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Microbial-Based Cancer Therapy: Diagnostic Tools and Therapeutic Strategies

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Microbial Technology for the Welfare of Society

Part of the book series: Microorganisms for Sustainability ((MICRO,volume 17))

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Abstract

It has been more than a century that researchers are focusing on microbial-based cancer treatment and trying to explore novel approaches that can overcome the devastating effects associated with conventional cancer treatments. Great effort has been put to develop live, attenuated, or engineered bacterial strains that can treat cancer by inhibiting or reducing tumor growth. However, uses of bacterial strains have been associated with infections, toxicity, and other harmful effects. Therefore, scientists move toward the idea of using specifically engineered microbial strains and their protein products and compounds that have specific antitumor activity with no or minimal side effects and can be used as antitumor agents. In this way attenuated bacterial strains with embedded foreign genes have been used to convert nontoxic pro-drugs to cytotoxic drugs. Other novel microbial-based cancer treatment modalities include the use of bacterial products like enzymes, proteins, secondary metabolites, and immunotoxins which are capable of targeting cancer cells and reducing/inhibiting their growth either by cell cycle arrest or inducing apoptosis. Current chapter focuses on the available knowledge and future directions regarding microbial-based cancer treatment.

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Authors and Affiliations

  1. Fatima Jinnah Women University, Rawalpindi, Pakistan

    Saima Shakil Malik, Nosheen Masood & Zehra Kazmi

  2. Armed Forces Institute of Pathology, Rawalpindi, Pakistan

    Saima Shakil Malik

  3. Quaid-i-Azam University, Islamabad, Pakistan

    Iffat Fatima

Authors
  1. Saima Shakil Malik
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  2. Nosheen Masood
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  3. Iffat Fatima
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  4. Zehra Kazmi
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Editors and Affiliations

  1. Department of Microbiology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India

    Pankaj Kumar Arora

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Malik, S.S., Masood, N., Fatima, I., Kazmi, Z. (2019). Microbial-Based Cancer Therapy: Diagnostic Tools and Therapeutic Strategies. In: Arora, P. (eds) Microbial Technology for the Welfare of Society. Microorganisms for Sustainability, vol 17. Springer, Singapore. https://doi.org/10.1007/978-981-13-8844-6_3

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