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Ganoderma and Health pp 201–215Cite as

Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Diabetes

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1182))

Abstract

As extracts from Ganoderma lucidum (G. lucidum, Lingzhi) have been reported to be an alternative adjuvant treatment for diabetes, numerous of work have been carried out on it. Among the many biologically active constituents of Ganoderma, polysaccharides, proteoglycans, proteins, and triterpenoids have been shown to have hypoglycemic effects. Based on our research and other references, this article discusses the antidiabetic effect of Ganoderma mediated by protecting pancreas islet; inhibiting protein tyrosine phosphatase 1B, a promising therapeutic target of diabetes; decreasing lymphocyte infiltration; and increasing the antibody detection of insulin in diabetic mice. This review summarizes researches about the hypoglycemic action effects of polysaccharides, proteoglycans, proteins, and triterpenoids from Ganoderma as a guide for future research on diabetes and its complications. In addition, clinical studies with diabetic indexes are reviewed.

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Author information

Authors and Affiliations

  1. State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Qian Liu & Lu Tie

  2. Beijing Key Laboratory of Tumor Systems Biology, Peking University, Beijing, China

    Qian Liu & Lu Tie

Authors
  1. Qian Liu
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  2. Lu Tie
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Correspondence to Lu Tie .

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Editors and Affiliations

  1. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Zhibin Lin

  2. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Baoxue Yang

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Liu, Q., Tie, L. (2019). Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Diabetes. In: Lin, Z., Yang, B. (eds) Ganoderma and Health. Advances in Experimental Medicine and Biology, vol 1182. Springer, Singapore. https://doi.org/10.1007/978-981-32-9421-9_8

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