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Biocompatible Thermoresponsive Polymers: Property and Synthesis

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Advances in Sustainable Polymers

Part of the book series: Materials Horizons: From Nature to Nanomaterials ((MHFNN))

Abstract

Thermoresponsive polymers are responsive to slight changes in temperatures. In many cases, particularly with N-isopropylacrylamide group as repeating unit, the temperature at which the change takes place falls in physiological range. Hence, such polymers can be used for biological applications, even though biocompatibility is major issue in many cases. There is no universal solution to this; however, copolymerization is one strategy to address the issue. Choice of polymerization process also emerges as critical standpoint in several cases. In this chapter, such issues have been discussed with special emphasis on lower critical solution temperature (LCST) of most polymers. In certain cases, polymers with upper critical solution temperature (UCST) have been described briefly. Finally, the description along with schematic representation of preparation of various biocompatible thermoresponsive polymers using various controlled living radical polymerization techniques has been presented with references (total 86 references).

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Abbreviations

PVCa:

poly(n-vinyl caprolactam)

PMVE:

poly(methyl vinyl ether)

PEtOx:

poly(n-ethyl oxazoline)

CLRP:

controlled living radical polymerization

ATRP:

atom transfer radical polymerization

RAFT:

reversible addition-fragmentation chain transfer polymerization

NMP:

nitroxide mediated polymerization

LCST:

lower critical solution temperature

UCST:

upper critical solution temperature

PDI:

polydispersity index

NIPAM/NIPAAm/NIPAm/NIPAAM :

N-isopropylacrylamide

PNIPAM/PNIPAAm/ PNIPAm/PNIPAAM :

poly(n-isopropylacrylamide)

PLL:

poly(l-lysine)

VP:

vinyl pyridine

PAM:

polyacrylamide

PHB:

poly[(r)-3-hydroxybutyrate]

HMTETA:

hexamethyltriethylenetetramine

PS:

polystyrene

EBiB:

ethyl 2-bromoisobutyrate

DCM:

dichloromethane

DMF:

n,n-dimethylformamide

PEG:

polyethylene glycol

PCL:

polycaprolactone

PCLDMA:

polycaprolactonedimethacrylate

Me6TREN:

tris [2-(dimethylamino)ethyl]amine

DMSO:

dimethyl sulfoxide

PPO:

poly(propylene oxide)

MPC:

2-methacryloyloxyethylphosphorylcholine

PMPC:

poly(2-methacryloyloxyethylphosphorylcholine)

bpy:

2,2’-bipyridine

Me4Cyclam:

1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane

TsOH:

ρ-toluenesulfonic acid

DEA:

2-(1,3-dioxan-2-yloxy)ethyl acrylate

DMDEA:

2-(5,5-dimethyl-1,3-dioxan-2-yloxy) ethyl acrylate

OEGA:

oligo(ethylene glycol) acrylate

DE-ATRP:

deactivation enhanced atom transfer radical polymerization

PEGMEMA:

poly(ethylene glycol) methyl ether methylacrylate

PPGMA:

poly(propylene glycol) methacrylate

EGDMA:

ethylene glycol dimethacrylate

poly(A-Pro-OMe):

poly(n-acryloyl-l-prolinemethylester)

BDB:

benzyl dithiobenzoate

CTA:

chain transfer agent

DMA:

n,n-dimethylacrylamide

AIBN:

azobisisobutyronitrile

ADMO:

(n-acryloyl-2,2-dimethyl-1,3-oxazolidine)

PADMO:

poly(n-acryloyl-2,2-dimethyl-1,3-oxazolidine)

HEMA:

2-hydroxylethyl methacrylate

BSPA:

benzylsulfanylthiocarbonylsulfanylpropionic acid

PAGA:

poly(acryloyl glucosamine)

EIPPMMA:

4-(1-ethyl-1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl) phenyl methacrylate]

PVPhol:

poly(vinylphenol)

FITC:

fluorescein isothiocyanate

PDS:

pyridylsulfide

DTT:

dithiothreitol

OEG:

oligoethyleneglycol

VCL:

vinylcaprolactam

AA:

acrylic acid

DODAB:

dimethyldioctadecylammonium bromide

DBTTC:

dibenzyltrithiocarbonate

EGDMA:

ethyleneglycoldimethacrylate

MBA:

N,N’-methylenebisacrylamide

PHMPA:

poly((n-2-hydroxyproply)-methacrylamide)

P(OEG-A):

poly(oligoethylene glycol methyl ether acrylate)

P(OEG-MA):

poly-(oligoethylene glycol methyl ether methacrylate)

CDTB:

cyanopentanoic acid dithiobenzoate

BSPA:

3-(benzyl sulfanylthiocarbonylsulfanyl)-propionic acid

CDB:

cumyldithiobenzoate

PPEGMAxTTC:

poly[poly(ethylene glycol) methyl ether methacrylate]-trithiocarbonate

DT:

dithioester

MEO2MA:

poly(2-(2-methoxyethoxy)ethyl methacrylate

PVPip:

poly(n-vinylpiperidone)

VAc:

vinylacetate

LDH:

lactate dehydrogenase

PNASME:

poly(n-acryloylsarcosine methyl ester)

C2NVP:

3-ethyl-1-vinyl-2-pyrrolidone

NVP:

n-vinylpyrrolidone

MHEX:

s-(1-methyl-4-hydroxyethyl acetate) o-ethyl xanthate

Mw:

molecular weight

MADIX:

Macromolecular design by interchange of xanthate

MeO2VAc:

oligo (ethylene glycol) vinyl acetate

ABCN:

1,1’-azobis-(cyclohexanocarbonitrile)

BMDO:

5,6-benzo-2-methylene-1,3-dioxepane

MDO:

2-methylene-1,3-dioxepane

TEMPO:

(2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl

MePEGMA:

poly(ethylene glycol) methyl ether methacrylate

AN:

acrylonitrile

HEA:

2-hydroxyethyl acrylate

FRP:

free radical polymerization

DEGEA:

diethylene glycol ethyl ether acrylate

DHHA/PDHHA:

dihydroxyhexyl acrylate/poly(dihydroxyhexyl acrylate)

MA:

methyl acrylate

OEGMA:

oligo(ethylene glycol) methyl ether methacrylate

POEGMA:

poly[oligo(ethylene glycol) methyl ether methacrylate]

OEGMEAs:

oligo(ethylene glycol) methyl ether amines

CPADB:

4-cyano-4-((phenylcarbonothioyl)thio)pentanoic acid

PFP(M)A:

pentafluorophenyl(meth)acrylate

PFPA:

pentafluorophenyl acrylate

MEO2MAM:

diethylene glycol methacrylamide

MEO2AM:

diethylene glycol acrylamide

mPEG:

methoxy poly(ethylene glycol)

AAm/AM:

acrylamide

APEG:

α-acryloyl-ω-methoxypoly(ethyleneglycol)

CMC:

critical micelle concentration

DOX:

doxorubicin

PVP:

polyvinylpyrrolidone

CMPC:

cyanomethyl methyl(4-pyridyl)carbamodithioate

LbL:

layer by layer

OEtOxA:

oligo(2-ethyl-2-oxazoline)acrylate

TA:

tannic acid

CROP:

cationic ring-opening polymerization

P[VBTP][Cl]:

poly(triphenyl-4-vinylbenzylphosphonium chloride)

P[VBuIm][Br]:

poly(3-n-butyl-1-vinylimidazolium bromide)

P2VP:

poly (2-vinylpyridine)

PHEA:

poly(2-hydroxyethyl acrylate)

PEA:

poly(ethyl acrylate)

PEGMA:

poly(ethylene glycol) methacrylate

Hex:

Hexylamine

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Authors and Affiliations

  1. Polymer Science and Technology Department, CSIR-Central Leather Research Institute, Chennai, India

    Varnakumar Gayathri, Nagaraju Pentela & Debasis Samanta

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  1. Varnakumar Gayathri
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  2. Nagaraju Pentela
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  3. Debasis Samanta
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Correspondence to Debasis Samanta .

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  1. Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

    Vimal Katiyar

  2. Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

    Amit Kumar

  3. Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

    Neha Mulchandani

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Gayathri, V., Pentela, N., Samanta, D. (2020). Biocompatible Thermoresponsive Polymers: Property and Synthesis. In: Katiyar, V., Kumar, A., Mulchandani, N. (eds) Advances in Sustainable Polymers. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-15-1251-3_7

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