Abstract
Indigenous severe fever with thrombocytopenia syndrome (SFTS) has been reported to be endemic to China, South Korea, and Japan. To date, several molecular epidemiology and phylogenetic studies of SFTS virus (SFTSV) have been performed. At the beginning of this review, the impact of the source of the samples (i.e., patient specimens vs. in vitro isolates) that potentially affect the phylogenetic analysis was explained in detail. Next, the nucleotide sequences of more than 200 SFTSV strains identified in China, South Korea, and Japan were phylogenetically reanalyzed. The SFTSV strains were clustered into two clades, which were consistent with the geographic distribution (i.e., China and South Korea/Japan) of the viruses. Interestingly, several strains identified in a specific region in China and most of the strains in South Korea were clustered into the Japanese clade. On the other hand, some strains identified in Japan were clustered into the Chinese clade. These results imply that some strains of SFTSV in China and South Korea were transmitted, likely several times, from Japan across the East China Sea and/or the Sea of Japan, and vice versa.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M (2013) Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antivir Res 100(1):159–189
Chang MS, Woo JH (2013) Severe fever with thrombocytopenia syndrome: tick-mediated viral disease. J Korean Med Sci 28(6):795–796
Choi SJ, Park SW, Bae IG, Kim SH, Ryu SY, Kim HA, Jang HC, Hur J, Jun JB, Jung Y, Chang HH, Kim YK, Yi J, Kim KH, Hwang JH, Kim YS, Jeong HW, Song KH, Park WB, Kim ES, Oh MD, S. C. N. for Korea (2016) Severe fever with thrombocytopenia syndrome in South Korea, 2013–2015. PLoS Negl Trop Dis 10(12):e0005264
Elfving K, Olsen B, Bergstrom S, Waldenstrom J, Lundkvist A, Sjostedt A, Mejlon H, Nilsson K (2010) Dissemination of spotted fever Rickettsia agents in Europe by migrating birds. PLoS One 5(1):e8572
Fu Y, Li S, Zhang Z, Man S, Li X, Zhang W, Zhang C, Cheng X (2016) Phylogeographic analysis of severe fever with thrombocytopenia syndrome virus from Zhoushan Islands, China: implication for transmission across the ocean. Sci Rep 6:19563
Ishiguro F, Takada N, Masuzawa T, Fukui T (2000) Prevalence of Lyme disease Borrelia spp. in ticks from migratory birds on the Japanese mainland. Appl Environ Microbiol 66(3):982–986
Kawabata H, Ando S, Kishimoto T, Kurane I, Takano A, Nogami S, Fujita H, Tsurumi M, Nakamura N, Sato F, Takahashi M, Ushijima Y, Fukunaga M, Watanabe H (2006) First detection of Rickettsia in soft-bodied ticks associated with seabirds, Japan. Microbiol Immunol 50(5):403–406
Lindeborg M, Barboutis C, Ehrenborg C, Fransson T, Jaenson TG, Lindgren PE, Lundkvist A, Nystrom F, Salaneck E, Waldenstrom J, Olsen B (2012) Migratory birds, ticks, and Crimean-Congo hemorrhagic fever virus. Emerg Infect Dis 18(12):2095–2097
Palomar AM, Portillo A, Santibanez P, Mazuelas D, Arizaga J, Crespo A, Gutierrez O, Cuadrado JF, Oteo JA (2013) Crimean-Congo hemorrhagic fever virus in ticks from migratory birds, Morocco. Emerg Infect Dis 19(2):260–263
Park SW, Ryou J, Choi WY, Han MG, Lee WJ (2016) Epidemiological and clinical features of severe fever with thrombocytopenia syndrome during an outbreak in South Korea, 2013–2015. Am J Trop Med Hyg 95(6):1358–1361
Shi J, Hu S, Liu X, Yang J, Liu D, Wu L, Wang H, Hu Z, Deng F, Shen S (2017) Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus. Infect Genet Evol 47:109–117
Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, Kamei T, Honda M, Ninomiya D, Sakai T, Senba T, Kaneyuki S, Sakaguchi S, Satoh A, Hosokawa T, Kawabe Y, Kurihara S, Izumikawa K, Kohno S, Azuma T, Suemori K, Yasukawa M, Mizutani T, Omatsu T, Katayama Y, Miyahara M, Ijuin M, Doi K, Okuda M, Umeki K, Saito T, Fukushima K, Nakajima K, Yoshikawa T, Tani H, Fukushi S, Fukuma A, Ogata M, Shimojima M, Nakajima N, Nagata N, Katano H, Fukumoto H, Sato Y, Hasegawa H, Yamagishi T, Oishi K, Kurane I, Morikawa S, Saijo M (2014) The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J Infect Dis 209(6):816–827
Yoshikawa T, Shimojima M, Fukushi S, Tani H, Fukuma A, Taniguchi S, Singh H, Suda Y, Shirabe K, Toda S, Shimazu Y, Nomachi T, Gokuden M, Morimitsu T, Ando K, Yoshikawa A, Kan M, Uramoto M, Osako H, Kida K, Takimoto H, Kitamoto H, Terasoma F, Honda A, Maeda K, Takahashi T, Yamagishi T, Oishi K, Morikawa S, Saijo M (2015) Phylogenetic and geographic relationships of severe fever with thrombocytopenia syndrome virus in China, South Korea, and Japan. J Infect Dis 212(6):889–898
Yun Y, Heo ST, Kim G, Hewson R, Kim H, Park D, Cho NH, Oh WS, Ryu SY, Kwon KT, Medlock JM, Lee KH (2015) Phylogenetic analysis of severe fever with thrombocytopenia syndrome virus in South Korea and migratory bird routes between China, South Korea, and Japan. Am J Trop Med Hyg 93(3):468–474
Yun SM, Park SJ, Park SW, Choi W, Jeong HW, Choi YK, Lee WJ (2017) Molecular genomic characterization of tick- and human-derived severe fever with thrombocytopenia syndrome virus isolates from South Korea. PLoS Negl Trop Dis 11(9):e0005893
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Yoshikawa, T. (2019). Molecular Epidemiology of SFTSV. In: Saijo, M. (eds) Severe Fever with Thrombocytopenia Syndrome. Springer, Singapore. https://doi.org/10.1007/978-981-13-9562-8_6
Download citation
DOI: https://doi.org/10.1007/978-981-13-9562-8_6
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-9561-1
Online ISBN: 978-981-13-9562-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)