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Can Autophagy Stop the Clock: Unravelling the Mystery in Dictyostelium discoideum

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Abstract

Autophagy is a major catabolic process in eukaryotes that helps to degrade and recycle macromolecules and organelles. Recent findings show inhibition of nutrient or growth-related signaling pathways or anti-aging pathways mediates lifespan extensions via autophagy. In the present communication, we have emphasized on the lower eukaryotic model organism Dictyostelium discoideum to study longevity and compared it to other model organisms, which uses autophagy as a major mechanism for increasing lifespan. We observed that both genetic and pharmacological manipulations on the nutrient-signaling pathway increased autophagy-mediated cell survival.

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Acknowledgements

SS would like to thanks Indian Council of Medical Research, India, (54/41/CFP/GER/2011-NCD-II) and University Grants Commission, India (42-181/2013-SR), for the research grants. PS thanks UGC for JRF and PJ thanks DST for the INSPIRE fellowship.

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  1. Authors Priyanka Sharma and Punita Jain have equally contributed to this chapter

Authors and Affiliations

  1. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

    Priyanka Sharma, Punita Jain & Shweta Saran

  2. Department of Zoology, University of Delhi, New Delhi, India

    Punita Jain & Anju Shrivastava

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  1. Priyanka Sharma
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    Pramod C. Rath

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Sharma, P., Jain, P., Shrivastava, A., Saran, S. (2020). Can Autophagy Stop the Clock: Unravelling the Mystery in Dictyostelium discoideum. In: Rath, P. (eds) Models, Molecules and Mechanisms in Biogerontology. Springer, Singapore. https://doi.org/10.1007/978-981-32-9005-1_13

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