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Effects of Lead on the Maturation of the Female Gamete and Fertility

  • B. Lefèvre
  • J. Poupon
  • A. Pesty
  • V. Machelon
  • J. Testart
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Conclusion

It has been demonstrated in many cellular models that Pb2+ ions can replace Ca2+ ions thus impairing the Ca2+-dependent functions of the cell. As calcium metabolism plays an important role in the ooctyte meiosis, deleterious effects of lead on the female mouse fertility could be linked to the disturbance of this metabolism.

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • B. Lefèvre
    • 1
  • J. Poupon
    • 2
  • A. Pesty
    • 1
  • V. Machelon
    • 1
  • J. Testart
    • 1
  1. 1.INSERM U355 & IFR 14ClamartFrance
  2. 2.Laboratoire de Biochimie-ToxicologieHôpital Fernand WidalParisFrance

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