pp 1-6 | Cite as

Intraoperative Treatment with 5-FU

  • Guillermo BlugermanEmail author
  • Diego Schavelzon
  • Roberto Rodrigo Cáceres
  • Victoria Schavelzon
  • Miguel Mussi
  • Guido Blugerman
Part of the Recent Clinical Techniques, Results, and Research in Wounds book series


The use of 5-FU and its effectiveness in the treatment of keloid and hypertrophic scar have been evidenced in several studies reaching very favorable results. Currently, the use has been directed as therapy on healing states with poor evolution already established, where the inhibitory effect of 5-FU on fibroblastic proliferation results in the improvement of the epithelial characteristics of healing. In this work, the premise of reducing the risk of pathological scarring, in people with high probabilities, or recurrence in patients with a history of poor healing, by using gauze soaked with 5-FU applied topically for 5 min over the incisions of the surgical approach made during surgery.

We present the experience of 5 years and the results obtained with intraoperative therapy with this methodology.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Guillermo Blugerman
    • 1
    Email author
  • Diego Schavelzon
    • 1
  • Roberto Rodrigo Cáceres
    • 1
  • Victoria Schavelzon
    • 1
  • Miguel Mussi
    • 1
  • Guido Blugerman
    • 1
  1. 1.Centro B & S Excelencia en Cirugía PlásticaBuenos AiresArgentina

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