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Book cover Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes

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Abstract

N-Heterocyclic carbene (NHC) has been well known as one of the most powerful organocatalysts for promoting a wide range of transformations. In this chapter, the Umpolung ability of NHC to convert the electrophilic carbonyl group to the nucleophilic acyl anion or homoenolate intermediates will be discuss. Another unique character of NHC, generation of acyl azolium intermediates, will also be described here.

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  1. Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

    Dr. Yinli Wang

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Correspondence to Yinli Wang .

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Wang, Y. (2019). Introduction. In: Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-13-9398-3_1

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