Functions of Nuclear Polyphosphoinositides

  • Manuel Olazabal-Morán
  • Ana González-García
  • Ana C. CarreraEmail author
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 259)


Despite interest in phosphoinositide (PtdIns) kinases, such as PtdIns 3 kinases (PI3K), as targets for controlling plasma membrane PtdIns levels in disease, the PtdIns have another less well-known site of action in the cell nucleus.

Recent studies show that PtdIns use a variety of strategies to alter DNA responses. Here, we provide an overview of these newly identified forms of gene expression control, which should be considered when studying the therapeutic use of PtdIns-directed compounds. As PI3K is one of the most important clinical targets in recent years, we will focus on two polyphosphoinositides, the PI3K substrate PtdIns(4,5)di-phosphate (PI4,5P2) and its product PtdIns(3,4,5)tri-phosphate (PI3,4,5P3).


Chromatin remodeling Gene expression Lipid transport proteins Nuclear lipids Nuclear phosphoinositide Phosphoinositide transport proteins PI3,4,5P3 PI3K PI4,5P2 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Manuel Olazabal-Morán
    • 1
  • Ana González-García
    • 1
  • Ana C. Carrera
    • 1
    Email author
  1. 1.Department of Immunology and OncologyCentro Nacional de Biotecnología/CSICMadridSpain

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