Dietary Boron is a Physiological Regulator of the Normal Inflammatory Response

  • Curtiss D. Hunt


Various diverse research findings have been summarized to develop the boron-inflammation regulation hypothesis that boron reduces the risk for inflammatory disease by serving as a suppressive signal that down-regulates enzymatic activities typically elevated during the normal inflammatory process. There is in vivo evidence for an immunomodulatory effect of physiologic amounts of dietary boron. Specifically, boron helps control the normal inflammatory process by modulating the response of key immune cells to antigens by an undefined mechanism. Boron may act to regulate the normal inflammatory process by serving as a signal suppressor that down-regulates the activities of specific enzymes involved in the inflammatory process and thus may play a role in modulating the development of inflammatory disease. Suppression, but not elimination, of activities of these enzymes is hypothesized to reduce the incidence and severity of the symptoms of inflammatory disease.


Grand Fork Transition State Analogue Physiologic Amount Dietary Boron Orthoboric Acid 
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© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Curtiss D. Hunt
    • 1
  1. 1.United State Department of Agriculture Agricultural Research Service 1U.S. Department of Agriculture Agricultural Research ServiceGrand ForksUSA

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