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Metallothioneins

Their Cellular Function and Relationship with Zinc
  • John H. Beattie
  • Ian Bremner
Chapter
  • 21 Downloads

Keywords

Brown Adipose Tissue Pancreatic Acinar Cell Glucocorticoid Response Element Metallothionein Gene Glutathione Disulphide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abdel-Mageed, A. and Agrawal, K.C., 1997, Antisense down-regulation of metallothionein induces growth arrest and apoptosis in human breast carcinoma cells. Cancer Gene Ther., 4:199–207.PubMedGoogle Scholar
  2. Abdel-Mageed, A.B. and Agrawal, K.C., 1998, Activation of nuclear factor kappaB: potential role in metallothionein-mediated mitogenic response. Cancer Res., 58:2335–2338.PubMedGoogle Scholar
  3. Beattie, J.H., Black, D.J., Duncan, J.S., Wood, A.M., and Trayhurn, P., 1996, Cold-induced expression of the metallothionein-1 gene in brown adipose tissue of rats. Am. J. Physiol, 270:R971–R977.PubMedGoogle Scholar
  4. Beattie, J.H., Wood, A.M., and Duncan, J.S., 1999, Rat metallothionein-2 contains N α-acetylated and unacetylated isoforms. Electrophoresis, (In Press).Google Scholar
  5. Beattie, J.H., Wood, A.M., Newman, A.M., Bremner, I., Choo, K.H.A., Michalska, A.E., Duncan, J.S., and Trayhurn, P., 1998, Obesity and hyperleptinemia in metallothionein (-I and-II) null mice. Proc. Natl. Acad. Sci. U.S.A., 95:358–363.CrossRefGoogle Scholar
  6. Bittel, D. and Andrews, G.K., 1998a, The Zn-fingers of MTF-1 contain a mechanism for sensing intracellular free Zn (Abstract). International Conference on Metal-binding Proteins in Biology, Banff, Alberta, Canada, p. 46.Google Scholar
  7. Bittel, D., Dalton, T., Samson, S.A., Gedamu, L., and Andrews, G.K., 1998b, The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals. J. Biol. Chem., 273:7127–7133.CrossRefGoogle Scholar
  8. Chu, W.A., Moehlenkamp, J.D., Bittel, D., Andrews, G.K., and Johnson, J.A., 1999, Cadmium-mediated activation of the metal response element in human neuroblastoma cells lacking functional metal response element-binding transcription factor-1. J. Biol. Chem., 274:5279–5284.CrossRefGoogle Scholar
  9. Erickson, J.C., Hollopeter, G., Thomas, S.A., Froelick, G.J., and Palmiter, R.D., 1997, Disruption of the metailothionem-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures. J. Neurosci., 17:1271–1281.CrossRefGoogle Scholar
  10. Gasull, T. and Hidalgo, J., 1996, Evidence for a high molecular weight cytosolic factor that binds brain and liver metallothionein. Neurochem. Res., 21:969–974.CrossRefGoogle Scholar
  11. Gunes, C., Heuchel, R., Georgiev, O., Muller, K.H., Lichtlen, P., Bluthmann, H., Marino, S., Aguzzi, A., and Schaffner, W, 1998, Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J., 17:2846–2854.CrossRefGoogle Scholar
  12. Jasani, B. and Schmid, K.W., 1997, Significance of metallothionein overexpression in human tumours [In Process Citation]. Histopathology, 31:211–214.CrossRefGoogle Scholar
  13. Jiang, L.J., Maret, W., and Vallee, B.L., 1998, The glutathioneredox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase [In Process Citation], Proc. Natl. Acad. Sci. U.S.A., 95:3483–3488.CrossRefGoogle Scholar
  14. Kelly, E.J., Sandgren, E.P., Brinster, B.L., and Palmiter, R.D., 1997, A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes. Proc. Natl. Acad. Sci. U.S.A., 94:10045–10050.CrossRefGoogle Scholar
  15. Klaassen, C.D. and Liu, J., 1998, Metallothionein transgenic and knock-out mouse models in the study of cadmium toxicity [In Process Citation]. J. Toxicol. Sci., 23 Suppl 2:97–102:97–102.CrossRefGoogle Scholar
  16. Koizumi, S., Suzuki, K., Ogra, Y, Yamada, H., and Otsuka, F., 1999, Transcriptional activity and regulatory protein binding of metal-responsive elements of the human metallothionein-IIA gene. Eur. J. Biochem., 259:635–642.CrossRefGoogle Scholar
  17. Kondo, Y., Rusnak, J.M., Hoyt, D.G., Settineri, C.E., Pitt, B.R., and Lazo, J.S., 1997, Enhanced apoptosis in metallothionein null cells. Mol. Pharmacol, 52:195–201.CrossRefGoogle Scholar
  18. Lazo, J.S., Kondo, Y., Dellapiazza, D., Michalska, A.E., Choo, K.H.A., and Pitt, B.R., 1995, Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem., 270:5506–5510.CrossRefGoogle Scholar
  19. Lee, D.K., Carrasco, J., Hidalgo, J., and Andrews, G.K., 1999, Identification of a signal transducer and activator of transcription, (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression. Biochem. J, 337:59–65.CrossRefGoogle Scholar
  20. Liu, J., Liu, Y., Michalska, A.E., Choo, K.H.A., and Klaassen, C.D., 1996a, Distribution and retention of cadmium in metallothionein I and II null mice. Toxicol. Appl. Pharmacol, 136:260–268.CrossRefGoogle Scholar
  21. Liu, J., Liu, Y.P., Michalska, A.E., Choo, K.H.A., and Klaassen, CD., 1996b, Distribution and retention of cadmium in metallothionein I and II null mice. Toxicol. Appl. Pharmacol, 136:260–268.CrossRefGoogle Scholar
  22. Mahon, P., Partridge, K., Beattie, J.H., Glover, L.A., and Hesketh, J.E., 1997, The 3′ untranslated region plays a role in the targeting of metallothionein-I mRNA to the perinuclear cytoplasm and cytoskeletal-bound polysomes. Biochim. Biophys. Acta, 1358:153–162.CrossRefGoogle Scholar
  23. Masters, B.A., Kelly, E.J., Quaife, C.J., Brinster, R.L., and Palmiter, R.D., 1994, Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. U.S.A., 91:584–588.CrossRefGoogle Scholar
  24. Michalska, A.E. and Choo, K.H.A., 1993, Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. U.S.A., 90:8088–8092.CrossRefGoogle Scholar
  25. Moffatt, P. and Seguin, C., 1998, Expression of the gene encoding metallothionein-3 in organs of the reproductive system [In Process Citation]. DNA Cell Biol., 17:501–510.CrossRefGoogle Scholar
  26. Murphy, B.J., Andrews, G.K., Bittel, D., Discher, D.J., McCue, J., Green, C.J., Yanovsky, M., Giaccia, A., Sutherland, R.M., Laderoute, K.R., and Webster, K.A., 1999, Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. Cancer Res., 59:1315–1322.PubMedGoogle Scholar
  27. Pitt, B.R., Schwarz, M., Woo, E.S., Yee, E., Wasserloos, K., Tran, S., Weng, W., Mannix, R.J., Watkins, S.A., Tyurina, Y.Y., Tyurin, V.A., Kagan, V.E., and Lazo, J.S., 1997, Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury. Am. J. Physiol, 273:L856–L865.PubMedGoogle Scholar
  28. Quaife, C.J., Kelly, E.J., Masters, B.A., Brinster, R.L., and Palmiter, R.D., 1998, Ectopic expression of metallothionein-III causes pancreatic acinar cell necrosis in transgenic mice [Full text delivery]. Toxicol. Appl. Pharmacol., 148:148–157.CrossRefGoogle Scholar
  29. Samson, S.L. and Gedamu, L., 1998, Molecular analyses of metallothionein gene regulation. Prog. Nucleic Acid Res. Mol. Biol., 59:257–288.CrossRefGoogle Scholar
  30. Sato, M., Apostolova, M.D., Hamaya, M., Yamaki, J., Choo, K.H.A., Michalska, A.E., Kodama, N., and Tohyama, C., 1996, Susceptibility of metallothionein-null mice to paraquat. Environ. Toxicol. Pharmacol., 1:221–225.CrossRefGoogle Scholar
  31. Sewell, A.K., Jensen, L.T., Erickson, J.C., Palmiter, R.D., and Winge, D.R., 1995, Bioactivity of metallothionein-3 correlates with its novel beta domain sequence rather than metal binding properties. Biochemistry, 34:4740–4747.CrossRefGoogle Scholar
  32. Studer, R., Vogt, C.P., Cavigelli, M., Hunziker, P.E., and Kagi, J.H., 1997, Metallothionein accretion in human hepatic cells is linked to cellular proliferation. Biochem. J., 328:63–67.CrossRefGoogle Scholar
  33. Thornalley, P.J. and Vasak, M., 1985, Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim. Biophys. Acta, 827:36–44.CrossRefGoogle Scholar
  34. Tohyama, C., Suzuki, J.S., Hemelraad, J., Nishimura, N., and Nishimura, H., 1993, Induction of metallothionein and its localization in the nucleus of rat hepatocytes after partial hepatectomy. Hepatology, 18:1193–1201.CrossRefGoogle Scholar
  35. Tsujikawa, K., Imai, T., Kakutani, M., Kayamori, Y., Mimura, T., Otaki, N., Kimura, M., Fukuyama, R., and Shimizu, N., 1991, Localization of metallothionein in nuclei of growing primary cultured adult rat hepatocytes. FEBS Lett., 283:239–242.CrossRefGoogle Scholar
  36. Uchida, Y. and Ihara, Y., 1995, The N-terminal portion of growth inhibitory factor is sufficient for biological activity. J. Biol.Chem., 270:3365–3369.CrossRefGoogle Scholar
  37. Vasconcelos, H., Tam, S.C., Beattie, J.H., and Hesketh, J., 1995, Evidence for differences in the posttranscriptional regulation of rat metallothionein isoforms. Biochem. J., 314:665–671.Google Scholar
  38. Whitacre, C.M., 1996, Application of Western blotting to the identification of metallothionein binding proteins. Anal. Biochem., 234:99–102.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • John H. Beattie
    • 1
  • Ian Bremner
    • 1
  1. 1.Trace Element and Gene Expression GroupRowett Research InstituteBucksburnUK

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