Tuberculosis in the Intensive Care Unit: The North American Perspective

  • Loren C. Denlinger
  • Jeffrey Glassroth
Part of the Perspective on Critical Care Infectious Diseases book series (CCID, volume 9)


Septic Shock Pulmonary Tuberculosis Respir Crit Adenosine Deaminase Adult Respiratory Distress Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Dye, C., S. Scheele, P. Dolin, V. Pathania, and M. C. Raviglione. 1999. Global burden of tuberculosis: estimated incitdence, prevalence, and mortality by country. JAMA 282:677–86PubMedGoogle Scholar
  2. 2.
    Cantwell, M. F., D. E. Snider, G. M. Cauthen, and I. M. Onorato. 1994. Epidemiology of tubeculosis in the United States, 1985 through 1992. JAMA 272:535–9.PubMedCrossRefGoogle Scholar
  3. 3.
    McCray, E., C. M. Weinbaum, C. R. Braden, and I. M. Onorato. 1997. The epidemiology of tuberculosis in the United States. Clin Chest Med 18:99–113.PubMedCrossRefGoogle Scholar
  4. 4.
    Iademarco, M. F., and K. G. Castro. 2003. Epidemiology of tuberculosis. Semin Respir Infect 18:225–40.PubMedGoogle Scholar
  5. 5.
    Hopewell, P. C. 1992. Impact of human immunodeficiency virus infection on the epidemiology, clinical features, management and control of tuberculosis. Clin Infect Dis 15:540–7.PubMedGoogle Scholar
  6. 6.
    Pablos-Mendez, A., T. R. Sterling, and T. R. Frieden. 1996. The relationship between delayed or incomplete treatment and all cause mortality in patients with tuberculosis. JAMA 276:1223–8.PubMedCrossRefGoogle Scholar
  7. 7.
    Sacks, L. V., and S. Pendle. 1998. Factors related to in-hospital deaths in patients with tuberculosis. Arch Intern Med 158:1916–22.PubMedCrossRefGoogle Scholar
  8. 8.
    Rao, V. K., E. P. Iademarco, V. J. Fraser, and M. H. Kollef. 1999. Delays in the suspicion and treatment of tuberculosis among hospitalized patients. Ann Intern Med 130:404–11.PubMedGoogle Scholar
  9. 9.
    Mathur, P., L. Sacks, G. Auten, R. Sall, C. Levy, and F. Gordin. 1994. Delayed diagnosis of pulmonary tuberculosis in city hospitals. Arch Intern Med 154:306–10.PubMedCrossRefGoogle Scholar
  10. 10.
    Keane, J., S. Gershon, R. P. Wise, E. Mirabile-Levens, J. Kasnica, W. D. Schwieterman, J. N. Siegel, and M. M. Braun. 2001. Tuberculosis associated with infliximab, a tumor necrosis factor α-neutralizing agent. New England J Med 345:1098–104.CrossRefGoogle Scholar
  11. 11.
    Khan, M. A., D. M. Kovnat, B. Bachus, M. E. Whitcomb, J. S. Brody, and G. L. Snider. 1977. Clinical and roentgenographic spectrum of pulmonary tuberculosis in the adult. Am J Med 62:31–6.PubMedCrossRefGoogle Scholar
  12. 12.
    Perez-Guzman, C., A. Torres-Cruz, H. Villarreal-Velarde, and M. H. Vargas. 2000. Progressive age-related changes in pulmonary tuberculosis images and the effect of diabetes. Am J Respir Crit Care Med 162:1738–40.PubMedGoogle Scholar
  13. 13.
    Agarwal, M. K., P. P. Muthuswamy, R. S. Shah, and W. W. Addington. 1977. Respiratory failure in pulmonary tuberculosis. Chest 72:605–9.PubMedGoogle Scholar
  14. 14.
    Murray, H. W., C. U. Tuazon, N. Kirmani, and J. N. Sheagren. 1978. The adult respiratory distress syndrome associated with miliary tuberculosis. Chest 73:37–43.PubMedGoogle Scholar
  15. 15.
    Dyer, R. A., and P. D. Potgieter. 1984. The adult respiratory distress syndrome and bronchogenic pulmonary tuberculosis. Thorax 39:383–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Dyer, R. A., W. A. Chappell, and P. D. Potgieter. 1985. Adult respiratory distress syndrome associated with miliary tuberculosis. Crit Care Med 13:12–5.PubMedGoogle Scholar
  17. 17.
    Penner, C., D. Roberts, D. Kunimoto, J. Manfreda, and R. Long. 1995. Tuberculosis as a primary cause of respiratory failure requiring mechanical ventilation. Am J Respir Crit Care Med 151:867–72.PubMedGoogle Scholar
  18. 18.
    Heffner, J. E., C. Strange, and S. A. Sahn. 1988. The impact of respiratory failure on the diagnosis of tuberculosis. Arch Intern Med 148:1103–8.PubMedCrossRefGoogle Scholar
  19. 19.
    Ahuja, S. S., S. K. Ahuja, K. R. Phelps, W. Thelmo, and A. R. Hill. 1992. Hemodynamic confirmation of septic shock in disseminated tuberculosis. Crit Care Med 20:901–3.PubMedGoogle Scholar
  20. 20.
    Clark, A. M., W. J. Burman, D. L. Cohn, and P. S. Mehler. 1998. Septic shock from Mycobacterium tuberculosis after therapy for Pneumocystis carinii. Arch Intern Med 158:1033–5.PubMedCrossRefGoogle Scholar
  21. 21.
    Pene, F., T. Papo, L. Burudy-Gulphe, A. Cariou, J. C. Peiette, and C. Vinsonneau. 2001. Septic shock and thrombotic microangiopathy due to Mycobacterium tuberculosis in a nonimmunocompromised patient. Arch Intern Med 161:1347–8.PubMedCrossRefGoogle Scholar
  22. 22.
    George, S., L. Papa, L. Sheils, and C. R. Magnussen. 1996. Septic shock due to disseminated tuberculosis. Clin Infect Dis 22:188–9.PubMedGoogle Scholar
  23. 23.
    Crump, J. A, and L. B. Reller. 2003. Two decades of disseminated tuberculosis at a university medical center: the expanding role of mycobacterial blood culture. Clin Infect Dis 37:1037–43.PubMedGoogle Scholar
  24. 24.
    Guttman, P. H. 1930. Addison’s desease — a statistical analysis of 566 cases and a study of the pathology. Arch Pathol 10:742–85.Google Scholar
  25. 25.
    Lam, K. Y., and C. Y. Lo. 2001. A critical examination of adrenal tuberculosis and a 28-year autopsy experience of active tuberculosis. Clin Endocrinol 54:633–9.CrossRefGoogle Scholar
  26. 26.
    Barnes, D. J., S. Naraqi, P. Temu, and J. R. Turtle. 1989. Adrenal function in patients with active tuberculosis. Thorax 44:422–4.PubMedGoogle Scholar
  27. 27.
    Annane, D., V. Sebille, G. Troche, J. C. Raphael, P. Gajdos, and E. Bellissant 2000. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA. 283:1038–45.PubMedCrossRefGoogle Scholar
  28. 28.
    Annane, D., V. Sebille, C. Charpentier, P. E. Bollaert, B. Francois, J. M. Korach, G. Capellier, Y. Cohen, E. Azoulay, G. Troche, P. Chaumet-Riffaut, and E. Bellissant. 2002. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288:862–71.PubMedCrossRefGoogle Scholar
  29. 29.
    Rogers, R. M., C. Bedrossian, J. J. Coalson, W. W. Cook, J. R. Christiansen, S. Deutsch, R. P. Elkins, B. A. Gray, J. F. Hammarsten, C. Harvey, T. H. Johnson, J. A. Juers, J. A. Mohr, E. R. Rhoades, and G. R. Williams. 1976. The management of massive hemoptysis in a patient with pulmonary tuberculosis. Chest 70:519–26.Google Scholar
  30. 30.
    Cahill, B. C., and D. H. Ingbar. 1994. Massive hemoptysis: assessment and management. Clin Chest Med 15:147–68.PubMedGoogle Scholar
  31. 31.
    Farer, L. S., A. M. Lowell, and M. P. Meador. 1979. Extrapulmonary tuberculosis in the United States. Am J Epidemiol 109:205–17.PubMedGoogle Scholar
  32. 32.
    Mehta, J. B., A. Dutt, L. Harvill, and K. M. Mathews. 1991. Epidemiology of extrapulmonary tuberculosis. A comparative analysis with pre-AIDS era. Chest 99:1134–8.PubMedGoogle Scholar
  33. 33.
    Simon, H. B., A. J. Weinstein, M. S. Pasternak, M. N. Swartz, and L. J. Kunz. 1977. Genitourinary tuberculosis: clinical features in a general hospital population. Am J Med 63:410–20.PubMedCrossRefGoogle Scholar
  34. 34.
    Goldman, G., and J. L. Bolognia. 1995. Recognizing cutaneous signs of tuberculosis. J Respir Dis 16:646–51.Google Scholar
  35. 35.
    Fowler, N. O. 1991. Tuberculous pericarditis. JAMA 266:99–103.PubMedCrossRefGoogle Scholar
  36. 36.
    Klein, N. C., B. Damsker, and S. Z. Hirschman. 1985. Mycobacterial meningitis: retrospective analysis from 1970 to 1983. Am J Med 79:29–34.PubMedCrossRefGoogle Scholar
  37. 37.
    Rieder, H. L., G. D. Kelly, A. B. Bloch, G. M. Cauthen, and D. E. Snider, Jr. 1991. Tuberculosis diagnosed at death in the United States. Chest 100:678–81.PubMedGoogle Scholar
  38. 38.
    American Thoracic Society. 2003. Treatment of tuberculosis. Am J Respir Crit Care Med 167:603–62.Google Scholar
  39. 39.
    American Thoracic Society. 2000. Diagnostic standards and classification of tuberculosis in adults and children. Am J Respir Crit Care Med 161:1376–95.Google Scholar
  40. 40.
    Segura, R. M., C. Pascual, I. Ocana, J. M. Martinez-Vazquez, E. Ribera, I. Ruiz, and M. D. Pelegri. 1989. Adenosine deaminase in body fluids: a useful diagnostic tool in tuberculosis. Clin Biochem 22:141–8.PubMedCrossRefGoogle Scholar
  41. 41.
    Aoe, K., A. Hiraki, T. Murakami, R. Eda, T. Maeda, K. Sugi, and H. Takeyama. 2003. Diagnostic significance of interferon-gamma in tuberculous pleural effusions. Chest 123:740–4.PubMedCrossRefGoogle Scholar
  42. 42.
    Andersen, P., M. E. Munk, and T. M. Doherty. 2000. Specific imune-based diagnosis of tuberculosis. Lancet 356:1099–104.PubMedCrossRefGoogle Scholar
  43. 43.
    Pottumarthy, S., A. J. Morris, A. C. Harrison, and V. C. Wells. 1999. Evaluation of the tuberculin gamma interferon assay: potential to replace the Mantoux skin test. J Clin Microbiol 37:3229–32.PubMedGoogle Scholar
  44. 44.
    Lalvani, A., A. A. Pathan, H. McShane, R. J. Wilkinson, M. Latif, C. P. Conlon, G. Pasvol, and A. V. Hill. 2001. Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells. Am J Respir Crit Care Med 163:824–8.PubMedGoogle Scholar
  45. 45.
    Catanzaro, A., S. Perry, J. E. Clarridge, S. Dunbar, S. Goodnight-White, P. A. LoBue, C. Peter, G. E. Pfyffer, M. F. Sierra, R. Weber, G. Woods, G. Mathews, V. Jonas, K. Smith, and P. Della-Latta. 2000. The role of clinical suspicion in evaluating a new diagnostic test for active tuberculosis: results of a multicenter prospective trial. JAMA 283:639–45.PubMedCrossRefGoogle Scholar
  46. 46.
    Broccolo, F., P. Scarpellini, G. Locatelli, A. Zingale, A. M. Brambilla, P. Cichero, L. A. Sechi, A. Lazzarin, P. Lusso, and M. S. Malnati. 2003. Rapid diagnosis of mycobacterial infections and quantitation of Mycobacterium tuberculosis load by two real-time calibrated PCR assays. J Clin Microbiol 41:4565–72.PubMedCrossRefGoogle Scholar
  47. 47.
    Hasaneen, N. A., M. E. Zaki, H. M. Shalaby, and A. S. El-Morsi. 2003. Polymerase chain reaction of pleural biopsy is a rapid and sensitive method for the diagnosis of tuberculous pleural effusion. Chest 124:2105–11.PubMedGoogle Scholar
  48. 48.
    Lima, D. M., J. K. Colares, and B. A. da Fonseca. 2003. Combined use of the polymerase chain reaction and detection of adenosine deaminase activity on pleural fluid improves the rate of diagnosis of pleural tuberculosis. Chest 124:909–14.PubMedCrossRefGoogle Scholar
  49. 49.
    Ardito, F., B. Posteraro, M. Sanguinetti, S. Zanetti, and G. Fadda. 2001. Evaluation of BACTEC Mycobacteria Growth Indicator Tube (MGIT 960) automated system for drug susceptibility testing of Mycobacterium tuberculosis. J Clin Microbiol 39:4440–4.PubMedCrossRefGoogle Scholar
  50. 50.
    Scarparo, C., P. Ricordi, G. Ruggiero, and P. Piccoli. 2004. Evaluation of the fully automated BACTEC MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide, streptomycin, isoniazid, rifampin, and ethambutol and comparison with the radiometric BACTEC 460TB method. J Clin Microbiol 42:1109–14.PubMedCrossRefGoogle Scholar
  51. 51.
    Small, P. M., and P. I. Fujiwara. 2001. Management of tuberculosis in the United States. New England J Med 345:189–200.CrossRefGoogle Scholar
  52. 52.
    Burman, W. J., and B. E. Jones. 2001. Treatement of HIV-related tuberculosis in the era of effective antiretroviral therapy. Am J Respir Crit Care Med 164:7–12.PubMedGoogle Scholar
  53. 53.
    Peloquin, C. A. 1997. Using therapeutic drug monitoring to dose antimycobacterial drugs. Clin Chest Med. 18:79–87.PubMedCrossRefGoogle Scholar
  54. 54.
    American College of Chest Physicians. 1995. Institutional control measures for tuberculosis in the era of multiple drug resistance. Chest 108:1690–1710.Google Scholar
  55. 55.
    Davis, Y. M., E. McCray, and P. M. Simone. 1997. Hospital infection control practices for tuberculosis. Clin Chest Med. 18:19–33.PubMedCrossRefGoogle Scholar
  56. 56.
    Bock, N. N., J. E. McGowan, J. Ahn, J. Tapia, and H. M. Blumberg. 1996. Clinical predictors of tuberculosis as a guide for a respiratory isolation policy. Am J Respir Crit Care Med 154:1468–72.PubMedGoogle Scholar
  57. 57.
    Scott, B., M. Schmid, and M. D. Nettleman. 1994. Early identification and isolation of inpatients at high risk for tuberculosis. Arch Intern Med 154:326–30.PubMedGoogle Scholar
  58. 58.
    American Thoracic Society. 2000. Targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med 161:S221–47.Google Scholar
  59. 59.
    von Reyn, C. F., and J. M. Vuola. 2002. New vaccines for the prevention of tuberculosis. Clin Infect Dis 35:465–74.Google Scholar
  60. 60.
    Hoft, D. F., S. Worku, B. Kampmann, C. C. Whalen, J. J. Ellmer, C. S. Hirsch, R. B. Brown, R. Larkin, Q. Li, H. Yun, and R. F. Silver. 2002. Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity. J Infect Dis 186:1448–57.PubMedCrossRefGoogle Scholar
  61. 61.
    Barnes, P. F., and M. D. Cave. 2003. Molecular epidemiology of tuberculosis. New England J Med 349:1149–56.CrossRefGoogle Scholar
  62. 62.
    Delgado, J. C., A. Baena, S. Thim, and A. E. Goldfeld. 2002. Ethnic-specific genetic associations with pulmonary tuberculosis. J Infect Dis 186:1463–8.PubMedGoogle Scholar
  63. 63.
    Lopez-Maderuelo, D., F. Arnalich, R. Serantes, A. Gonzalez, R. Codoceo, R. Madero, J. J. Vazquez, and C. Montiel. 2003. Interferon-gamma and interleukin-10 gene polymorphisms in pulmonary tuberculosis. Am J Respir Crit Care Med 167:970–5.PubMedCrossRefGoogle Scholar
  64. 64.
    Bellamy, R., M. Beyers, W. J. McAdam, C. Ruwende, R. Gie, P. Samaai, D. Bester, M. Meyer, T. Corrah, M. Collin, D. R. Camidge, D. Wilkinson, E. Hoal-van Helden, H. C. Whittle, W. Amos, P. van Helden, and A. V. S. Hill. 2000. Genetic susceptibility to tuberculosis in Africans: a genome wide scan. Proceed Nat’l Acad Sci. 97:8005–9.Google Scholar
  65. 65.
    Li, C. M., S. J. Campbell, D. S. Kumararatne, R. Bellamy, C. Ruwende, W. J. McAdam, A. V. S. Hill, and D. A. Lammas. 2002. Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population. J Infect Dis 186:1458–62.PubMedCrossRefGoogle Scholar
  66. 66.
    Fairbairn, I. P., C. B. Stober, D. S. Kumararatne, and D. A. Lammas. 2001. ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion. J Immunol 167:3300–7.PubMedGoogle Scholar
  67. 67.
    Saunders, B. M., S. L. Fernando, R. Sluyter, W. J. Britton, and J. S. Wiley. 2003. A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria. J Immunol 171:5442–6.PubMedGoogle Scholar
  68. 68.
    Denlinger, L. C., G. Angelini, K. Schell, D. N. Green, A. G. Guadarrama, U. Prabhu, D. B. Coursin, P. J. Bertics, and K. Hogan. 2004. Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in LPS-induced cytokine production. Unpublished data.Google Scholar

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Loren C. Denlinger
    • 1
  • Jeffrey Glassroth
    • 1
  1. 1.Division of Pulmonary & Critical Care, Department of MedicineUniversity of Wisconsin-Madison and the University of Wisconsin Hospital & ClinicsMadisonUSA

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