy C, Lancaster T, Staed L et al. (2003) Nicotine replacement therapy for smoking cessation (Cochrane Review) In: The Cochrane Library, Issue 2, Update Software, Oxford

    Google Scholar 

  • Stead LF, Lancaster T (2003) Group behaviour therapy programmes for smoking cessation (Cochrane Review). In: The Cochrane Library, Issue 2. Update Software, Oxford

    Google Scholar 

  • Sutherland G, Stapleton JA, Russell MAH et al. (1992) Randomised controlled trial of nasal nicotine spray in smoking cessation. Lancet 340: 324–329

    Article  PubMed  CAS  Google Scholar 

  • Tønnesen P, Nørregaard J, Mikkelsen K et al. (1993) Double-blind trial of a nicotine inhaler for smoking cessation. JAMA 269: 1268–1271

    Article  PubMed  Google Scholar 

  • Tønnesen P, Paoletti P, Gustavsson G et al. (1999) Higher dosage nicotine patches increase one-year smoking cessation rates: results from the European CEASE trial. Eur Respir J 13: 238–246

    Article  PubMed  Google Scholar 

  • Tonstad S (2002) Use of sustained-release bupropion in specific patient populations for smoking cessation. Drugs 62[Suppl 2]: 37–43

    Article  PubMed  CAS  Google Scholar 

  • White AR, Rampes H, Erns E (2003) Acupuncture for smoking cessation (Cochrane Review). In: The Cochrane Library, Issue 2. Update Software, Oxford

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag/Wien

About this chapter

Cite this chapter

Böning, J. et al. (2006). Suchttherapeutika zur Sucht. In: Riederer, P., Laux, G. (eds) Neuro-Psychopharmaka Ein Therapie-Handbuch. Springer, Vienna. https://doi.org/10.1007/3-211-37774-3_4

Download citation

  • DOI: https://doi.org/10.1007/3-211-37774-3_4

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-22956-9

  • Online ISBN: 978-3-211-37774-1

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics