Skip to main content
SpringerLink
Log in
Book cover

Renal Fibrosis: Mechanisms and Therapies pp 525–541Cite as

Lipid Metabolism Disorder and Renal Fibrosis

  • Chapter
  • First Online:

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1165))

Abstract

Since the lipid nephrotoxicity hypothesis was proposed in 1982, increasing evidence has supported the hypothesis that lipid abnormalities contributed to the progression of glomerulosclerosis. In this chapter, we will discuss the general promises of the original hypothesis, focusing especially on the role of lipids and metabolic inflammation accompanying CKD in renal fibrosis and potential new strategies of prevention.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Al-Aly Z (2008) Arterial calcification: a tumor necrosis factor-alpha mediated vascular Wnt-opathy. Transl Res 151:233–239

    Article  CAS  PubMed  Google Scholar 

  • Antonov AS, Kolodgie FD, Munn DH, Gerrity RG (2004) Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis. Am J Pathol 165:247–258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arici M, Chana R, Lewington A, Brown J, Brunskill NJ (2003) Stimulation of proximal tubular cell apoptosis by albumin-bound fatty acids mediated by peroxisome proliferator activated receptor-gamma. J Am Soc Nephrol 14:17–27

    Article  CAS  PubMed  Google Scholar 

  • Ashby DT, Rye KA, Clay MA, Vadas MA, Gamble JR, Barter PJ (1998) Factors influencing the ability of HDL to inhibit expression of vascular cell adhesion molecule-1 in endothelial cells. Arterioscler Thromb Vasc Biol 18:1450–1455

    Article  CAS  PubMed  Google Scholar 

  • Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N et al (2009) Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1. PLoS ONE 4:e4954

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Baranova IN, Vishnyakova TG. Bocharov AV, Kurlander R, Chen Z et al. (2005) Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p 38 mitogen-activated protein kinases. J Biol Chem 280:8031–8040

    Article  PubMed  CAS  Google Scholar 

  • Berliner JA, Territo MC, Sevanian A, Ramin S, Kim JA et al (1990) Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest 85:1260–1266

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Berneis KK, Krauss RM (2002) Metabolic origins and clinical significance of LDL heterogeneity. J Lipid Res 43:1363–1379

    Article  CAS  PubMed  Google Scholar 

  • Borrell-Pages M, Romero JC, Badimon L (2015) LRP5 deficiency down-regulates Wnt signalling and promotes aortic lipid infiltration in hypercholesterolaemic mice. J Cell Mol Med 19:770–777

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brenner BM (1985) Nephron adaptation to renal injury or ablation. Am J Physiol 249:F324–F337

    CAS  PubMed  Google Scholar 

  • Brown PM, Kennedy DJ, Morton RE, Febbraio M (2015) CD36/SR-B2-TLR2 dependent pathways enhance Porphyromonas gingivalis mediated atherosclerosis in the Ldlr KO mouse model. PLoS ONE 10:e0125126

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bussolati B, Deregibus MC, Fonsato V, Doublier S, Spatola T et al (2005) Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the phosphatidylinositol 3-kinase/AKT-signaling pathway. J Am Soc Nephrol 16:1936–1947

    Article  CAS  PubMed  Google Scholar 

  • Cao W, Xu J, Zhou ZM, Wang GB, Hou FF et al (2013) Advanced oxidation protein products activate intrarenal renin-angiotensin system via a CD36-mediated, redox-dependent pathway. Antioxid Redox Signal 18:19–35

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cases A, Coll E (2005) Dyslipidemia and the progression of renal disease in chronic renal failure patients. Kidney Int Suppl S87–S93

    Article  Google Scholar 

  • Chade AR, Mushin OP, Zhu X, Rodriguez-Porcel M, Grande JP et al (2005) Pathways of renal fibrosis and modulation of matrix turnover in experimental hypercholesterolemia. Hypertension 46:772–779

    Article  CAS  PubMed  Google Scholar 

  • Chade AR, Zhu XY, Grande JP, Krier JD, Lerman A, Lerman LO (2008) Simvastatin abates development of renal fibrosis in experimental renovascular disease. J Hypertens 26:1651–1660

    Article  CAS  PubMed  Google Scholar 

  • Chalmers L, Kaskel FJ, Bamgbola O (2006) The role of obesity and its bioclinical correlates in the progression of chronic kidney disease. Adv Chronic Kidney Dis 13:352–364

    Article  PubMed  Google Scholar 

  • Cheng R, Ding L, He X, Takahashi Y, Ma JX (2016) Interaction of PPARalpha with the canonic Wnt pathway in the regulation of renal fibrosis. Diabetes 65:3730–3743

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Clark JS, Carter AJ, Dixit M, Arany I (2016) Simvastatin inhibits epithelial-to-mesenchymal transition through induction of HO-1 in cultured renal proximal tubule cells. Vivo 30:407–411

    CAS  Google Scholar 

  • Coritsidis G, Rifici V, Gupta S, Rie J, Shan ZH et al (1991) Preferential binding of oxidized LDL to rat glomeruli in vivo and cultured mesangial cells in vitro. Kidney Int 39:858–866

    Article  CAS  PubMed  Google Scholar 

  • Dai C, Stolz DB, Kiss LP, Monga SP, Holzman LB, Liu Y (2009) Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol 20:1997–2008

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ding G, Pesek-Diamond I, Diamond JR (1993) Cholesterol, macrophages, and gene expression of TGF-beta 1 and fibronectin during nephrosis. Am J Physiol 264:F577–F584

    Article  CAS  PubMed  Google Scholar 

  • Ding G, van Goor H, Frye J, Diamond JR (1994) Transforming growth factor-beta expression in macrophages during hypercholesterolemic states. Am J Physiol 267:F937–F943

    CAS  PubMed  Google Scholar 

  • Eddy AA (1996) Interstitial inflammation and fibrosis in rats with diet-induced hypercholesterolemia. Kidney Int 50:1139–1149

    Article  CAS  PubMed  Google Scholar 

  • Feng XL, Theodoratou E, Liu L, Chan KY, Hipgrave D et al (2012) Social, economic, political and health system and program determinants of child mortality reduction in China between 1990 and 2006: a systematic analysis. J Glob Health 2:010405

    PubMed  PubMed Central  Google Scholar 

  • Feng X, Gao X, Jia Y, Zhang H, Xu Y, Wang G (2016) PPAR-alpha agonist fenofibrate decreased RANTES levels in type 2 diabetes patients with hypertriglyceridemia. Med Sci Monit 22:743–751

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fernando RL, Varghese Z, Moorhead JF (1993) Oxidation of low-density lipoproteins by rat mesangial cells and the interaction of oxidized low-density lipoproteins with rat mesangial cells in vitro. Nephrol Dial Transplant 8:512–518

    Article  CAS  PubMed  Google Scholar 

  • Gao X, Wu J, Qian Y, Fu L, Wu G et al (2014) Oxidized high-density lipoprotein impairs the function of human renal proximal tubule epithelial cells through CD36. Int J Mol Med 34:564–572

    Article  CAS  PubMed  Google Scholar 

  • Gheith OA, Sobh MA, Mohamed Kel S, El-Baz MA, El-Husseini F et al (2002) Impact of treatment of dyslipidemia on renal function, fat deposits and scarring in patients with persistent nephrotic syndrome. Nephron 91:612–619

    Article  CAS  PubMed  Google Scholar 

  • Ginsberg HN, Le NA, Goldberg IJ, Gibson JC, Rubinstein A et al (1986) Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo. J Clin Invest 78:1287–1295

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grone HJ, Walli A, Grone E, Niedmann P, Thiery J et al (1989) Induction of glomerulosclerosis by dietary lipids. A functional and morphologic study in the rat. Lab Invest 60:433–446

    CAS  PubMed  Google Scholar 

  • Grone HJ, Walli AK, Grone EF (1993) Arterial hypertension and hyperlipidemia as determinants of glomerulosclerosis. Clin Investig 71:834–839

    Article  CAS  PubMed  Google Scholar 

  • Guijarro C, Egido J (2001) Transcription factor-kappa B (NF-kappa B) and renal disease. Kidney Int 59:415–424

    Article  CAS  PubMed  Google Scholar 

  • Guo Y, Xiao L, Sun L, Liu F (2012) Wnt/beta-catenin signaling: a promising new target for fibrosis diseases. Physiol Res 61:337–346

    CAS  PubMed  Google Scholar 

  • Hamasaki Y, Doi K, Okamoto K, Ijichi H, Seki G et al (2012) 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor simvastatin ameliorates renal fibrosis through HOXA13-USAG-1 pathway. Lab Invest 92:1161–1170

    Article  CAS  PubMed  Google Scholar 

  • He W, Dai C, Li Y, Zeng G, Monga SP et al (2009) Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 20:765–776

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • He W, Tan R, Dai C, Li Y, Wang D et al (2010) Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/beta-catenin signaling. J Biol Chem 285:24665–24675

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • He W, Tan RJ, Li Y, Wang D, Nie J et al (2012) Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/beta-catenin activity in CKD. J Am Soc Nephrol 23:294–304

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Heikkila E, Juhila J, Lassila M, Messing M, Perala N et al (2010) beta-Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys. Nephrol Dial Transplant 25:2437–2446

    Article  PubMed  CAS  Google Scholar 

  • Heinecke JW, Baker L, Rosen H, Chait A (1986) Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. J Clin Invest 77:757–761

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hua W, Huang HZ, Tan LT, Wan JM, Gui HB et al (2015) CD36 mediated fatty acid-induced podocyte apoptosis via oxidative stress. PLoS ONE 10:e0127507

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Huang W, Febbraio M, Silverstein RL (2011) CD9 tetraspanin interacts with CD36 on the surface of macrophages: a possible regulatory influence on uptake of oxidized low density lipoprotein. PLoS ONE 6:e29092

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Iglesias DM, Hueber PA, Chu L, Campbell R, Patenaude AM et al (2007) Canonical WNT signaling during kidney development. Am J Physiol Renal Physiol 293:F494–F500

    Article  CAS  PubMed  Google Scholar 

  • Imai Y, Matsumura H, Shino A, Oka K, Suzuoki Z (1977) Induction of aortic lipid deposition in a high-response (ExHC) rat fed a diet containing cholesterol and cholic acid. Atherosclerosis 28:453–461

    Article  CAS  PubMed  Google Scholar 

  • Iwao Y, Nakajou K, Nagai R, Kitamura K, Anraku M et al (2008) CD36 is one of important receptors promoting renal tubular injury by advanced oxidation protein products. Am J Physiol Renal Physiol 295:F1871–F1880

    Article  CAS  PubMed  Google Scholar 

  • Jiang XS, Chen XM, Wan JM, Gui HB, Ruan XZ et al (2017) Autophagy protects against palmitic acid-induced apoptosis in podocytes in vitro. Sci Rep 7:42764

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Johnson DW, Saunders HJ, Field MJ, Pollock CA (1999) In vitro effects of simvastatin on tubulointerstitial cells in a human model of cyclosporin nephrotoxicity. Am J Physiol 276:F467–F475

    CAS  PubMed  Google Scholar 

  • Kasiske BL, Cleary MP, O’Donnell MP, Keane WF (1985) Effects of genetic obesity on renal structure and function in the Zucker rat. J Lab Clin Med 106:598–604

    CAS  PubMed  Google Scholar 

  • Kasiske BL, O’Donnell MP, Schmitz PG, Kim Y, Keane WF (1990) Renal injury of diet-induced hypercholesterolemia in rats. Kidney Int 37:880–891

    Article  CAS  PubMed  Google Scholar 

  • Kasuga H, Ito Y, Sakamoto S, Kawachi H, Shimizu F et al (2001) Effects of anti-TGF-beta type II receptor antibody on experimental glomerulonephritis. Kidney Int 60:1745–1755

    Article  CAS  PubMed  Google Scholar 

  • Kato H, Gruenwald A, Suh JH, Miner JH, Barisoni-Thomas L et al (2011) Wnt/beta-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem 286:26003–26015

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kaysen GA, Eiserich JP (2004) The role of oxidative stress-altered lipoprotein structure and function and microinflammation on cardiovascular risk in patients with minor renal dysfunction. J Am Soc Nephrol 15:538–548

    Article  CAS  PubMed  Google Scholar 

  • Kim HJ, Moradi H, Yuan J, Norris K, Vaziri ND (2009) Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney. Am J Physiol Renal Physiol 296:F1297–F1306

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kobashigawa JA, Kasiske BL (1997) Hyperlipidemia in solid organ transplantation. Transplantation 63:331–338

    Article  CAS  PubMed  Google Scholar 

  • Kobori H, Nangaku M, Navar LG, Nishiyama A (2007) The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 59:251–287

    Article  CAS  PubMed  Google Scholar 

  • Koitabashi Y, Ikoma M, Miyahira T, Fujita R, Mio H et al (1990) Long-term follow-up of a paediatric case of lipoprotein glomerulopathy. Pediatr Nephrol 4:122–128

    Article  CAS  PubMed  Google Scholar 

  • Koletsky S (1975) Pathologic findings and laboratory data in a new strain of obese hypertensive rats. Am J Pathol 80:129–142

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kovacs WJ, Tape KN, Shackelford JE, Wikander TM, Richards MJ et al (2009) Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress. J Biol Chem 284:7232–7245

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee HS (1999) Oxidized LDL, glomerular mesangial cells and collagen. Diabetes Res Clin Pract 45:117–122

    Article  CAS  PubMed  Google Scholar 

  • Lee HS, Lee JS, Koh HI, Ko KW (1991) Intraglomerular lipid deposition in routine biopsies. Clin Nephrol 36:67–75

    CAS  PubMed  Google Scholar 

  • Lee HS, Jeong JY, Kim BC, Kim YS, Zhang YZ et al (1997) Dietary antioxidant inhibits lipoprotein oxidation and renal injury in experimental focal segmental glomerulosclerosis. Kidney Int 51:1151–1159

    Article  CAS  PubMed  Google Scholar 

  • Lee PH, Chang HY, Tung CW, Hsu YC, Lei CC et al (2009) Hypertriglyceridemia: an independent risk factor of chronic kidney disease in Taiwanese adults. Am J Med Sci 338:185–189

    Article  PubMed  Google Scholar 

  • Li Y, Qi X, Tong X, Wang S (2013) Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway. Cell Mol Immunol 10:506–512

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu Y (2010) New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 21:212–222

    Article  CAS  PubMed  Google Scholar 

  • Liu Y (2011) Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol 7:684–696

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu Y, Coresh J, Eustace JA, Longenecker JC, Jaar B et al (2004) Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutrition. JAMA 291:451–459

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Yang P, Zuo G, He S, Tan W et al (2018) Long-chain fatty acid activates hepatocytes through CD36 mediated oxidative stress. Lipids Health Dis 17:153

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lowrie EG, Lew NL (1990) Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis 15:458–482

    Article  CAS  PubMed  Google Scholar 

  • Ma Z, Zhu L, Liu Y, Wang Z, Yang Y et al (2017) Lovastatin alleviates endothelial-to-mesenchymal transition in glomeruli via suppression of oxidative stress and TGF-beta1 signaling. Front Pharmacol 8:473

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Malliou F, Andreadou I, Gonzalez FJ, Lazou A, Xepapadaki E et al (2018) The olive constituent oleuropein, as a PPARalpha agonist, markedly reduces serum triglycerides. J Nutr Biochem 59:17–28

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moe SM, Chen NX (2005) Inflammation and vascular calcification. Blood Purif 23:64–71

    Article  PubMed  Google Scholar 

  • Moorhead JF, Chan MK, El-Nahas M, Varghese Z (1982) Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitial disease. Lancet 2:1309–1311

    Article  CAS  PubMed  Google Scholar 

  • Moradi H, Pahl MV, Elahimehr R, Vaziri ND (2009) Impaired antioxidant activity of high-density lipoprotein in chronic kidney disease. Transl Res 153:77–85

    Article  CAS  PubMed  Google Scholar 

  • Muntner P, Coresh J, Smith JC, Eckfeldt J, Klag MJ (2000) Plasma lipids and risk of developing renal dysfunction: the atherosclerosis risk in communities study. Kidney Int 58:293–301

    Article  CAS  PubMed  Google Scholar 

  • Murphy SR, Dahly-Vernon AJ, Dunn KM, Chen CC, Ledbetter SR et al (2012) Renoprotective effects of anti-TGF-beta antibody and antihypertensive therapies in Dahl S rats. Am J Physiol Regul Integr Comp Physiol 303:R57–R69

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nam HK, Lee SJ, Kim MH, Rho JH, Son YK et al (2013) Rosuvastatin attenuates inflammation, apoptosis and fibrosis in a rat model of cyclosporine-induced nephropathy. Am J Nephrol 37:7–15

    Article  CAS  PubMed  Google Scholar 

  • Oberle GP, Niemeyer J, Thaiss F, Schoeppe W, Stahl RA (1992) Increased oxygen radical and eicosanoid formation in immune-mediated mesangial cell injury. Kidney Int 42:69–74

    Article  CAS  PubMed  Google Scholar 

  • Okamura DM, Pennathur S, Pasichnyk K, Lopez-Guisa JM et al (2009) CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD. J Am Soc Nephrol 20:495–505

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pascual M, Theruvath T, Kawai T, Tolkoff-Rubin N, Cosimi AB (2002) Strategies to improve long-term outcomes after renal transplantation. N Engl J Med 346:580–590

    Article  PubMed  Google Scholar 

  • Pennathur S, Pasichnyk K, Bahrami NM, Zeng L, Febbraio M et al (2015) The macrophage phagocytic receptor CD36 promotes fibrogenic pathways on removal of apoptotic cells during chronic kidney injury. Am J Pathol 185:2232–2245

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Peric-Golia L, Peric-Golia M (1983) Aortic and renal lesions in hypercholesterolemic adult, male, virgin sprague-dawley rats. Atherosclerosis 46:57–65

    Article  CAS  PubMed  Google Scholar 

  • Quinn MT, Parthasarathy S, Fong LG, Steinberg D (1987) Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA 84:2995–2998

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rahman MM, Varghese Z, Fuller BJ, Moorhead JF (1999) Renal vasoconstriction induced by oxidized LDL is inhibited by scavengers of reactive oxygen species and l-arginine. Clin Nephrol 51:98–107

    CAS  PubMed  Google Scholar 

  • Reisin E, Ebenezer PJ, Liao J, Lee BS, Larroque M et al (2009) Effect of the HMG-CoA reductase inhibitor rosuvastatin on early chronic kidney injury in obese zucker rats fed with an atherogenic diet. Am J Med Sci 338:301–309

    Article  PubMed  Google Scholar 

  • Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519–529

    Article  CAS  PubMed  Google Scholar 

  • Ruan XZ, Varghese Z, Powis SH, Moorhead JF (1999) Human mesangial cells express inducible macrophage scavenger receptor. Kidney Int 56:440–451

    Article  CAS  PubMed  Google Scholar 

  • Ruggiero C, Elks CM, Kruger C, Cleland E, Addison K et al (2014) Albumin-bound fatty acids but not albumin itself alter redox balance in tubular epithelial cells and induce a peroxide-mediated redox-sensitive apoptosis. Am J Physiol Renal Physiol 306:F896–F906

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Samuelsson O, Attman PO, Knight-Gibson C, Larsson R, Mulec H et al (1998) Complex apolipoprotein B-containing lipoprotein particles are associated with a higher rate of progression of human chronic renal insufficiency. J Am Soc Nephrol 9:1482–1488

    CAS  PubMed  Google Scholar 

  • Sedeek M, Hebert RL, Kennedy CR, Burns KD, Touyz RM (2009) Molecular mechanisms of hypertension: role of Nox family NADPH oxidases. Curr Opin Nephrol Hypertens 18:122–127

    Article  CAS  PubMed  Google Scholar 

  • Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J et al (2010) CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol 11:155–161

    Article  CAS  PubMed  Google Scholar 

  • Stremmel W, Pohl L, Ring A, Herrmann T (2001) A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids. Lipids 36:981–989

    Article  CAS  PubMed  Google Scholar 

  • Surendran K, Schiavi S, Hruska KA (2005) Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 16:2373–2384

    Article  CAS  PubMed  Google Scholar 

  • Tabas I (2002) Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J Clin Invest 110:905–911

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Takemura T, Yoshioka K, Aya N, Murakami K, Matumoto A et al (1993) Apolipoproteins and lipoprotein receptors in glomeruli in human kidney diseases. Kidney Int 43:918–927

    Article  CAS  PubMed  Google Scholar 

  • Tanaka Y, Kume S, Araki S, Isshiki K, Chin-Kanasaki M et al (2011) Fenofibrate, a PPARalpha agonist, has renoprotective effects in mice by enhancing renal lipolysis. Kidney Int 79:871–882

    Article  CAS  PubMed  Google Scholar 

  • Tomiyama-Hanayama M, Rakugi H, Kohara M, Mima T, Adachi Y et al (2009) Effect of interleukin-6 receptor blockage on renal injury in apolipoprotein E-deficient mice. Am J Physiol Renal Physiol 297:F679–F684

    Article  CAS  PubMed  Google Scholar 

  • Tozawa M, Iseki K, Iseki C, Oshiro S, Ikemiya Y et al (2002) Triglyceride, but not total cholesterol or low-density lipoprotein cholesterol levels, predict development of proteinuria. Kidney Int 62:1743–1749

    Article  CAS  PubMed  Google Scholar 

  • Tsuruya K, Yoshida H, Nagata M, Kitazono T, Iseki K et al (2015) Impact of the triglycerides to high-density lipoprotein cholesterol ratio on the incidence and progression of CKD: A longitudinal study in a large Japanese Population. Am J Kidney Dis 66:972–983

    Article  CAS  PubMed  Google Scholar 

  • van Goor H, van der Horst ML, Atmosoerodjo J, Joles JA, van Tol A et al (1993) Renal apolipoproteins in nephrotic rats. Am J Pathol 142:1804–1812

    PubMed  PubMed Central  Google Scholar 

  • van Tienen FH, Laeremans H, van der Kallen CJ, Smeets HJ et al (2009) Wnt5b stimulates adipogenesis by activating PPARgamma, and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5a. Biochem Biophys Res Commun 387:207–211

    Article  PubMed  CAS  Google Scholar 

  • Vaziri ND (2008) Causal link between oxidative stress, inflammation, and hypertension. Iran J Kidney Dis 2:1–10

    PubMed  Google Scholar 

  • Vaziri ND, Moradi H, Pahl MV, Fogelman AM, Navab M (2009) In vitro stimulation of HDL anti-inflammatory activity and inhibition of LDL pro-inflammatory activity in the plasma of patients with end-stage renal disease by an apoA-1 mimetic peptide. Kidney Int 76:437–444

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • von Toerne C, Schmidt C, Adams J, Kiss E, Bedke J et al (2009) Wnt pathway regulation in chronic renal allograft damage. Am J Transplant 9:2223–2239

    Article  CAS  Google Scholar 

  • Wang D, Dai C, Li Y, Liu Y (2011) Canonical Wnt/beta-catenin signaling mediates transforming growth factor-beta1-driven podocyte injury and proteinuria. Kidney Int 80:1159–1169

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang W, He B, Shi W, Liang X, Ma J et al (2012) Deletion of scavenger receptor A protects mice from progressive nephropathy independent of lipid control during diet-induced hyperlipidemia. Kidney Int 81:1002–1014

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wanner C, Ritz E (2008) Reducing lipids for CV protection in CKD patients-current evidence. Kidney Int Suppl S24–S28

    Article  CAS  Google Scholar 

  • Weinberg JM (2006) Lipotoxicity. Kidney Int 70:1560–1566

    Article  CAS  PubMed  Google Scholar 

  • Yakubenko VP, Bhattacharjee A, Pluskota E, Cathcart MK (2011) alphaMbeta(2) integrin activation prevents alternative activation of human and murine macrophages and impedes foam cell formation. Circ Res 108:544–554

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang X, Okamura DM, Lu X, Chen Y, Moorhead J et al (2017) CD36 in chronic kidney disease: novel insights and therapeutic opportunities. Nat Rev Nephrol 13:769–781

    Article  CAS  PubMed  Google Scholar 

  • Zeisberg M, Neilson EG (2009) Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119:1429–1437

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang M, Gao X, Wu J, Liu D, Cai H et al (2010) Oxidized high-density lipoprotein enhances inflammatory activity in rat mesangial cells. Diabetes Metab Res Rev 26:455–463

    Article  CAS  PubMed  Google Scholar 

  • Zhou L, Liu Y (2015) Wnt/beta-catenin signalling and podocyte dysfunction in proteinuric kidney disease. Nat Rev Nephrol 11:535–545

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

“Lipid Nephrotoxicity: New Concept for an Old Disease” was reported by our group in Dyslipidemias in Kidney Disease (Ruan et al. 2014). The related contents are reused with permission.

Author information

Authors and Affiliations

  1. Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University of Medical Science, Chongqing, China

    Xiao-Gang Du & Xiong-Zhong Ruan

Authors
  1. Xiao-Gang Du
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiong-Zhong Ruan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiong-Zhong Ruan .

Editor information

Editors and Affiliations

  1. Zhongda Hospital, Southeast University School of Medicine, Southeast University, Nanjing, Jiangsu, China

    Bi-Cheng Liu

  2. Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, Hong Kong

    Hui-Yao Lan

  3. Zhongda Hospital, Southeast University School of Medicine, Southeast University, Nanjing, Jiangsu, China

    Lin-Li Lv

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Du, XG., Ruan, XZ. (2019). Lipid Metabolism Disorder and Renal Fibrosis. In: Liu, BC., Lan, HY., Lv, LL. (eds) Renal Fibrosis: Mechanisms and Therapies. Advances in Experimental Medicine and Biology, vol 1165. Springer, Singapore. https://doi.org/10.1007/978-981-13-8871-2_26

Download citation

Publish with us

Policies and ethics

Search

Navigation