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Effects of Aluminum on Glutamate Metabolism

A Possible Explanation for Its Toxicity in the Aged Rats and in an Experimental Model of Aluminum Overload
  • Cécile Struys-Ponsar
  • Olivier Guillard
  • Philippe van den Bosch de Aguilar
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Conclusion

Definition of Al toxicity is traditionally presented in terms of neurone injury and glial cells are generally relagated to a secondary role involving reactive or suportive responses. However, the observations of the present work point out the astrocyte population as a potential target for Al toxic action. In vivo, significant increase in glutamine concentration was observed during aging and after Al exposure in brain regions characterized by Al accumulation, the hippocampus and the neocortex. In vitro, exposure of astrocytes to Al significantly increased GS activity. Some steps of glutamate metabolism appeared therefore to increase in the brain of rats after Al exposure.

Keywords

Glutamine Synthetase Lead Acetate Cobalt Chloride Glutamine Synthetase Activity Zinc Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Cécile Struys-Ponsar
    • 1
  • Olivier Guillard
    • 2
  • Philippe van den Bosch de Aguilar
    • 1
  1. 1.Laboratoire de Biologie CellulaireUniversité Catholique de LouvainLouvain-la-NeuveFrance
  2. 2.Institut des Xénobiotiques et Laboratoire de ToxicologieCHU de PoitiersPoitiersFrance

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