Abstract
It should be recalled that the creation, control, and use of nano-scale structures, devices, and systems is the domain of nanotechnology and bionanotechnology deals with the diagnostic, therapeutic, and clinical applications of nanotechnology in biomedical, bioscience, and any subunit of health care for that matter. A key stage in health care is diagnosis as timely diagnosis can lead to the higher effectiveness of disease treatment, thus giving more positive outcomes and curtailed total costs. New technologies are necessary to speed the diagnostic processes and help the clinicians and scientists in the initiation of targeted treatments and in the monitoring of treatment responses. An important objective of medicine now is to exploit initial accomplishments and combining them with available technologies to identify the earliest signatures of fatal conditions, allowing us to provide immediate and specific interventions and monitor the condition progresses before chronic inflammation and malignancy happen. The improvement of diagnostic technologies can be supported by bionanotechnology, as a result of unique mechanical, chemical, electrical, and optical properties at nano-scale. Immediate benefits to the users can be presented by the development and use of tools in diagnostic field. The technologies of 1–100 nm size can assist in sensing or visualizing interactions with receptors, specific organelles, cytoskeletons, and nuclear components within the cells. They are expected to be able to migrate into monitoring the health condition by means of non-invasive methods in vivo. The growth in nanotechnology assists us in differentiating between abnormal and normal cells and detecting and quantifying minor amounts of signature molecules produced by the cells [1].
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Papazoglou ES, Parthasarathy A. Bionanotechnology. Morgan & Claypool; 2007.
Moghimi SM, Hunter AC, Murray JC. Nanomedicine: current status and future prospects. FASEB J. 2005;19:311–30. https://doi.org/10.1096/fj.04-2747rev.
Hayes ME, et al. Genospheres: self-assembling nucleic acid-lipid nanoparticles suitable for targeted gene delivery. Gene Therapy. 2005; 13: 646. doi:https://doi.org/10.1038/sj.gt.3302699.
Cloninger MJ. Biological applications of dendrimers. Curr Opin Chem Biol. 2002;6:742–8. https://doi.org/10.1016/S1367-5931(02)00400-3.
Vercoutere W, et al. Rapid discrimination among individual DNA hairpin molecules at single-nucleotide resolution using an ion channel. Nat Biotechnol. 2001; 19, 248, doi:https://doi.org/10.1038/85696.
Wang S, Zhao Z, Haque F, Guo P. Engineering of protein nanopores for sequencing, chemical or protein sensing and disease diagnosis. Curr Opin Biotechnol. 2018;51:80–9. https://doi.org/10.1016/j.copbio.2017.11.006.
Thomas H, et al. Nanopore sequencing as a rapidly deployable Ebola outbreak tool. Emerg Infect Dis J. 2016; 22, 331, doi:https://doi.org/10.3201/eid2202.151796.
Ashton PM, et al. MinION nanopore sequencing identifies the position and structure of a bacterial antibiotic resistance island. Nat Biotechnol. 2014; 33: 296. doi:https://doi.org/10.1038/nbt.3103.
Garalde DR, et al. Highly parallel direct RNA sequencing on an array of nanopores. Nat Methods. 2018; 15, 201. doi:https://doi.org/10.1038/nmeth.4577.
Wongsurawat T, et al. Rapid sequencing of multiple RNA viruses in their native form. Front Microbiol. 2019; 10: 260. doi:https://doi.org/10.3389/fmicb.2019.00260.
Chen M, McDaniel JR, Mackay JA, Chilkoti A. Nanoscale self-assembly for delivery of therapeutics and imaging agents. Technol Innov. 2011;13:5–25. https://doi.org/10.3727/194982411X13003853539948.
Allen M, et al. Paramagnetic viral nanoparticles as potential high-relaxivity magnetic resonance contrast agents. Mgn Reson Med. 2005; 54: 807–12. doi:https://doi.org/10.1002/mrm.20614.
Bhushan B. Encyclopedia of nanotechnology, 2012.
McLoughlin KS. Microarrays for pathogen detection and analysis. Brief Funct Genomics. 2011;10:342–53. https://doi.org/10.1093/bfgp/elr027.
Chen H, Li J. In Jang B. Rampal (ed) Microarrays: volume 1: synthesis methods. Humana Press, 2007. 411–436.
Huang D, Patel K, Perez-Garrido S, Marshall JF, Palma M. DNA origami Nanoarrays for multivalent investigations of Cancer cell spreading with Nanoscale spatial resolution and single-molecule control. ACS Nano. 2019;13:728–36. https://doi.org/10.1021/acsnano.8b08010.
Han M, Gao X, Su JZ, Nie S. Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat Biotechnol. 2001;19:631–5. https://doi.org/10.1038/90228.
Medintz IL, Uyeda HT, Goldman ER, Mattoussi H. Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater. 2005;4:435–46. https://doi.org/10.1038/nmat1390.
Mitchell P. Turning the spotlight on cellular imaging. Nat Biotechnol. 2001;19:1013–7. https://doi.org/10.1038/nbt1101-1013.
Michalet X, et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science. 2005; 307, 538–544. doi:https://doi.org/10.1126/science.1104274.
Jaiswal JK, Simon SM. Potentials and pitfalls of fluorescent quantum dots for biological imaging. Trends Cell Biol. 2004;14:497–504. https://doi.org/10.1016/j.tcb.2004.07.012.
Lee CC, MacKay JA, Fréchet JMJ, Szoka FC. Designing dendrimers for biological applications. Nat Biotechnol. 2005;23:1517–26. https://doi.org/10.1038/nbt1171.
Yang H, Kao W. J. Dendrimers for pharmaceutical and biomedical applications. Journal of biomaterials science. Polymer Edition. 2006;17:3–19. https://doi.org/10.1163/156856206774879171.
Yan G-P, Hu B, Liu M-L, Li L-Y. Synthesis and evaluation of gadolinium complexes based on PAMAM as MRI contrast agents. J Pharm Pharmacol. 2005;57:351–7. https://doi.org/10.1211/0022357055506.
Chen Z, et al. The advances of carbon nanotubes in Cancer diagnostics and therapeutics. J Nanomater. 2017, 2017:13. https://doi.org/10.1155/2017/3418932.
Avti PK, et al. Detection, mapping, and quantification of single walled carbon nanotubes in histological specimens with photoacoustic microscopy. PloS One. 2012; 7, e35064, doi:https://doi.org/10.1371/journal.pone.0035064.
Perez JM, Josephson L, Weissleder R. Use of magnetic nanoparticles as nanosensors to probe for molecular interactions. Chem Bio Chem. 2004;5:261–4. https://doi.org/10.1002/cbic.200300730.
Bogdanov A, Matuszewski L, Bremer C, Petrovsky A, Weissleder R. Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets. Mol Imaging. 2002;1:153. https://doi.org/10.1162/15353500200200001.
Anzai Y. Superparamagnetic Iron oxide nanoparticles: nodal metastases and beyond. Top Magn Reson Imaging. 2004;15:103–11. https://doi.org/10.1097/01.rmr.0000130602.65243.87.
Harisinghani MG, et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med. 2003; 348: 2491–9. doi:https://doi.org/10.1056/NEJMoa022749.
Lee H, et al. High-performance nanogap electrode-based impedimetric sensor for direct DNA assays. Biosens Bioelectr. 2018; 118: 153–9, doi:https://doi.org/10.1016/j.bios.2018.07.050.
Hartung G, et al. Phase I trial of methotrexate-albumin in a weekly intravenous bolus regimen in Cancer patients. Clin Cancer Res. 1999;5:753–9.
Kim J-G, et al. Development and characterization of a glucagon-like peptide 1-albumin conjugate. the ability to activate the glucagon-like peptide 1 receptor in vivo. 2003; 52:751–9. doi:https://doi.org/10.2337/diabetes.52.3.751.
Kratz F. Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. J Control Release. 2008;132:171–83. https://doi.org/10.1016/j.jconrel.2008.05.010.
Mao W, et al. EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer. Cancer Res. 2004; 64: 781–8. doi:https://doi.org/10.1158/0008-5472.can-03-1047.
Cattel L, Ceruti M, Dosio F. From conventional to Stealth liposomes: a new frontier in Cancer chemotherapy. J Chemother. 2004;16:94–7. https://doi.org/10.1179/joc.2004.16.Supplement-1.94.
Santoro A, et al. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX™/Doxil®) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann Oncol. 2004; 15: 440–9. doi:https://doi.org/10.1093/annonc/mdh097.
Mastrobattista E, Koning GA, Storm G. Immunoliposomes for the targeted delivery of antitumor drugs. Adv Drug Deliv Rev. 1999;40:103–27. https://doi.org/10.1016/S0169-409X(99)00043-5.
Discher DE, Ahmed F. Polymersomes. Annu Rev Biomed Eng. 2006;8:323–41. https://doi.org/10.1146/annurev.bioeng.8.061505.095838.
Peppas NA, Hilt JZ, Khademhosseini A, Langer R. Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv Mater. 2006;18:1345–60. https://doi.org/10.1002/adma.200501612.
Brewster ME, Loftsson T. Cyclodextrins as pharmaceutical solubilizers. Adv Drug Deliv Rev. 2007;59:645–66. https://doi.org/10.1016/j.addr.2007.05.012.
Choucha Snouber L, et al. Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips. Toxicol Sci. 2012; 132: 8–20. doi:https://doi.org/10.1093/toxsci/kfs230.
Hirsch LR, et al. Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci U S A. 2003; 100: 13549–54. doi:https://doi.org/10.1073/pnas.2232479100.
Saito R, et al. Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain. Exp Neurol. 2005; 196: 381–9. doi:10.1016/j.expneurol.2005.08.016.
Tsourkas A, et al. In vivo imaging of activated endothelium using an anti-VCAM-1 magnetooptical probe. Bioconjug Chem. 2005; 16: 576–81. doi:https://doi.org/10.1021/bc050002e.
Stendahl J. C. & Sinusas, A. J. nanoparticles for cardiovascular imaging and therapeutic delivery, part 1: compositions and features. Journal of nuclear medicine: official publication. Society of Nuclear Medicine. 2015;56:1469–75. https://doi.org/10.2967/jnumed.115.160994.
Jeong W-J, et al. Peptide-nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms? Nano Convergence. 2018; 5: 38. doi:https://doi.org/10.1186/s40580-018-0170-1.
Fan Z, et al. Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy. Nat Commun. 2018; 9: 2605. doi:https://doi.org/10.1038/s41467-018-04763-y.
Fan Z, Sun L, Huang Y, Wang Y, Zhang M. Bioinspired fluorescent dipeptide nanoparticles for targeted cancer cell imaging and real-time monitoring of drug release. Nat Nanotechnol. 2016;11:388–94. https://doi.org/10.1038/nnano.2015.312.
Zhu J, Fu F, Xiong Z, Shen M, Shi X. Dendrimer-entrapped gold nanoparticles modified with RGD peptide and alpha-tocopheryl succinate enable targeted theranostics of cancer cells. Colloids Surf B: Biointerfaces. 2015;133:36–42. https://doi.org/10.1016/j.colsurfb.2015.05.040.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Lee, YC., Moon, JY. (2020). Bionanotechnology in Medicine. In: Introduction to Bionanotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-15-1293-3_8
Download citation
DOI: https://doi.org/10.1007/978-981-15-1293-3_8
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-1292-6
Online ISBN: 978-981-15-1293-3
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)