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Theranostics Approaches to Gastric and Colon Cancer pp 29–48Cite as

Adiponectin Signaling in Colorectal Cancer

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Part of the book series: Diagnostics and Therapeutic Advances in GI Malignancies ((DTAGIM))

Abstract

Colorectal cancer (CRC) is an obesity-correlated malignancy. Obesity leads to dysregulation of adipocytokines. The adiponectin is an adipokine, secreted by adipose tissue, plays an essential role in energy metabolism, anti-inflammatory and insulin sensitizing properties. Besides this it also possess anti-neoplastic properties including promotion of apoptosis and inhibition of differentiation and progression of tumor cells. Adiponectin in serum/plasma level always depend on physical activity, diet and inheritance. High concentration of adiponectin are observed to play a crucial role in inhibiting tumor growth, which is also evidenced from the EPIC study where lower adiponectin circulation are at higher risk of cancer including CRC. Thus these results suggest an epidemiological link existing between obesity and cancer in association with adiponectin, playing its crucial role. Even though there are several studies reported in regard of CRC, the results with anti-cancerous property of adiponectin are still inconsistent. Adiponectin has numerous systemic effects that regulates homeostasis and constantly exists in high concentration. However, from the epidemological studies it was reported that low concentration of adiponectin are always at higher risk for CRC. The present article includes molecular evidence with a prominence on the regulation of adiponectin signalling pathways and their crosstalk with other signalling pathways in relation to CRC progression and provides several therapeutic future perspectives for the crucial role of adiponectin, aiming it as a target for the prevention of CRC.

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Abbreviations

5-FU:

Fluorouracil

Acrp30:

Adipocyte complement related protein 30

ADP 355:

Adenosine di phosphate

Akt:

Protein kinase B

AMPK:

Adenosine monophosphate Activated protein-kinase

BMI:

Body mass index

CRC:

Colorectal cancer

DFS:

Disease free survival

EGFR:

Epidermal growth factor receptor

EPIC:

European prospective investigation into cancer and nutrition study

ERK:

Extracellular signal—regulated kinase

FAS:

Fatty acid synthase

GBP28:

Gelatin binding protein

IGF-1:

Insulin—like growth factor

IGFBP-1:

Insulin like growth factor binding protein-1

IL:

Interleukin

mTOR:

Mammalian target of rapamycin

NF-κB:

Nuclear factor kappa B cells

OS:

Overall survival

PCI-1:

Plasminogen activator inhibitor-1

PI3K:

Phosphadidylinositol-3-kinase

PPARγ:

Peroxisome proliferator activated receptor γ

SIRT1:

Sirtulin (Silent mating type information regulation 2 homolog) 1

STAT3:

Signal transducer and activator of transcription

TNF-α:

Tumour necrosis factor

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Department of Bioscience and Biotechnology, Banasthali University, Vanasthali, Rajasthan, India

    Gowru Srivani, Begum Dariya & Afroz Alam

  2. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Ganji Purnachandra Nagaraju

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  1. Gowru Srivani
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  2. Begum Dariya
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  1. Department of Energy and Materials Engineering, Dongguk University-Seoul, Jung-gu, Seoul, Korea (Republic of)

    Ganji Seeta Rama Raju

  2. Guru Ghasidas University, Bilaspur, Chhattisgarh, India

    L.V.K.S. Bhaskar

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Srivani, G., Dariya, B., Nagaraju, G.P., Alam, A. (2020). Adiponectin Signaling in Colorectal Cancer. In: Raju, G., Bhaskar, L. (eds) Theranostics Approaches to Gastric and Colon Cancer. Diagnostics and Therapeutic Advances in GI Malignancies. Springer, Singapore. https://doi.org/10.1007/978-981-15-2017-4_2

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