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Zinc-Induced Excessive Glutamate Release may Cause Accelerated Senescence with Defect in Learning and Memory in Senescence Accelerated Mouse

  • Takeshi Saito
  • Noriko Nakagawa
  • Kyoko Takahashi
  • Dan Li
  • Yuwako Yamamoto
  • Hiroko Sasaki
  • Nozomu Nakamura
  • Kazuhiro Ogawa
  • Hiroyoshi Fujita
  • Masaaki Kurasaki
  • Masashi Okabe
  • Toshiyuki Hosokawa
Chapter
  • 21 Downloads

Conclusion

Our results demonstrated that an abnormal glutamate neurotransmission caused by Zn deficiency induces neuronal cell injury in the hippocampus of SAMP 10. These neuronal disturbances may cause accelerated aging of brain of SAMP 10 with deficits in learning and memory (Fig. 2).

Keywords

NMDA Receptor Glial Fibrillary Acidic Protein Glutamate Release Mossy Fiber Accelerate Senescence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Assaf, S.Y. and Chung, S.-H., 1984, Release of endogenous Zn2+ from rat brain tissue during activity, Nature 308:734–736.CrossRefGoogle Scholar
  2. Guidolin, D., Polato, P., Venturin, G., Zanotti, A., Mocchegiani, E., Fabris, N., and Nunzi, M.G., 1992, Correlation between zinc level in hippocampal mossy fibers and Spatial memory in aged rats, Ann. N Y Acad. Sci. 673:187–193.CrossRefGoogle Scholar
  3. Itoh, T., Saito, T., Fujimura, M., Watanabe, S., and Saito, K., 1993, Restraint stress-induced changes in endogenous zinc release from the rat hippocampus, Brain Res. 618:318–322.CrossRefGoogle Scholar
  4. Saito, K., Watanabe, S., Itoh, T., and Saito, T., 1994, Dynamics of trace and ultra-trace elements in the brain, Hokkaido Univ. Med. Lib. 31:11–17.Google Scholar
  5. Takeda, T., Hosokawa, M., Takeshita, S., Irio, K., Higuchi, T., Matsushita, T., Tomita, Y., Yasuhira, K., Hashimoto, H., Shimizu, K., Ishii, M., and Yamamura, T., 1981, A new murine model of accelerated senescence, Mech. Aging Dev. 17:183–194.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Takeshi Saito
    • 1
  • Noriko Nakagawa
    • 1
  • Kyoko Takahashi
    • 1
  • Dan Li
    • 1
  • Yuwako Yamamoto
    • 1
  • Hiroko Sasaki
    • 1
  • Nozomu Nakamura
    • 1
  • Kazuhiro Ogawa
    • 1
  • Hiroyoshi Fujita
    • 1
  • Masaaki Kurasaki
    • 2
  • Masashi Okabe
    • 2
  • Toshiyuki Hosokawa
    • 3
  1. 1.Laboratory of Environmental Biology Department of Preventive MedicineHokkaido University School of MedicineSapporoJapan
  2. 2.Department of Environmental Medicine and Informatics Graduate School of Environmental Earth ScienceHokkaido UniversitySapporoJapan
  3. 3.Center for Research and Development in Higher EducationHokkaido UniversitySapporoJapan

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