Zinc-Induced Excessive Glutamate Release may Cause Accelerated Senescence with Defect in Learning and Memory in Senescence Accelerated Mouse
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Our results demonstrated that an abnormal glutamate neurotransmission caused by Zn deficiency induces neuronal cell injury in the hippocampus of SAMP 10. These neuronal disturbances may cause accelerated aging of brain of SAMP 10 with deficits in learning and memory (Fig. 2).
KeywordsNMDA Receptor Glial Fibrillary Acidic Protein Glutamate Release Mossy Fiber Accelerate Senescence
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