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Molecular Profiling of Breast Cancer in Clinical Trials: A Perspective

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'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

Abstract

Breast cancer molecular profiling is a fundamental criterion to identify novel molecular targets and determine pertinent treatment options. Advancement in molecular profiling has provided greater and in-depth insight into this heterogeneous disease, over and above hormone receptor and HER2 status. Agents targeting newly investigated biomarkers are under clinical development, and their success most likely depends on exploring the patient population, going to be benefitted/treated. Therefore, pre-screening and stratification of biomarkers that can predict or monitor treatment response with respect to the tumor type and stage are the essential prerequisites for conducting breast cancer clinical trials. In the current chapter, we have discussed available molecular profiling technologies for breast cancer diagnosis, prognosis, and treatment.

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Author notes

  1. Nosheen Akhtar and Iffat Fatima contributed equally with all other contributors.

Authors and Affiliations

  1. Fatima Jinnah Women University, Rawalpindi, Pakistan

    Saima Shakil Malik

  2. Armed Forces Institute of Pathology, Rawalpindi, Pakistan

    Saima Shakil Malik

  3. Microbiology and Biotechnology Research Lab, Fatima Jinnah Women University, Rawalpindi, Pakistan

    Iqra & Nosheen Masood

  4. National University of Medical Science, Rawalpindi, Pakistan

    Nosheen Akhtar

  5. Quaid-i-Azam University, Islamabad, Pakistan

    Iffat Fatima

  6. Armed Forces Bone Marrow Transplant Centre, Rawalpindi, Pakistan

    Zaineb Akram

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  1. Saima Shakil Malik
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  2. Iqra
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  3. Nosheen Akhtar
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  4. Iffat Fatima
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  5. Zaineb Akram
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  6. Nosheen Masood
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Correspondence to Saima Shakil Malik .

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  1. Fatima Jinnah Women University, Rawalpindi, Pakistan

    Nosheen Masood

  2. Fatima Jinnah Women University, Rawalpindi, Pakistan

    Saima Shakil Malik

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Malik, S.S., Iqra, Akhtar, N., Fatima, I., Akram, Z., Masood, N. (2020). Molecular Profiling of Breast Cancer in Clinical Trials: A Perspective. In: Masood, N., Shakil Malik, S. (eds) 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-15-1067-0_12

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