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Autophagy Regulation of Bacterial Pathogen Invasion

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Autophagy Regulation of Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1209))

Abstract

Autophagy pathway is highly conserved in all eukaryotic species and responsible for targeting of cytosol components, such as protein aggregates, damaged or unnecessary organelles, and intracellular bacterial pathogens for lysosome-dependent degradation. Besides severing as a catabolic process, autophagy pathway furthermore has been discovered to function pivotally in both innate and adaptive immune responses. At present, it has been well demonstrated that certain types of bacteria could be targeted by autophagy upon their invasion. However, several bacterial pathogens have developed strategies to evade this degradation and clearance. Here, we review the role and mechanism of autophagy in the regulation of bacteria invasion, which may facilitate the designing of clinical drugs for efficient and safe cure of infection diseases caused by toxic bacteria.

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Acknowledgments

The authors thank members from K.F. Lu laboratory for advice and help in preparing the manuscript. The K.F. Lu laboratory was supported by the National Key R&D Program of China under grant 2017YFA0506300 (to K.L.) and the National Natural Science Foundation under grants 31770820 (to K.L.).

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Authors and Affiliations

  1. Department of Neurosurgery, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China

    Yuqing Lei & Kefeng Lu

  2. State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China

    Huihui Li

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  1. Yuqing Lei
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Correspondence to Kefeng Lu .

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  1. School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China

    Jun Cui

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Lei, Y., Li, H., Lu, K. (2019). Autophagy Regulation of Bacterial Pathogen Invasion. In: Cui, J. (eds) Autophagy Regulation of Innate Immunity. Advances in Experimental Medicine and Biology, vol 1209. Springer, Singapore. https://doi.org/10.1007/978-981-15-0606-2_4

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