Abstract
Overexpression of fibrous tissue results in formation of hypertrophic scars and keloids. Normal apoptosis of fibroblasts is lacking in such abnormal scars. Chest wall scars and scars crossing the joints have more chances to be hypertrophic. This also leads to joint contractures.
These scars can be managed by pressure garments, pressure bandages, local application of silicone gel material and certain local creams. Steroid injections, 5-fluorouracil injection help in regression of keloids.
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References
Tanaka A, Hatoko M, Tada H, et al. Expression of p53 family in scars. J Dermatol Sci 2004;34:303–304.
Ladin DA, Hou Z, Patel D, et al. p53 and apoptosis alteration in keloid and keloid fibroblast. Wound Repair Regen. 1998;6:28–37.
Nilsson GE. Measurements of water exchange through skin. Med Biol Eng Comput. 1977;15:209–18.
Sawada Y, Sone K. Hydration and occlusion treatment for hypertrophic scars and keloids. Br J Plast Surg. 1992;45:599–603.
Vet Med. 2012;57(6):287–92.
J Clin Asthet Dermatol. 2012;5(6):18–24.
J Drugs Dermatol. 2012;11(1):74–81.
Wiseman, et al. Trials. 2017;18:72. J Cutan Aesthet Surg 2009;2(2):104-106.
J Cutan Aesthet Surg. 2009;2(2):104–6.
Tang HL, KSR L, Ing T. BMJ Case Rep. 2015;2015
Cohen JK, Diegelmann RF. The biology of keloid and hypertrophic scar and the influence of corticosteroids. Clin Plast Surg. 1977;4:297–9.
Sclafani AP, Gordon L, Chadha M, et al. Prevention of earlobe keloid recurrence with postoperative corticosteroid injection versus radiation therapy: a randomized, prospective study and review of the literature. Dermatol Surg. 1996;22:569–74.
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Vachhrajani, V., Khakhkhar, P. (2020). Hypertrophic Scars and Keloids. In: Science of Wound Healing and Dressing Materials. Springer, Singapore. https://doi.org/10.1007/978-981-32-9236-9_12
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DOI: https://doi.org/10.1007/978-981-32-9236-9_12
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