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Retinoblastoma and Other Malignant Intraocular Tumors

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Handbook of Pediatric Retinal Disease

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Abstract

Much of the vision loss that we as pediatric ophthalmologists accept as normal with retinoblastoma can be prevented or reversed with aggressive screening, early diagnosis, and treat- ment. In fact, we are convinced that in the coming decades detecting early disease by lowering the average age at initial diagnosis will prove to be a much more efficient and cost- effective way to manage retinoblastoma than developing exotic new drugs or gene therapy for advanced disease. For retinopathy of prematurity (ROP), we readily accept that early detection and treatment can prevent vision loss. The problem there, however, seems a bit more manageable; the children at risk for ROP all belong to a small and easily identifiable group based on low birth weight.

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References

  1. Abramson DH, Wachtel A, Watson CW, Jereb B, Wollner N. Leukemic hypopyon. J Pediatr Ophthalmol Strabismus 1981;18:42.

    PubMed  CAS  Google Scholar 

  2. Adler R, Lappe M, Murphree AL. Pupil dilatation at the first well-baby examination for documenting choroidal light reflex. J Pediatr 1991;118:249–252.

    Article  PubMed  CAS  Google Scholar 

  3. Apt L. Uveal melanomas in children and adolescents. Int Ophthalmol Clin 1962;2:403–410.

    Article  Google Scholar 

  4. Barr CC, McLean IW, Zimmerman LE. Uveal melanoma in children and adolescents. Arch Ophthalmol 1981;99:2133.

    PubMed  CAS  Google Scholar 

  5. Bhatnagar R, Vine AK. Diffuse infiltrating retinoblastoma. Ophthalmology 1991;98:1657–1661.

    PubMed  CAS  Google Scholar 

  6. Broughton WL, Zimmerman LE. A clinicopathologic study of 56 cases of intraocular medulloepitheliomas. Am J Ophthalmol 1978;85:407–418.

    PubMed  CAS  Google Scholar 

  7. Bunin NJ, Pui CH, Hustu O, Rivera GK. Unusual extramedullary relapses in children with acute lymphoblastic leukemia. J Pediatr 1986;109:665–669.

    Article  PubMed  CAS  Google Scholar 

  8. Canning CR, McCartney AC, Hungerford J. Medulloepithelioma (diktyoma). Br J Ophthalmol 1988;72:764–767.

    PubMed  CAS  Google Scholar 

  9. Cavenee WK, Dryja TP, Phillips RA, et al. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature (Lond) 1983;305:779–784.

    Article  PubMed  CAS  Google Scholar 

  10. Collaborative Ocular Melanoma Study Group. The COMS randomized trial of Iodine 125 Brachytherapy for choroidal melanoma, III: Initial Mortality findings: COMS report number 18. Arch Ophthalmol 2001;119:969–982.

    Google Scholar 

  11. Collaborative Ocular Melanoma Study Group. The COMS randomized trial of pre-enucleation radiation of large choroidal melanoma, II: inital mortaliy findings: COMS report number 10 Am J Ophthalmol 1998;125:779–796.

    Article  Google Scholar 

  12. De Juan E, Green WR, Rive TA, Erozan YS. Optic disc neovascularization associated with ocular involvement in acute lymphocytic leukemia. Retina 1982;2:61–64.

    Article  PubMed  Google Scholar 

  13. Devesa SS. The incidence of retinoblastoma. Am J Ophthalmol 1975;80:263–265.

    PubMed  CAS  Google Scholar 

  14. Fledelius H, Land AM. Malignant melanoma of the choroid in an 11-month-old infant. Acta Ophthalmol 1975;53:160–166.

    CAS  Google Scholar 

  15. Floyd BB, Minckler DS, Valentin L. Intraocular medulloepithelioma in a 79-year-old man. Ophthalmology 1982;89:1088–1094.

    PubMed  CAS  Google Scholar 

  16. Friend SH, Bernards R, Rogeli S, et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature (Lond) 1986;323:643–646.

    Article  CAS  Google Scholar 

  17. Fung YKT, Murphree AL, Zhang FH, et al. The Rb gene suppresses the growth of normal cells. Oncogene 1993;8(10);2659–2672.

    PubMed  CAS  Google Scholar 

  18. Gallie BL. Retinoblastoma gene mutations in human cancer [Letter, Comment]. N Engl J Med 1994;330(11):786–787.

    Article  PubMed  CAS  Google Scholar 

  19. Green WR, Iliff WJ, Trotter RR. Malignant Teratoid Medulloepithelioma of the Optic Nerve. Arch Ophthalmol 1974;91:451–454.

    PubMed  CAS  Google Scholar 

  20. Greer CH. Congenital melanoma of the anterior uvea. Arch Ophthalmol 1966;76:77–78.

    PubMed  CAS  Google Scholar 

  21. Guyer DR, Schachat AP, Vitale S, et al. Leukemic retinopathy. Relationship between fundus lesions and hematologic parameters at diagnosis. Ophthalmology 1989;96:860–864.

    PubMed  CAS  Google Scholar 

  22. Haas BD, Jakobiec FA, Iwamoto T, Cox M, Bernacki EG, Pokorny KL. Diffuse choroidal melanocytoma in a child. A lesion extending the spectrum of melanocytic hamartomas. Ophthalmology 1986;93:1632–1638.

    PubMed  CAS  Google Scholar 

  23. Haik BG, Siedlecki A, Ellsworth RM, Sturgis-Buckhout L. Documented delays in the diagnosis of retinoblastoma. Ann Ophththalmol 1985;17:731–732.

    CAS  Google Scholar 

  24. Hamburg A. Medulloepithelioma arising from the posterior pole. Ophthalmologica 1980;181:152–159.

    PubMed  CAS  Google Scholar 

  25. Hill JC, Stannard C, Bowen RM. Ciliary body malignant melanoma in a black child. J Pediatr Ophthalmol Strabismus 1991;28:38–40.

    PubMed  CAS  Google Scholar 

  26. Holbrook CT, Felsas FJ, Crist WM, Castleberry RP. Acute leukemia and hypopyon. J Pediatr 1978;93:626–628.

    Article  PubMed  CAS  Google Scholar 

  27. Hungerford J. Personal communication, Los Angeles, January 1992.

    Google Scholar 

  28. Jensen OA, Movin M, Mueller J. Malignant melanoma of the choroids in an infant with the dysplastic naevus syndrome. Acta Ophthalmol Copenh 1987;65:91–100.

    PubMed  CAS  Google Scholar 

  29. Kallioneimi A, Kallioneimi OP, Waldman F, et al. Detection of retinoblastoma gene deletions in metaphase chromosomes and interphase nuclei by fluorescence in situ hybridization. Cytogenet Cell Genet 1992;60(3–4):190–193.

    Google Scholar 

  30. Kincaid MC, Green WR. Ocular and orbital involvement in leukemia. Surv Ophthalmol 1983;27:211–232.

    Article  PubMed  CAS  Google Scholar 

  31. Kivela T, Tarkkanen A. Recurrent medulloepithelioma of the ciliary body. Immunohistochemical characteristics. Ophthalmology 1988;95:1565–1575.

    PubMed  CAS  Google Scholar 

  32. Knudson AG Jr. Genetics of human cancer. J Cell Physiol (Suppl) 1986;4:7–11.

    Article  Google Scholar 

  33. Knudson AG Jr. Hereditary cancer, oncogenes, and antioncogenes. Cancer Res 1985;45:1437–1443.

    PubMed  CAS  Google Scholar 

  34. Knudson AG Jr. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971;68:820–823.

    Article  PubMed  Google Scholar 

  35. Kock E, Naeser P. Retinoblastoma in Sweden 1958–1971: a clinical and histopathological study. Acta Ophthalmol 1979;57:344–350.

    CAS  Google Scholar 

  36. Leonard BD, Shields JA, McDonald PR. Malignant melanomas of the uveal tract in children and young adults. Can J Ophthalmol 1975;10:441–449.

    PubMed  CAS  Google Scholar 

  37. Los G, Smals OAG, van Vugt MJH, et al. A rationale for carboplatin treatment and abdominal hyperthermia in cancers restricted to the peritoneal cavity. Cancer Res 1992;52:1252–1258.

    PubMed  CAS  Google Scholar 

  38. Messmer EP, Fritze H, Mohr C, et al. Long-term treatment effects in patients with bilateral retinoblastoma: ocular and mid-facial findings. Graefe’s Arch Clin Exp Ophthalmol 1991;229:309.

    Article  CAS  Google Scholar 

  39. Murphree AL. Personal observation, 1992.

    Google Scholar 

  40. Murphree AL. Unpublished data, 1992.

    Google Scholar 

  41. Murphree AL, Benedict WF. Retinoblastoma: clues to human oncogenesis. Science 1984;223:1028–1033.

    Article  PubMed  CAS  Google Scholar 

  42. Murphree AL, Gomer CJ, Sato J. Transpupillary diode laserthermia is synergistic with systemic carboplatin in the treatment of focal retinoblastoma. J Pediatr Ophthalmol Strabismus. Submitted.

    Google Scholar 

  43. Murphree AL, Rother C. Retinoblastoma. In: Ryan SJ (ed) Retina, vol VI. Part II. St. Louis: Mosby, 1989:529–530.

    Google Scholar 

  44. Nadol JB Jr. Pseudocellulitis of the orbit: a case report of retinoblastoma masquerading as orbital cellulitis. Ann Otol 1977;86:86–88.

    Google Scholar 

  45. Ninane J. The eye as a sanctuary in acute lymphoblastic leukemia. Lancet 1980;1:452–453.

    Article  PubMed  CAS  Google Scholar 

  46. Orjuela M, Castaneda VP, Ridaura C, et al. Presence of human papilloma virus in tumor tissue from children with retinoblastoma: an alternative mechanism for tumor development. Clin Cancer Res 2000;6(10):4010–4016.

    PubMed  CAS  Google Scholar 

  47. Orellana J, Moura RA, Font RL, Boniuk M, Murphy D. Medulloepithelioma diagnosed by ultrasound and vitreous aspirate: electron microscopic observations. Ophthalmology 1983;90:1531–1539.

    PubMed  CAS  Google Scholar 

  48. Pendergrass TW, Davis S. Incidence of retinoblastoma in the United States. Arch Ophthalmol 1980;98:1204–1210.

    PubMed  CAS  Google Scholar 

  49. Reeh MJ, Petersen P, Kobrin JG, Chenoweth RG. Malignant melanoma of choroid developing in the eye of a three-year-old boy. Ann Ophthalmol 1979;11(1):57–70.

    PubMed  CAS  Google Scholar 

  50. Reese AB. Tumors of the Eye. New York: Harper and Row, 1976.

    Google Scholar 

  51. Robb RM, Ervin LD, Sallan SE. A pathological study of eye involvement in acute leukemia of childhood. Trans Am Ophthalmol Soc 1978;76:90–101.

    PubMed  CAS  Google Scholar 

  52. Roldan M, Llanes F, Negrete O, Valverde F. Malignant melanoma of the choroid associated with melanosis oculi in a child. Am J Ophthalmol 1987;104:662–663.

    PubMed  CAS  Google Scholar 

  53. Rosenbaum PS, Boniuk M, Font RL. Diffuse uveal melanoma in a 5-year-old child. Am J Ophthalmol 1988;106:601–606.

    Article  PubMed  CAS  Google Scholar 

  54. Rosenthal AR. Ocular manifestations of leukemia. A review. Ophthalmology 1983;90:899–905.

    PubMed  CAS  Google Scholar 

  55. Rowan PJ, Sloan JB. Iris and anterior chamber involvement in leukemia. Ann Ophthalmol 1976;8(9):1081–1085.

    PubMed  CAS  Google Scholar 

  56. Saraux H, Dhermy P, Bechetoille A, Nou B. Les hyphemas revelateurs de retinoblastome. Bull Soc Ophthalmol (Fr) 1974;74(3):301–304.

    CAS  Google Scholar 

  57. Schachat AP, Jabs DA, Graham ML, Ambinder RF, Green WR, Saral R. Leukemic iris infiltration. J Pediatr Ophthalmol Strabismus 1988;25:135–138.

    PubMed  CAS  Google Scholar 

  58. Scheffer CH, Binkhorst PG, Hamburg A. Malignant melanoma of the choroid in a 2-year-old infant. Ophthalmologica 1974;169:401–410.

    Article  PubMed  CAS  Google Scholar 

  59. Schmiegelow K, Scherfig E, Prause JU, Jensen OA. Isolated leukemic choroidal relapse in a child with acute lymphoblastic leukemia, one year off therapy, diagnosed through transvitreal retinochoroidal biopsy. Acta Ophthalmol Copenh 1988;66:33–37.

    PubMed  CAS  Google Scholar 

  60. Shields CL, Shields JA, Milite J, De Potter P, Sabbagh R, Menduke H. Uveal melanoma in teenagers and children. A report of 40 cases. Ophthalmology 1991;98:1662–1666.

    PubMed  CAS  Google Scholar 

  61. Shields JA, Shields CL, Schwartz RL. Malignant teratoid medulloepithelioma of the ciliary body simulating persistent hyperplastic primary vitreous. Am J Ophthalmol 1989;107:296–298.

    PubMed  CAS  Google Scholar 

  62. Shields JA. Diagnosis and management of intraocular tumors. St. Louis: Mosby, 1983.

    Google Scholar 

  63. Shields C, et al. Plaque radiotherapy for uveal melanoma: Long term visual outcome in 1106 consecutive patients. Arch Ophth 2000;118(9):1219–1228.

    CAS  Google Scholar 

  64. Stafford WR, Yanoff M, Parnell BL. Retinoblastomas initially misdiagnosed as primary ocular inflammations. Arch Ophthalmol 1969;82:771–773.

    PubMed  CAS  Google Scholar 

  65. Stewart MW, Gitter KA, Cohen G. Acute leukemia presenting as a unilateral exudative retinal detachment. Retina 1989;9:110–114.

    Article  PubMed  CAS  Google Scholar 

  66. Suckling RD, Fitzgerald PH, Stewart J, Wells E. The incidence and epidemiology of retinoblastoma in New Zealand: a 30-year survey. Br J Cancer 1982;46:729–736.

    PubMed  CAS  Google Scholar 

  67. T’Ang A, Varley JM, Chakraborty S, Murphree AL, Fung YKT. Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science 1988;242:263–266.

    Article  PubMed  CAS  Google Scholar 

  68. Taylor D, Day S, Tiedemann K, Chessels J, Marshall WC, Constable IJ. Chorioretinal biopsy in a patient with leukaemia. Br J Ophthalmol 1981;65:489–493.

    PubMed  CAS  Google Scholar 

  69. Velazquez N, Jones IS. Ocular and oculodermal melanocytosis associated with uveal melanoma. Ophthalmology 1983;90:1472–1476.

    PubMed  CAS  Google Scholar 

  70. Verdaguer J. Prepubertal and pubertal melanomas in ophthalmology. Am J Ophthalmol 1965;60:1002–1011.

    PubMed  Google Scholar 

  71. Zakka KA, Yee RD, Shorr N, Smith GS, Pettit TH, Foos RY. Leukemic iris infiltration. Am J Ophthalmol 1980;89:204–209.

    PubMed  CAS  Google Scholar 

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Authors
  1. A. Linn Murphree
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  2. Laurie E. Christensen
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Editor information

Editors and Affiliations

  1. Wright Foundation for Pediatric Ophthalmology, Los Angeles, CA, USA

    Kenneth W. Wright MD (Director and Clinical Professor of Ophthalmology) (Director and Clinical Professor of Ophthalmology)

  2. Pediatric Ophthalmology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Kenneth W. Wright MD (Director and Clinical Professor of Ophthalmology) (Director and Clinical Professor of Ophthalmology)

  3. University of Southern California—Keck School of Medicine, Los Angeles, CA, USA

    Kenneth W. Wright MD (Director and Clinical Professor of Ophthalmology) (Director and Clinical Professor of Ophthalmology)

  4. Focus On You, Inc., Palm Desert, CA, USA

    Peter H. Spiegel MD

  5. Inland Eye Clinic, Murrieta, CA, USA

    Peter H. Spiegel MD

  6. Children’s Eye Institute, Upland, CA, USA

    Peter H. Spiegel MD

  7. Stroger Hospital of Cook County, Chicago, IL, USA

    Lisa S. Thompson MD (Attending Physician) (Attending Physician)

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Murphree, A.L., Christensen, L.E. (2006). Retinoblastoma and Other Malignant Intraocular Tumors. In: Wright, K.W., Spiegel, P.H., Thompson, L.S. (eds) Handbook of Pediatric Retinal Disease. Springer, New York, NY. https://doi.org/10.1007/0-387-27933-4_9

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  • DOI: https://doi.org/10.1007/0-387-27933-4_9

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