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Lipid-Modifying Drugs: Pharmacology and Perspectives

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Coronary Artery Disease: Therapeutics and Drug Discovery

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1177))

Abstract

Coronary artery disease (CAD) is one of the leading causes of death worldwide. It is well known that dyslipidemia is a major pathogenic risk factor for atherosclerosis and CAD, which results in cardiac ischemic injury and myocardial infarction. Lipid-modifying drugs can effectively improve lipid abnormalities including reducing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) or increasing high-density lipoprotein cholesterol (HDL-C), and eventually decrease the incidence of cardiovascular events. This chapter will review basic principles of lipid metabolism and focus on the therapeutic strategies of lipids modifying drugs (statins, proprotein convertase subtilisin/kexin type 9 inhibitors, ezetimibe, niacin, polyunsaturated fatty acids, and so on) in patients with arteriosclerotic cardiovascular disease. Meanwhile, the challenges and perspectives of the lipid-lowering agents currently in clinical practice as well as their limitations will be outlined.

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  1. Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing, 100037, China

    Rui-Xia Xu & Yong-Jian Wu

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  1. Rui-Xia Xu
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Correspondence to Yong-Jian Wu .

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  1. Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Miao Wang

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Xu, RX., Wu, YJ. (2020). Lipid-Modifying Drugs: Pharmacology and Perspectives. In: Wang, M. (eds) Coronary Artery Disease: Therapeutics and Drug Discovery. Advances in Experimental Medicine and Biology, vol 1177. Springer, Singapore. https://doi.org/10.1007/978-981-15-2517-9_5

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