Xanthine Oxidase in Biology and Medicine

  • Dale A. Parks
  • Kelly A. Skinner
  • Sidhartha Tan
  • Henry B. Skinner


Uric Acid Xanthine Oxidase Aldehyde Oxidase Xanthine Oxidase Activity Xanthine Dehydrogenase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Abello, P. A., Buchman, T. G., and Bulkley, G. B., 1994, Shock and multiple organ failure, Adv. Exp. Med. Biol. 366:253–268.PubMedGoogle Scholar
  2. Adachi, T., and Marklund, S. L., 1989, Interactions between human extracellular superoxide dismutase C and sulfated polysaccharides, J. Biol. Chem. 264:8537–8541.PubMedGoogle Scholar
  3. Adachi, T., Fukushima, T., Usami, Y., and Hirano, K., 1993, Binding of human xanthine oxidase to sulphated glycosaminoglycans on the endothelial-cell surface, Biochem. J. 289(Pt. 2):523–527.PubMedGoogle Scholar
  4. Akaike, T., Ando, M. Oda, T., Ijiri. S., and Maeda, H., 1990, Dependence on O2+ generation by xanthineoxidase of pathogenesis of influenza virus infection in mice, J. Clin. Invest. 85:739–745.PubMedGoogle Scholar
  5. Amaya, Y, Yamazaki, K., Sato, M., Noda, K., and Nishino, T., 1990, Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2- dependent type. Amino acid sequence of rat liver xanthine dehydrogenase and identification of the cleavage sites of the enzyme protein during irreversible conversion by trypsin, J. Biol. Chem. 265:14170–14175.PubMedGoogle Scholar
  6. Ames, B. N., Cathcart, R., Schwiers, E., and Hochstein, P., 1981, Uric acid provides an antioxidant defense in humans against oxidant and radical-caused aging and cancer: A hypothesis, Proc. Natl. Acad. Sci. USA 78:6858–6862.PubMedGoogle Scholar
  7. Anderson, B. O., Moore, E. E., Moore, F. A., Leff, J. A., Terada, L. S., Harken, A. H., and Repine, J. E., 1991, Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism, J. Appl. Physiol. 71:1862–1865.PubMedGoogle Scholar
  8. Avis, P.G., Bergel, F., and Bray, R. C., 1955, Cellular constituents. The chemistry of xanthine oxidase. Part 1. Thepreparation of a crystalline xanthine oxidase from cow’smilk, Genetics 129(4): 1099–1109.Google Scholar
  9. Baggiolini, M., Boulay, F., Badwey, J.A., and Curnutte, J.T, 1993, Activationofneutrophilleukocytes: chemoattractant receptors and respiratory burst [review], FASEB J. 7(11):1004–1010.PubMedGoogle Scholar
  10. Ball, E. G., 1939, Xanthine oxidase: Purification and properties, J.Biol. Chem. 128:51–67.Google Scholar
  11. Barber, M. J., Coughlan, M. P., Rajagopalan, K. V., and Siegel, L. M., 1982, Properties of the prosthetic groups of rabbit liver aldehyde oxidase: A comparison of molybdenum hydroxylase enzymes, Biochemistry 21:3561–3568.PubMedGoogle Scholar
  12. Becker, B. F., Reinholz, D. N., Leipert, B., Raschke, P., Permanetter, B., and Gerlach, E., 1991, Role of uric acid as an endogenous radical scavenger and antioxidant, Chest 100(Suppl. 3): 176S–181S.PubMedGoogle Scholar
  13. Beck man, J. S., 1996, Oxidalive damage and tyrosine nitration from peroxynitrite, Chem. Res. Toxicol. 9(5):836–844.Google Scholar
  14. Beckman, J. S., Ye, Y. Z., and Anderson, P. G., Chen, J., Accavitti, M. A., Tarpey, M. M., and White, C. R., 1994, Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry, Biol. Chem. Hoppe Seyler 375:81–88.Google Scholar
  15. Beckman, J. S.. and Koppenol, W. H., 1996, Superoxide dismutase, toxicity, neuronal networks. Nitric oxide, superoxide, andperoxynitrite—the good, the bad, and the ugly, Am. J. Physiol. Cell Physiol. 40(5):C1424–C1437.Google Scholar
  16. Beedham, C., 1985, Molybdenum hydroxy lases as drug-metabolizing enzymes [review], Drug Metab. Rev. 16(1–2). 119–156.PubMedGoogle Scholar
  17. Beedham, C., Critchley, D.J., and Rance, D.J., 1995, Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: A comparisonwith hepaticenzyme fromguinea pig, rabbit, and baboon, Arch. Biochem. Biophys. 319:481–490.CrossRefPubMedGoogle Scholar
  18. Bienvenu, K., and Granger, D. N., 1993, Leukocyte adhesion in ischemia/reperfusion [review] [23 refs.]. Blood Cells 19(2):279–288; discussion 288-289.PubMedGoogle Scholar
  19. Boda, D., Nemeth, I., Hencz, P., and Denes, K., 1984, Effect of allopurinol treatment in premature infants with idiopathic respiratory distress syndrome, Dev. Pharmacol. Ther. 7(6):357–367.PubMedGoogle Scholar
  20. Bray, R. C., Bennett, B., Burke, J. F, Chovnick, A., Doyle, W. A., Howes, B. D., Lowe, D. J., Richards, R. L., Turner, N. A., Ventom, A., and Whittle, J. R., 1996, Recent studies on xanthine oxidase and related enzymes [review], Biochem. Soc. Trans. 24(1):99–105.PubMedGoogle Scholar
  21. Calzi, M.L., Raviolo, C., Ghibaudi, E., deGioia, L., Salmona, M., Cazzaniga, G., Kurosaki, M., Terao, M., and Garattini, E., 1995, Purification,cDNA cloning, and tissuedistribution ofbovineliveraldehyde oxidase, J. Biol. Chem. 270:31037–31045.PubMedGoogle Scholar
  22. Carithers, R. L., Fairman, R. P., Mendez-Picon, G., Posner, M. P., and Mills, A. S., 1988, Postoperative care, in Transplantation of the Liver (W. C. Maddrey, ed.), pp. 111–142, Elsevier, Amsterdam.Google Scholar
  23. Cazzaniga, G., Terao, M., LoSchiavo, P., Galbiati, F, Segalla, F, Seldin, M.F, and Garattini, E., 1994, Chromosomal mapping, isolation, and characterization of themouse xanthine dehydrogenase gene, Genomics 23(2):390–402.CrossRefPubMedGoogle Scholar
  24. Chen, L.H., Huang, C.Y., and Osio, Y., 1996, Large doses of ethanol and activities of liver enzymes which detoxify reactive oxygen species: Effects of antioxidants, Biochem. Arch. 12(2):95–104.Google Scholar
  25. Clare, D. A., and Lecce, J.G., 1991, Copurification ofbovine milk xanthine oxidase and immunoglobulin, Arch. Biochem. Biophys. 286:233–237.CrossRefPubMedGoogle Scholar
  26. Contreras, M., Hariharan, N., Lewandoski, J.R., Ciesielski, W., Koscik, R., and Zimmerman, J.J., 1996, Bronchoalveolar oxyradical inflammatory elements herald bronchopulmonary dysplasia, Crit. Care Med. 24(1):29–37.PubMedGoogle Scholar
  27. DeGroote, H., and Littauer, A., 1988, Reoxygenation injury inisolated hepatocytes: Cell death precedes conversion of xanthine dehydrogenase to xanthine oxidase, Biochem. Biophys. Res. Commun. 155:278–282.Google Scholar
  28. Deloria, L., Abbott, V, Gooderham, N., and Mannering, G.J., 1985, Induction ofxanthine oxidase and degression of cytochrome P-450 by interferon inducers: Genetic difference in the responses of mice, Biochem. Biophys. Res. Commun. 131:109–114.PubMedGoogle Scholar
  29. DeRenzo, E.C., Kaleita, E., Heyler, P., Oleson, J.J., Hutchings, B.L., and Williams, J.H., 1953, The nature of the xanthine oxidase factor, J. Am. Chem. Soc. 75:753–758.Google Scholar
  30. Dupont, G. P., Huecksteadt, T. P., Marshall, B. C., Ryan, U. S., Michael, J. R., and Hoidal, J. R., 1992, Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells, J. Clin. Invest. 89:197–202.PubMedGoogle Scholar
  31. Duran, M., Beemer, F.A., van de Heiden, C, Korteland, J., de Bree, P.K., Brink, M., Wadman, S.K., and Lombeck, I., 1978, Combined deficiency of xanthine oxidase and sulphite oxidase: A defect of molybdenum metabolism or transport? J. Inherit. Metab. Dis. 1(4): 175–178.CrossRefPubMedGoogle Scholar
  32. Duval, D.L., Sieg, D.J., and Billings, R.E., 1995, Regulation of hepaticnitricoxide synthase by reactive oxygen intermediates and glutathione, Arch. Biochem. Biophys. 316:699–706.CrossRefPubMedGoogle Scholar
  33. Engerson, T. D., McKelvey, T. G., Rhyne, D. B., Boggio, E. B., Snyder, S. J., and Jones, H. P., 1987, Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues, J. Clin. Invest. 79:1564–1570.PubMedGoogle Scholar
  34. Falciani, F., Ghezzi, P., Terao, M., Cazzaniga, G., and Garattini, E., 1992, Interferons induce xanthine dehydrogenase gene expression in L929 cells, Biochem. J. 285(Pt. 3): 1001–1008.PubMedGoogle Scholar
  35. Frank, L., and Sosenko, I. R., 1987, Prenatal development of lung antioxidant enzymes in four species, J. Pediatr. 110(1):106–110.PubMedGoogle Scholar
  36. Frederiks, W. M., Kooij, A., and Bosch, K. S., 1995, Role of xanthine oxidase activity in tissue damage of rat liverafterischemia, Transplant. Proc. 27(5):2855–2856.PubMedGoogle Scholar
  37. Freeman, B. A., and Crapo, J. D., 1982, Biology of disease: Free radicals and tissue injury, Lab. Invest. 47:412–426.PubMedGoogle Scholar
  38. Freeman, B. A., White, C. R., Gutierrez, H., Paler-Martinez, A., Tarpey, M. M., and Rubbo, H., 1995, Oxygen radical-nitric oxide reactions in vascular diseases [review], Adv. Pharmacol. 34:45–69.PubMedGoogle Scholar
  39. Fridovich, I., 1966, The mechanism of the enzymatic oxidation of aldehydes, J. Biol. Chem. 241:3126–3128.PubMedGoogle Scholar
  40. Fridovich, I., 1986, Biological effects of the superoxide radical [review], Arch. Biochem. Biophys. 247:1–11.CrossRefPubMedGoogle Scholar
  41. Fridovich, I., and Handler, P., 1958, Xanthine oxidase, III. Sulfite oxidation as an ultrasensitive assay, J. Biol. Chem. 233:1578–1580.PubMedGoogle Scholar
  42. Friedl, H. P., Smith, D. J., Till, G. O., Thomson, P. D., Louis, D. S., and Ward, P. A., 1990, Ischemia-reperfusion in humans. Appearance of xanthine oxidase activity, Am. J. Pathol. 136:491–495.PubMedGoogle Scholar
  43. Fukahori, M., Ichimori, K., Ishida, H., Nakagawa, H., and Okino, H., 1994, Nitric oxide reversibly suppresses xanthine oxidase activity, Free Radical Res. 21(4):203–2I2.Google Scholar
  44. Fukushima, T, Adachi, T., and Hirano, K., 1995, The heparin-binding site of human xanthine oxidase, Biol. Pharm. Bull. 18(1):156–158.PubMedGoogle Scholar
  45. Ghezzi, P., Bianchi, M, Mantovani, A., Spreafico, F., and Salmona, M., 1984, Enhanced xanthine oxidase activity in mice treated with interferon and interferon inducers, Biochem. Biophys. Res. Commun. 119(1):144–149.CrossRefPubMedGoogle Scholar
  46. Ghezzi, P., Bianchi, M., Gianera, L., Landolfo, S., and Salmona, M., 1985, Role of reactive oxygen intermediates in the interferon-mediated depression of hepatic drug metabolism and protective effect of N-acetylcysteine in mice, Cancer Res. 45(8):3444–3447.PubMedGoogle Scholar
  47. Giler, S., Sperling, O., Brosh, S., Urea, I., and DeVries, A., 1975, Serum xanthine oxidase in jaundice, Clin. Chim. Acta 63:37–40.CrossRefPubMedGoogle Scholar
  48. Granger, D. N., and Korthuis, R. J., 1995, Physiologic mechanisms of postischemic tissue injury [review], Annu. Rev. Physiol. 57:311–332.PubMedGoogle Scholar
  49. Granger, D. N., Rutili, G., and McCord, J. M., 1981, Role of superoxide radicals in feline intestinalischemia, Gastroenterology 81:22–29.PubMedGoogle Scholar
  50. Grogaard, B., Parks, D. A., Granger, D. N., McCord, J. M., and Forsberg, J. O., 1982, Effects of ischemia and oxygen radicals on mucosal albumin clearance in intestine, Am. J. Physiol. 242(5):G448–454.PubMedGoogle Scholar
  51. Grootveld, M., and Halliwell, B., 1987, Measurement of allantoin and uric acid in human body fluids. A potential index of free-radicalreactionsinvivo, Biochem. J. 243:803–808.PubMedGoogle Scholar
  52. Grum, C. M., Ragsdale, R. A., Ketai, L. H., and Simon, R. H., 1991, Plasma xanthine oxidase activity in patients with adult respiratory distress syndrome, J. Crit. Care 2:22–26.Google Scholar
  53. Guerri, C., Montoliu, C., and Renau-Piqueras, J., 1994, Involvement of free radical mechanism in the toxic effects of alcohol:Implications for fetal alcohol syndrome [review], Adv. Exp. Med. & Biol. 366:291–305.Google Scholar
  54. Haddad, I. Y, Beckman, J. S., Carver, R. I., and Matalon, S., 1994, Structural and function alalterations of surfactant protein A by peroxynitrite, Chest 105(Suppl. 3):84SGoogle Scholar
  55. Hull, W. W., and Krenitsky, T. A., 1986, Aldehyde oxidase from rabbit liver: Specificity toward purines and their analogs, Arch. Biochem. Biophys. 251:36–46.Google Scholar
  56. Harkness, R. A., McCreanor, G. M., Simpson, D., and MacFadyen, I. R., 1986, Pregnancy in and incidence of xanthine oxidase deficiency, J. Inherit Metab. Dis. 9(4):407–408.PubMedGoogle Scholar
  57. Hassoun, P. M., Yu, F. S., Zulueta, J. J., White, A. C., and Lanzillo, J. J., 1995, Effect of nitric oxide and cell redoxstatus onthe regulation of endothelial cell xanthine dehydrogenase, Am. J. Physiol. 268(5Pt.1):L809–8I7.PubMedGoogle Scholar
  58. Hellsten-Westing, Y, 1993, Immunohisto chemical localization of xanthine oxidase in human cardiac and skeletal muscle, Histochemistry 100(3):215–222.CrossRefPubMedGoogle Scholar
  59. Hicks, M., Wong, L. S., and Day, R. O., 1993, Identification of products from oxidation of uric acid induced by hydroxyl radicals, Free Radical Res. Commun. 18(6):337–351.Google Scholar
  60. Hiebert, L. M., and Liu, J., 1991, Heparin protects cultured arterial endothelial cells from damage by toxic oxygen metabolites, Atherosclerosis 83:47–51.Google Scholar
  61. Hille, R., and Nishino, T, 1995, Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase [review], FASEB J. 9(11):995–1003.PubMedGoogle Scholar
  62. Hook, M., Kjellen, L., and Johansson, S., 1984, Cell-surface glycosaminoglycans, Annu. Rev. Biochem. 53:847–869.CrossRefPubMedGoogle Scholar
  63. Houde, M., Tiveron, M. C., and Bregegere, F, 1989, Divergence of the nucleotide sequences encoding xanthine dehydrogenase in Calliphora vicina and Drosophila melanogaster, Gene 85(2):391–402.CrossRefPubMedGoogle Scholar
  64. Hu, P., Ischiropoulos, H., Beckman, J. S., and Matalon, S., 1994, Peroxynitrite inhibition of oxygen consumption and sodium transport in alveolar type I I cells, Am. J. Physiol. 266(6 Pt. l):L628–634.PubMedGoogle Scholar
  65. Huie, R. E., and Padmaja, S., 1993, The reaction of NO with superoxide, Free Radical Res. Commun. 18(4):195–199.Google Scholar
  66. Ichida, K., Amaya, Y., Noda, K., Minoshima, S., Hosoya, T., Sakai, O., Shimizu, N., and Nishino, T., 1993, Cloning of the cDNA encoding human xanthine dehydrogenase (oxidase):Structural analysis of the protein and chromosomal location of the gene, Gene 133:279–284.PubMedGoogle Scholar
  67. Ichida, K., Amaya, Y., Kamatani, N., Nishino, T., Hosoya, T., and Sakai, O., 1997, Identification of two mutations in human xanthine dehydrogenase gene responsible for classical typeI xanthinuria, J. Clin. Invest. 99(10):2391–2397PubMedGoogle Scholar
  68. Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D., and Beckman, J. S., 1992, Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase, Arch. Biochem. Biophys. 298:431–437.PubMedGoogle Scholar
  69. Janssen, M., De Jong, J. W., Pasini, E., and Ferrari, R., 1993, Myocardial xanthine oxidoreductase activity in hypertensive and hypercholesterolemic rats, Cardioscience 4(1):25–29.PubMedGoogle Scholar
  70. Jarasch, E. D., Grund, C., Bruder, G., Heid, H. W., Keenan, T. W., and Franke, W. W., 1981, Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium, Cell 25(1):67–82.CrossRefPubMedGoogle Scholar
  71. Jarasch, E. D., Bruder, G., and Heid, H. W., 1986, Significance of xanthine oxidase in capillary endothelial cells, Ada Physiol. Scand. 548:39–46.Google Scholar
  72. Jenkinson, S. G., Roberts, R. J., DeLemos, R. A., Lawrence, R. A., Coalson, J. J., King, R. J., Null, D. M., Jr., and Gerstmann, D. R., 1991, Allopurinol-induced effects in premature baboons with respiratory distress syndrome, J. Appl. Physiol. 70(3):1160–1167.PubMedGoogle Scholar
  73. Kaur, H., and Halliwell, B., 1990, Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products, Chem. Biol. Interact. 73:235–247.PubMedGoogle Scholar
  74. Keith, T. P., Riley, M. A., Kreitman, M., Lewontin, R. C., Curtis, D., and Chambers, G., 1987, Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster, Genetics 116(1):67–73.PubMedGoogle Scholar
  75. Klatsky, A. L., 1995, Cardiovascular effects of alcohol, Sci. Am. Sci. Med. 2(2):28–37.Google Scholar
  76. Knights, K. M., Gourlay, G. K., and Cousins, M. J., 1987, Changes in rat hepatic microsomal mixed function oxidase activity following exposure to halothane under various oxygen concentrations, Biochem. Pharmacol. 36:897–906.CrossRefPubMedGoogle Scholar
  77. Kooij, A. 1994, A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase [review], Histochem. J. 26(12):889–915.CrossRefPubMedGoogle Scholar
  78. Kooij, A., Schiller, H. J., Schijns, M., Van Noorden, C. F. J., and Frederiks, W. M., 1994, Conversion of xanthine dehydrogenase into xanthine oxidase in rat liver and plasma at the onset of reperfusion after ischemia, Hepatology 19:1488–1495.CrossRefPubMedGoogle Scholar
  79. Krenitsky, T. A., Tuttle, J. V., Cattau, E. L., and Wang, P. A., 1974, A comparison of the distribution and electron acceptor specificities of xanthine oxidase and aldehyde oxidase, Comp. Biochem. Physiol. 49:687–703.Google Scholar
  80. Krenitsky, T. A., Spector, T., and Hall, W. W., 1986, Xanthine oxidase from human liver: Purification and characterization, Arch. Biochem. Biophys. 247:108–119.CrossRefPubMedGoogle Scholar
  81. Kurose, I., and Granger, D. N., 1994, Evidence implicating xanthine oxidase and neutrophils in reperfusion-induced microvascular dysfunction [review], Ann. N. Y. Acad. Sci. 723:158–179.PubMedGoogle Scholar
  82. Lemasters, J. J., Bunzendahl, H., and Thurman, R. G., 1995, Reperfusion injury to donorliversstored for transplantation, Liver Transplant. Surg. 1(2):124–138.CrossRefGoogle Scholar
  83. Lieber, C. S., 1994, Alcohol and the liver: 1994 update, Gastroenterology 106:1085–1105.PubMedGoogle Scholar
  84. Marubayashi, S., Dohi, K., and Kawasaki, T., 1994, Role of free radicals in hepatic reperfusion injury, Ann. N. Y. Acad. Sci. 723:368–370.PubMedGoogle Scholar
  85. McCay, P. B., Reinke, L. A., and Rau, J. M., 1992, Hydroxyl radicals are generated by hepatic microsomes during NADPH oxidation. Relationship to ethanol metabolism, Free Radical Res. Commun. 15(6):335–346Google Scholar
  86. Mendez, C., Garcia, I., and Maier, R. V., 1996, Oxidants augment endotoxin-induced activation of alveolar macrophages, Shock 6(3): 157–163.PubMedGoogle Scholar
  87. Mira, L., Maia, L., Barreira, L., and Manso, C. F., 1995, Evidence for free radical generation due to NADH oxidation by aldehyde oxidase during ethanol metabolism, Arch. Biochem. Biophys. 318:53–58.CrossRefPubMedGoogle Scholar
  88. Mishra, O. P., and Delivoria-Papadopoulos, M., 1988, Anti-oxidant enzymes in fetal guinea pig brain during development and the effect of maternal hypoxia, Brain Res. 470(2):173–179.PubMedGoogle Scholar
  89. Miyamoto, Y., Akaike, T., Yoshida, M., Goto, S., Horie, H., and Maeda, H., 1996, Potentiation of nitric oxide-mediated vasorelaxation by xanthine oxidase inhibitors, Proc. Soc. Exp. Biol. Med. 211(4):366–373.PubMedGoogle Scholar
  90. Mize, C., Johnson, J. L., and Rajagopalan, K. V., 1995, Defective molybdopterin biosynthesis: Clinical heterogeneity associated with molybdenum cofactor deficiency,. Inherit. Metab. Dis. 18(3):283–290.Google Scholar
  91. Mohacsi, A., Kozlovszky, B., Kiss, I., Seres, I., and Fulop, T., Jr., 1996, Neutrophils obtained from obliterative atherosclerotic patients exhibit enhanced resting respiratory burst and increased degranulation in response to various stimuli, Biochim. Biophys. Acta 1316(3):210–2I6.PubMedGoogle Scholar
  92. Moochhala, S. M., and Renton, K. W., 1991, A role for xanthine oxidase in the loss of cytochrome P-450 evoked by interferon, Can. J. Physiol. Pharmacol. 69(7):944–950.PubMedGoogle Scholar
  93. Moreno, J. J., and Pryor, W. A., 1992, Inactivation of alpha 1-proteinase inhibitor by peroxynitrite, Chem. Res. Toxicol. 5(3):425–431.CrossRefPubMedGoogle Scholar
  94. Moriwaki, Y., Yamamoto, T., Suda, M., Nasako, Y, Takahashi, S., Agbedana, O. E., Hada, T., and Higashino, K., 1993, Purification and immunohistochemical tissue localization of human xanthine oxidase, Biochim. Biophys. Acta 1164(3):327–330.PubMedGoogle Scholar
  95. Moss, M., Bucher, B., Moore, F. A., Moore, E. E., and Parsons, P. E., 1996, The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults, J. Am. Med. Assoc. 275(1):50–54.CrossRefGoogle Scholar
  96. Mugge, A., Brandes, R. P., Boger, R. H., Dwenger, A., Bode-Boger, S., Kienke, S., Frolich, J. C., and Lichtlen, P. R., 1994, Vascular release of superoxide radicals is enhanced in hypercholesterolemic rabbits, J. Cardiovasc. Pharmacol. 24(6):994–998.PubMedGoogle Scholar
  97. Nanji, A. A., Griniuviene, B., Sadrzadeh, S. M., Levitsky, S., and McCully, J. D., 1995, Effect of type of dietary fat and ethanol on antioxidant enzyme mRNA induction in rat liver, J. Lipid Res. 36(4):736–744.PubMedGoogle Scholar
  98. Newaz, M. A., Adeeb, N. N., Muslim, N., Razak. T. A., and Htut, N. N., 1996, Uric acid, xanthine oxidase and other risk factors of hypertension in normotensive subjects, Clin. Exp. Hypertens. 18(8): 1035–1050.PubMedGoogle Scholar
  99. Nielsen, V. G., Weinbroum, A., Tan, S., Samuelson, P. N., Gelman, S., and Parks, D. A., 1994, Xanthine oxidoreductase release after descending thoracic aorta occlusion and reperfusion in rabbits, J. Thorac. Cardiovasc. Surg. 107(5): 1222–1227.PubMedGoogle Scholar
  100. Nielsen, V. G., McCammon, A. T., Tan, S., Kirk, K. A., Samuelson, P. N., and Parks, D. A., 1995, Xanthine oxidase inactivation attenuates postocclusion shock after descending thoracic aorta occlusion and reperfusion in rabbits, J. Thorac. Cardiovasc. Surg 110(3):7l5–722.Google Scholar
  101. Nielsen, V. G., Tan, S., Weinbroum, A., McCammon, A. T, Samuelson, P. N., Gelman, S., and Parks, D. A., 1996, Lung injury after hepatoenteric ischemia-reperfusion: Role of xanthine oxidase, Am. J. Respir. Crit. Care Med. 154(5): 1364–1369.PubMedGoogle Scholar
  102. Nielsen, V. G., Tan, S., Baird, M. S., Samuelson, P. N., and Parks, D. A., 1997, Xanthine oxidase mediates myocardial injury after hepatoenteric ischemia-reperfusion, Crit. Care Med. 25(6): 1044–1050.PubMedGoogle Scholar
  103. Nordmann, R., 1994, Alcohol and antioxidant systems [review], Alcohol 29(5):513–522.Google Scholar
  104. Oda, T., Akaike, T., Hamamoto, T., Suzuki, F, Hirano, T., and Maeda, H., 1989, Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD, Science 244:974–976.PubMedGoogle Scholar
  105. Ohara, Y, Peterson, T. E., and Harrison, D. G., 1993, Hypercholesterolemia increases endothelial superoxide anion production, J. Clin. Invest. 91(6):2546–2551.PubMedGoogle Scholar
  106. Palmer, C., Vannucci, R. C., and Towfighi, J., 1990, Reduction of perinatal hypoxic-ischemic brain damage with allopurinol, Pediatr. Res. 27:332–336.PubMedGoogle Scholar
  107. Palmer, C., Towfighi, J., Roberts, R. L., and Heitjan, D. F., 1993, Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats, Pediatr. Res. 33(4 Pt. 1):405–411.PubMedGoogle Scholar
  108. Parks, D. A., and Freeman, B. A., 1987, Anesthesia and Organ Transplantation, Saunders, Philadelphia.Google Scholar
  109. Parks, D. A., and Granger, D. N., 1983, Ischemia-induced vascular changes: Role of xanthine oxidase and hydroxyl radicals, Am. J. Physiol. 245:G285–G289.PubMedGoogle Scholar
  110. Parks, D. A., and Granger, D. N., 1986a, Contributions of ischemia and reperfusion to mucosal lesion formation, Am. J. Physiol. 250:G749–G753.PubMedGoogle Scholar
  111. Parks, D. A., and Granger, D. N., 1986b, Xanthine oxidase: Biochemistry, distribution and physiology, Acta Physiol. Scand. 548:87–99.Google Scholar
  112. Parks, D. A., Bulkley, G. B., Granger, D. N., Hamilton, S. R., and McCord, J. M., 1982, Ischemic injury in the cat small intestine: Role of superoxide radicals, Gastroenterology 82:9–15.PubMedGoogle Scholar
  113. Partridge, C. A., Blumenstock, F. A., and Malik, A. B., 1992, Pulmonary microvascular endothelial cells constitutively release xanthine oxidase, Arch. Biochem. Biophys. 294:184–187.CrossRefPubMedGoogle Scholar
  114. Patetsios, P., Rodino, W., Wisselink, W., Bryan, D., Kirwin, J. D., and Panetta, T. F., 1996, Identification of uric acid in aortic aneurysms and atherosclerotic artery, Ann. N.Y. Acad. Sci. 800:243–245.PubMedGoogle Scholar
  115. Phan, S. H., Gannon, D. E., Varini, J., Ryan, U. S., and Ward, P. A., 1989, Xanthine oxidase activity in rat pulmonary artery endothelial cells and its alteration by activated neutrophils, Am. J. Pathol. 134:1201–1211.PubMedGoogle Scholar
  116. Pietz, J., Guttenberg, N., and Gluck, L, 1988, Hypoxanthine: A marker for asphyxia, Obstet. Gynecol. 72(5):762–766.PubMedGoogle Scholar
  117. Pryor, W. A., and Squadrito, G. L., 1995, The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide, Am. J. Physiol. 268(5 Pt. 1):L699–L722.PubMedGoogle Scholar
  118. Radi, R., Rubbo, H., Bush, K., and Freeman, B. A., 1997, Xanthine oxidase binding to glycosaminoglycans—Kinetics and superoxide dismutase interactions of immobilized xanthine oxidase-heparin complexes, Arch. Biochem. Biophys. 339:125–135.CrossRefPubMedGoogle Scholar
  119. Rajagopalan, K. V., Handler, P., Palmer, G., and Beinert, H., 1968, Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. I. Spectra at equilibrium states, J. Biol. Chem. 243:3784–3796.PubMedGoogle Scholar
  120. Ramboer, C., Piessens, F, and DeGroote, J., 1972, Serum xanthine oxidase and liver disease, Digestion 7:183–195.PubMedGoogle Scholar
  121. Reinke, L. A., Lai, E. K., DuBose, C. M., and McCay, P. B., 1987, Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: Correlation with radical formation in vitro, Proc. Natl. Acad. Sci. USA 84:9223–9227.PubMedGoogle Scholar
  122. Reinke, L. A., Kotake, Y., McCay, P. B., and Janzen, E. G., 1991, Spin-trapping studies of hepatic free radicals formed following the acute administration of ethanol to rats: In vivo detection of 1-hydroxyethyl radicals with PBN, Free Radical Biol. Med. 11l(1):31–39.Google Scholar
  123. Repine, J. E., Cheronis, J. C., Rodell, T. C., Unas, S. L., and Patt, A., 1987, Pulmonary oxygen toxicity and ischemia-reperfusion injury: A mechanism in common involving xanthine oxidase and neutrophils, Am. Rev. Respir. Dis. 136:483–485.PubMedGoogle Scholar
  124. Roesel, R. A., Bowyer, F, Blankenship, P. R., and Hommes, F. A., 1986, Combined xanthine and sulphite oxidase defect due to a deficiency of molybdenum cofactor, J. Inherit. Metab. Dis. 9(4):343–347.CrossRefPubMedGoogle Scholar
  125. Rosser, B. G., and Gores, G. J., 1995, Liver cell necrosis: Cellular mechanisms and clinical implications [review], Gastroenterology 108(1):252–275.CrossRefPubMedGoogle Scholar
  126. Rubbo, H., Radi, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., Kirk, M., and Freeman, B. A., 1994, Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives, J. Biol. Chem. 269:26066–26075.PubMedGoogle Scholar
  127. Rump, A. F. E., Rösen, R., and Klaus, W., 1993, Free radical scavenging properties of β-adrenoceptor blockers are not relevant for cardioprotection in isolated rabbit hearts, Naunyn Schmiedebergs Arch. Pharmakol. 348:431–434.Google Scholar
  128. Russell, G. A., and Cooke, R. W., 1995, Randomised controlled trial of allopurinol prophylaxis in very preterm infants, Arch. Dis. Child Fetal Neonatal Ed. 73(1):F27–F31.PubMedGoogle Scholar
  129. Russell, G. A., Jeffers, G., and Cooke, R. W., 1992, Plasma hypoxanthine: A marker for hypoxic-ischaemic induced periventrieular leucomalacia? Arch. Dis. Child 67(4 Spec. No.):388–392.PubMedGoogle Scholar
  130. Sackler, M. L., 1966, Xanthine oxidase from liver and duodenum of the rat: Histochemical localization and electrophoretic heterogeneity, J. Histochem. Cytochem. 14(4):326–333.PubMedGoogle Scholar
  131. Sakai, H., and Takeguchi, N., 1994, A GTP-binding protein inhibits a gastric housekeeping chloride channel via intracellular production of superoxide, J. Biol. Chem. 269:23426–23430.PubMedGoogle Scholar
  132. Sardesai, V. M., 1993, Molybdenum: An essential trace element, Nutr. Clin. Pract. 8(6):277–281.PubMedGoogle Scholar
  133. Sarnesto, A., Linder, N., and Raivio, K. O., 1996, Organ distribution and molecular forms of human xanthine dehydrogenase/xanthine oxidase protein, Lab. Invest. 74(1):48–56.PubMedGoogle Scholar
  134. Sato, A., Nishino, T., Noda, K., and Amaya, Y., 1995, The structure of chicken liver xanthine dehydrogenase. cDNA cloning and the domain structure, J. Biol. Chem. 270:2818–2826.PubMedGoogle Scholar
  135. Saxena, U., Klein, M. G., and Goldberg, I. J., 1990, Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling, J. Biol. Chem. 265:12880–12886.PubMedGoogle Scholar
  136. Schwartz, M. D., Repine, J. E., and Abraham, E., 1995, Xanthine oxidase-derived oxygen radicals increase lung cytokine expression in mice subjected to hemorrhagic shock, Am. J. Respir. Cell Mol. Biol. 12(4):434–440.PubMedGoogle Scholar
  137. Shaw, S., and Jayatilleke, E., 1990, The role of aldehyde oxidase in ethanol-induced hepatic lipid peroxidation in the rat, Biochem. J. 268(3):579–583.PubMedGoogle Scholar
  138. Shenkar, R., and Abraham, E., 1996, Plasma from hemorrhaged mice activates CREB and increases cytokine expression in lung mononuclear cells through a xanthine oxidase-dependent mechanism, Am. J. Respir. Cell Mol. Biol. 14(2):198–206.PubMedGoogle Scholar
  139. Simmonds, H. A., Reiter, S., and Nishino, T., 1995, The Metabolic Basis of Inherited Disease, 7th ed., McGraw-Hill, New York.Google Scholar
  140. Singh, N., and Aggarwal, S., 1995, The effect of active oxygen generated by xanthine/xanthine oxidase on genes and signal transduction in mouse epidermal JB6 cells, Int. J. Cancer 62(1): 107–114.PubMedGoogle Scholar
  141. Skinner, K. A., Crow, J. P., Skinner, H. B., Thompson, J. A., Chandler, R. T, and Parks, D. A., 1997, Free and protein associated nitrolyrosine formation following rat liver transplantation, Arch. Biochem. Biophys. 342(2):282–288.CrossRefPubMedGoogle Scholar
  142. Slot, H. M., Overweg-Plandsoen, W. C., Bakker, H. D., Abeling, N. G., Tamminga, P., Barth, P. G., and van Gennip, A. H., 1993, Molybdenum-cofactor deficiency: An easily missed cause of neonatal convulsions, Neuropediatrics 24:139–142.PubMedGoogle Scholar
  143. Sumimoto, K., Matsura, T, Oku, J. I., Fukuda, Y, Yamada, K., and Dohi, K., 1996, Protective effect of UW solution on postischemic injury in rat liver: Suppression of reduction in hepatic antioxidants during reperfusion, Transplantation 62(10):1391–1398.PubMedGoogle Scholar
  144. Supnet, M. C., David-Cu, R., and Walther, F. J., 1994, Plasma xanthine oxidase activity and lipid hydroperoxide levels in preterm infants, Pediatr. Res. 36(3):283–287.PubMedGoogle Scholar
  145. Swain, J., and Gutteridge, J. M., 1995, Prooxidant iron and copper, with ferroxidase and xanthine oxidase activities in human atherosclerotic material, FEBS Lett. 368(3):513–515.CrossRefPubMedGoogle Scholar
  146. Tan, C. M., Xenoyannis, S., and Feldman, R. D., 1995, Oxidant stress enhances adenylyl cyclase activation, Circ. Res. 77(4):710–717.PubMedGoogle Scholar
  147. Tan, S., Radi, R., Gaudier, F, Evans, R. A., Rivera, A., Kirk, K. A., and Parks, D. A., 1993a, Physiologic levels of uric acid inhibit xanthine oxidase in human plasma, Pediatr. Res. 34(3):303–307.Google Scholar
  148. Tan, S., Yokoyama, Y, Dickens, E., Cash, T. G., Freeman, B. A., and Parks, D. A., 1993b, Xanthine oxidase activity in the circulation of rats following hemorrhagic shock, Free Radical Biol. Med. 15(4):407–414.CrossRefGoogle Scholar
  149. Tan, S., Gelman, S., Wheat, J. K., and Parks, D. A., 1995, Circulating xanthine oxidase in human ischemia reperfusion, South. Med. J. 88(4):479–482.PubMedGoogle Scholar
  150. Tan, S., Liu, Y. Y, Nielsen, V. G., Skinner, K., Kirk, K. A., Baldwin, S. T, and Parks, D. A., 1996, Maternal infusion of antioxidants (Trolox and ascorbic acid) protects the fetal heart in rabbit fetal hypoxia, Pediatr. Res. 39(3):499–503.PubMedGoogle Scholar
  151. Tan, S., Yokoyama, Y, Nielsen, V. G., Murdock, A. D., Adams, C., and Parks, D. A., 1998, Hypoxia-reoxygenation is as damaging as ischemia-reperfusion in the rat liver, Crit. Care Med. 26:1089–1085.PubMedGoogle Scholar
  152. Terada, L. S., Dormish, J. J., Shanley, P. F, Leff, J. A., Anderson, B. O., and Repine, J. E., 1992, Circulating xanthine oxidase mediates lung neutrophil sequestration after intestinal ischemia-reperfusion, Am. J. Physiol. 263:L394–L401.PubMedGoogle Scholar
  153. Terao, M., Cazzaniga, G., Ghezzi, P., Bianchi, M., Falciani, F., Perani, P., and Garattini, E., 1992, Molecular cloning of a cDNA coding for mouse liver xanthine dehydrogenase. Regulation of its transcript by interferons in vivo, Biochem. J. 283:863–870.PubMedGoogle Scholar
  154. Toledo-Pereyra, L. H., 1991, Liver transplantation reperfusion injury. Factors in its development and avenues for treatment, Klin. Wochenschr. 69:1099–1104.CrossRefPubMedGoogle Scholar
  155. Turner, N. A., Doyle, W. A., Ventom, A.M., and Bray, R. C., 1995, Properties of rabbit liver aldehyde oxidase and the relationship of the enzyme to xanthine oxidase and dehydrogenase, Eur. J. Biochem. 232(2):646–657.CrossRefPubMedGoogle Scholar
  156. van der Vliet, A., Smith, D., O’Neill, C. A., Kaur, H., Darley-Usmar, V., Cross, C. E., and Halliwell, B., 1994, Interactions of peroxynitrite with human plasma and its constituents: Oxidative damage and antioxidant depletion, Biochem. J. 303(Pt. 1):295–301.PubMedGoogle Scholar
  157. Vettenranta, K., and Raivio, K. O., 1990, Xanthine oxidase during human fetal development, Pediatr. Res. 27(3):286–288.PubMedGoogle Scholar
  158. Wang, J. F., Greenberg, S. S., and Spitzer, J. J., 1995, Chronic alcohol administration stimulates nitric oxide formation in the rat liver with or without pretreatment by lipopolysaccharide. Alcoholism Clin. Exp. Res. 19(2):387–393.Google Scholar
  159. Weinbroum, A., Nielsen, V. G., Tan, S., Skinner, K. A., Gelman, S., Matalon, S., Bradley, E., and Parks, D. A., 1995, Liver ischemia-reperfusion increases pulmonary permeability in the rat: Role of circulating xanthine oxidase, Am. J. Physiol. 268(6):G988–G996.PubMedGoogle Scholar
  160. Weiner, F. R., Esposti, S. D., and Zern, M. A., 1994, The Liver: Biology and Pathobiology, 3rd ed., Raven Press, New York.Google Scholar
  161. Wesson, D. E., and Elliott, S. J., 1994, Xanthine oxidase inhibits transmembrane signal transduction in vascular endothelial cells, J. Pharmacol. Exp. Ther. 270(3):1197–1207.PubMedGoogle Scholar
  162. White, C. R., Darley-Usmar, V, Berrington, W. R., McAdams, M., Thompson, J. A., Parks, D. A., Tarpey, M. M., and Freeman, B. A.. 1996, Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits, Proc. Natl. Acad. Sci. USA 93:8745–8749.PubMedGoogle Scholar
  163. Wiezorek, J. S., Brown, D. H., Kupperman, D. E., and Brass, C. A., 1994, Rapid conversion to high xanthine oxidase activity in viable Kupffer cells during hypoxia, J. Clin. Invest. 94(6):2224–2230.PubMedGoogle Scholar
  164. Winkler, C., Tan, S., Wheat, J. K., and Parks, D. A., 1990, Xanthine oxidase activity in human fetal tissues, Pediatr. Res. 27(4):231A.Google Scholar
  165. Wood, R. P., Shaw, B. W., Jr., and Starzl, T. E., 1985, Extrahepatic complications of liver transplantation, Semin. Liver Dis. 5:377–384.PubMedGoogle Scholar
  166. Wright, R. M., Vaitaitis, G. M., Wilson, C. M., Repine, T. B., Terada, L. S., and Repine, J. E., 1993, cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase, Proc. Natl. Acad. Sci. USA 90:10690–10694.PubMedGoogle Scholar
  167. Wright, R. M., Vaitaitis, G. M., Weigel, L. K., Repine, T. B., McManaman, J. L., and Repine, J. E. 1995, Identification of the candidate ALS2 gene at chromosome 2q33 as a human aldehyde oxidase gene, Redox Rep. 1:313–321.Google Scholar
  168. Wu, X., Lee, C. C., Muzny, D. M., and Caskey, C. T, 1989, Urate oxidase: Primary structure and evolutionary implications, Proc. Natl. Acad. Sci. USA 86:9412–9416.PubMedGoogle Scholar
  169. Yokoyama, Y, Beckman, J. S., Beckman, T. K., Wheat, J. K., Cash, T. G., Freeman, B. A., and Parks, D. A., 1990, Circulating xanthine oxidase: Potential mediator of ischemic injury, Am. J. Physiol. 258:G564–G570.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Dale A. Parks
    • 1
  • Kelly A. Skinner
    • 1
  • Sidhartha Tan
    • 1
  • Henry B. Skinner
    • 1
  1. 1.Department of AnesthesiologyUniversity of Alabama at BirminghamBirmingham

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