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Autophagy Regulation of Innate Immunity pp 109–123Cite as

Regulation of Inflammasome by Autophagy

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1209))

Abstract

Inflammasome is a molecular platform that mediates the activation of caspases, maturation of interleukin-1 (IL-1) family members, and leads to inflammatory cell death called pyroptosis. It is vital for innate immune responses, providing protection against infectious agents, sterile environmental insults, and host cell damages. Aberrant activation of inflammasome is closely correlated with numerous hereditary and acquired inflammatory disorders. Therefore, a better understanding of how inflammasome is regulated may provide more promising therapeutics for controlling inflammasome-associated diseases. In recent years, it becomes apparent that autophagy, a cellular machinery essential for the recycling of intracellular components and maintenance of cellular homeostasis, acts as a key player in the activation and regulation of inflammasome, and ameliorates symptoms of inflammasome-related diseases. This review will discuss the recent insights into inflammasome activation and regulation mediated by autophagy.

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References

  1. Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J (2004) NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20:319–325

    Article  CAS  PubMed  Google Scholar 

  2. Battu S, Afroz S, Giddaluru J, Naz S, Huang W, Khumukcham SS, Khan RA, Bhat SY, Qureshi IA, Manavathi B et al (2018) Amino acid starvation sensing dampens IL-1beta production by activating riboclustering and autophagy. PLoS Biol 16:e2005317

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Broz P, Dixit VM (2016) Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol 16:407–420

    Article  CAS  PubMed  Google Scholar 

  4. Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, Jahn H, Planyavsky M, Bilban M, Colinge J, Bennett KL, Superti-Furga G (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 10:266–272

    Article  PubMed  CAS  Google Scholar 

  5. Chavarria-Smith J, Vance RE (2015) The NLRP1 inflammasomes. Immunol Rev 265:22–34

    Article  CAS  PubMed  Google Scholar 

  6. Chen J, Chen ZJ (2018) PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature 564:71–76

    Article  CAS  PubMed  Google Scholar 

  7. Cho MH, Cho K, Kang HJ, Jeon EY, Kim HS, Kwon HJ, Kim HM, Kim DH, Yoon SY (2014) Autophagy in microglia degrades extracellular beta-amyloid fibrils and regulates the NLRP3 inflammasome. Autophagy 10:1761–1775

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. D’Osualdo A, Weichenberger CX, Wagner RN, Godzik A, Wooley J, Reed JC (2011) CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain. PLoS One 6:e27396

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Di A, Xiong S, Ye Z, Malireddi RKS, Kometani S, Zhong M, Mittal M, Hong Z, Kanneganti TD, Rehman J, Malik AB (2018) The TWIK2 potassium efflux channel in macrophages mediates NLRP3 inflammasome-induced inflammation. Immunity 49(56–65):e54

    Google Scholar 

  10. Du Y, Duan T, Feng Y, Liu Q, Lin M, Cui J, Wang RF (2018) LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation. EMBO J 37:351–366

    Article  CAS  PubMed  Google Scholar 

  11. Duncan JA, Canna SW (2018) The NLRC4 inflammasome. Immunol Rev 281:115–123

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Dupont N, Lacas-Gervais S, Bertout J, Paz I, Freche B, Van Nhieu GT, van der Goot FG, Sansonetti PJ, Lafont F (2009) Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe 6:137–149

    Article  CAS  PubMed  Google Scholar 

  13. Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA (2011) NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145:745–757

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458:509–513

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Franchi L, Nunez G (2012) Immunology. Orchestrating inflammasomes. Science 337:1299–1300

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Gatica D, Lahiri V, Klionsky DJ (2018) Cargo recognition and degradation by selective autophagy. Nat Cell Biol 20:233–242

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Ge Y, Xu X, Liang Q, Xu Y, Huang M (2019) Alpha-Mangostin suppresses NLRP3 inflammasome activation via promoting autophagy in LPS-stimulated murine macrophages and protects against CLP-induced sepsis in mice. Inflamm Res: Off J Eur Histamine Res Soc … [et al.] 68:471–479

    Article  CAS  PubMed  Google Scholar 

  18. Geng J, Liu J, Yuan X, Liu W, Guo W (2019) Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice. Toxicol Appl Pharmacol 379:114688

    Article  PubMed  CAS  Google Scholar 

  19. Georgakopoulos ND, Wells G, Campanella M (2017) The pharmacological regulation of cellular mitophagy. Nat Chem Biol 13:136–146

    Article  CAS  PubMed  Google Scholar 

  20. Han X, Sun S, Sun Y, Song Q, Zhu J, Song N, Chen M, Sun T, Xia M, Ding J et al (2019) Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease. Autophagy 1–22

    Google Scholar 

  21. Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458:514–518

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E (2008) Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9:847–856

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Houtman J, Freitag K, Gimber N, Schmoranzer J, Heppner FL, Jendrach M (2019) Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3. EMBO J 38

    Google Scholar 

  24. Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C et al (2016) The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science 354:765–768

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF, Chai J (2015) Structural and biochemical basis for induced self-propagation of NLRC4. Science 350:399–404

    Article  CAS  PubMed  Google Scholar 

  26. Ives A, Nomura J, Martinon F, Roger T, LeRoy D, Miner JN, Simon G, Busso N, So A (2015) Xanthine oxidoreductase regulates macrophage IL1beta secretion upon NLRP3 inflammasome activation. Nat Commun 6:6555

    Article  CAS  PubMed  Google Scholar 

  27. Jabir MS, Hopkins L, Ritchie ND, Ullah I, Bayes HK, Li D, Tourlomousis P, Lupton A, Puleston D, Simon AK et al (2015) Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy. Autophagy 11:166–182

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  28. Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW et al (2012) Structures of the HIN domain: DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 36:561–571

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Kang R, Xie Y, Zeh HJ, Klionsky DJ, Tang D (2019) Mitochondrial quality control mediated by PINK1 and PRKN: links to iron metabolism and tumor immunity. Autophagy 15:172–173

    Article  CAS  PubMed  Google Scholar 

  30. Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S et al (2011) Non-canonical inflammasome activation targets caspase-11. Nature 479:117–121

    Article  CAS  PubMed  Google Scholar 

  31. Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B (2011) IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 9:363–375

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Khare S, Dorfleutner A, Bryan NB, Yun C, Radian AD, de Almeida L, Rojanasakul Y, Stehlik C (2012) An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. Immunity 36:464–476

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Kim MJ, Bae SH, Ryu JC, Kwon Y, Oh JH, Kwon J, Moon JS, Kim K, Miyawaki A, Lee MG et al (2016) SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages. Autophagy 12:1272–1291

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Lacey CA, Miao EA (2019) NLRP1—One NLR to guard them all. EMBO J 38:e102494

    Google Scholar 

  35. Li W, Li Y, Siraj S, Jin H, Fan Y, Yang X, Huang X, Wang X, Wang J, Liu L et al (2019) FUN14 domain-containing 1-mediated mitophagy suppresses hepatocarcinogenesis by inhibition of inflammasome activation in mice. Hepatology 69:604–621

    Article  CAS  PubMed  Google Scholar 

  36. Liu T, Tang Q, Liu K, Xie W, Liu X, Wang H, Wang RF, Cui J (2016) TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy. Cell Rep 16:1988–2002

    Article  CAS  PubMed  Google Scholar 

  37. Liu W, Bai F, Wang H, Liang Y, Du X, Liu C, Cai D, Peng J, Zhong G, Liang X et al (2019) Tim-4 Inhibits NLRP3 inflammasome via the LKB1/AMPKalpha pathway in macrophages. J Immunol 203:990–1000

    Google Scholar 

  38. Ma S, Chen J, Feng J, Zhang R, Fan M, Han D, Li X, Li C, Ren J, Wang Y, Cao F (2018) Melatonin ameliorates the progression of atherosclerosis via mitophagy activation and NLRP3 inflammasome inhibition. Oxidative Med Celllo Longev 2018:9286458

    Google Scholar 

  39. Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417–426

    Article  CAS  PubMed  Google Scholar 

  40. Mehto S, Chauhan S, Jena KK, Chauhan NR, Nath P, Sahu R, Dhar K, Das SK, Chauhan S (2019) IRGM restrains NLRP3 inflammasome activation by mediating its SQSTM1/p62-dependent selective autophagy. Autophagy 15:1645–1647

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Mitchell PS, Sandstrom A, Vance RE (2019) The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries. Curr Opin Immunol 60:37–45

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW et al (2016) IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome. Cell Metab 23:155–164

    Article  CAS  PubMed  Google Scholar 

  43. O’Neill LA (2008) The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol Rev 226:10–18

    Article  PubMed  Google Scholar 

  44. Oikonomou V, Moretti S, Renga G, Galosi C, Borghi M, Pariano M, Puccetti M, Palmerini CA, Amico L, Carotti A et al (2016) Noncanonical fungal autophagy inhibits inflammation in response to IFN-gamma via DAPK1. Cell Host Microbe 20:744–757

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Palikaras K, Lionaki E, Tavernarakis N (2018) Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nat Cell Biol 20:1013–1022

    Article  CAS  PubMed  Google Scholar 

  46. Place DE, Kanneganti TD (2018) Recent advances in inflammasome biology. Curr Opin Immunol 50:32–38

    Article  CAS  PubMed  Google Scholar 

  47. Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschlager N, Schlee M, Rothenfusser S, Barchet W et al (2010) Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat Immunol 11:63–69

    Article  CAS  PubMed  Google Scholar 

  48. Pu Q, Gan C, Li R, Li Y, Tan S, Li X, Wei Y, Lan L, Deng X, Liang H et al (2017) Atg7 deficiency intensifies inflammasome activation and pyroptosis in pseudomonas sepsis. J Immunol 198:3205–3213

    Article  CAS  PubMed  Google Scholar 

  49. Qu X, Gao H, Tao L, Zhang Y, Zhai J, Sun J, Song Y, Zhang S (2019) Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats. J Toxicol Sci 44:167–175

    Article  CAS  PubMed  Google Scholar 

  50. Ravindran R, Loebbermann J, Nakaya HI, Khan N, Ma H, Gama L, Machiah DK, Lawson B, Hakimpour P, Wang YC et al (2016) The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature 531:523–527

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Rodrigue-Gervais IG, Doiron K, Champagne C, Mayes L, Leiva-Torres GA, Vanie P Jr, Douglas T, Vidal SM, Alnemri ES, Saleh M (2018) The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. Sci Rep 8:8446

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  52. Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M et al (2008) Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456:264–268

    Article  CAS  PubMed  Google Scholar 

  53. Sandstrom A, Mitchell PS, Goers L, Mu EW, Lesser CF, Vance RE (2019) Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes. Science 364

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  54. Schroder K, Zhou R, Tschopp J (2010) The NLRP3 inflammasome: a sensor for metabolic danger? Science 327:296–300

    Article  CAS  PubMed  Google Scholar 

  55. Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Nunez G, Mao Y, Wu H (2019) Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature 570:338–343

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Sharma V, Verma S, Seranova E, Sarkar S, Kumar D (2018) Selective autophagy and xenophagy in infection and disease. Front Cell Dev Biol 6:147

    Article  PubMed  PubMed Central  Google Scholar 

  57. Shi CS, Shenderov K, Huang NN, Kabat J, Abu-Asab M, Fitzgerald KA, Sher A, Kehrl JH (2012) Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol 13:255–263

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, Hu L, Shao F (2014) Inflammatory caspases are innate immune receptors for intracellular LPS. Nature 514:187–192

    Article  CAS  PubMed  Google Scholar 

  59. Spalinger MR, Lang S, Gottier C, Dai X, Rawlings DJ, Chan AC, Rogler G, Scharl M (2017) PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner. Autophagy 13:1590–1601

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, Alnemri ES (2002) The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem 277:21119–21122

    Article  CAS  PubMed  Google Scholar 

  61. Stolz A, Ernst A, Dikic I (2014) Cargo recognition and trafficking in selective autophagy. Nat Cell Biol 16:495–501

    Article  CAS  PubMed  Google Scholar 

  62. Stowe I, Lee B, Kayagaki N (2015) Caspase-11: arming the guards against bacterial infection. Immunol Rev 265:75–84

    Article  CAS  PubMed  Google Scholar 

  63. Strowig T, Henao-Mejia J, Elinav E, Flavell R (2012) Inflammasomes in health and disease. Nature 481:278–286

    Article  CAS  PubMed  Google Scholar 

  64. Sumpter R Jr, Sirasanagandla S, Fernandez AF, Wei Y, Dong X, Franco L, Zou Z, Marchal C, Lee MY, Clapp DW et al (2016) Fanconi anemia proteins function in mitophagy and immunity. Cell 165:867–881

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Sun C, Diao Q, Lu J, Zhang Z, Wu D, Wang X, Xie J, Zheng G, Shan Q, Fan S et al (2019) Purple sweet potato color attenuated NLRP3 inflammasome by inducing autophagy to delay endothelial senescence. J Cell Physiol 234:5926–5939

    Article  CAS  PubMed  Google Scholar 

  66. Swanson KV, Deng M, Ting JP (2019) The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol 19:477–489

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Tschopp J, Schroder K (2010) NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nature reviews. Immunology 10:210–215

    CAS  PubMed  Google Scholar 

  68. Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M, Penington JS, Harapas CR, Souza-Fonseca-Guimaraes F, Wockner LF et al (2018) NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease. Nat Commun 9:3728

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  69. Van Opdenbosch N, Lamkanfi M (2019) Caspases in cell death, inflammation, and disease. Immunity 50:1352–1364

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  70. Vladimer GI, Weng D, Paquette SW, Vanaja SK, Rathinam VA, Aune MH, Conlon JE, Burbage JJ, Proulx MK, Liu Q et al (2012) The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 37:96–107

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Wang Y, Meng C, Zhang J, Wu J, Zhao J (2019) Inhibition of GSK-3beta alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy. Int Immunopharmacol 68:234–241

    Article  CAS  PubMed  Google Scholar 

  72. Xia Y, Liu N, Xie X, Bi G, Ba H, Li L, Zhang J, Deng X, Yao Y, Tang Z et al (2019) The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion. Autophagy 15:960–975

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Xian H, Yang S, Jin S, Zhang Y, Cui J (2019) LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I. Autophagy 1–11

    Google Scholar 

  74. Xu Y, Wang J, Xu W, Ding F, Ding W (2019) Prohibitin 2-mediated mitophagy attenuates renal tubular epithelial cells injury by regulating mitochondrial dysfunction and NLRP3 inflammasome activation. Am J Physiol Renal Physiol 316:F396–F407

    Article  PubMed  Google Scholar 

  75. Xu H, Yang J, Gao W, Li L, Li P, Zhang L, Gong YN, Peng X, Xi JJ, Chen S et al (2014) Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature 513:237–241

    Article  CAS  PubMed  Google Scholar 

  76. Yang F, Qin Y, Wang Y, Meng S, Xian H, Che H, Lv J, Li Y, Yu Y, Bai Y, Wang L (2019) Metformin inhibits the NLRP3 inflammasome via AMPK/mTOR-dependent effects in diabetic cardiomyopathy. Int J Biol Sci 15:1010–1019

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Zhai Y, Lin P, Feng Z, Lu H, Han Q, Chen J, Zhang Y, He Q, Nan G, Luo X et al (2018) TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes. Autophagy 14:1629–1643

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL et al (2015) Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science 350:404–409

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Zheng X, Hu M, Zang X, Fan Q, Liu Y, Che Y, Guan X, Hou Y, Wang G, Hao H (2019) Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress. Brain Behav Immun 79:244–255

    Article  CAS  PubMed  Google Scholar 

  80. Zhong FL, Mamai O, Sborgi L, Boussofara L, Hopkins R, Robinson K, Szeverenyi I, Takeichi T, Balaji R, Lau A et al (2016) Germline NLRP1 mutations cause skin inflammatory and cancer susceptibility syndromes via inflammasome activation. Cell 167(187–202):e117

    Google Scholar 

  81. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B et al (2018) New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature 560:198–203

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR et al (2016) NF-kappaB restricts inflammasome activation via elimination of damaged mitochondria. Cell 164:896–910

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G et al (2017) Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature 546:667–670

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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  1. Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02115, USA

    Tao Liu

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  1. School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China

    Jun Cui

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Liu, T. (2019). Regulation of Inflammasome by Autophagy. In: Cui, J. (eds) Autophagy Regulation of Innate Immunity. Advances in Experimental Medicine and Biology, vol 1209. Springer, Singapore. https://doi.org/10.1007/978-981-15-0606-2_7

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