Zinc as a Cellular Regulator of Apoptosis

  • Alain Favier


Intracellular Zinc Free Zinc Transient Global Cerebral Ischemia Zinc Depletion Mitochondrial Calcium Uniporter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Beletsky, P., Matyasova, J., Nikonova, L.V., Shalka, M., and Umansky, S.R. 1989 On the role of Ca, Mg-dependent nuclease in the post-irradiation degradation of chromatin in lymphoid tissues. Gen. Physiol. Biophys. 8, 381–398.PubMedGoogle Scholar
  2. Buttke, T.M. and Sandstrom, P.A. 1994 Oxidative stress as a mediator of apoptosis. Immunol Today 15, 7–10.CrossRefGoogle Scholar
  3. Duke, R.C., Chervenak, R., and Cohen, J.J. 1983 Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis. Proc. Natl. Acad. Sci. U S A 80, 6361–6365.CrossRefGoogle Scholar
  4. Elmes, M. 1977 Apoptosis in the small intestine of zinc-deficient and fasted rats. J. Pathol. 123, 219–223.CrossRefGoogle Scholar
  5. Favier, A. 1995 Zinc-ligand interactions and oxygen free radicals formation in,. Handbook on metal-ligand interactions in biological fluids. New-York: Marcel Dekker Inc.Google Scholar
  6. Fehsel, K., Kroncke, K., Meyer, K., Huber, H,, Wahn, V., and Kolb-Bachofen, V. 1995 Nitric oxide induces apoptosis in mouse thymocytes. J. Immunol 155, 2858–2865PubMedGoogle Scholar
  7. Fieger, D., Riethmuller, G., and Ziegler-Heitbrock, H. 1989 Zn ++ inhibits both tumor necrosis factor-mediated DNA fragmentation and cytolysis. Int. J. Cancer 44, 315–319.CrossRefGoogle Scholar
  8. Hainaut, P. and Milner, J. 1993 Redox modulation of p53 conformation and sequence-specific DNA binding in vitro. Cancer Res. 53, 4469–473.PubMedGoogle Scholar
  9. Hechtenberg, S. and Beyersmann, D. 1993 Differential control of free calcium and free zinc levels in isolated bovine liver nuclei. tBiochem. J. 289, 757–760.CrossRefGoogle Scholar
  10. Kim, Y., Kim, E., Gwag, B., Sohn, S., and Koh, J. 1999 Zinc-induced cortical neuronal death with featuures of apoptosis and necrosis: mediation by free radicals. Neuroscience 89, 175–182.CrossRefGoogle Scholar
  11. Koh, J., Suh, S., Gwag, B., He, Y, Hsu, C., and Choi, D. 1996 The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272, 1àl31016.CrossRefGoogle Scholar
  12. Kolenko, V., Uzzo, R.G., Bukowski, R., Bander, N.H., Novick, A.C., Hsi, E.D., and Finke, J.H. 1999 Dead or dying: necrosis versus apoptosis in capase-deficient human renal cell carcinoma [In Process Citation], Cancer Res. 59, 2838–2842.Google Scholar
  13. Lazebnik, Y.A., Cole, S., Cooke, C.A., Nelson, W.G., and Earnshaw, W.C. 1993 Nuclear events in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis. J. Cell Biol. 123, 7–22.CrossRefGoogle Scholar
  14. Leccia, M.T., Richard, M.J., Beani, J.C., Faure, H., Monjo, A.M., Cadet, J., Amblard, P., and Favier, A. 1993 Protective effect of selenium and zinc on UV-A damage in human skin fibroblasts. Photochem. Photobiol. 58, 548–553.CrossRefGoogle Scholar
  15. Lohmann, R. and Beyersmann, D. 1994 Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei. Env. Health Perspect. 102, 269–271.Google Scholar
  16. Lohmann, R.D. and Beyersmann, D. 1993 Cadmium and zinc mediated changes of the Ca(2+)-dependent endonuclease in apoptosis. Biochem. Biophys. Res. Commun 190, 1097–1103.CrossRefGoogle Scholar
  17. Longin, A.S., Mezin, P., Favier, A., and Verdetti, J. 1997 Presence of zinc and calcium permeant channels in the inner membrane of the nuclear envelope. Biochem. Biophys. Res. Commun 235, 236–241.CrossRefGoogle Scholar
  18. Mc Cabe, M., Jiang, S., and Orrenius, S. 1993 Chelation of intracellular zinctriggers apoptosis in mature thymocytes. J. Lab. Invest. 69, 101–110.Google Scholar
  19. Morana, S., Li, J., Springer, E., and Eastman, A. 1994 The inhibition of etoposide-induced apotosis by zinc is associated with modulation of intracellular pH. Int. J. Oncol. 5, 153–158.PubMedGoogle Scholar
  20. Parat, M.O., Richard, M.J., Beani, J.C., and Favier, A. 1997a Involvement of zinc in intracellular oxidant/antioxidant balance. Biol. Trace. Elem. Res. 60, 187–204.CrossRefGoogle Scholar
  21. Parat, M.O., Richard, M.J., Pollet, S., Hadjur, C., Favier, A., and Beani, J.C. 1997b Zinc and DNA fragmentation in keratinocyte apoptosis: its inhibitory effect in UVB irradiated cells. J. Photochem. Photobiol. 37, 101–106.CrossRefGoogle Scholar
  22. Perry, D.K., Smyth, M.J., Stennicke, H.R., Salvesen, G.S., Duriez, P., Poirier, G.G., and Hannun, Y.A. 1997 Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J. Biol. Chem. 272, 18530–18533.CrossRefGoogle Scholar
  23. Saris, N. and Niva, K. 1994 Is Zn2+ transported by the mitochondrial calcium uniporter. FEBS Let. 356, 195–198.CrossRefGoogle Scholar
  24. Sarma, V., Lin, Z., Clark, L., Rust, M., Tewari, M., Noelle, R.J., and Dixit, V.M. 1995 Activation of the B-cell surface reptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J. Biol. Chem. 2705, 12343–12346.CrossRefGoogle Scholar
  25. Seve, M., Favier, A., Osman, M., Hernandez, D., Vaitaitis, G., Flores, N.C., McCord, J.M., and Flores, S.C. 1999 The Human Immunodeficiency Virus-1 Tat Protein Increases Cell Proliferation, Alters Sensitivity to Zinc Chelator-Induced Apoptosis, and Changes Spl DNA Binding in HeLa Cells. Arch. Biochem. Biophys. 361, 165–172.CrossRefGoogle Scholar
  26. Tate, D., Miceli, M., Newsome, D., Alcock, N., and Oliver, P. 1995 Influence of zinc on selected cellular funcions of cultured human retinal pigment epithelium. Curr. Eye. Res., 897–903.CrossRefGoogle Scholar
  27. Treves, S., Trentini, P.L., Ascanelli, M., and Bucci, G. 1994 Apoptosis is dependent on intracellular zinc and independent of intracellular calcium in lymphocytes. Exp. Cell Res. 211, 339–343.CrossRefGoogle Scholar
  28. Yamaguchi, M. and Oishi, K. 1995 Effect of nuclear Ca2+ uptake inhibitors on Ca(2+)-activated DNA fragmentation in rat liver nuclei. Mol. Cell Biochem. 148, 33–37.CrossRefGoogle Scholar
  29. Zalewski, P.D., Forbes, I.J., Seamark, R.F., Borlinghaus, R., Belts, W.H., Lincoln, S.F., and Ward, A.D. 1994 Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin. Chem. Biol. 3, 153–161.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Alain Favier
    • 1
  1. 1.LBSO, Research Laboratory on Biology of Oxidative StressUniversity of Grenoble Faculty of PharmacyLa TroncheFrance

Personalised recommendations