Abstract
Biomarkers are the monitorable changes associated with physiological or pathological changes. Urine is not regulated by the homeostatic mechanism and can reflect multiple changes in the body. Animal models can simulate human disease processes, monitor disease changes, and provide clues for early diagnosis. In this chapter, clues are provided for the dominant model animals associated with disease selection by comparing the urine proteome of rats, guinea pigs, and golden hamsters. The peptides were cleaved by membrane digestion and analyzed by LC-MS/MS. The number of urine proteins in the three different animals was different, and also different in every system of the body. This provides a basis for selecting the best animal models for different diseases.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Basketter D. Skin sensitisation, adverse outcome pathways and alternatives. Altern Lab Anim. 2016;44(5):431–6.
Cambier L, Heinen MP, Mignon B. Relevant animal models in dermatophyte research. Mycopathologia. 2017;182(1/2):229–40.
Carter JL, Parker CT, Stevens PE, et al. Biological variation of plasma and urinary markers of acute kidney injury in patients with chronic kidney disease. Clin Chem. 2016;62(6):876–83.
Cui XX, Shang SC, Zhang XF, et al. Analysis and determination of blood biochemical parameters in mesocricetus auratus and albino mutant. Chin J Compar Med. 2014;24(1):31–4, 30 (in Chinese)
Gao YH. Urine—an untapped goldmine for biomarker discovery? Sci China Life Sci. 2013;56(12):1145–6.
Gao YH. Urine is a better biomarker source than blood especially for kidney diseases. Adv Exp Med Biol. 2015;845:3–12.
Kawaura A, Tanida N, Akiyama J, et al. Inhibitory effect of 1α-hydroxyvitamin D3 on N-nitrosobis (2-oxopropyl) amine-induced cholangiocarcinogenesis in Syrian hamsters. Acta Med Okayama. 2011;65(3):193–7.
Mullen W, Gonzalez J, Siwy J, et al. A pilot study on the effect of short-term consumption of a polyphenol rich drink on biomarkers of coronary artery disease defined by urinary proteomics. J Agric Food Chem. 2011;59:12850–7.
Ni N, Wu JQ, Li L, et al. Comparison of urinary proteomes among rats, guinea pigs and golden hamsters. Chin J Biotechnol. 2018;34(4):578–85.
Paapstel K, Zilmer M, Eha J, et al. Early biomarkers of renal damage in relation to arterial stiffness and inflammation in male coronary artery disease patients. Kidney Blood Press Res. 2016;41(4):488–97.
Ramírez-Ramírez E, Torres-Ramírez A, Alquicira-Mireles J, et al. Characteristic plethysmographic findings in a guinea pig model of COPD. Exp Lung Res. 2017;43(2):57–65.
Rosner MH. Urinary biomarkers for the detection of renal injury. Adv Clin Chem. 2009;49:73–97.
Takahashi M, Hori M, Mutoh M, et al. Experimental animal models of pancreatic carcinogenesis for prevention studies and their relevance to human disease. Cancers (Basel). 2011;3(1):582–602.
Vrooman OP, Witjes JA. Urinary markers in bladder cancer. Eur Urol. 2008;53:909–16.
Wu JQ, Gao YH. Physiological conditions can be reflected in human urine proteome and metabolome. Expert Rev Proteomics. 2015;12(6):623–36.
Zhao MD, Li ML, Li XD, et al. Dynamic changes of urinary proteins in a focal segmental glomerulosclerosis rat model. Proteome Sci. 2014;12:42.
Zhu X, Qiao Y, Liu WH, et al. CXCL5 is a potential diagnostic and prognostic marker for bladder cancer patients. Tumour Biol. 2016;37(4):4569–77.
Zimmerli LU, Schiffer E, Zürbig P, et al. Urinary proteomic biomarkers in coronary artery disease. Mol Cell Proteomics. 2008;7:290–8.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Ni, N., Wu, J. (2019). Comparison of Urinary Proteomes Among Three Animal Models. In: Gao, Y. (eds) Urine. Springer, Singapore. https://doi.org/10.1007/978-981-13-9109-5_3
Download citation
DOI: https://doi.org/10.1007/978-981-13-9109-5_3
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-9108-8
Online ISBN: 978-981-13-9109-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)