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Antitumor Effect of Ganoderma (Lingzhi) Mediated by Immunological Mechanism and Its Clinical Application

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Book cover Ganoderma and Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1182))

Abstract

The antitumor effect of Ganoderma (Lingzhi) is closely related to immunoregulation. Based on our research and other references, this article discussed the antitumor effect of Ganoderma mediated by immunological mechanism, including promoting the function of mononuclear-macrophages and natural killers; promoting M1-type macrophage polarization vs M2-type; promoting maturation and differentiation of dendritic cells, increasing its antigen presentation, activating lymphocytes and increasing cytotoxicity of cytotoxin T lymphocyte; promoting production of cytokines; and inhibiting tumor escape from immune surveillance. Also, clinical studies with immunological indexes were reviewed.

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Authors and Affiliations

  1. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Zhibin Lin

  2. Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China

    Lixin Sun

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  1. Zhibin Lin
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  2. Lixin Sun
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  1. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Zhibin Lin

  2. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China

    Baoxue Yang

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Lin, Z., Sun, L. (2019). Antitumor Effect of Ganoderma (Lingzhi) Mediated by Immunological Mechanism and Its Clinical Application. In: Lin, Z., Yang, B. (eds) Ganoderma and Health. Advances in Experimental Medicine and Biology, vol 1182. Springer, Singapore. https://doi.org/10.1007/978-981-32-9421-9_2

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