Viral Subversion of the Immune System

  • Laurent Gillet
  • Alain Vanderplasschen
Conference paper


The continuous interactions between host and viruses during their co-evolution have shaped not only the immune system but also the countermeasures used by viruses. Studies in the last decade have described the diverse arrays of pathways and molecular targets that are used by viruses to elude immune detection or destruction, or both. These include targeting of pathways for major histocompatibility complex class I and class II antigen presentation, natural killer cell recognition, apoptosis, cytokine signalling, and complement activation. This paper provides an overview of the viral immune-evasion mechanisms described to date. It highlights the contribution of this field to our understanding of the immune system, and the importance of understanding this aspect of the biology of viral infection to develop efficacious and safe vaccines.


Major Histocompatibility Complex Natural Killer Cell Major Histocompatibility Complex Class Human Cytomegalovirus Transporter Associate With Antigen Processing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© IAEA 2005

Authors and Affiliations

  • Laurent Gillet
    • 1
  • Alain Vanderplasschen
    • 1
  1. 1.Immunology-Vaccinology (B43b), Department of Infectious and Parasitic Diseases, Faculty of Veterinary MedicineUniversity of LiègeLiègeBelgium

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