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Transport of Iron in Health and Diseases

  • Andreas Rolfs
  • Matthias A. Hediger
Chapter
  • 24 Downloads

Keywords

Iron Uptake Iron Transporter Hypochromic Anemia Iron Responsive Element Intestinal Iron Absorption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anderson, G.J., Murphy, T.L., Cowley, L., Evans, B.A., Halliday, J.W., and Mclaren, G.D., 1998, Mapping the gene for sex-linked anemia—An inherited defect of intestinal iron absorption in the mouse, Genomics 48, 34–39.CrossRefGoogle Scholar
  2. Dix, D.R., Bridgham, J.T., Broderius, M.A., Byersdorfer, C.A., and Eide, D.J., 1994, The FET4 gene encodes the low affinity Fe(II) transport protein of Saccharomyces cerevisiae, Journal of Biological Chemistry 269, 26092–26099.PubMedGoogle Scholar
  3. Eastham, E.J., Bell, J.I., and Douglas, A.P., 1977, Iron-transport characteristics of vesicles of brush-border and basolateral plasma membrane from the rat enterocyte, Biochemical Journal 164, 289–294.CrossRefGoogle Scholar
  4. Eide, D., Broderius, M., Fett, J., and Guerinot, M.L., 1996, A noveliron-regulated metal transporter from plants identified by functional expression in yeast, Proceedings of the National Academy of Sciences USA 93, 5624–5628.CrossRefGoogle Scholar
  5. Feder, J.N., Penny, D.M., Irrinki, A., Lee, V.K., Lebron, J.A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P.J., and Schatzman, R.C., 1998, The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding, Proceedings of the National Academy of Sciences USA 95, 1472–1477.CrossRefGoogle Scholar
  6. Fleming, M.D., Trenor, C.C., Su, M.A., Foernzler, D., Beier, D.R., Dietrich, W.F., and Andrews, N.C., 1997, Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene, Nature Genetics 16, 383–386.CrossRefGoogle Scholar
  7. Green, R., Charlton, R., Seftel, H., Bothwell, T., Mayet, K, Adams, B., Finch, C., and Layrisse, M., 1968, Body iron excretion in man: a collaborative study, American Journal of Medicine 45, 336–353.CrossRefGoogle Scholar
  8. Gunshin, H., Mackenzie, B., Berger, U.V., Gunshin, Y., Romero, M.F., Boron, W.F., Nussberger, S., Gollan, J.L., and Hediger, M.A., 1997, Cloning and characterization of a mammalian proton-coupled metalion transporter, Nature 388, 182–188.CrossRefGoogle Scholar
  9. Iancu, T.C., Shiloh, H., Raja, K.B., Simpson, R.J., Peters, T.J., Perl, D.P., Hsu, A., and Good, P.F., 1995, The hypotransferrinaemic mouse: ultrastructural and laser microprobe analysis observations, Journal of Pathology 177, 83–94.CrossRefGoogle Scholar
  10. Kammler, M., Schon, C., and Hantke, K., 1993, Characterization of the ferrous iron uptake system of Escherichia coli, Journal of Bacteriology 175, 6212–6219.CrossRefGoogle Scholar
  11. Stearman, R., Yuan, D.S., Yamaguchi-Iwai, Y., Klausner, R.D., and Dancis, A., 1996, A permease-oxidase complex involved in high-affinity iron uptake in yeast, Science 271, 1552–1557.CrossRefGoogle Scholar
  12. Supek, F., Supekova, L., Nelson, H., and Nelson, N, 1996, A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria, Proce Natl. Acad. Sci. USA 93, 5105–5110.CrossRefGoogle Scholar
  13. Wardrop, S.L. and Richardson, D.R., 1999, The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake, Eur. J. Biochem. 263, 41–49.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Andreas Rolfs
    • 1
    • 2
  • Matthias A. Hediger
    • 1
    • 2
  1. 1.Membrane Biology Program and Renal Division Department of MedicineBrigham & Women’s Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of Biological Chemistry & Molecular PharmacologyHarvard MedicalBostonUSA

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