Risk Assessment of Processes and Products in Industrial Biotechnology

  • Chao Chen
  • Genserik ReniersEmail author
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 173)


Risk assessment has been used extensively as the main approach to prevent accidents in the chemical and process industry. Industrial biotechnology has many of the same hazards as chemical technology, but also encounters biological hazards related to biological agents. Employees in the biotechnology industry are susceptible to health risks because of different types of exposure to harmful agents. The external environment may also be affected by these agents in cases of accidental release. This chapter first presents several traditional risk assessment methods that may be used in industrial biotechnology after comparing differences between industrial biotechnology and chemical technology. Hazard identification in industrial biotechnology is then discussed, for biological as well as traditional hazards. Furthermore, risk assessment of occupational health and safety related to biological hazards is examined using exposure analysis and risk characterization. A two-stage risk assessment method is recommended to assess environmental and ecological risks in industrial biotechnology. Risk analysis of traditional accidents (fire, explosions, and toxic releases) in industrial biotechnology is also described.

Graphical Abstract


Environmental and ecological risks Hazard identification Industrial biotechnology Occupational health and safety Risk assessment 


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Copyright information

© Springer International Publishing AG, part of Springer Nature  2018

Authors and Affiliations

  1. 1.Faculty of TechnologyPolicy and Management, Safety and Security Science Group (S3G), TU DelftDelftThe Netherlands
  2. 2.National Institute for Public Health and the Environment (RIVM)BilthovenThe Netherlands

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