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Breast Cancer

  • Dean A. Shumway
  • Aaron Sabolch
  • Reshma JagsiEmail author
Chapter
  • 30 Downloads
Part of the Medical Radiology book series (MEDRAD)

Abstract

Radiation therapy plays an integral role in the multidisciplinary management of breast cancer. In appropriately selected patients, radiotherapy not only prevents local recurrences by eliminating residual disease but also results in improved survival. However, not all patients have the same risk of harboring residual locoregional disease, resulting in considerable controversy regarding the role of radiotherapy in individual scenarios. Evidence from clinical trials and observational data analyses can help identify which patients with breast cancer are most likely to achieve a net benefit from adjuvant radiation therapy, both after lumpectomy and mastectomy. Additionally, evidence is emerging now about novel approaches in breast radiotherapy that may reduce burden or toxicity in ways that can optimize the therapeutic ratio, including hypofractionated whole breast radiation, accelerated partial breast irradiation (APBI), intensity-modulated radiation (IMRT), and cardiac avoidance techniques. The objective of this chapter is to review both established and emerging evidence regarding these important issues in an effort to clarify the rationale for increasingly complex and individualized decisions regarding breast radiotherapy.

References

  1. Aaronson NK, Bartelink H, van Dongen JA, van Dam FS (1988) Evaluation of breast conserving therapy: clinical, methodological and psychosocial perspectives. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol 14:133–140Google Scholar
  2. Abdulkarim BS, Cuartero J, Hanson J, Deschenes J, Lesniak D, Sabri S (2011) Increased risk of locoregional recurrence for women with T1-2 N0 triple-negative breast cancer treated with modified radical mastectomy without adjuvant radiation therapy compared with breast-conserving therapy. J Clin Oncol Off J Am Soc Clin Oncol 29(21):2852–2858. doi: 10.1200/jco.2010.33.4714CrossRefGoogle Scholar
  3. Agrawal RK, Alhasso A, Barrett-Lee PJ, Bliss JM, Bliss P, Bloomfield D, Bowen J, Brunt AM, Donovan E, Emson M, Goodman A, Harnett A, Haviland JS, Kaggwa R, Morden JP, Robinson A, Simmons S, Stewart A, Sydenham MA, Syndikus I, Tremlett J, Tsang Y, Wheatley D, Venables K, Yarnold JR (2011) First results of the randomised UK FAST Trial of radiotherapy hypofractionation for treatment of early breast cancer (CRUKE/04/015). Radiother Oncol J Eur Soc Ther Radiol Oncol 100:93–100. doi: 10.1016/j.radonc.2011.06.026CrossRefGoogle Scholar
  4. Akashi-Tanaka S, Fukutomi T, Nanasawa T, Matsuo K, Hasegawa T, Tsuda H (2000) Treatment of noninvasive carcinoma: fifteen-year results at the National Cancer Center Hospital in Tokyo. Breast Cancer (Tokyo, Japan) 7:341–344CrossRefGoogle Scholar
  5. Albert JM, Pan IW, Shih YC, Jiang J, Buchholz TA, Giordano SH, Smith BD (2012) Effectiveness of radiation for prevention of mastectomy in older breast cancer patients treated with conservative surgery. Cancer 118(19):4642–4651. doi: 10.1002/cncr.27457CrossRefPubMedPubMedCentralGoogle Scholar
  6. Antonucci JV, Wallace M, Goldstein NS, Kestin L, Chen P, Benitez P, Dekhne N, Martinez A, Vicini F (2009) Differences in patterns of failure in patients treated with accelerated partial breast irradiation versus whole-breast irradiation: a matched-pair analysis with 10-year follow-up. Int J Radiat Oncol Biol Phys 74:447–452. doi: 10.1016/j.ijrobp.2008.08.025CrossRefPubMedPubMedCentralGoogle Scholar
  7. Aristei C, Palumbo I, Cucciarelli F, Cavalli A, Tarducci R, Raymondi C, Perrucci E, Cavaliere A, Latini P, Rulli A (2009) Partial breast irradiation with interstitial high-dose-rate brachytherapy in early breast cancer: results of a phase II prospective study. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol 35:144–150. doi: 10.1016/j.ejso.2008.06.002CrossRefGoogle Scholar
  8. Aristei C, Palumbo I, Capezzali G, Farneti A, Bini V, Falcinelli L, Margaritelli M, Lancellotta V, Zucchetti C, Perrucci E (2013) Outcome of a phase II prospective study on partial breast irradiation with interstitial multi-catheter high-dose-rate brachytherapy. Radiother Oncol J Eur Soc Ther Radiol Oncol 108:236–241. doi: 10.1016/j.radonc.2013.08.005CrossRefGoogle Scholar
  9. Arriagada R, Le MG, Rochard F, Contesso G (1996) Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data. Institut Gustave-Roussy Breast Cancer Group. J Clin Oncol Off J Am Soc Clin Oncol 14(5):1558–1564CrossRefGoogle Scholar
  10. Arthur DW, Vicini FA, Kuske RR, Wazer DE, Nag S (2003) Accelerated partial breast irradiation: an updated report from the American Brachytherapy Society. Brachytherapy 2:124–130. doi: 10.1016/S1538-4721(03)00107-7CrossRefPubMedPubMedCentralGoogle Scholar
  11. Arthur DW, Winter K, Kuske RR, Bolton J, Rabinovitch R, White J, Hanson WF, Wilenzick RM, McCormick B (2008) A Phase II trial of brachytherapy alone after lumpectomy for select breast cancer: tumor control and survival outcomes of RTOG 95-17. Int J Radiat Oncol Biol Phys 72:467–473. doi: 10.1016/j.ijrobp.2007.12.056CrossRefPubMedPubMedCentralGoogle Scholar
  12. Arthur DW, Vicini FA, Todor DA, Julian TB, Cuttino LW, Mukhopadhyay ND (2013) Contura Multi-Lumen Balloon breast brachytherapy catheter: comparative dosimetric findings of a phase 4 trial. Int J Radiat Oncol Biol Phys 86:264–269. doi: 10.1016/j.ijrobp.2013.01.005CrossRefPubMedPubMedCentralGoogle Scholar
  13. Ashworth A, Kong W, Whelan T, Mackillop WJ (2013) A population-based study of the fractionation of postlumpectomy breast radiation therapy. Int J Radiat Oncol Biol Phys 86:51–57. doi: 10.1016/j.ijrobp.2012.12.015CrossRefPubMedPubMedCentralGoogle Scholar
  14. Bane AL, Whelan TJ, Pond GR, Parpia S, Gohla G, Fyles AW, Pignol J-P, Pritchard KI, Chambers S, Levine MN (2014) Tumor factors predictive of response to hypofractionated radiotherapy in a randomized trial following breast conserving therapy. Ann Oncol Off J Eur Soc Med Oncol 25:992–998. doi: 10.1093/annonc/mdu090CrossRefGoogle Scholar
  15. Bartelink H, Horiot J-C, Poortmans PM, Struikmans H, Van den Bogaert W, Fourquet A, Jager JJ, Hoogenraad WJ, Oei SB, Wárlám-Rodenhuis CC, Pierart M, Collette L (2007) Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881–10882 trial. J Clin Oncol Off J Am Soc Clin Oncol 25:3259–3265. doi: 10.1200/JCO.2007.11.4991CrossRefGoogle Scholar
  16. Bedwinek J (1994) Natural history and management of isolated local-regional recurrence following mastectomy. Semin Radiat Oncol 4(4):260–269. doi: 10.1053/srao00400260CrossRefPubMedPubMedCentralGoogle Scholar
  17. Bekelman JE, Sylwestrzak G, Barron J, Liu J, Epstein AJ, Freedman G, Malin J, Emanuel EJ (2014) Uptake and costs of hypofractionated vs conventional whole breast irradiation after breast conserving surgery in the United States, 2008-2013. JAMA 312(23):2542–2550. doi: 10.1001/jama.2014.16616CrossRefPubMedPubMedCentralGoogle Scholar
  18. Benitez PR, Keisch ME, Vicini F, Stolier A, Scroggins T, Walker A, White J, Hedberg P, Hebert M, Arthur D, Zannis V, Quiet C, Streeter O, Silverstein M (2007) Five-year results: the initial clinical trial of MammoSite balloon brachytherapy for partial breast irradiation in early-stage breast cancer. Am J Surg 194:456–462. doi: 10.1016/j.amjsurg.2007.06.010CrossRefPubMedPubMedCentralGoogle Scholar
  19. Bentz JS, Yassa N, Clayton F (1998) Pleomorphic lobular carcinoma of the breast: clinicopathologic features of 12 cases. Mod Pathol Off J U S Can Acad Pathol 11:814–822Google Scholar
  20. Bentzen SM, Yarnold JR (2010) Reports of unexpected late side effects of accelerated partial breast irradiation – radiobiological considerations. Int J Radiat Oncol Biol Phys 77:969–973. doi: 10.1016/j.ijrobp.2010.01.059CrossRefPubMedPubMedCentralGoogle Scholar
  21. Bentzen SM, Agrawal RK, Aird EGA, Barrett JM, Barrett-Lee PJ, Bliss JM, Brown J, Dewar JA, Dobbs HJ, Haviland JS, Hoskin PJ, Hopwood P, Lawton PA, Magee BJ, Mills J, Morgan DAL, Owen JR, Simmons S, Sumo G, Sydenham MA, Venables K, Yarnold JR (2008a) The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet 371:1098–1107. doi: 10.1016/S0140-6736(08)60348-7CrossRefPubMedPubMedCentralGoogle Scholar
  22. Bentzen SM, Agrawal RK, Aird EGA, Barrett JM, Barrett-Lee PJ, Bliss JM, Brown J, Dewar JA, Dobbs HJ, Haviland JS, Hoskin PJ, Hopwood P, Lawton PA, Magee BJ, Mills J, Morgan DAL, Owen JR, Simmons S, Sumo G, Sydenham MA, Venables K, Yarnold JR (2008b) The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet Oncol 9:331–341. doi: 10.1016/S1470-2045(08)70077-9CrossRefPubMedPubMedCentralGoogle Scholar
  23. Berrang TS, Olivotto I, Kim D-H, Nichol A, Cho BCJ, Mohamed IG, Parhar T, Wright JR, Truong P, Tyldesley S, Sussman J, Wai E, Whelan T (2011) Three-year outcomes of a Canadian multicenter study of accelerated partial breast irradiation using conformal radiation therapy. Int J Radiat Oncol Biol Phys 81:1220–1227. doi: 10.1016/j.ijrobp.2010.07.2003CrossRefPubMedPubMedCentralGoogle Scholar
  24. Bijker N, Peterse JL, Duchateau L, Julien JP, Fentiman IS, Duval C, Di Palma S, Simony-Lafontaine J, de Mascarel I, van de Vijver MJ (2001) Risk factors for recurrence and metastasis after breast-conserving therapy for ductal carcinoma-in-situ: analysis of European Organization for Research and Treatment of Cancer Trial 10853. J Clin Oncol Off J Am Soc Clin Oncol 19:2263–2271CrossRefGoogle Scholar
  25. Bijker N, Meijnen P, Peterse JL, Bogaerts J, Van Hoorebeeck I, Julien J-P, Gennaro M, Rouanet P, Avril A, Fentiman IS, Bartelink H, Rutgers EJT (2006) Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: ten-year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853 – a study by the EORTC Breast Cancer Cooperative Group. J Clin Oncol Off J Am Soc Clin Oncol 24:3381–3387. doi: 10.1200/JCO.2006.06.1366CrossRefGoogle Scholar
  26. Blamey RW, Bates T, Chetty U, Duffy SW, Ellis IO, George D, Mallon E, Mitchell MJ, Monypenny I, Morgan DA, Macmillan RD, Patnick J, Pinder SE (2013) Radiotherapy or tamoxifen after conserving surgery for breast cancers of excellent prognosis: British Association of Surgical Oncology (BASO) II trial. Eur J Cancer (Oxford, England: 1990) 49(10):2294–2302. doi: 10.1016/j.ejca.2013.02.031CrossRefGoogle Scholar
  27. Bleyer A, Welch HG (2012) Effect of three decades of screening mammography on breast-cancer incidence. N Engl J Med 367(21):1998–2005. doi: 10.1056/NEJMoa1206809CrossRefPubMedPubMedCentralGoogle Scholar
  28. Blichert-Toft M, Rose C, Andersen JA, Overgaard M, Axelsson CK, Andersen KW, Mouridsen HT (1992) Danish randomized trial comparing breast conservation therapy with mastectomy: six years of life-table analysis. Danish Breast Cancer Cooperative Group. J Natl Cancer Inst Monogr 1992(11):19–25Google Scholar
  29. Boekel NB, Schaapveld M, Gietema JA, Rutgers EJ, Versteegh MI, Visser O, Aleman BM, van Leeuwen FE (2014) Cardiovascular morbidity and mortality after treatment for ductal carcinoma in situ of the breast. J Natl Cancer Inst 106(8):pii: dju156. doi: 10.1093/jnci/dju156CrossRefGoogle Scholar
  30. Boland GP, Chan KC, Knox WF, Roberts SA, Bundred NJ (2003) Value of the Van Nuys Prognostic Index in prediction of recurrence of ductal carcinoma in situ after breast-conserving surgery. Br J Surg 90:426–432. doi: 10.1002/bjs.4051CrossRefPubMedPubMedCentralGoogle Scholar
  31. Boyages J, Delaney G, Taylor R (1999) Predictors of local recurrence after treatment of ductal carcinoma in situ: a meta-analysis. Cancer 85:616–628CrossRefPubMedPubMedCentralGoogle Scholar
  32. Brautigam E, Track C, Seewald DH, Feichtinger J, Spiegl K, Hammer J (2009) Medial tumor localization in breast cancer – an unappreciated risk factor? Strahlenther Onkol 185(10):663–668. doi: 10.1007/s00066-009-1984-xCrossRefPubMedPubMedCentralGoogle Scholar
  33. Buchanan CL, Flynn LW, Murray MP, Darvishian F, Cranor ML, Fey JV, King TA, Tan LK, Sclafani LM (2008) Is pleomorphic lobular carcinoma really a distinct clinical entity? J Surg Oncol 98:314–317. doi: 10.1002/jso.21121CrossRefPubMedPubMedCentralGoogle Scholar
  34. Buchholz TA (2000) Internal mammary lymph nodes: to treat or not to treat. Int J Radiat Oncol Biol Phys 46(4):801–803CrossRefPubMedPubMedCentralGoogle Scholar
  35. Buchholz TA, Lehman CD, Harris JR, Pockaj BA, Khouri N, Hylton NF, Miller MJ, Whelan T, Pierce LJ, Esserman LJ, Newman LA, Smith BL, Bear HD, Mamounas EP (2008) Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer: a National Cancer Institute conference. J Clin Oncol Off J Am Soc Clin Oncol 26(5):791–797. doi: 10.1200/jco.2007.15.0326CrossRefGoogle Scholar
  36. Carlson GW, Page A, Johnson E, Nicholson K, Styblo TM, Wood WC (2007) Local recurrence of ductal carcinoma in situ after skin-sparing mastectomy. J Am Coll Surg 204:1074–1078 . doi: 10.1016/j.jamcollsurg.2007.01.063discussion 1078-1080CrossRefPubMedPubMedCentralGoogle Scholar
  37. Caudle AS, Hunt KK, Tucker SL, Hoffman K, Gainer SM, Lucci A, Kuerer HM, Meric-Bernstam F, Shah R, Babiera GV, Sahin AA, Mittendorf EA (2012) American College of Surgeons Oncology Group (ACOSOG) Z0011: impact on surgeon practice patterns. Ann Surg Oncol 19(10):3144–3151. doi: 10.1245/s10434-012-2531-zCrossRefPubMedPubMedCentralGoogle Scholar
  38. Ceilley E, Jagsi R, Goldberg S, Grignon L, Kachnic L, Powell S, Taghian A (2005) Radiotherapy for invasive breast cancer in North America and Europe: results of a survey. Int J Radiat Oncol Biol Phys 61:365–373. doi: 10.1016/j.ijrobp.2004.05.069CrossRefPubMedPubMedCentralGoogle Scholar
  39. Center MAC Breast Cancer Nomogram to Predict Additional Positive Non-SLN, without Neoadjuvant ChemotherapyGoogle Scholar
  40. Center MSKC Breast Cancer Nomogram: Breast Additional Non SLN MetastasesGoogle Scholar
  41. Chafe S, Moughan J, McCormick B, Wong J, Pass H, Rabinovitch R, Arthur DW, Petersen I, White J, Vicini FA (2013) Late toxicity and patient self-assessment of breast appearance/satisfaction on RTOG 0319: a phase 2 trial of 3-dimensional conformal radiation therapy-accelerated partial breast irradiation following lumpectomy for stages I and II breast cancer. Int J Radiat Oncol Biol Phys 86:854–859. doi: 10.1016/j.ijrobp.2013.04.005CrossRefPubMedPubMedCentralGoogle Scholar
  42. Chen RC, Lin NU, Golshan M, Harris JR, Bellon JR (2008) Internal mammary nodes in breast cancer: diagnosis and implications for patient management – a systematic review. J Clin Oncol Off J Am Soc Clin Oncol 26(30):4981–4989. doi: 10.1200/jco.2008.17.4862CrossRefGoogle Scholar
  43. Cheng SH, Horng CF, West M, Huang E, Pittman J, Tsou MH, Dressman H, Chen CM, Tsai SY, Jian JJ, Liu MC, Nevins JR, Huang AT (2006) Genomic prediction of locoregional recurrence after mastectomy in breast cancer. J Clin Oncol Off J Am Soc Clin Oncol 24(28):4594–4602. doi: 10.1200/jco.2005.02.5676CrossRefGoogle Scholar
  44. Childs SK, Chen YH, Duggan MM, Golshan M, Pochebit S, Wong JS, Bellon JR (2012) Surgical margins and the risk of local-regional recurrence after mastectomy without radiation therapy. Int J Radiat Oncol Biol Phys 84(5):1133–1138. doi: 10.1016/j.ijrobp.2012.02.048CrossRefPubMedPubMedCentralGoogle Scholar
  45. Chuba PJ, Hamre MR, Yap J, Severson RK, Lucas D, Shamsa F, Aref A (2005) Bilateral risk for subsequent breast cancer after lobular carcinoma-in-situ: analysis of surveillance, epidemiology, and end results data. J Clin Oncol Off J Am Soc Clin Oncol 23:5534–5541. doi: 10.1200/JCO.2005.04.038CrossRefGoogle Scholar
  46. Chung E, Corbett JR, Moran JM, Griffith KA, Marsh RB, Feng M, Jagsi R, Kessler ML, Ficaro EC, Pierce LJ (2013) Is there a dose-response relationship for heart disease with low-dose radiation therapy? Int J Radiat Oncol Biol Phys 85(4):959–964. doi: 10.1016/j.ijrobp.2012.08.002CrossRefPubMedPubMedCentralGoogle Scholar
  47. Clark RM, McCulloch PB, Levine MN, Lipa M, Wilkinson RH, Mahoney LJ, Basrur VR, Nair BD, McDermot RS, Wong CS (1992) Randomized clinical trial to assess the effectiveness of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer. J Natl Cancer Inst 84:683–689CrossRefPubMedPubMedCentralGoogle Scholar
  48. Clark RM, Whelan T, Levine M, Roberts R, Willan A, McCulloch P, Lipa M, Wilkinson RH, Mahoney LJ (1996) Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. Ontario Clinical Oncology Group. J Natl Cancer Inst 88(22):1659–1664CrossRefPubMedPubMedCentralGoogle Scholar
  49. Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E, Godwin J, Gray R, Hicks C, James S, MacKinnon E, McGale P, McHugh T, Peto R, Taylor C, Wang Y (2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 366(9503):2087–2106. doi: 10.1016/s0140-6736(05)67887-7CrossRefPubMedPubMedCentralGoogle Scholar
  50. Clavel S, Roy I, Carrier JF, Rousseau P, Fortin MA (2010) Adjuvant regional irradiation after breast-conserving therapy for early stage breast cancer: a survey of canadian radiation oncologists. Clin Oncol R Coll Radiol (Great Britain) 22(1):39–45. doi: 10.1016/j.clon.2009.09.026CrossRefGoogle Scholar
  51. Cohen L (1952) Radiotherapy in breast cancer. I. The dose-time relationship theoretical considerations. Br J Radiol 25:636–642CrossRefPubMedPubMedCentralGoogle Scholar
  52. Collins LC, Tamimi RM, Baer HJ, Connolly JL, Colditz GA, Schnitt SJ (2005) Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy: results from the Nurses’ Health Study. Cancer 103:1778–1784. doi: 10.1002/cncr.20979CrossRefPubMedPubMedCentralGoogle Scholar
  53. Collins L, Achacoso N, Sharafali Z, Al E (2012) Predictors of local recurrence (LR) in patients with ductal carcinoma in situ (DCIS) treated by breast conserving therapy (BCT): value of the Memorial Sloan-Kettering (MSK) nomogram. Proceedings of the 101st annual meeting of the United States and Canadian Academy of PathologyGoogle Scholar
  54. Correa C, McGale P, Taylor C, Wang Y, Clarke M, Davies C, Peto R, Bijker N, Solin L, Darby S (2010) Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr 2010:162–177. doi: 10.1093/jncimonographs/lgq039CrossRefPubMedPubMedCentralGoogle Scholar
  55. Cuttino LW, White JR, Rabinovitch R, Gewirtz DA, Anscher MS, Wazer DE, Vicini FA, Julian TB, Arthur DW (2012) Accelerated partial-breast irradiation: trial by media or by science? Int J Radiat Oncol Biol Phys 83:1075–1077. doi: 10.1016/j.ijrobp.2012.02.059CrossRefPubMedPubMedCentralGoogle Scholar
  56. Cuttino LW, Arthur DW, Vicini F, Todor D, Julian T, Mukhopadhyay N (2014) Long-term results from the contura multilumen balloon breast brachytherapy catheter phase 4 registry trial. Int J Radiat Oncol Biol Phys 90:1025–1029. doi: 10.1016/j.ijrobp.2014.08.341CrossRefPubMedPubMedCentralGoogle Scholar
  57. Cutuli B, Cohen-Solal-Le Nir C, De Lafontan B, Mignotte H, Fichet V, Fay R, Servent V, Giard S, Charra-Brunaud C, Auvray H, Penault-Llorca F, Charpentier JC (2001) Ductal carcinoma in situ of the breast results of conservative and radical treatments in 716 patients. Eur J Cancer (Oxford, England: 1990) 37:2365–2372CrossRefGoogle Scholar
  58. Cuzick J, Stewart H, Peto R, Baum M, Fisher B, Host H, Lythgoe JP, Ribeiro G, Scheurlen H, Wallgren A (1987) Overview of randomized trials of postoperative adjuvant radiotherapy in breast cancer. Cancer Treat Rep 71(1):15–29PubMedPubMedCentralGoogle Scholar
  59. Cuzick J, Stewart H, Rutqvist L, Houghton J, Edwards R, Redmond C, Peto R, Baum M, Fisher B, Host H et al (1994) Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol Off J Am Soc Clin Oncol 12(3):447–453CrossRefGoogle Scholar
  60. Cuzick J, Sestak I, Pinder SE, Ellis IO, Forsyth S, Bundred NJ, Forbes JF, Bishop H, Fentiman IS, George WD (2011) Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK/ANZ DCIS trial. Lancet Oncol 12:21–29. doi: 10.1016/S1470-2045(10)70266-7CrossRefPubMedPubMedCentralGoogle Scholar
  61. Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, Cutter D, Davies C, Ewertz M, Godwin J, Gray R, Pierce L, Whelan T, Wang Y, Peto R (2011a) Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 378(9804):1707–1716. doi: 10.1016/s0140-6736(11)61629-2CrossRefPubMedPubMedCentralGoogle Scholar
  62. Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, Cutter D, Davies C, Ewertz M, Godwin J, Gray R, Pierce L, Whelan T, Wang Y, Peto R (2011b) Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 378:1707–1716. doi: 10.1016/S0140-6736(11)61629-2CrossRefPubMedPubMedCentralGoogle Scholar
  63. Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen M-B, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P (2013a) Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 368:987–998. doi: 10.1056/NEJMoa1209825CrossRefPubMedPubMedCentralGoogle Scholar
  64. Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Bronnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen MB, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P (2013b) Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 368(11):987–998. doi: 10.1056/NEJMoa1209825CrossRefPubMedPubMedCentralGoogle Scholar
  65. de Mascarel I, Bonichon F, MacGrogan G, de Lara CT, Avril A, Picot V, Durand M, Mauriac L, Trojani M, Coindre JM (2000) Application of the van nuys prognostic index in a retrospective series of 367 ductal carcinomas in situ of the breast examined by serial macroscopic sectioning: practical considerations. Breast Cancer Res Treat 61:151–159CrossRefPubMedPubMedCentralGoogle Scholar
  66. Di Saverio S, Catena F, Santini D, Ansaloni L, Fogacci T, Mignani S, Leone A, Gazzotti F, Gagliardi S, De Cataldis A, Taffurelli M (2008) 259 Patients with DCIS of the breast applying USC/Van Nuys prognostic index: a retrospective review with long term follow up. Breast Cancer Res Treat 109:405–416. doi: 10.1007/s10549-007-9668-7CrossRefPubMedPubMedCentralGoogle Scholar
  67. Dodwell DJ, Dyker K, Brown J, Hawkins K, Cohen D, Stead M, Ash D (2005) A randomised study of whole-breast vs tumour-bed irradiation after local excision and axillary dissection for early breast cancer. Clin Oncol R Coll Radiol (Great Britain) 17:618–622CrossRefGoogle Scholar
  68. Donker M, van Tienhoven G, Straver ME, Meijnen P, van de Velde CJ, Mansel RE, Cataliotti L, Westenberg AH, Klinkenbijl JH, Orzalesi L, Bouma WH, van der Mijle HC, Nieuwenhuijzen GA, Veltkamp SC, Slaets L, Duez NJ, de Graaf PW, van Dalen T, Marinelli A, Rijna H, Snoj M, Bundred NJ, Merkus JW, Belkacemi Y, Petignat P, Schinagl DA, Coens C, Messina CG, Bogaerts J, Rutgers EJ (2014) Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol 15(12):1303–1310. doi: 10.1016/s1470-2045(14)70460-7CrossRefPubMedPubMedCentralGoogle Scholar
  69. Donovan E, Bleakley N, Denholm E, Evans P, Gothard L, Hanson J, Peckitt C, Reise S, Ross G, Sharp G, Symonds-Tayler R, Tait D, Yarnold J (2007) Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol J Eur Soc Ther Radiol Oncol 82(3):254–264. doi: 10.1016/j.radonc.2006.12.008CrossRefGoogle Scholar
  70. Douglas BG, Castro JR (1984) Novel fractionation schemes and high linear energy transfer. Prog Exp Tumor Res 28:152–165CrossRefPubMedPubMedCentralGoogle Scholar
  71. Early Breast Cancer Trialists’ Collaborative Group (1995) Effects of radiotherapy and surgery in early breast cancer. An overview of the randomized trials. N Engl J Med 333(22):1444–1455. doi: 10.1056/nejm199511303332202CrossRefGoogle Scholar
  72. Early Breast Cancer Trialists’ Collaborative Group (1998) Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 351(9114):1451–1467CrossRefGoogle Scholar
  73. Early Breast Cancer Trialists’ Collaborative Group (2000) Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet 355(9217):1757–1770CrossRefGoogle Scholar
  74. Emdin SO, Granstrand B, Ringberg A, Sandelin K, Arnesson L-G, Nordgren H, Anderson H, Garmo H, Holmberg L, Wallgren A (2006) SweDCIS: Radiotherapy after sector resection for ductal carcinoma in situ of the breast. Results of a randomised trial in a population offered mammography screening. Acta Oncol (Stockholm, Sweden) 45:536–543. doi: 10.1080/02841860600681569CrossRefGoogle Scholar
  75. Ernster VL, Barclay J, Kerlikowske K, Grady D, Henderson C (1996) Incidence of and treatment for ductal carcinoma in situ of the breast. JAMA 275:913–918CrossRefPubMedPubMedCentralGoogle Scholar
  76. Eusebi V, Magalhaes F, Azzopardi JG (1992) Pleomorphic lobular carcinoma of the breast: an aggressive tumor showing apocrine differentiation. Hum Pathol 23:655–662CrossRefPubMedPubMedCentralGoogle Scholar
  77. Farrus B, Vidal-Sicart S, Velasco M, Zanon G, Fernandez PL, Munoz M, Santamaria G, Albanell J, Biete A (2004) Incidence of internal mammary node metastases after a sentinel lymph node technique in breast cancer and its implication in the radiotherapy plan. Int J Radiat Oncol Biol Phys 60(3):715–721. doi: 10.1016/j.ijrobp.2004.04.021CrossRefPubMedPubMedCentralGoogle Scholar
  78. Feng M, Pierce LJ (2014) Getting to the heart of the matter. J Natl Cancer Inst 106(8):dju210. doi: 10.1093/jnci/dju210CrossRefPubMedPubMedCentralGoogle Scholar
  79. Fentiman IS, Poole C, Tong D, Winter PJ, Mayles HM, Turner P, Chaudary MA, Rubens RD (1991) Iridium implant treatment without external radiotherapy for operable breast cancer: a pilot study. Eur J Cancer (Oxford, England: 1990) 27:447–450CrossRefGoogle Scholar
  80. Fentiman IS, Poole C, Tong D, Winter PJ, Gregory WM, Mayles HM, Turner P, Chaudary MA, Rubens RD (1996) Inadequacy of iridium implant as sole radiation treatment for operable breast cancer. Eur J Cancer (Oxford, England: 1990) 32A:608–611CrossRefGoogle Scholar
  81. Fisher B, Costantino J, Redmond C, Poisson R, Bowman D, Couture J, Dimitrov NV, Wolmark N, Wickerham DL, Fisher ER et al (1989) A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors. N Engl J Med 320(8):479–484. doi: 10.1056/nejm198902233200802CrossRefPubMedPubMedCentralGoogle Scholar
  82. Fisher B, Costantino J, Redmond C, Fisher E, Margolese R, Dimitrov N, Wolmark N, Wickerham DL, Deutsch M, Ore L (1993) Lumpectomy compared with lumpectomy and radiation therapy for the treatment of intraductal breast cancer. N Engl J Med 328:1581–1586. doi: 10.1056/NEJM199306033282201CrossRefPubMedPubMedCentralGoogle Scholar
  83. Fisher B, Dignam J, Wolmark N, Mamounas E, Costantino J, Poller W, Fisher ER, Wickerham DL, Deutsch M, Margolese R, Dimitrov N, Kavanah M (1998) Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17. J Clin Oncol Off J Am Soc Clin Oncol 16:441–452CrossRefGoogle Scholar
  84. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N (2002a) Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347(16):1233–1241. doi: 10.1056/NEJMoa022152CrossRefPubMedPubMedCentralGoogle Scholar
  85. Fisher B, Bryant J, Dignam JJ, Wickerham DL, Mamounas EP, Fisher ER, Margolese RG, Nesbitt L, Paik S, Pisansky TM, Wolmark N (2002b) Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less. J Clin Oncol Off J Am Soc Clin Oncol 20(20):4141–4149CrossRefGoogle Scholar
  86. Fisher ER, Land SR, Fisher B, Mamounas E, Gilarski L, Wolmark N (2004) Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: twelve-year observations concerning lobular carcinoma in situ. Cancer 100:238–244. doi: 10.1002/cncr.11883CrossRefPubMedPubMedCentralGoogle Scholar
  87. Flegal KM, Carroll MD, Kit BK, Ogden CL (2012) Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 307:491–497. doi: 10.1001/jama.2012.39CrossRefPubMedPubMedCentralGoogle Scholar
  88. Floyd SR, Buchholz TA, Haffty BG, Goldberg S, Niemierko A, Raad RA, Oswald MJ, Sullivan T, Strom EA, Powell SN, Katz A, Taghian AG (2006) Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger. Int J Radiat Oncol Biol Phys 66(2):358–364. doi: 10.1016/j.ijrobp.2006.05.001CrossRefPubMedPubMedCentralGoogle Scholar
  89. Ford HT, Coombes RC, Gazet JC, Gray R, McConkey CC, Sutcliffe R, Quilliam J, Lowndes S (2006) Long-term follow-up of a randomised trial designed to determine the need for irradiation following conservative surgery for the treatment of invasive breast cancer. Ann Oncol Off J Eur Soc Med Oncol 17(3):401–408. doi: 10.1093/annonc/mdj080CrossRefGoogle Scholar
  90. Formenti SC, Hsu H, Fenton-Kerimian M, Roses D, Guth A, Jozsef G, Goldberg JD, Dewyngaert JK (2012) Prone accelerated partial breast irradiation after breast-conserving surgery: five-year results of 100 patients. Int J Radiat Oncol Biol Phys 84:606–611. doi: 10.1016/j.ijrobp.2012.01.039CrossRefPubMedPubMedCentralGoogle Scholar
  91. Forrest AP, Stewart H, Everington D, Prescott RJ, McArdle CS, Harnett AN, Smith DC, George WD (1996) Randomized controlled trial of conservation therapy for breast cancer: 6-year analysis of the Scottish trial. Lancet 348(9029):708–713CrossRefPubMedPubMedCentralGoogle Scholar
  92. Freedman GM, Fowble BL, Hanlon AL, Myint MA, Hoffman JP, Sigurdson ER, Eisenberg BL, Goldstein LJ, Fein DA (1998) A close or positive margin after mastectomy is not an indication for chest wall irradiation except in women aged fifty or younger. Int J Radiat Oncol Biol Phys 41(3):599–605CrossRefPubMedPubMedCentralGoogle Scholar
  93. Freedman GM, Fowble BL, Nicolaou N, Sigurdson ER, Torosian MH, Boraas MC, Hoffman JP (2000) Should internal mammary lymph nodes in breast cancer be a target for the radiation oncologist? Int J Radiat Oncol Biol Phys 46(4):805–814CrossRefPubMedPubMedCentralGoogle Scholar
  94. Freedman GM, Anderson PR, Goldstein LJ, Ma C-M, Li J, Swaby RF, Litwin S, Watkins-Bruner D, Sigurdson ER, Morrow M (2007) Four-week course of radiation for breast cancer using hypofractionated intensity modulated radiation therapy with an incorporated boost. Int J Radiat Oncol Biol Phys 68:347–353. doi: 10.1016/j.ijrobp.2006.12.035CrossRefPubMedPubMedCentralGoogle Scholar
  95. Fyles AW, McCready DR, Manchul LA, Trudeau ME, Merante P, Pintilie M, Weir LM, Olivotto IA (2004) Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Engl J Med 351(10):963–970. doi: 10.1056/NEJMoa040595CrossRefPubMedPubMedCentralGoogle Scholar
  96. Gainer SM, Hunt KK, Beitsch P, Caudle AS, Mittendorf EA, Lucci A (2012) Changing behavior in clinical practice in response to the ACOSOG Z0011 trial: a survey of the American Society of Breast Surgeons. Ann Surg Oncol 19(10):3152–3158. doi: 10.1245/s10434-012-2523-zCrossRefPubMedPubMedCentralGoogle Scholar
  97. Galimberti V, Cole BF, Zurrida S, Viale G, Luini A, Veronesi P, Baratella P, Chifu C, Sargenti M, Intra M, Gentilini O, Mastropasqua MG, Mazzarol G, Massarut S, Garbay JR, Zgajnar J, Galatius H, Recalcati A, Littlejohn D, Bamert M, Colleoni M, Price KN, Regan MM, Goldhirsch A, Coates AS, Gelber RD, Veronesi U (2013) Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial. Lancet Oncol 14(4):297–305. doi: 10.1016/s1470-2045(13)70035-4CrossRefPubMedPubMedCentralGoogle Scholar
  98. Galland-Girodet S, Pashtan I, MacDonald SM, Ancukiewicz M, Hirsch AE, Kachnic LA, Specht M, Gadd M, Smith BL, Powell SN, Recht A, Taghian AG (2014) Long-term cosmetic outcomes and toxicities of proton beam therapy compared with photon-based 3-dimensional conformal accelerated partial-breast irradiation: a phase 1 trial. Int J Radiat Oncol Biol Phys 90:493–500. doi: 10.1016/j.ijrobp.2014.04.008CrossRefPubMedPubMedCentralGoogle Scholar
  99. Garsa AA, Ferraro DJ, DeWees T, Margenthaler JA, Naughton M, Aft R, Gillanders WE, Eberlein T, Matesa MA, Zoberi I (2013) Cosmetic analysis following breast-conserving surgery and adjuvant high-dose-rate interstitial brachytherapy for early-stage breast cancer: a prospective clinical study. Int J Radiat Oncol Biol Phys 85:965–970. doi: 10.1016/j.ijrobp.2012.08.027CrossRefPubMedPubMedCentralGoogle Scholar
  100. Georgian-Smith D, Lawton TJ (2001) Calcifications of lobular carcinoma in situ of the breast: radiologic-pathologic correlation. AJR Am J Roentgenol 176:1255–1259. doi: 10.2214/ajr.176.5.1761255CrossRefPubMedPubMedCentralGoogle Scholar
  101. Giordano SH, Kuo YF, Freeman JL, Buchholz TA, Hortobagyi GN, Goodwin JS (2005) Risk of cardiac death after adjuvant radiotherapy for breast cancer. J Natl Cancer Inst 97(6):419–424. doi: 10.1093/jnci/dji067CrossRefPubMedPubMedCentralGoogle Scholar
  102. Giuliano AE, McCall L, Beitsch P, Whitworth PW, Blumencranz P, Leitch AM, Saha S, Hunt KK, Morrow M, Ballman K (2010) Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial. Ann Surg 252(3):426–432 . doi: 10.1097/SLA.0b013e3181f08f32discussion 432-423CrossRefPubMedPubMedCentralGoogle Scholar
  103. Giuliano AE, Hunt KK, Ballman KV, Beitsch PD, Whitworth PW, Blumencranz PW, Leitch AM, Saha S, McCall LM, Morrow M (2011) Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA 305(6):569–575. doi: 10.1001/jama.2011.90CrossRefPubMedPubMedCentralGoogle Scholar
  104. Glass AG, Lacey JV Jr, Carreon JD, Hoover RN (2007) Breast cancer incidence, 1980-2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status. J Natl Cancer Inst 99(15):1152–1161. doi: 10.1093/jnci/djm059CrossRefPubMedPubMedCentralGoogle Scholar
  105. Greene FL, Page DL, Fleming ID et al (2002) AJCC cancer staging handbook, 6th edn. Springer, New YorkCrossRefGoogle Scholar
  106. Grills IS, Kestin LL, Goldstein N, Mitchell C, Martinez A, Ingold J, Vicini FA (2003) Risk factors for regional nodal failure after breast-conserving therapy: regional nodal irradiation reduces rate of axillary failure in patients with four or more positive lymph nodes. Int J Radiat Oncol Biol Phys 56(3):658–670CrossRefPubMedPubMedCentralGoogle Scholar
  107. Gustavsson A, Bendahl PO, Cwikiel M, Eskilsson J, Thapper KL, Pahlm O (1999) No serious late cardiac effects after adjuvant radiotherapy following mastectomy in premenopausal women with early breast cancer. Int J Radiat Oncol Biol Phys 43(4):745–754CrossRefPubMedPubMedCentralGoogle Scholar
  108. Gyenes G, Rutqvist LE, Liedberg A, Fornander T (1998) Long-term cardiac morbidity and mortality in a randomized trial of pre- and postoperative radiation therapy versus surgery alone in primary breast cancer. Radiother Oncol J Eur Soc Ther Radiol Oncol 48(2):185–190CrossRefGoogle Scholar
  109. Haffty BG, Buchholz TA, McCormick B (2008) Should intensity-modulated radiation therapy be the standard of care in the conservatively managed breast cancer patient? J Clin Oncol Off J Am Soc Clin Oncol 26(13):2072–2074. doi: 10.1200/jco.2007.15.9442CrossRefGoogle Scholar
  110. Haffty BG, Hunt KK, Harris JR, Buchholz TA (2011) Positive sentinel nodes without axillary dissection: implications for the radiation oncologist. J Clin Oncol Off J Am Soc Clin Oncol 29(34):4479–4481. doi: 10.1200/jco.2011.36.1667CrossRefGoogle Scholar
  111. Harris JR, Halpin-Murphy P, McNeese M, Mendenhall NP, Morrow M, Robert NJ (1999) Consensus Statement on postmastectomy radiation therapy. Int J Radiat Oncol Biol Phys 44(5):989–990CrossRefPubMedPubMedCentralGoogle Scholar
  112. Harris EE, Correa C, Hwang WT, Liao J, Litt HI, Ferrari VA, Solin LJ (2006) Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatment. J Clin Oncol Off J Am Soc Clin Oncol 24(25):4100–4106. doi: 10.1200/jco.2005.05.1037CrossRefGoogle Scholar
  113. Harsolia A, Kestin L, Grills I, Wallace M, Jolly S, Jones C, Lala M, Martinez A, Schell S, Vicini FA (2007) Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy. Int J Radiat Oncol Biol Phys 68(5):1375–1380. doi: 10.1016/j.ijrobp.2007.02.044CrossRefPubMedPubMedCentralGoogle Scholar
  114. Hattangadi JA, Powell SN, MacDonald SM, Mauceri T, Ancukiewicz M, Freer P, Lawenda B, Alm El-Din MA, Gadd MA, Smith BL, Taghian AG (2012) Accelerated partial breast irradiation with low-dose-rate interstitial implant brachytherapy after wide local excision: 12-year outcomes from a prospective trial. Int J Radiat Oncol Biol Phys 83:791–800. doi: 10.1016/j.ijrobp.2011.09.003CrossRefPubMedPubMedCentralGoogle Scholar
  115. Haviland JS, Owen JR, Dewar JA, Agrawal RK, Barrett J, Barrett-Lee PJ, Dobbs HJ, Hopwood P, Lawton PA, Magee BJ, Mills J, Simmons S, Sydenham MA, Venables K, Bliss JM, Yarnold JR (2013) The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol 14:1086–1094. doi: 10.1016/S1470-2045(13)70386-3CrossRefPubMedPubMedCentralGoogle Scholar
  116. Hennequin C, Bossard N, Servagi-Vernat S, Maingon P, Dubois JB, Datchary J, Carrie C, Roullet B, Suchaud JP, Teissier E, Lucardi A, Gerard JP, Belot A, Iwaz J, Ecochard R, Romestaing P (2013) Ten-year survival results of a randomized trial of irradiation of internal mammary nodes after mastectomy. Int J Radiat Oncol Biol Phys 86(5):860–866. doi: 10.1016/j.ijrobp.2013.03.021CrossRefPubMedPubMedCentralGoogle Scholar
  117. Hepel JT, Tokita M, MacAusland SG, Evans SB, Hiatt JR, Price LL, DiPetrillo T, Wazer DE (2009) Toxicity of three-dimensional conformal radiotherapy for accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 75:1290–1296. doi: 10.1016/j.ijrobp.2009.01.009CrossRefPubMedPubMedCentralGoogle Scholar
  118. Hojris I, Overgaard M, Christensen JJ, Overgaard J (1999) Morbidity and mortality of ischaemic heart disease in high-risk breast-cancer patients after adjuvant postmastectomy systemic treatment with or without radiotherapy: analysis of DBCG 82b and 82c randomised trials. Radiotherapy Committee of the Danish Breast Cancer Cooperative Group. Lancet 354(9188):1425–1430CrossRefPubMedPubMedCentralGoogle Scholar
  119. Holland R, Veling SH, Mravunac M, Hendriks JH (1985) Histologic multifocality of Tis, T1-2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer 56:979–990CrossRefPubMedPubMedCentralGoogle Scholar
  120. Holli K, Hietanen P, Saaristo R, Huhtala H, Hakama M, Joensuu H (2009) Radiotherapy after segmental resection of breast cancer with favorable prognostic features: 12-year follow-up results of a randomized trial. J Clin Oncol Off J Am Soc Clin Oncol 27(6):927–932. doi: 10.1200/jco.2008.19.7129CrossRefGoogle Scholar
  121. Holmberg L, Garmo H, Granstrand B, Ringberg A, Arnesson L-G, Sandelin K, Karlsson P, Anderson H, Emdin S (2008) Absolute risk reductions for local recurrence after postoperative radiotherapy after sector resection for ductal carcinoma in situ of the breast. J Clin Oncol Off J Am Soc Clin Oncol 26:1247–1252. doi: 10.1200/JCO.2007.12.7969CrossRefGoogle Scholar
  122. Houghton J, George WD, Cuzick J, Duggan C, Fentiman IS, Spittle M (2003) Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia, and New Zealand: randomised controlled trial. Lancet 362:95–102CrossRefPubMedPubMedCentralGoogle Scholar
  123. Huang EH, Tucker SL, Strom EA, McNeese MD, Kuerer HM, Buzdar AU, Valero V, Perkins GH, Schechter NR, Hunt KK, Sahin AA, Hortobagyi GN, Buchholz TA (2004) Postmastectomy radiation improves local-regional control and survival for selected patients with locally advanced breast cancer treated with neoadjuvant chemotherapy and mastectomy. J Clin Oncol Off J Am Soc Clin Oncol 22(23):4691–4699. doi: 10.1200/jco.2004.11.129CrossRefGoogle Scholar
  124. Hughes KS, Schnaper LA, Berry D, Cirrincione C, McCormick B, Shank B, Wheeler J, Champion LA, Smith TJ, Smith BL, Shapiro C, Muss HB, Winer E, Hudis C, Wood W, Sugarbaker D, Henderson IC, Norton L (2004) Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med 351(10):971–977. doi: 10.1056/NEJMoa040587CrossRefPubMedPubMedCentralGoogle Scholar
  125. Hughes LL, Wang M, Page DL, Gray R, Solin LJ, Davidson NE, Lowen MA, Ingle JN, Recht A, Wood WC (2009) Local excision alone without irradiation for ductal carcinoma in situ of the breast: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol Off J Am Soc Clin Oncol 27:5319–5324. doi: 10.1200/JCO.2009.21.8560CrossRefGoogle Scholar
  126. Hughes KS, Schnaper LA, Bellon JR, Cirrincione CT, Berry DA, McCormick B, Muss HB, Smith BL, Hudis CA, Winer EP, Wood WC (2013) Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. J Clin Oncol Off J Am Soc Clin Oncol 31(19):2382–2387. doi: 10.1200/jco.2012.45.2615CrossRefGoogle Scholar
  127. Iyer RV, Hanlon A, Fowble B, Freedman G, Nicolaou N, Anderson P, Hoffman J, Sigurdson E, Boraas M, Torosian M (2000) Accuracy of the extent of axillary nodal positivity related to primary tumor size, number of involved nodes, and number of nodes examined. Int J Radiat Oncol Biol Phys 47(5):1177–1183CrossRefPubMedPubMedCentralGoogle Scholar
  128. Jacobs TW, Pliss N, Kouria G, Schnitt SJ (2001) Carcinomas in situ of the breast with indeterminate features: role of E-cadherin staining in categorization. Am J Surg Pathol 25:229–236CrossRefPubMedPubMedCentralGoogle Scholar
  129. Jagsi R, Haffty BG (2013) External-beam accelerated partial-breast irradiation: exploring the limits of tolerability. J Clin Oncol Off J Am Soc Clin Oncol 31:4029–4031. doi: 10.1200/JCO.2013.51.1717CrossRefGoogle Scholar
  130. Jagsi R, Pierce L (2013) Radiation therapy to the internal mammary nodal region in breast cancer: the debate continues. Int J Radiat Oncol Biol Phys 86(5):813–815. doi: 10.1016/j.ijrobp.2013.04.002CrossRefPubMedPubMedCentralGoogle Scholar
  131. Jagsi R, Raad RA, Goldberg S, Sullivan T, Michaelson J, Powell SN, Taghian AG (2005) Locoregional recurrence rates and prognostic factors for failure in node-negative patients treated with mastectomy: implications for postmastectomy radiation. Int J Radiat Oncol Biol Phys 62(4):1035–1039. doi: 10.1016/j.ijrobp.2004.12.014CrossRefPubMedPubMedCentralGoogle Scholar
  132. Jagsi R, Griffith KA, Koelling T, Roberts R, Pierce LJ (2007a) Rates of myocardial infarction and coronary artery disease and risk factors in patients treated with radiation therapy for early-stage breast cancer. Cancer 109(4):650–657. doi: 10.1002/cncr.22452CrossRefPubMedPubMedCentralGoogle Scholar
  133. Jagsi R, Moran JM, Kessler ML, Marsh RB, Balter JM, Pierce LJ (2007b) Respiratory motion of the heart and positional reproducibility under active breathing control. Int J Radiat Oncol Biol Phys 68(1):253–258. doi: 10.1016/j.ijrobp.2006.12.058CrossRefPubMedPubMedCentralGoogle Scholar
  134. Jagsi R, Ben-David MA, Moran JM, Marsh RB, Griffith KA, Hayman JA, Pierce LJ (2010) Unacceptable cosmesis in a protocol investigating intensity-modulated radiotherapy with active breathing control for accelerated partial-breast irradiation. Int J Radiat Oncol Biol Phys 76:71–78. doi: 10.1016/j.ijrobp.2009.01.041CrossRefPubMedPubMedCentralGoogle Scholar
  135. Jagsi R, Griffith KA, Heimburger D, Walker EM, Grills IS, Boike T, Feng M, Moran JM, Hayman J, Pierce LJ (2014a) Choosing wisely? Patterns and correlates of the use of hypofractionated whole-breast radiation therapy in the state of Michigan. Int J Radiat Oncol Biol Phys 90:1010–1016. doi: 10.1016/j.ijrobp.2014.09.027CrossRefPubMedGoogle Scholar
  136. Jagsi R, Falchook AD, Hendrix LH, Curry H, Chen RC (2014b) Adoption of hypofractionated radiation therapy for breast cancer after publication of randomized trials. Int J Radiat Oncol Biol Phys 90:1001–1009. doi: 10.1016/j.ijrobp.2014.09.032CrossRefPubMedGoogle Scholar
  137. Jagsi R, Chadha M, Moni J, Ballman K, Laurie F, Buchholz TA, Giuliano A, Haffty BG (2014c) Radiation field design in the ACOSOG Z0011 (Alliance) trial. J Clin Oncol Off J Am Soc Clin Oncol 32(32):3600–3606. doi: 10.1200/jco.2014.56.5838CrossRefGoogle Scholar
  138. Jemal A, Ward E, Thun MJ (2007) Recent trends in breast cancer incidence rates by age and tumor characteristics among U.S. women. Breast Cancer Res 9(3):R28. doi: 10.1186/bcr1672CrossRefPubMedPubMedCentralGoogle Scholar
  139. Joensuu H, Lehtimaki T, Holli K, Elomaa L, Turpeenniemi-Hujanen T, Kataja V, Anttila A, Lundin M, Isola J, Lundin J (2004) Risk for distant recurrence of breast cancer detected by mammography screening or other methods. JAMA 292(9):1064–1073. doi: 10.1001/jama.292.9.1064CrossRefPubMedGoogle Scholar
  140. Julien JP, Bijker N, Fentiman IS, Peterse JL, Delledonne V, Rouanet P, Avril A, Sylvester R, Mignolet F, Bartelink H, Van Dongen JA (2000) Radiotherapy in breast-conserving treatment for ductal carcinoma in situ: first results of the EORTC randomised phase III trial 10853. EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group. Lancet 355:528–533CrossRefGoogle Scholar
  141. Katz A, Strom EA, Buchholz TA, Thames HD, Smith CD, Jhingran A, Hortobagyi G, Buzdar AU, Theriault R, Singletary SE, McNeese MD (2000) Locoregional recurrence patterns after mastectomy and doxorubicin-based chemotherapy: implications for postoperative irradiation. J Clin Oncol Off J Am Soc Clin Oncol 18(15):2817–2827CrossRefGoogle Scholar
  142. Kaufman SA, DiPetrillo TA, Price LL, Midle JB, Wazer DE (2007) Long-term outcome and toxicity in a Phase I/II trial using high-dose-rate multicatheter interstitial brachytherapy for T1/T2 breast cancer. Brachytherapy 6:286–292. doi: 10.1016/j.brachy.2007.09.001CrossRefPubMedPubMedCentralGoogle Scholar
  143. Keller LM, Sopka DM, Li T, Klayton T, Li J, Anderson PR, Bleicher RJ, Sigurdson ER, Freedman GM (2012) Five-year results of whole breast intensity modulated radiation therapy for the treatment of early stage breast cancer: the Fox Chase Cancer Center experience. Int J Radiat Oncol Biol Phys 84(4):881–887. doi: 10.1016/j.ijrobp.2012.01.069CrossRefPubMedPubMedCentralGoogle Scholar
  144. Kelley L, Silverstein M, Guerra L (2011) Analyzing the risk of recurrence after mastectomy for DCIS: a new use for the USC/Van Nuys Prognostic Index. Ann Surg Oncol 18:459–462. doi: 10.1245/s10434-010-1335-2CrossRefPubMedPubMedCentralGoogle Scholar
  145. Khoury T, Karabakhtsian RG, Mattson D, Yan L, Syriac S, Habib F, Liu S, Desouki MM (2014) Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 47 cases. Histopathology 64:981–993. doi: 10.1111/his.12353CrossRefPubMedPubMedCentralGoogle Scholar
  146. Kimple RJ, Klauber-DeMore N, Kuzmiak CM, Pavic D, Lian J, Livasy CA, Chiu WM, Moore DT, Sartor CI, Ollila DW (2011) Local control following single-dose intraoperative radiotherapy prior to surgical excision of early-stage breast cancer. Ann Surg Oncol 18:939–945. doi: 10.1245/s10434-010-1392-6CrossRefPubMedPubMedCentralGoogle Scholar
  147. King TA, Bolton JS, Kuske RR, Fuhrman GM, Scroggins TG, Jiang XZ (2000) Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for T(is,1,2) breast cancer. Am J Surg 180:299–304CrossRefPubMedPubMedCentralGoogle Scholar
  148. Kong AL, Tereffe W, Hunt KK, Yi M, Kang T, Weatherspoon K, Mittendorf EA, Bedrosian I, Hwang RF, Babiera GV, Buchholz TA, Meric-Bernstam F (2012) Impact of internal mammary lymph node drainage identified by preoperative lymphoscintigraphy on outcomes in patients with stage I to III breast cancer. Cancer 118(24):6287–6296. doi: 10.1002/cncr.27564CrossRefPubMedPubMedCentralGoogle Scholar
  149. Kuske RR, Winter K, Arthur DW, Bolton J, Rabinovitch R, White J, Hanson W, Wilenzick RM (2006) Phase II trial of brachytherapy alone after lumpectomy for select breast cancer: toxicity analysis of RTOG 95-17. Int J Radiat Oncol Biol Phys 65:45–51. doi: 10.1016/j.ijrobp.2005.11.027CrossRefPubMedPubMedCentralGoogle Scholar
  150. Kyndi M, Sorensen FB, Knudsen H, Overgaard M, Nielsen HM, Overgaard J (2008) Estrogen receptor, progesterone receptor, HER-2, and response to postmastectomy radiotherapy in high-risk breast cancer: the Danish Breast Cancer Cooperative Group. J Clin Oncol Off J Am Soc Clin Oncol 26(9):1419–1426. doi: 10.1200/jco.2007.14.5565CrossRefGoogle Scholar
  151. Lakhani S, Ellis I, Schnitt S, Tan P, van de Vijver M (2012) WHO classification of tumours of the breastGoogle Scholar
  152. Lei RY, Leonard CE, Howell KT, Henkenberns PL, Johnson TK, Hobart TL, Fryman SP, Kercher JM, Widner JL, Kaske T, Carter DL (2013) Four-year clinical update from a prospective trial of accelerated partial breast intensity-modulated radiotherapy (APBIMRT). Breast Cancer Res Treat 140:119–133. doi: 10.1007/s10549-013-2623-xCrossRefPubMedPubMedCentralGoogle Scholar
  153. Leonard KL, Hepel JT, Hiatt JR, Dipetrillo TA, Price LL, Wazer DE (2013) The effect of dose-volume parameters and interfraction interval on cosmetic outcome and toxicity after 3-dimensional conformal accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 85:623–629. doi: 10.1016/j.ijrobp.2012.06.052CrossRefPubMedGoogle Scholar
  154. Levine MN, Guyatt GH, Gent M, De Pauw S, Goodyear MD, Hryniuk WM, Arnold A, Findlay B, Skillings JR, Bramwell VH (1988) Quality of life in stage II breast cancer: an instrument for clinical trials. J Clin Oncol Off J Am Soc Clin Oncol 6:1798–1810CrossRefGoogle Scholar
  155. Liljegren G, Holmberg L, Bergh J, Lindgren A, Tabar L, Nordgren H, Adami HO (1999a) 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial. J Clin Oncol Off J Am Soc Clin Oncol 17(8):2326–2333CrossRefGoogle Scholar
  156. Liljegren G, Holmberg L, Bergh J, Lindgren A, Tabár L, Nordgren H, Adami HO (1999b) 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial. J Clin Oncol Off J Am Soc Clin Oncol 17:2326–2333CrossRefGoogle Scholar
  157. Lim M, Bellon JR, Gelman R, Silver B, Recht A, Schnitt SJ, Harris JR (2006) A prospective study of conservative surgery without radiation therapy in select patients with Stage I breast cancer. Int J Radiat Oncol Biol Phys 65(4):1149–1154. doi: 10.1016/j.ijrobp.2006.02.006CrossRefPubMedGoogle Scholar
  158. Liss AL, Ben-David MA, Jagsi R, Hayman JA, Griffith KA, Moran JM, Marsh RB, Pierce LJ (2014) Decline of cosmetic outcomes following accelerated partial breast irradiation using intensity modulated radiation therapy: results of a single-institution prospective clinical trial. Int J Radiat Oncol Biol Phys 89:96–102. doi: 10.1016/j.ijrobp.2014.01.005CrossRefPubMedPubMedCentralGoogle Scholar
  159. Livi L, Buonamici FB, Simontacchi G, Scotti V, Fambrini M, Compagnucci A, Paiar F, Scoccianti S, Pallotta S, Detti B, Agresti B, Talamonti C, Mangoni M, Bianchi S, Cataliotti L, Marrazzo L, Bucciolini M, Biti G (2010) Accelerated partial breast irradiation with IMRT: new technical approach and interim analysis of acute toxicity in a phase III randomized clinical trial. Int J Radiat Oncol Biol Phys 77:509–515. doi: 10.1016/j.ijrobp.2009.04.070CrossRefPubMedGoogle Scholar
  160. Livi L, Meattini I, Marrazzo L, Pallotta S, Simontacchi G, Saieva C, Scotti V, Cardillo CDL, Bastiani P, Nori J, Orzalesi L, Bianchi S (2014) Accelerated partial breast irradiation using intensity modulated radiotherapy versus whole breast irradiation: 5-year survival results of a phase 3 randomized trial. San Antonio Breast Cancer SymposiumGoogle Scholar
  161. Lu SM, Scanderbeg DJ, Barna P, Yashar W, Yashar C (2012) Evaluation of two intracavitary high-dose-rate brachytherapy devices for irradiating additional and irregularly shaped volumes of breast tissue. Med Dosim Off J Am Assoc Med Dosim 37:9–14. doi: 10.1016/j.meddos.2010.12.005CrossRefGoogle Scholar
  162. MacAusland SG, Hepel JT, Chong FK, Galper SL, Gass JS, Ruthazer R, Wazer DE (2007) An attempt to independently verify the utility of the Van Nuys Prognostic Index for ductal carcinoma in situ. Cancer 110:2648–2653. doi: 10.1002/cncr.23089CrossRefPubMedGoogle Scholar
  163. Mamounas EP, Tang G, Fisher B, Paik S, Shak S, Costantino JP, Watson D, Geyer CE Jr, Wickerham DL, Wolmark N (2010) Association between the 21-gene recurrence score assay and risk of locoregional recurrence in node-negative, estrogen receptor-positive breast cancer: results from NSABP B-14 and NSABP B-20. J Clin Oncol Off J Am Soc Clin Oncol 28(10):1677–1683. doi: 10.1200/jco.2009.23.7610CrossRefGoogle Scholar
  164. Mamounas EP, Anderson SJ, Dignam JJ, Bear HD, Julian TB, Geyer CE Jr, Taghian A, Wickerham DL, Wolmark N (2012) Predictors of locoregional recurrence after neoadjuvant chemotherapy: results from combined analysis of National Surgical Adjuvant Breast and Bowel Project B-18 and B-27. J Clin Oncol Off J Am Soc Clin Oncol 30(32):3960–3966. doi: 10.1200/jco.2011.40.8369CrossRefGoogle Scholar
  165. Manoharan SR, Rodriguez RR, Bobba VS, Chandrashekar M (2010) Dosimetry evaluation of SAVI-based HDR brachytherapy for partial breast irradiation. J Med Phy Assoc Med Phys India 35:131–136. doi: 10.4103/0971-6203.62127CrossRefGoogle Scholar
  166. Marks LB, Yu X, Prosnitz RG, Zhou SM, Hardenbergh PH, Blazing M, Hollis D, Lind P, Tisch A, Wong TZ, Borges-Neto S (2005) The incidence and functional consequences of RT-associated cardiac perfusion defects. Int J Radiat Oncol Biol Phys 63(1):214–223. doi: 10.1016/j.ijrobp.2005.01.029CrossRefPubMedGoogle Scholar
  167. Marks LB, Zeng J, Prosnitz LR (2008) One to three versus four or more positive nodes and postmastectomy radiotherapy: time to end the debate. J Clin Oncol Off J Am Soc Clin Oncol 26(13):2075–2077. doi: 10.1200/jco.2007.15.5200CrossRefGoogle Scholar
  168. Massimino KP, Hessman CJ, Ellis MC, Naik AM, Vetto JT (2012) Impact of American College of Surgeons Oncology Group Z0011 and National Surgical Adjuvant Breast and Bowel Project B-32 trial results on surgeon practice in the Pacific Northwest. Am J Surg 203(5):618–622. doi: 10.1016/j.amjsurg.2011.12.015CrossRefPubMedGoogle Scholar
  169. McCormick B, Moughan J, Hudis C, Kuerer H, Rakovitch E, Smith B, Sneige N, Shah A, Germain I, White J (2012) Low-risk breast Ductal Carcinoma In Situ (DCIS): results from the Radiation Therapy Oncology Group 9804 phase 3 trial. Int J Radiat Oncol Biol Phys 84(3):S5CrossRefGoogle Scholar
  170. McGale P, Taylor C, Correa C, Cutter D, Duane F, Ewertz M, Gray R, Mannu G, Peto R, Whelan T, Wang Y, Wang Z, Darby S (2014) Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet 383(9935):2127–2135. doi: 10.1016/s0140-6736(14)60488-8CrossRefPubMedGoogle Scholar
  171. McGuire SE, Gonzalez-Angulo AM, Huang EH, Tucker SL, Kau SW, Yu TK, Strom EA, Oh JL, Woodward WA, Tereffe W, Hunt KK, Kuerer HM, Sahin AA, Hortobagyi GN, Buchholz TA (2007) Postmastectomy radiation improves the outcome of patients with locally advanced breast cancer who achieve a pathologic complete response to neoadjuvant chemotherapy. Int J Radiat Oncol Biol Phys 68(4):1004–1009. doi: 10.1016/j.ijrobp.2007.01.023CrossRefPubMedPubMedCentralGoogle Scholar
  172. Middleton LP, Palacios DM, Bryant BR, Krebs P, Otis CN, Merino MJ (2000) Pleomorphic lobular carcinoma: morphology, immunohistochemistry, and molecular analysis. Am J Surg Pathol 24:1650–1656CrossRefGoogle Scholar
  173. Mignano JE, Gage I, Piantadosi S, Ye X, Henderson G, Dooley WC (2007) Local recurrence after mastectomy in patients with T3pN0 breast carcinoma treated without postoperative radiation therapy. Am J Clin Oncol 30(5):466–472. doi: 10.1097/COC.0b013e31805c13baCrossRefPubMedGoogle Scholar
  174. Millar EK, Graham PH, O’Toole SA, McNeil CM, Browne L, Morey AL, Eggleton S, Beretov J, Theocharous C, Capp A, Nasser E, Kearsley JH, Delaney G, Papadatos G, Fox C, Sutherland RL (2009) Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel. J Clin Oncol Off J Am Soc Clin Oncol 27(28):4701–4708. doi: 10.1200/jco.2008.21.7075CrossRefGoogle Scholar
  175. Moran JM, Ben-David MA, Marsh RB, Balter JM, Griffith KA, Hayman JA, Pierce LJ (2009) Accelerated partial breast irradiation: what is dosimetric effect of advanced technology approaches? Int J Radiat Oncol Biol Phys 75:294–301. doi: 10.1016/j.ijrobp.2009.03.043CrossRefPubMedPubMedCentralGoogle Scholar
  176. Morimoto T, Okazaki K, Komaki K, Sasa M, Mori T, Tsuzuki H, Kamamura Y, Miki H, Monden Y (1993) Cancerous residue in breast-conserving surgery. J Surg Oncol 52:71–76CrossRefPubMedPubMedCentralGoogle Scholar
  177. Morrow M, White J, Moughan J, Owen J, Pajack T, Sylvester J, Wilson JF, Winchester D (2001) Factors predicting the use of breast-conserving therapy in stage I and II breast carcinoma. J Clin Oncol Off J Am Soc Clin Oncol 19:2254–2262CrossRefGoogle Scholar
  178. Mukesh MB, Barnett GC, Wilkinson JS, Moody AM, Wilson C, Dorling L, Chan Wah Hak C, Qian W, Twyman N, Burnet NG, Wishart GC, Coles CE (2013) Randomized controlled trial of intensity-modulated radiotherapy for early breast cancer: 5-year results confirm superior overall cosmesis. J Clin Oncol Off J Am Soc Clin Oncol 31(36):4488–4495. doi: 10.1200/jco.2013.49.7842CrossRefGoogle Scholar
  179. National Quality Measures for Breast CentersGoogle Scholar
  180. Nattinger AB, Gottlieb MS, Veum J, Yahnke D, Goodwin JS (1992) Geographic variation in the use of breast-conserving treatment for breast cancer. N Engl J Med 326:1102–1107. doi: 10.1056/NEJM199204233261702CrossRefPubMedPubMedCentralGoogle Scholar
  181. NCCN (2014) NCCN clinical practice guidelines in oncology: breast cancer. Version 3.2014Google Scholar
  182. Nemoto T, Patel JK, Rosner D, Dao TL, Schuh M, Penetrante R (1991) Factors affecting recurrence in lumpectomy without irradiation for breast cancer. Cancer 67(8):2079–2082CrossRefPubMedPubMedCentralGoogle Scholar
  183. Nguyen PL, Taghian AG, Katz MS, Niemierko A, Abi Raad RF, Boon WL, Bellon JR, Wong JS, Smith BL, Harris JR (2008) Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy. J Clin Oncol Off J Am Soc Clin Oncol 26(14):2373–2378. doi: 10.1200/jco.2007.14.4287CrossRefGoogle Scholar
  184. Olivotto IA, Whelan TJ, Parpia S, Kim D-H, Berrang T, Truong PT, Kong I, Cochrane B, Nichol A, Roy I, Germain I, Akra M, Reed M, Fyles A, Trotter T, Perera F, Beckham W, Levine MN, Julian JA (2013) Interim cosmetic and toxicity results from RAPID: a randomized trial of accelerated partial breast irradiation using three-dimensional conformal external beam radiation therapy. J Clin Oncol Off J Am Soc Clin Oncol 31:4038–4045. doi: 10.1200/JCO.2013.50.5511CrossRefGoogle Scholar
  185. Osa E-OO, DeWyngaert K, Roses D, Speyer J, Guth A, Axelrod D, Fenton Kerimian M, Goldberg JD, Formenti SC (2014) Prone breast intensity modulated radiation therapy: 5-year results. Int J Radiat Oncol Biol Phys 89:899–906. doi: 10.1016/j.ijrobp.2014.03.036CrossRefPubMedPubMedCentralGoogle Scholar
  186. Ott OJ, Hildebrandt G, Pötter R, Hammer J, Lotter M, Resch A, Sauer R, Strnad V (2007) Accelerated partial breast irradiation with multi-catheter brachytherapy: Local control, side effects and cosmetic outcome for 274 patients. Results of the German-Austrian multi-centre trial. Radiother Oncol J Eur Soc Ther Radiol Oncol 82:281–286. doi: 10.1016/j.radonc.2006.08.028CrossRefGoogle Scholar
  187. Overgaard M (1999) Overview of randomized trials in high risk breast cancer patients treated with adjuvant systemic therapy with or without postmastectomy irradiation. Semin Radiat Oncol 9(3):292–299. doi: 10.1053/srao00900292CrossRefPubMedPubMedCentralGoogle Scholar
  188. Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, Bach F, Kjaer M, Gadeberg CC, Mouridsen HT, Jensen MB, Zedeler K (1997) Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med 337(14):949–955. doi: 10.1056/nejm199710023371401CrossRefPubMedPubMedCentralGoogle Scholar
  189. Overgaard M, Jensen MB, Overgaard J, Hansen PS, Rose C, Andersson M, Kamby C, Kjaer M, Gadeberg CC, Rasmussen BB, Blichert-Toft M, Mouridsen HT (1999) Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 353(9165):1641–1648. doi: 10.1016/s0140-6736(98)09201-0CrossRefPubMedPubMedCentralGoogle Scholar
  190. Overgaard M, Nielsen HM, Overgaard J (2007) Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials. Radiother Oncol J Eur Soc Ther Radiol Oncol 82(3):247–253. doi: 10.1016/j.radonc.2007.02.001CrossRefGoogle Scholar
  191. Owen JR, Ashton A, Bliss JM, Homewood J, Harper C, Hanson J, Haviland J, Bentzen SM, Yarnold JR (2006) Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial. Lancet Oncol 7:467–471. doi: 10.1016/S1470-2045(06)70699-4CrossRefPubMedPubMedCentralGoogle Scholar
  192. Owen D, Tyldesley S, Alexander C, Speers C, Truong P, Nichol A, Wai ES (2013) Outcomes in patients treated with mastectomy for ductal carcinoma in situ. Int J Radiat Oncol Biol Phys 85:e129–e134. doi: 10.1016/j.ijrobp.2012.10.020CrossRefPubMedPubMedCentralGoogle Scholar
  193. Page DL, Kidd TE, Dupont WD, Simpson JF, Rogers LW (1991) Lobular neoplasia of the breast: higher risk for subsequent invasive cancer predicted by more extensive disease. Hum Pathol 22:1232–1239CrossRefPubMedPubMedCentralGoogle Scholar
  194. Paik S, Tang G, Shak S, Kim C, Baker J, Kim W, Cronin M, Baehner FL, Watson D, Bryant J, Costantino JP, Geyer CE Jr, Wickerham DL, Wolmark N (2006) Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J Clin Oncol Off J Am Soc Clin Oncol 24(23):3726–3734. doi: 10.1200/jco.2005.04.7985CrossRefGoogle Scholar
  195. Palmer MK, Ribeiro GG (1985) Thirty-four year follow up of patients with breast cancer in clinical trial of postoperative radiotherapy. Br Med J (Clin Res Ed) 291(6502):1088–1091CrossRefGoogle Scholar
  196. Paredes P, Vidal-Sicart S, Zanon G, Pahisa J, Fernandez PL, Velasco M, Santamaria G, Ortin J, Duch J, Pons F (2005) Clinical relevance of sentinel lymph nodes in the internal mammary chain in breast cancer patients. Eur J Nucl Med Mol Imaging 32(11):1283–1287. doi: 10.1007/s00259-005-1867-zCrossRefPubMedPubMedCentralGoogle Scholar
  197. Pashtan IM, Recht A, Ancukiewicz M, Brachtel E, Abi-Raad RF, D’Alessandro HA, Levy A, Wo JY, Hirsch AE, Kachnic LA, Goldberg S, Specht M, Gadd M, Smith BL, Powell SN, Taghian AG (2012) External beam accelerated partial-breast irradiation using 32 gy in 8 twice-daily fractions: 5-year results of a prospective study. Int J Radiat Oncol Biol Phys 84:e271–e277. doi: 10.1016/j.ijrobp.2012.04.019CrossRefPubMedPubMedCentralGoogle Scholar
  198. Paszat LF, Mackillop WJ, Groome PA, Boyd C, Schulze K, Holowaty E (1998) Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries. J Clin Oncol Off J Am Soc Clin Oncol 16(8):2625–2631CrossRefGoogle Scholar
  199. Pierce LJ (2005) The use of radiotherapy after mastectomy: a review of the literature. J Clin Oncol Off J Am Soc Clin Oncol 23(8):1706–1717. doi: 10.1200/jco.2005.08.109CrossRefGoogle Scholar
  200. Pignol JP, Olivotto I, Rakovitch E, Gardner S, Sixel K, Beckham W, Vu TT, Truong P, Ackerman I, Paszat L (2008) A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol Off J Am Soc Clin Oncol 26(13):2085–2092. doi: 10.1200/jco.2007.15.2488CrossRefGoogle Scholar
  201. Pinder SE, Duggan C, Ellis IO, Cuzick J, Forbes JF, Bishop H, Fentiman IS, George WD (2010) A new pathological system for grading DCIS with improved prediction of local recurrence: results from the UKCCCR/ANZ DCIS trial. Br J Cancer 103:94–100. doi: 10.1038/sj.bjc.6605718CrossRefPubMedPubMedCentralGoogle Scholar
  202. Poggi MM, Danforth DN, Sciuto LC, Smith SL, Steinberg SM, Liewehr DJ, Menard C, Lippman ME, Lichter AS, Altemus RM (2003) Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: the National Cancer Institute Randomized Trial. Cancer 98(4):697–702. doi: 10.1002/cncr.11580CrossRefPubMedPubMedCentralGoogle Scholar
  203. Polgár C, Fodor J, Major T, Németh G, Lövey K, Orosz Z, Sulyok Z, Takácsi-Nagy Z, Kásler M (2007) Breast-conserving treatment with partial or whole breast irradiation for low-risk invasive breast carcinoma – 5-year results of a randomized trial. Int J Radiat Oncol Biol Phys 69:694–702. doi: 10.1016/j.ijrobp.2007.04.022CrossRefPubMedPubMedCentralGoogle Scholar
  204. Polgár C, Fodor J, Major T, Sulyok Z, Kásler M (2013) Breast-conserving therapy with partial or whole breast irradiation: ten-year results of the Budapest randomized trial. Radiother Oncol J Eur Soc Ther Radiol Oncol 108:197–202. doi: 10.1016/j.radonc.2013.05.008CrossRefGoogle Scholar
  205. Poortmans P, Kirkove C, Budach V, Maingon P, Valli M, Collette S, Fourquet A, Bartelink H, Van den Bogaert W (2013) Irradiation of the internal mammary and medial supraclavicular lymph nodes in stage I to III breast cancer: 10 years results of the EORTC radiation oncology and breast cancer groups phase III trial 22922/10925. Eur J Cancer (Oxford, England: 1990) 49(Suppl 3):S1–19Google Scholar
  206. Potter R, Gnant M, Kwasny W, Tausch C, Handl-Zeller L, Pakisch B, Taucher S, Hammer J, Luschin-Ebengreuth G, Schmid M, Sedlmayer F, Stierer M, Reiner G, Kapp K, Hofbauer F, Rottenfusser A, Postlberger S, Haider K, Draxler W, Jakesz R (2007) Lumpectomy plus tamoxifen or anastrozole with or without whole breast irradiation in women with favorable early breast cancer. Int J Radiat Oncol Biol Phys 68(2):334–340. doi: 10.1016/j.ijrobp.2006.12.045CrossRefPubMedPubMedCentralGoogle Scholar
  207. Rabinovitch R, Winter K, Kuske R, Bolton J, Arthur D, Scroggins T, Vicini F, McCormick B, White J (2014) RTOG 95–17, a Phase II trial to evaluate brachytherapy as the sole method of radiation therapy for Stage I and II breast carcinoma – year-5 toxicity and cosmesis. Brachytherapy 13:17–22. doi: 10.1016/j.brachy.2013.08.002CrossRefPubMedPubMedCentralGoogle Scholar
  208. Ragaz J, Olivotto IA, Spinelli JJ, Phillips N, Jackson SM, Wilson KS, Knowling MA, Coppin CM, Weir L, Gelmon K, Le N, Durand R, Coldman AJ, Manji M (2005) Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial. J Natl Cancer Inst 97(2):116–126. doi: 10.1093/jnci/djh297CrossRefPubMedPubMedCentralGoogle Scholar
  209. Recht A, Gray R, Davidson NE, Fowble BL, Solin LJ, Cummings FJ, Falkson G, Falkson HC, Taylor SG, Tormey DC (1999) Locoregional failure 10 years after mastectomy and adjuvant chemotherapy with or without tamoxifen without irradiation: experience of the Eastern Cooperative Oncology Group. J Clin Oncol Off J Am Soc Clin Oncol 17(6):1689–1700CrossRefGoogle Scholar
  210. Recht A, Edge SB, Solin LJ, Robinson DS, Estabrook A, Fine RE, Fleming GF, Formenti S, Hudis C, Kirshner JJ, Krause DA, Kuske RR, Langer AS, Sledge GW Jr, Whelan TJ, Pfister DG (2001) Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol Off J Am Soc Clin Oncol 19(5):1539–1569CrossRefGoogle Scholar
  211. Remouchamps VM, Letts N, Vicini FA, Sharpe MB, Kestin LL, Chen PY, Martinez AA, Wong JW (2003) Initial clinical experience with moderate deep-inspiration breath hold using an active breathing control device in the treatment of patients with left-sided breast cancer using external beam radiation therapy. Int J Radiat Oncol Biol Phys 56(3):704–715CrossRefPubMedPubMedCentralGoogle Scholar
  212. Ribeiro GG, Dunn G, Swindell R, Harris M, Banerjee SS (1990) Conservation of the breast using two different radiotherapy techniques: interim report of a clinical trial. Clin Oncol R Coll Radiol (Great Britain) 2:27–34CrossRefGoogle Scholar
  213. Ribeiro GG, Magee B, Swindell R, Harris M, Banerjee SS (1993) The Christie Hospital breast conservation trial: an update at 8 years from inception. Clin Oncol R Coll Radiol (Great Britain) 5:278–283CrossRefGoogle Scholar
  214. Roberts KB, Soulos PR, Herrin J, Yu JB, Long JB, Dostaler E, Gross CP (2013) The adoption of new adjuvant radiation therapy modalities among Medicare beneficiaries with breast cancer: clinical correlates and cost implications. Int J Radiat Oncol Biol Phys 85(5):1186–1192. doi: 10.1016/j.ijrobp.2012.10.009CrossRefPubMedPubMedCentralGoogle Scholar
  215. Rodríguez N, Sanz X, Dengra J, Foro P, Membrive I, Reig A, Quera J, Fernández-Velilla E, Pera Ó, Lio J, Lozano J, Algara M (2013) Five-year outcomes, cosmesis, and toxicity with 3-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 87:1051–1057. doi: 10.1016/j.ijrobp.2013.08.046CrossRefPubMedPubMedCentralGoogle Scholar
  216. Rosen PP, Kosloff C, Lieberman PH, Adair F, Braun DW (1978) Lobular carcinoma in situ of the breast. Detailed analysis of 99 patients with average follow-up of 24 years. Am J Surg Pathol 2:225–251CrossRefPubMedPubMedCentralGoogle Scholar
  217. Rosen PP, Braun DW, Kinne DE (1980) The clinical significance of pre-invasive breast carcinoma. Cancer 46:919–925CrossRefPubMedPubMedCentralGoogle Scholar
  218. Rudloff U, Jacks LM, Goldberg JI, Wynveen CA, Brogi E, Patil S, Van Zee KJ (2010) Nomogram for predicting the risk of local recurrence after breast-conserving surgery for ductal carcinoma in situ. J Clin Oncol Off J Am Soc Clin Oncol 28:3762–3769. doi: 10.1200/JCO.2009.26.8847CrossRefGoogle Scholar
  219. Russell NS, Kunkler IH, van Tienhoven G, Canney PA, Thomas J, Bartlett J, van de Vijver MJ, Belkacemi Y, Yarnold JR, Barrett-Lee PJ (2009) Postmastectomy radiotherapy: will the selective use of postmastectomy radiotherapy study end the debate? J Clin Oncol Off J Am Soc Clin Oncol 27(6):996–997 . doi: 10.1200/jco.2008.18.7062author reply 997-998CrossRefGoogle Scholar
  220. Rusthoven KE, Carter DL, Howell K, Kercher JM, Henkenberns P, Hunter KL, Leonard CE (2008) Accelerated partial-breast intensity-modulated radiotherapy results in improved dose distribution when compared with three-dimensional treatment-planning techniques. Int J Radiat Oncol Biol Phys 70:296–302. doi: 10.1016/j.ijrobp.2007.08.047CrossRefPubMedPubMedCentralGoogle Scholar
  221. Rutqvist LE, Liedberg A, Hammar N, Dalberg K (1998) Myocardial infarction among women with early-stage breast cancer treated with conservative surgery and breast irradiation. Int J Radiat Oncol Biol Phys 40(2):359–363CrossRefPubMedPubMedCentralGoogle Scholar
  222. Sanders ME, Schuyler PA, Dupont WD, Page DL (2005) The natural history of low-grade ductal carcinoma in situ of the breast in women treated by biopsy only revealed over 30 years of long-term follow-up. Cancer 103:2481–2484. doi: 10.1002/cncr.21069CrossRefPubMedPubMedCentralGoogle Scholar
  223. Schlembach PJ, Buchholz TA, Ross MI, Kirsner SM, Salas GJ, Strom EA, McNeese MD, Perkins GH, Hunt KK (2001) Relationship of sentinel and axillary level I-II lymph nodes to tangential fields used in breast irradiation. Int J Radiat Oncol Biol Phys 51(3):671–678CrossRefPubMedPubMedCentralGoogle Scholar
  224. Schroen AT, Brenin DR, Kelly MD, Knaus WA, Slingluff CL (2005) Impact of patient distance to radiation therapy on mastectomy use in early-stage breast cancer patients. J Clin Oncol Off J Am Soc Clin Oncol 23:7074–7080. doi: 10.1200/JCO.2005.06.032CrossRefGoogle Scholar
  225. Shah C, Wilkinson JB, Lyden M, Beitsch P, Vicini FA (2012) Predictors of local recurrence following accelerated partial breast irradiation: a pooled analysis. Int J Radiat Oncol Biol Phys 82:e825–e830. doi: 10.1016/j.ijrobp.2011.11.042CrossRefPubMedPubMedCentralGoogle Scholar
  226. Shah C, Wilkinson JB, Lanni T, Jawad M, Wobb J, Fowler A, Wallace M, Chen P, Grills IS, Vicini F (2013a) Five-year outcomes and toxicities using 3-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation. Clin Breast Cancer 13:206–211. doi: 10.1016/j.clbc.2012.09.020CrossRefPubMedPubMedCentralGoogle Scholar
  227. Shah C, Vicini F, Wazer DE, Arthur D, Patel RR (2013b) The American Brachytherapy Society consensus statement for accelerated partial breast irradiation. Brachytherapy 12:267–277. doi: 10.1016/j.brachy.2013.02.001CrossRefPubMedPubMedCentralGoogle Scholar
  228. Shahar KH, Hunt KK, Thames HD, Ross MI, Perkins GH, Kuerer HM, Strom EA, McNeese MD, Meric F, Schechter NR, Sahin AA, Middleton LP, Buchholz TA (2004) Factors predictive of having four or more positive axillary lymph nodes in patients with positive sentinel lymph nodes: implications for selection of radiation fields. Int J Radiat Oncol Biol Phys 59(4):1074–1079. doi: 10.1016/j.ijrobp.2004.01.003CrossRefPubMedPubMedCentralGoogle Scholar
  229. Shumway D, Kapadia N, Do T, Griffith K, Feng M, Jagsi R, Helfrich Y, Liss A, Gillespie E, Miller A, Pierce L (2014) Development of a Photonumeric Scale for Acute Radiation Dermatitis in Breast Cancer Patients. Int J Radiat Oncol Biol Phys 90:238. doi: 10.1016/j.ijrobp.2014.06.008CrossRefGoogle Scholar
  230. Siegel R, Ma J, Zou Z, Jemal A (2014) Cancer statistics. CA Cancer J Clin 64:9–29. doi: 10.3322/caac.21208CrossRefPubMedPubMedCentralGoogle Scholar
  231. Silverstein MJ (2003) The University of Southern California/Van Nuys prognostic index for ductal carcinoma in situ of the breast. Am J Surg 186:337–343CrossRefPubMedPubMedCentralGoogle Scholar
  232. Silverstein MJ, Lagios MD, Craig PH, Waisman JR, Lewinsky BS, Colburn WJ, Poller DN (1996) A prognostic index for ductal carcinoma in situ of the breast. Cancer 77:2267–2274. doi: 10.1002/(SICI)1097-0142(19960601)77:11<2267::AID-CNCR13>3.0.CO;2-VCrossRefPubMedPubMedCentralGoogle Scholar
  233. Smith BD, Gross CP, Smith GL, Galusha DH, Bekelman JE, Haffty BG (2006) Effectiveness of radiation therapy for older women with early breast cancer. J Natl Cancer Inst 98(10):681–690. doi: 10.1093/jnci/djj186CrossRefPubMedPubMedCentralGoogle Scholar
  234. Smith BD, Arthur DW, Buchholz TA, Haffty BG, Hahn CA, Hardenbergh PH, Julian TB, Marks LB, Todor DA, Vicini FA, Whelan TJ, White J, Wo JY, Harris JR (2009) Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO). Int J Radiat Oncol Biol Phys 74:987–1001. doi: 10.1016/j.ijrobp.2009.02.031CrossRefPubMedPubMedCentralGoogle Scholar
  235. Smith BD, Bentzen SM, Correa CR, Hahn CA, Hardenbergh PH, Ibbott GS, McCormick B, McQueen JR, Pierce LJ, Powell SN, Recht A, Taghian AG, Vicini FA, White JR, Haffty BG (2011a) Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Int J Radiat Oncol Biol Phys 81:59–68. doi: 10.1016/j.ijrobp.2010.04.042CrossRefPubMedPubMedCentralGoogle Scholar
  236. Smith BD, Pan IW, Shih YC, Smith GL, Harris JR, Punglia R, Pierce LJ, Jagsi R, Hayman JA, Giordano SH, Buchholz TA (2011b) Adoption of intensity-modulated radiation therapy for breast cancer in the United States. J Natl Cancer Inst 103(10):798–809. doi: 10.1093/jnci/djr100CrossRefPubMedPubMedCentralGoogle Scholar
  237. Smith BD, Bentzen SM, Correa CR, Hahn CA, Hardenbergh PH, Ibbott GS, McCormick B, McQueen JR, Pierce LJ, Powell SN, Recht A, Taghian AG, Vicini FA, White JR, Haffty BG (2011c) Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Int J Radiat Oncol Biol Phys 81(1):59–68. doi: 10.1016/j.ijrobp.2010.04.042CrossRefPubMedPubMedCentralGoogle Scholar
  238. Smith GL, Xu Y, Buchholz TA, Giordano SH, Jiang J, Shih Y-CT, Smith BD (2012) Association between treatment with brachytherapy vs whole-breast irradiation and subsequent mastectomy, complications, and survival among older women with invasive breast cancer. JAMA 307:1827–1837. doi: 10.1001/jama.2012.3481CrossRefPubMedPubMedCentralGoogle Scholar
  239. Sneige N, Wang J, Baker B, Krishnamurthy S, Middleton L (2002) Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 cases. Mod Pathol 15:1044–1050CrossRefPubMedPubMedCentralGoogle Scholar
  240. Solin LJ, Yeh IT, Kurtz J, Fourquet A, Recht A, Kuske R, McCormick B, Cross MA, Schultz DJ, Amalric R (1993) Ductal carcinoma in situ (intraductal carcinoma) of the breast treated with breast-conserving surgery and definitive irradiation. Correlation of pathologic parameters with outcome of treatment. Cancer 71:2532–2542CrossRefPubMedPubMedCentralGoogle Scholar
  241. Solin LJ, Gray R, Baehner FL, Butler SM, Hughes LL, Yoshizawa C, Cherbavaz DB, Shak S, Page DL, Sledge GW, Davidson NE, Ingle JN, Perez EA, Wood WC, Sparano JA, Badve S (2013) A multigene expression assay to predict local recurrence risk for ductal carcinoma in situ of the breast. J Natl Cancer Inst 105:701–710. doi: 10.1093/jnci/djt067CrossRefPubMedPubMedCentralGoogle Scholar
  242. Speers C, Feng F, Liu M, Brenner J, Balbin O, Pierce L (2013) Identification and validation of a radiation sensitivity signature in human breast cancer. Int J Radiat Oncol Biol Phys 87(2):244CrossRefGoogle Scholar
  243. Surgeons ACo Commission on Cancer Quality of Care MeasuresGoogle Scholar
  244. Sweldens C, Peeters S, van Limbergen E, Janssen H, Laenen A, Patil S, Van Zee KJ, Weltens C (2014) Local relapse after breast-conserving therapy for ductal carcinoma in situ: a European single-center experience and external validation of the Memorial Sloan-Kettering Cancer Center DCIS nomogram. Cancer J (Sudbury, Mass) 20:1–7. doi: 10.1097/PPO.0000000000000025CrossRefGoogle Scholar
  245. Taghian A, Jeong JH, Mamounas E, Anderson S, Bryant J, Deutsch M, Wolmark N (2004a) Patterns of locoregional failure in patients with operable breast cancer treated by mastectomy and adjuvant chemotherapy with or without tamoxifen and without radiotherapy: results from five National Surgical Adjuvant Breast and Bowel Project randomized clinical trials. J Clin Oncol Off J Am Soc Clin Oncol 22(21):4247–4254. doi: 10.1200/jco.2004.01.042CrossRefGoogle Scholar
  246. Taghian A, Jagsi R, Makris A, Goldberg S, Ceilley E, Grignon L, Powell S (2004b) Results of a survey regarding irradiation of internal mammary chain in patients with breast cancer: practice is culture driven rather than evidence based. Int J Radiat Oncol Biol Phys 60(3):706–714. doi: 10.1016/j.ijrobp.2004.04.027CrossRefPubMedPubMedCentralGoogle Scholar
  247. Taghian AG, Kozak KR, Doppke KP, Katz A, Smith BL, Gadd M, Specht M, Hughes K, Braaten K, Kachnic LA, Recht A, Powell SN (2006a) Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation. Int J Radiat Oncol Biol Phys 64:1092–1099. doi: 10.1016/j.ijrobp.2005.09.042CrossRefPubMedPubMedCentralGoogle Scholar
  248. Taghian AG, Jeong JH, Mamounas EP, Parda DS, Deutsch M, Costantino JP, Wolmark N (2006b) Low locoregional recurrence rate among node-negative breast cancer patients with tumors 5 cm or larger treated by mastectomy, with or without adjuvant systemic therapy and without radiotherapy: results from five national surgical adjuvant breast and bowel project randomized clinical trials. J Clin Oncol Off J Am Soc Clin Oncol 24(24):3927–3932. doi: 10.1200/jco.2006.06.9054CrossRefGoogle Scholar
  249. Taylor ME, Perez CA, Halverson KJ, Kuske RR, Philpott GW, Garcia DM, Mortimer JE, Myerson RJ, Radford D, Rush C (1995) Factors influencing cosmetic results after conservation therapy for breast cancer. Int J Radiat Oncol Biol Phys 31:753–764. doi: 10.1016/0360-3016(94)00480-3CrossRefPubMedPubMedCentralGoogle Scholar
  250. Taylor ME, Haffty BG, Shank BM, Halberg FE, Martinez AA, McCormick B, McNeese MD, Mendenhall NP, Mitchell SE, Rabinovitch RA, Solin LJ, Singletary SE, Leibel S, Recht A (2000) Postmastectomy radiotherapy. American College of Radiology. ACR appropriateness criteria. Radiology 215(Suppl):1153–1170PubMedPubMedCentralGoogle Scholar
  251. Thorsen LB, Thomsen MS, Overgaard M, Overgaard J, Offersen BV (2013) Quality assurance of conventional non-CT-based internal mammary lymph node irradiation in a prospective Danish Breast Cancer Cooperative Group trial: the DBCG-IMN study. Acta Oncol (Stockholm, Sweden) 52(7):1526–1534. doi: 10.3109/0284186x.2013.813643CrossRefGoogle Scholar
  252. Thorsen LB, Thomsen MS, Berg M, Jensen I, Josipovic M, Overgaard M, Overgaard J, Skogholt P, Offersen BV (2014) CT-planned internal mammary node radiotherapy in the DBCG-IMN study: benefit versus potentially harmful effects. Acta Oncol (Stockholm, Sweden) 53(8):1027–1034. doi: 10.3109/0284186x.2014.925579CrossRefGoogle Scholar
  253. Tinterri C, Gatzemeier W, Costa A, Gentilini MA, Zanini V, Regolo L, Pedrazzoli C, Rondini E, Amanti C, Gentile G, Taffurelli M, Fenaroli P, Tondini C, Sacchetto G, Sismondi P, Murgo R, Orlandi M, Cianchetti E, Andreoli C (2014) Breast-conservative surgery with and without radiotherapy in patients aged 55-75 years with early-stage breast cancer: a prospective, randomized, multicenter trial analysis after 108 months of median follow-up. Ann Surg Oncol 21(2):408–415. doi: 10.1245/s10434-013-3233-xCrossRefPubMedGoogle Scholar
  254. Truong PT, Olivotto IA, Speers CH, Wai ES, Berthelet E, Kader HA (2004) A positive margin is not always an indication for radiotherapy after mastectomy in early breast cancer. Int J Radiat Oncol Biol Phys 58(3):797–804. doi: 10.1016/s0360-3016(03)01626-2CrossRefPubMedGoogle Scholar
  255. Truong PT, Olivotto IA, Kader HA, Panades M, Speers CH, Berthelet E (2005) Selecting breast cancer patients with T1-T2 tumors and one to three positive axillary nodes at high postmastectomy locoregional recurrence risk for adjuvant radiotherapy. Int J Radiat Oncol Biol Phys 61(5):1337–1347. doi: 10.1016/j.ijrobp.2004.08.009CrossRefPubMedGoogle Scholar
  256. Vaidya JS, Vyas JJ, Chinoy RF, Merchant N, Sharma OP, Mittra I (1996) Multicentricity of breast cancer: whole-organ analysis and clinical implications. Br J Cancer 74:820–824CrossRefPubMedPubMedCentralGoogle Scholar
  257. Vaidya JS, Baum M, Tobias JS, D’Souza DP, Naidu SV, Morgan S, Metaxas M, Harte KJ, Sliski AP, Thomson E (2001) Targeted intra-operative radiotherapy (Targit): an innovative method of treatment for early breast cancer. Ann Oncol Off J Eur Soc Med Oncol 12:1075–1080CrossRefGoogle Scholar
  258. Vaidya JS, Baum M, Tobias JS, Morgan S, D’Souza D (2002) The novel technique of delivering targeted intraoperative radiotherapy (Targit) for early breast cancer. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol 28:447–454Google Scholar
  259. Vaidya JS, Joseph DJ, Tobias JS, Bulsara M, Wenz F, Saunders C, Alvarado M, Flyger HL, Massarut S, Eiermann W, Keshtgar M, Dewar J, Kraus-Tiefenbacher U, Sütterlin M, Esserman L, Holtveg HMR, Roncadin M, Pigorsch S, Metaxas M, Falzon M, Matthews A, Corica T, Williams NR, Baum M (2010) Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet 376:91–102. doi: 10.1016/S0140-6736(10)60837-9CrossRefPubMedGoogle Scholar
  260. Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M, Flyger HL, Massarut S, Alvarado M, Saunders C, Eiermann W, Metaxas M, Sperk E, Sütterlin M, Brown D, Esserman L, Roncadin M, Thompson A, Dewar JA, Holtveg HMR, Pigorsch S, Falzon M, Harris E, Matthews A, Brew-Graves C, Potyka I, Corica T, Williams NR, Baum M (2014) Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial. Lancet 383:603–613. doi: 10.1016/S0140-6736(13)61950-9CrossRefPubMedGoogle Scholar
  261. Van de Steene J, Soete G, Storme G (2000) Adjuvant radiotherapy for breast cancer significantly improves overall survival: the missing link. Radiother Oncol J Eur Soc Ther Radiol Oncol 55(3):263–272CrossRefGoogle Scholar
  262. van Dongen JA, Voogd AC, Fentiman IS, Legrand C, Sylvester RJ, Tong D, van der Schueren E, Helle PA, van Zijl K, Bartelink H (2000) Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 92(14):1143–1150CrossRefGoogle Scholar
  263. Vanderwalde NA, Jones EL, Kimple RJ, Moore DT, Klauber-Demore N, Sartor CI, Ollila DW (2013) Phase 2 study of pre-excision single-dose intraoperative radiation therapy for early-stage breast cancers: six-year update with application of the ASTRO accelerated partial breast irradiation consensus statement criteria. Cancer 119:1736–1743. doi: 10.1002/cncr.27915CrossRefPubMedPubMedCentralGoogle Scholar
  264. Vargo JA, Verma V, Kim H, Kalash R, Heron DE, Johnson R, Beriwal S (2014) Extended (5-year) outcomes of accelerated partial breast irradiation using MammoSite balloon brachytherapy: patterns of failure, patient selection, and dosimetric correlates for late toxicity. Int J Radiat Oncol Biol Phys 88:285–291. doi: 10.1016/j.ijrobp.2013.05.039CrossRefPubMedPubMedCentralGoogle Scholar
  265. Veronesi U, Marubini E, Mariani L, Galimberti V, Luini A, Veronesi P, Salvadori B, Zucali R (2001a) Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial. Ann Oncol Off J Eur Soc Med Oncol 12(7):997–1003CrossRefGoogle Scholar
  266. Veronesi U, Marubini E, Mariani L, Galimberti V, Luini A, Veronesi P, Salvadori B, Zucali R (2001b) Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial. Ann Oncol Off J Eur Soc Med Oncol 12:997–1003CrossRefGoogle Scholar
  267. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E (2002) Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 347(16):1227–1232. doi: 10.1056/NEJMoa020989CrossRefPubMedPubMedCentralGoogle Scholar
  268. Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C, Luini A, Veronesi P, Galimberti V, Zurrida S, Leonardi MC, Lazzari R, Cattani F, Gentilini O, Intra M, Caldarella P, Ballardini B (2013) Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol 14:1269–1277. doi: 10.1016/S1470-2045(13)70497-2CrossRefPubMedPubMedCentralGoogle Scholar
  269. Vicini FA, Kestin L, Chen P, Benitez P, Goldstein NS, Martinez A (2003a) Limited-field radiation therapy in the management of early-stage breast cancer. J Natl Cancer Inst 95:1205–1210CrossRefPubMedPubMedCentralGoogle Scholar
  270. Vicini FA, Remouchamps V, Wallace M, Sharpe M, Fayad J, Tyburski L, Letts N, Kestin L, Edmundson G, Pettinga J, Goldstein NS, Wong J (2003b) Ongoing clinical experience utilizing 3D conformal external beam radiotherapy to deliver partial-breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys 57:1247–1253CrossRefPubMedPubMedCentralGoogle Scholar
  271. Vicini FA, Kestin LL, Goldstein NS (2004) Defining the clinical target volume for patients with early-stage breast cancer treated with lumpectomy and accelerated partial breast irradiation: a pathologic analysis. Int J Radiat Oncol Biol Phys 60:722–730. doi: 10.1016/j.ijrobp.2004.04.012CrossRefPubMedPubMedCentralGoogle Scholar
  272. Vicini F, Beitsch P, Quiet C, Keleher A, Garcia D, Snider H, Gittleman M, Zannis V, Kuerer H, Whitacre E (2006) Two year analysis of treatment efficacy and cosmesis by the American Society of Breast Surgeons (ASBS) MammoSite Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation (APBI). ASCO Meet Abstr 24:529Google Scholar
  273. Vicini FA, Chen P, Wallace M, Mitchell C, Hasan Y, Grills I, Kestin L, Schell S, Goldstein NS, Kunzman J, Gilbert S, Martinez A (2007) Interim cosmetic results and toxicity using 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys 69:1124–1130. doi: 10.1016/j.ijrobp.2007.04.033CrossRefPubMedPubMedCentralGoogle Scholar
  274. Vicini F, Winter K, Wong J, Pass H, Rabinovitch R, Chafe S, Arthur D, Petersen I, White J, McCormick B (2010) Initial efficacy results of RTOG 0319: three-dimensional conformal radiation therapy (3D-CRT) confined to the region of the lumpectomy cavity for stage I/ II breast carcinoma. Int J Radiat Oncol Biol Phys 77:1120–1127. doi: 10.1016/j.ijrobp.2009.06.067CrossRefPubMedGoogle Scholar
  275. Vinh-Hung V, Verschraegen C (2004) Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality. J Natl Cancer Inst 96(2):115–121CrossRefGoogle Scholar
  276. Voduc KD, Cheang MC, Tyldesley S, Gelmon K, Nielsen TO, Kennecke H (2010) Breast cancer subtypes and the risk of local and regional relapse. J Clin Oncol Off J Am Soc Clin Oncol 28(10):1684–1691. doi: 10.1200/jco.2009.24.9284CrossRefGoogle Scholar
  277. Vrieling C, Collette L, Fourquet A, Hoogenraad WJ, Horiot JC, Jager JJ, Pierart M, Poortmans PM, Struikmans H, Van der Hulst M, Van der Schueren E, Bartelink H (1999) The influence of the boost in breast-conserving therapy on cosmetic outcome in the EORTC “boost versus no boost” trial. EORTC Radiotherapy and Breast Cancer Cooperative Groups. European Organization for Research and Treatment of Cancer. Int J Radiat Oncol Biol Phys 45:677–685CrossRefGoogle Scholar
  278. Wallgren A, Bonetti M, Gelber RD, Goldhirsch A, Castiglione-Gertsch M, Holmberg SB, Lindtner J, Thurlimann B, Fey M, Werner ID, Forbes JF, Price K, Coates AS, Collins J (2003) Risk factors for locoregional recurrence among breast cancer patients: results from International Breast Cancer Study Group Trials I through VII. J Clin Oncol Off J Am Soc Clin Oncol 21(7):1205–1213CrossRefGoogle Scholar
  279. Wang J, Shi M, Ling R, Xia Y, Luo S, Fu X, Xiao F, Li J, Long X, Wang J, Hou Z, Chen Y, Zhou B, Xu M (2011) Adjuvant chemotherapy and radiotherapy in triple-negative breast carcinoma: a prospective randomized controlled multi-center trial. Radiother Oncol J Eur Soc Ther Radiol Oncol 100(2):200–204. doi: 10.1016/j.radonc.2011.07.007CrossRefGoogle Scholar
  280. Wang EH, Mougalian SS, Soulos PR, Rutter CE, Evans SB, Haffty BG, Gross CP, Yu JB (2014) Adoption of hypofractionated whole-breast irradiation for early-stage breast cancer: a national cancer data base analysis. Int J Radiat Oncol Biol Phys 90:993–1000. doi: 10.1016/j.ijrobp.2014.06.038CrossRefPubMedGoogle Scholar
  281. Wapnir IL, Dignam JJ, Fisher B, Mamounas EP, Anderson SJ, Julian TB, Land SR, Margolese RG, Swain SM, Costantino JP, Wolmark N (2011) Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS. J Natl Cancer Inst 103:478–488. doi: 10.1093/jnci/djr027CrossRefPubMedPubMedCentralGoogle Scholar
  282. Weed DW, Edmundson GK, Vicini FA, Chen PY, Martinez AA (2005) Accelerated partial breast irradiation: a dosimetric comparison of three different techniques. Brachytherapy 4:121–129. doi: 10.1016/j.brachy.2004.12.005CrossRefPubMedGoogle Scholar
  283. Welch HG, Frankel BA (2011) Likelihood that a woman with screen-detected breast cancer has had her “life saved” by that screening. Arch Intern Med 171(22):2043–2046. doi: 10.1001/archinternmed.2011.476CrossRefPubMedGoogle Scholar
  284. Wernicke AG, Gidea-Addeo D, Magnolfi C, Fenton-Kerimian M, Goldberg J, Formenti SC (2006) External beam partial breast irradiation following breast-conserving surgery: preliminary results of cosmetic outcome of NYU 00–23. Int J Radiat Oncol Biol Phys 66:S32. doi: 10.1016/j.ijrobp.2006.07.083CrossRefGoogle Scholar
  285. Wheeler JE, Enterline HT, Roseman JM, Tomasulo JP, McIlvaine CH, Fitts WT, Kirshenbaum J (1974) Lobular carcinoma in situ of the breast. Long-term followup. Cancer 34:554–563CrossRefGoogle Scholar
  286. Whelan TJ, Levine M, Julian J, Kirkbride P, Skingley P (2000a) The effects of radiation therapy on quality of life of women with breast carcinoma: results of a randomized trial. Ontario Clinical Oncology Group. Cancer 88:2260–2266CrossRefGoogle Scholar
  287. Whelan TJ, Julian J, Wright J, Jadad AR, Levine ML (2000b) Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis. J Clin Oncol Off J Am Soc Clin Oncol 18(6):1220–1229CrossRefGoogle Scholar
  288. Whelan TJ, Kim D-H, Sussman J (2008) Clinical experience using hypofractionated radiation schedules in breast cancer. Semin Radiat Oncol 18:257–264. doi: 10.1016/j.semradonc.2008.04.008CrossRefPubMedGoogle Scholar
  289. Whelan TJ, Pignol J-P, Levine MN, Julian JA, MacKenzie R, Parpia S, Shelley W, Grimard L, Bowen J, Lukka H, Perera F, Fyles A, Schneider K, Gulavita S, Freeman C (2010) Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med 362:513–520. doi: 10.1056/NEJMoa0906260CrossRefPubMedGoogle Scholar
  290. Whelan T, Olivotto I, Ackerman I, Chapman J, Chua B, Nabid A, Vallis K, White J, Rousseau P, Fortin A (2011) NCIC-CTG MA. 20: an intergroup trial of regional nodal irradiation in early breast cancer. J Clin Oncol Off J Am Soc Clin Oncol 29(18 suppl)Google Scholar
  291. Willner J, Kiricuta IC, Kolbl O (1997) Locoregional recurrence of breast cancer following mastectomy: always a fatal event? Results of univariate and multivariate analysis. Int J Radiat Oncol Biol Phys 37(4):853–863CrossRefGoogle Scholar
  292. Winzer KJ, Sauerbrei W, Braun M, Liersch T, Dunst J, Guski H, Schumacher M (2010) Radiation therapy and tamoxifen after breast-conserving surgery: updated results of a 2 x 2 randomised clinical trial in patients with low risk of recurrence. Eur J Cancer (Oxford, England: 1990) 46(1):95–101. doi: 10.1016/j.ejca.2009.10.007CrossRefGoogle Scholar
  293. Wolmark N, Curran WJ, Vicini F, White J, Costantino JP, Arthur D, Kuske R, Rabinovitch R, Julian TB, Parda DS (2010) Response to “Unacceptable cosmesis in a protocol investigating intensity-modulated radiotherapy with active breathing control for accelerated partial-breast irradiation” (Int J Radiat Oncol Biol Phys 2010;76:71-78) and “Toxicity of three-dimensional conformal radiotherapy for accelerated partial breast irradiation” (Int J Radiat Oncol Biol Phys 2009;75:1290-1296). Int J Radiat Oncol Biol Phys 77:317 . doi: 10.1016/j.ijrobp.2009.12.033author reply 318CrossRefPubMedGoogle Scholar
  294. Wong JS, Kaelin CM, Troyan SL, Gadd MA, Gelman R, Lester SC, Schnitt SJ, Sgroi DC, Silver BJ, Harris JR, Smith BL (2006) Prospective study of wide excision alone for ductal carcinoma in situ of the breast. J Clin Oncol Off J Am Soc Clin Oncol 24:1031–1036. doi: 10.1200/JCO.2005.02.9975CrossRefGoogle Scholar
  295. Wong JS, Chen Y-H, Gadd MA, Gelman R, Lester SC, Schnitt SJ, Sgroi DC, Silver BJ, Smith BL, Troyan SL, Harris JR (2014) Eight-year update of a prospective study of wide excision alone for small low- or intermediate-grade ductal carcinoma in situ (DCIS). Breast Cancer Res Treat 143:343–350. doi: 10.1007/s10549-013-2813-6CrossRefPubMedGoogle Scholar
  296. Yao MS, Kurland BF, Smith AH, Schubert EK, Dunnwald LK, Byrd DR, Mankoff DA (2007) Internal mammary nodal chain drainage is a prognostic indicator in axillary node-positive breast cancer. Ann Surg Oncol 14(10):2985–2993. doi: 10.1245/s10434-007-9473-xCrossRefPubMedPubMedCentralGoogle Scholar
  297. Yarnold J, Ashton A, Bliss J, Homewood J, Harper C, Hanson J, Haviland J, Bentzen S, Owen R (2005) Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomised trial. Radiother Oncol J Eur Soc Ther Radiol Oncol 75:9–17. doi: 10.1016/j.radonc.2005.01.005CrossRefGoogle Scholar
  298. Yarnold J, Bentzen SM, Coles C, Haviland J (2011) Hypofractionated whole-breast radiotherapy for women with early breast cancer: myths and realities. Int J Radiat Oncol Biol Phys 79:1–9. doi: 10.1016/j.ijrobp.2010.08.035CrossRefPubMedPubMedCentralGoogle Scholar
  299. Yashar CM, Scanderbeg D, Kuske R, Wallace A, Zannis V, Blair S, Grade E, Swenson VH, Quiet C (2011) Initial clinical experience with the Strut-Adjusted Volume Implant (SAVI) breast brachytherapy device for accelerated partial-breast irradiation (APBI): first 100 patients with more than 1 year of follow-up. Int J Radiat Oncol Biol Phys 80:765–770. doi: 10.1016/j.ijrobp.2010.02.018CrossRefPubMedPubMedCentralGoogle Scholar
  300. Yi M, Meric-Bernstam F, Kuerer HM, Mittendorf EA, Bedrosian I, Lucci A, Hwang RF, Crow JR, Luo S, Hunt KK (2012) Evaluation of a breast cancer nomogram for predicting risk of ipsilateral breast tumor recurrences in patients with ductal carcinoma in situ after local excision. J Clin Oncol Off J Am Soc Clin Oncol 30:600–607. doi: 10.1200/JCO.2011.36.4976CrossRefGoogle Scholar
  301. Zucali R, Mariani L, Marubini E, Kenda R, Lozza L, Rilke F, Veronesi U (1998) Early breast cancer: evaluation of the prognostic role of the site of the primary tumor. J Clin Oncol Off J Am Soc Clin Oncol 16(4):1363–1366CrossRefGoogle Scholar

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Authors and Affiliations

  1. 1.Department of Radiation OncologyUniversity of MichiganAnn ArborUSA

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