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Curcumin in Advancing Treatment for Gynecological Cancers with Developed Drug- and Radiotherapy-Associated Resistance

  • Amir Abbas Momtazi-BorojeniEmail author
  • Jafar Mosafer
  • Banafsheh NikfarEmail author
  • Mahnaz Ekhlasi-Hundrieser
  • Shahla Chaichian
  • Abolfazl Mehdizadehkashi
  • Atefeh Vaezi
Chapter
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 176)

Abstract

The development of resistance toward current cancer therapy modalities is an ongoing challenge in gynecological cancers, especially ovarian and cervical malignancies that require further investigations in the context of drug- and irradiation-induced resistance. In this regard, curcumin has demonstrated beneficial and highly pleiotropic actions and increased the therapeutic efficiency of radiochemotherapy. The antiproliferative, anti-metastatic, anti-angiogenic, and anti-inflammatory effects of curcumin have been extensively reported in the literature, and it could also act as a chemopreventive agent which mitigates the out-of-target harmful impact of chemotherapeutics on surrounding normal tissues. The current review discussed the modulating influences of curcumin on some cell and molecular features, including the cell signaling and molecular pathways altered upon curcumin treatment, the expression of target genes involved in the progression of gynecological cancers, as well as the expression of genes accountable for the development of resistance toward common chemotherapeutics and radiotherapy. The cell molecular targets implicated in curcumin’s resensitizing effect, when used together with cisplatin, paclitaxel, and irradiation in gynecological cancers, are also addressed. Finally, rational approaches for improving the therapeutic benefits of curcumin, including curcumin derivatives with enhanced therapeutic efficacy, using nanoformulations to advance curcumin stability in physiological media and improve bioavailability have been elucidated.

Keywords

Cervical cancer Cisplatin Curcumin Nanoformulation Ovarian cancer Paclitaxel 

Abbreviations

CDK

Cyclin-dependent kinase

COX-2

Cyclooxygenase-2

Cur

Curcumin

DNMTs

DNA methyltransferases

GSTs

Glutathione S-transferases

HDAC

Histone deacetylases

IAPs

Inhibitor of apoptosis family of proteins

ICAM-1

Intercellular adhesion molecule 1

IKK

IκB kinase

iNOS

Inducible nitric oxide synthase

MT

Metallothionein

P-gp

P-glycoprotein

PI3K

Phosphatidylinositide 3-kinase

VEGF

Vascular endothelial growth factor

Notes

Acknowledgment

The authors would like to say special thanks to Dr. Amir Saberi-Demneh and Dr. Leila Ghalichi for their guidance and kindness.

Conflict of Interest

The authors declare that they have no conflicts of interest about this report.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Amir Abbas Momtazi-Borojeni
    • 1
    • 2
    Email author
  • Jafar Mosafer
    • 3
  • Banafsheh Nikfar
    • 4
    Email author
  • Mahnaz Ekhlasi-Hundrieser
    • 5
  • Shahla Chaichian
    • 6
  • Abolfazl Mehdizadehkashi
    • 7
  • Atefeh Vaezi
    • 8
  1. 1.Nanotechnology Research Center, Bu-Ali Research InstituteMashhad University of Medical SciencesMashhadIran
  2. 2.Department of Medical Biotechnology, Student Research Committee, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  3. 3.Research Center of Advanced Technologies in MedicineTorbat Heydarieh University of Medical SciencesTorbat HeydariehIran
  4. 4.Pars Advanced and Minimally Invasive Medical Manners Research CenterPars Hospital, Iran University of Medical SciencesTehranIran
  5. 5.Werlhof-InstitutHannoverGermany
  6. 6.Minimally Invasive Techniques Research Center in Women, Tehran Medical Sciences BranchIslamic Azad UniversityTehranIran
  7. 7.Endometriosis Research CenterIran University of Medical SciencesTehranIran
  8. 8.Department of Community Medicine, School of MedicineIsfahan University of Medical SciencesIsfahanIran

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