Inductively Coupled Plasma Time of Flight Mass Spectrometry for Trace Element and Speciation Analysis
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The main advantage of ICP-TOF-MS to previous ICP-MS instrumentation is the high speed and full elemental coverage in μl-volumes or rapid transients. For trace element determinations in samples from various biological systems the levels of several essential trace elements may interact and depend on each other in an intricate way. ICP- TOF-MS should be the method of choice if such inter-relationships are to be characterised since it incorporates unsurpassed speed and isotopic information allowing the use of stable isotope tracers. Moreover, coupling to chromatographic or laser ablation systems may lead to a better understanding of the trace element content in specific bands from a gel or a chromatographic peak adding even more selectivity to the analysis. The need for the TRIP is one of the weakest points of the present system and this feature is likely to be refined further in the future.
KeywordsLead Isotope Trace Element Content Flight Path Essential Trace Element Quadrupole Mass Filter
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