Abstract
Oral diseases such as dental caries, lichen planus, oral cancer, and most importantly chronic periodontitis are also believed to be linked to oxidative stress. In periodontitis, the incessant presence of inflammation releases free radicals and via various mechanisms such as DNA damage, lipid peroxidation, protein damage, oxidation of antiproteases, and release of pro-inflammatory cytokines causes free radical-induced damage. The role of free radicals in carcinogenesis has been studied for many decades. The free radicals cause DNA alterations such as mutations, DNA-based oxidation, mutation of tumor suppressor genes, and oxidative protein damage which facilitate the development of oral cancer. The inflammatory infiltrate present in oral lichen planus has CD4+ lymphocytes and is a source of reactive oxygen species which causes cellular damage. Moreover, the saliva itself has an antioxidant system which prevents free radical-mediated damage in certain oral diseases. Hence this chapter is intended to provide an insight about oxidative stress and its association with various oral diseases.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kumar J, Teoh SL, Das S, Mahakknaukrauh P (2017) Oxidative stress in oral diseases: understanding its relation with other systemic diseases. Front Physiol 8:693. https://doi.org/10.3389/fphys.2017.00693
Katakwar P, Metgud R, Naik S, Mittal R (2016) Oxidative stress marker in oral cancer: a review. J Cancer Res Ther 12:438–446
Nazir MA (2017) Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim) 11(2):72–80
Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ, Marcenes W (2014) Global burden of severe periodontitis in 1990–2010: a systematic review and meta-regression. J Dent Res 93(11):1045–1053
Shiau HJ(2018) Periodontal disease in women and men. Curr Oral Health Rep 5:250. https://doi.org/10.1007/s40496-018-0195-x
Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ (2012) Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res 91(10):914–920. Represents one of the first national epidemiological surveys utilizing full mouth periodontal examination protocol
Nava-Villalba M, González-Pérez G, Liñan-Fernández M, Marco T-C (2013) Oxidative stress in periodontal disease and oral cancer, oxidative stress and chronic degenerative diseases - a role for antioxidants. IntechOpen, Rijeka, Croatia. https://doi.org/10.5772/52492
Novak JM, Novak KF (2006) Chronic periodontitis. In: Carranza FA (ed) Clinical periodontology. Saunders Elsevier, Philadelphia, pp 494–499
Fiorellini JP, Ishikawa SO, Kim DM (2006) Gingival inflammation. In: Carranza FA (ed) Clinical periodontology. Elsevier Saunders, Philadelphia, pp 355–361
Kinane DF, Lappin DF (2002) Immune processes in periodontal disease: a review. Ann Periodontol 7:62–71
Ding Y, Uitto V-J, Firth J et al (1995) Modulation of host matrix metalloproteinases by bacterial viruelence factors relevant in human periodontal diseases. Oral Dis 1:279–286
Waddington RJ, Moseley R, Embery G (2000) Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases. Oral Dis 6:138–151
Halliwell B, Gutteridge JMC, Cross CE (1992) Free radicals, antioxidants and human disease: where are we now? J Clin Lab Med 119:598–620
Babior BM, Kipnes RS, Curnutte JT (1973) The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest 52:741–744
Key LL, Wolf WC, Gundberg CM et al (1994) Superoxide and bone resorption. Bone 15:431–436
Gabig TG, Bearman SI, Babior BM (1979) Effects of oxygen tension and pH on the respiratory burst of human neutrophils. Blood 53:1133–1139
Mortazavi H, Baharvand M, Mehdipour M (2014) Oral potentially malignant disorders: an overview of more than 20 entities. J Dent Res Dent Clin Dent Prospects 8(1):6–14. https://doi.org/10.5681/joddd.2014.002
Czerninski R, Zeituni S, Maly A, Basile J (2015) Clinical characteristics of lichen and dysplasia vs. lichen planus cases and dysplasia cases. Oral Dis 21(4):478–560
Batu S, Ofluoglu D, Ergun S, Warnakulasuriya S, Uslu E, Güven Y, Tanyeri H (2016) Evaluation of prolidase activity and oxidative stress in patients with oral lichen planus and oral lichenoid contact reactions. J Oral Pathol Med 45(4):281–288
Li XR, Guo J, Li XM (2015) The expression and changes of apoptosis protein BCL-2 and BAX in oral lichen planus. Shanghai Kou Qiang Yi Xue 24(4):465–469
Darczuk D, Krzysciak W, Vyhouskaya P, Kesek B, Galecka-Wanatowicz D, Lipska W, Kacczmarzyk T, Gluch-Lutwin M, Mordyl B, Chomyszyn-Gajewska M (2016) Salivary oxidative status in patients with oral lichen planus. J Physiol Pharmacol 67(6):885–894
Warnakulasuriya S, Johnson NW, van der Waal I (2007) Nomenclature and classification of potential malignant disorders of the oral mucosa. J Oral Pathol Med 36(10):575–580
Petti S (2003) Pooled estimate of world leukoplakia prevalence: a systematic review. Oral Oncol 39(8):770–780
Vlková B, Stanko P, Minà rik G, Tòthovà L, Szemes T, Bañasovà L, Novotnáková D, Hodosy J, Celec P (2012) Salivary markers of oxidative stress in patients with oral premalignant lesions. Arch Oral Biol 57(12):1651–1656
Senghore T, Li YF, Sung FC, Tsai MH, Hua CH, Liu CS, Huang RJ, Yeh CC (2018) Biomarkers of oxidative stress associated with the risk of potentially malignant oral disorders. Anticancer Res 38(9):5211–5216. https://doi.org/10.21873/anticanres.12844
Nayyar AS, Khan M, Ahmed I, Vijayalakshmi KR, Anitha M, Chendil V (2012) Changing biochemical markers and ongoing process of transformation pilot study. Int J Phys Math Sci 2:164–173
Epstein J, Elad S (2015) Oral and oropharyngeal cancer. In: Glick M (ed) Burket’s oral medicine. PMPH-USA, Shelton, CT, pp 173–199
Shetti N, Patil R (2011) Antioxidants: its beneficial role against health damaging free radical. World J Sci Technol 1:46–51
Poulsen HE, Prieme H, Loft S (1998) Role of oxidative DNA damage in cancer initiation and promotion. Eur J Cancer Prev 7:9–16
Trueba GP, Sánchez GM, Giuliani A (2004) Oxygen free radical and antioxidant defence mechanism in cancer. Front Biosci 9:2029–2044
Maulik N (2002) Redox signaling of angiogenesis. Antioxid Redox Signal 4:805–815
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Subramanian, A.K., Narayan, V., Navaneethan, R. (2020). Oxidative Stress and Oral Diseases. In: Maurya, P., Dua, K. (eds) Role of Oxidative Stress in Pathophysiology of Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-15-1568-2_1
Download citation
DOI: https://doi.org/10.1007/978-981-15-1568-2_1
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-1567-5
Online ISBN: 978-981-15-1568-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)