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Oxidative Stress in Heart Diseases pp 39–57Cite as

Oxidative Stress-Driven Cardiotoicity of Cancer Drugs

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Abstract

Despite the recent advances in cancer handling, cytotoxic chemotherapy remains as the main approach for treating patients. These drugs are associated with a variety of acute and long-term side effects, including several levels of cardiac injury. Cardiotoxicity can be found in such patients as subclinical disease – where symptoms are not evidenced but changes can be observed in blood – or clinically symptomatic. The basis of chemotherapy-induced cardiotoxicity is multifactorial, but most of drugs present the same mechanism of damage: the generation of free radicals and redox homeostasis imbalance. In addition, several monoclonal antibodies employed in the personalized medicine against cancer have shown degrees of cardiotoxicity in patients. In this contect, this chapter discusses the main drugs capable to generate oxidative stress during cancer treatment, and highlight the main mechanisms mediated by redox mediators that are involved in cardiac damage.

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Authors and Affiliations

  1. Laboratory of Tumor Biology, State University of West Paraná, Unioeste, Francisco Beltrão, Paraná, Brazil

    Thalita Basso Scandolara, Bruno Ricardo Pires, Rodrigo Kern, Vanessa Jacob Victorino & Carolina Panis

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  1. Thalita Basso Scandolara
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  2. Bruno Ricardo Pires
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  3. Rodrigo Kern
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  4. Vanessa Jacob Victorino
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  5. Carolina Panis
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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Sciences, St Boniface Hospital, Albrechtsen Research Centre, Winnipeg, MB, Canada

    Naranjan S Dhalla

  3. Translational Health Science and Technology (THSTI), Department of Biotechnology, Faridabad, India

    Nirmal K Ganguly

  4. Translational Health Science and Technology (THSTI), Department of Biotechnology, Faridabad, India

    Madhu Dikshit

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Scandolara, T.B., Pires, B.R., Kern, R., Victorino, V.J., Panis, C. (2019). Oxidative Stress-Driven Cardiotoicity of Cancer Drugs. In: Chakraborti, S., Dhalla, N., Ganguly, N., Dikshit, M. (eds) Oxidative Stress in Heart Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8273-4_3

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